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TRPC3 determines osmosensitive [Ca2+]i signaling in the collecting duct and contributes to urinary concentration.

Tomilin VN, Mamenko M, Zaika O, Ren G, Marrelli SP, Birnbaumer L, Pochynyuk O.

PLoS One. 2019 Dec 18;14(12):e0226381. doi: 10.1371/journal.pone.0226381. eCollection 2019.


Thymopentin ameliorates dextran sulfate sodium-induced colitis by triggering the production of IL-22 in both innate and adaptive lymphocytes.

Cao Q, Gao X, Lin Y, Yue C, Wang Y, Quan F, Zhang Z, Liu X, Lu Y, Zhan Y, Yang H, Li X, Qin D, Birnbaumer L, Hao K, Yang Y.

Theranostics. 2019 Oct 12;9(25):7490-7505. doi: 10.7150/thno.35015. eCollection 2019.


Heteromeric TRPV4/TRPC1 channels mediate calcium-sensing receptor-induced relaxations and nitric oxide production in mesenteric arteries: comparative study using wild-type and TRPC1-/- mice.

Greenberg HZE, Carlton-Carew SRE, Zargaran AK, Jahan KS, Birnbaumer L, Albert AP.

Channels (Austin). 2019 Dec;13(1):410-423. doi: 10.1080/19336950.2019.1673131. Epub 2019 Oct 11.


TRPC6 Binds to and Activates Calpain, Independent of Its Channel Activity, and Regulates Podocyte Cytoskeleton, Cell Adhesion, and Motility.

Farmer LK, Rollason R, Whitcomb DJ, Ni L, Goodliff A, Lay AC, Birnbaumer L, Heesom KJ, Xu SZ, Saleem MA, Welsh GI.

J Am Soc Nephrol. 2019 Oct;30(10):1910-1924. doi: 10.1681/ASN.2018070729. Epub 2019 Aug 15.


Deletion of the α subunit of the heterotrimeric Go protein impairs cerebellar cortical development in mice.

Cha HL, Choi JM, Oh HH, Bashyal N, Kim SS, Birnbaumer L, Suh-Kim H.

Mol Brain. 2019 Jun 20;12(1):57. doi: 10.1186/s13041-019-0477-9.


TRPC6 regulates phenotypic switching of vascular smooth muscle cells through plasma membrane potential-dependent coupling with PTEN.

Numaga-Tomita T, Shimauchi T, Oda S, Tanaka T, Nishiyama K, Nishimura A, Birnbaumer L, Mori Y, Nishida M.

FASEB J. 2019 Sep;33(9):9785-9796. doi: 10.1096/fj.201802811R. Epub 2019 Jun 4.


TRPC channels are not required for graded persistent activity in entorhinal cortex neurons.

Egorov AV, Schumacher D, Medert R, Birnbaumer L, Freichel M, Draguhn A.

Hippocampus. 2019 Nov;29(11):1038-1048. doi: 10.1002/hipo.23094. Epub 2019 Apr 19.


Lipid-independent control of endothelial and neuronal TRPC3 channels by light.

Tiapko O, Shrestha N, Lindinger S, Guedes de la Cruz G, Graziani A, Klec C, Butorac C, Graier WF, Kubista H, Freichel M, Birnbaumer L, Romanin C, Glasnov T, Groschner K.

Chem Sci. 2019 Jan 15;10(9):2837-2842. doi: 10.1039/c8sc05536j. eCollection 2019 Mar 7.


Evidence for a regulated Ca2+ entry in proximal tubular cells and its implication in calcium stone formation.

Ibeh CL, Yiu AJ, Kanaras YL, Paal E, Birnbaumer L, Jose PA, Bandyopadhyay BC.

J Cell Sci. 2019 Apr 30;132(9). pii: jcs225268. doi: 10.1242/jcs.225268.


GNAI1 and GNAI3 Reduce Colitis-Associated Tumorigenesis in Mice by Blocking IL6 Signaling and Down-regulating Expression of GNAI2.

Li ZW, Sun B, Gong T, Guo S, Zhang J, Wang J, Sugawara A, Jiang M, Yan J, Gurary A, Zheng X, Gao B, Xiao SY, Chen W, Ma C, Farrar C, Zhu C, Chan OTM, Xin C, Winnicki A, Winnicki J, Tang M, Park R, Winnicki M, Diener K, Wang Z, Liu Q, Chu CH, Arter ZL, Yue P, Alpert L, Hui GS, Fei P, Turkson J, Yang W, Wu G, Tao A, Ramos JW, Moisyadi S, Holcombe RF, Jia W, Birnbaumer L, Zhou X, Chu WM.

Gastroenterology. 2019 Jun;156(8):2297-2312. doi: 10.1053/j.gastro.2019.02.040. Epub 2019 Mar 2.


Central role of G protein Gαi2 and Gαi2+ vomeronasal neurons in balancing territorial and infant-directed aggression of male mice.

Trouillet AC, Keller M, Weiss J, Leinders-Zufall T, Birnbaumer L, Zufall F, Chamero P.

Proc Natl Acad Sci U S A. 2019 Mar 12;116(11):5135-5143. doi: 10.1073/pnas.1821492116. Epub 2019 Feb 25.


Transient Receptor Potential Canonical 3 and Nuclear Factor of Activated T Cells C3 Signaling Pathway Critically Regulates Myocardial Fibrosis.

Saliba Y, Jebara V, Hajal J, Maroun R, Chacar S, Smayra V, Abramowitz J, Birnbaumer L, Farès N.

Antioxid Redox Signal. 2019 Jun 1;30(16):1851-1879. doi: 10.1089/ars.2018.7545. Epub 2018 Nov 29.


M1 Macrophage Polarization Is Dependent on TRPC1-Mediated Calcium Entry.

Chauhan A, Sun Y, Sukumaran P, Quenum Zangbede FO, Jondle CN, Sharma A, Evans DL, Chauhan P, Szlabick RE, Aaland MO, Birnbaumer L, Sharma J, Singh BB, Mishra BB.

iScience. 2018 Oct 26;8:85-102. doi: 10.1016/j.isci.2018.09.014. Epub 2018 Sep 20.


Transient receptor potential channel 6 knockdown prevents apoptosis of renal tubular epithelial cells upon oxidative stress via autophagy activation.

Hou X, Xiao H, Zhang Y, Zeng X, Huang M, Chen X, Birnbaumer L, Liao Y.

Cell Death Dis. 2018 Oct 3;9(10):1015. doi: 10.1038/s41419-018-1052-5.


Heterotrimeric G-protein subunit Gαi2 contributes to agonist-sensitive apoptosis and degranulation in murine platelets.

Cao H, Qadri SM, Lang E, Pelzl L, Umbach AT, Leiss V, Birnbaumer L, Nürnberg B, Pieske B, Voelkl J, Gawaz M, Bissinger R, Lang F.

Physiol Rep. 2018 Sep;6(17):e13841. doi: 10.14814/phy2.13841.


Melanopsin Phototransduction Is Repurposed by ipRGC Subtypes to Shape the Function of Distinct Visual Circuits.

Sonoda T, Lee SK, Birnbaumer L, Schmidt TM.

Neuron. 2018 Aug 22;99(4):754-767.e4. doi: 10.1016/j.neuron.2018.06.032. Epub 2018 Jul 12.


Gαi Proteins are Indispensable for Hearing.

Beer-Hammer S, Lee SC, Mauriac SA, Leiss V, Groh IAM, Novakovic A, Piekorz RP, Bucher K, Chen C, Ni K, Singer W, Harasztosi C, Schimmang T, Zimmermann U, Pfeffer K, Birnbaumer L, Forge A, Montcouquiol M, Knipper M, Nürnberg B, Rüttiger L.

Cell Physiol Biochem. 2018;47(4):1509-1532. doi: 10.1159/000490867. Epub 2018 Jun 21.


A NOX4/TRPC6 Pathway in Podocyte Calcium Regulation and Renal Damage in Diabetic Kidney Disease.

Ilatovskaya DV, Blass G, Palygin O, Levchenko V, Pavlov TS, Grzybowski MN, Winsor K, Shuyskiy LS, Geurts AM, Cowley AW Jr, Birnbaumer L, Staruschenko A.

J Am Soc Nephrol. 2018 Jul;29(7):1917-1927. doi: 10.1681/ASN.2018030280. Epub 2018 May 23.


Balance of Go1α and Go2α expression regulates motor function via the striatal dopaminergic system.

Baron J, Bilbao A, Hörtnagl H, Birnbaumer L, Leixner S, Spanagel R, Ahnert-Hilger G, Brunk I.

J Neurochem. 2018 Aug;146(4):374-389. doi: 10.1111/jnc.14460. Epub 2018 Aug 1.


Regional Heterogeneity of D2-Receptor Signaling in the Dorsal Striatum and Nucleus Accumbens.

Marcott PF, Gong S, Donthamsetti P, Grinnell SG, Nelson MN, Newman AH, Birnbaumer L, Martemyanov KA, Javitch JA, Ford CP.

Neuron. 2018 May 2;98(3):575-587.e4. doi: 10.1016/j.neuron.2018.03.038. Epub 2018 Apr 12.


Chronic stress promotes colitis by disturbing the gut microbiota and triggering immune system response.

Gao X, Cao Q, Cheng Y, Zhao D, Wang Z, Yang H, Wu Q, You L, Wang Y, Lin Y, Li X, Wang Y, Bian JS, Sun D, Kong L, Birnbaumer L, Yang Y.

Proc Natl Acad Sci U S A. 2018 Mar 27;115(13):E2960-E2969. doi: 10.1073/pnas.1720696115. Epub 2018 Mar 12. Erratum in: Proc Natl Acad Sci U S A. 2018 Apr 30;:.


Depression promotes prostate cancer invasion and metastasis via a sympathetic-cAMP-FAK signaling pathway.

Cheng Y, Gao XH, Li XJ, Cao QH, Zhao DD, Zhou JR, Wu HX, Wang Y, You LJ, Yang HB, He YL, Li YR, Bian JS, Zhu QY, Birnbaumer L, Yang Y.

Oncogene. 2018 May;37(22):2953-2966. doi: 10.1038/s41388-018-0177-4. Epub 2018 Mar 8.


Antidepression action of BDNF requires and is mimicked by Gαi1/3 expression in the hippocampus.

Marshall J, Zhou XZ, Chen G, Yang SQ, Li Y, Wang Y, Zhang ZQ, Jiang Q, Birnbaumer L, Cao C.

Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):E3549-E3558. doi: 10.1073/pnas.1722493115. Epub 2018 Mar 5.


Inhibition of TRPC1-Dependent Store-Operated Calcium Entry Improves Synaptic Stability and Motor Performance in a Mouse Model of Huntington's Disease.

Wu J, Ryskamp D, Birnbaumer L, Bezprozvanny I.

J Huntingtons Dis. 2018;7(1):35-50. doi: 10.3233/JHD-170266.


TRPC proteins contribute to development of diabetic retinopathy and regulate glyoxalase 1 activity and methylglyoxal accumulation.

Sachdeva R, Schlotterer A, Schumacher D, Matka C, Mathar I, Dietrich N, Medert R, Kriebs U, Lin J, Nawroth P, Birnbaumer L, Fleming T, Hammes HP, Freichel M.

Mol Metab. 2018 Mar;9:156-167. doi: 10.1016/j.molmet.2018.01.003. Epub 2018 Jan 5.


Differential effects of inhibitory G protein isoforms on G protein-gated inwardly rectifying K+ currents in adult murine atria.

Nobles M, Montaigne D, Sebastian S, Birnbaumer L, Tinker A.

Am J Physiol Cell Physiol. 2018 May 1;314(5):C616-C626. doi: 10.1152/ajpcell.00271.2016. Epub 2018 Jan 17.


Deletion of diacylglycerol-responsive TRPC genes attenuates diabetic nephropathy by inhibiting activation of the TGFβ1 signaling pathway.

Liu B, He X, Li S, Xu B, Birnbaumer L, Liao Y.

Am J Transl Res. 2017 Dec 15;9(12):5619-5630. eCollection 2017.


Reduced calcification and osteogenic features in advanced atherosclerotic plaques of mice with macrophage-specific loss of TRPC3.

Dube PR, Chikkamenahalli LL, Birnbaumer L, Vazquez G.

Atherosclerosis. 2018 Mar;270:199-204. doi: 10.1016/j.atherosclerosis.2017.12.025. Epub 2017 Dec 22.


Integration of TRPC6 and NADPH oxidase activation in lysophosphatidylcholine-induced TRPC5 externalization.

Chaudhuri P, Rosenbaum MA, Birnbaumer L, Graham LM.

Am J Physiol Cell Physiol. 2017 Nov 1;313(5):C541-C555. doi: 10.1152/ajpcell.00028.2017. Epub 2017 Aug 23.


TRPC6 counteracts TRPC3-Nox2 protein complex leading to attenuation of hyperglycemia-induced heart failure in mice.

Oda S, Numaga-Tomita T, Kitajima N, Toyama T, Harada E, Shimauchi T, Nishimura A, Ishikawa T, Kumagai Y, Birnbaumer L, Nishida M.

Sci Rep. 2017 Aug 8;7(1):7511. doi: 10.1038/s41598-017-07903-4.


Evidence for constitutive bone morphogenetic protein-2 secretion by M1 macrophages: Constitutive auto/paracrine osteogenic signaling by BMP-2 in M1 macrophages.

Dube PR, Birnbaumer L, Vazquez G.

Biochem Biophys Res Commun. 2017 Sep 9;491(1):154-158. doi: 10.1016/j.bbrc.2017.07.065. Epub 2017 Jul 12.


Increased glomerular filtration rate and impaired contractile function of mesangial cells in TRPC6 knockout mice.

Li W, Ding Y, Smedley C, Wang Y, Chaudhari S, Birnbaumer L, Ma R.

Sci Rep. 2017 Jun 23;7(1):4145. doi: 10.1038/s41598-017-04067-z.


TRPC1- and TRPC3-dependent Ca2+ signaling in mouse cortical astrocytes affects injury-evoked astrogliosis in vivo.

Belkacemi T, Niermann A, Hofmann L, Wissenbach U, Birnbaumer L, Leidinger P, Backes C, Meese E, Keller A, Bai X, Scheller A, Kirchhoff F, Philipp SE, Weissgerber P, Flockerzi V, Beck A.

Glia. 2017 Sep;65(9):1535-1549. doi: 10.1002/glia.23180. Epub 2017 Jun 21.


Corrigendum to "TRPC3 channels critically regulate hippocampal excitability and contextual fear memory" Behav. Brain Res. 281(March) 2015, 69-77.

Neuner SM, Wilmott LA, Hope KA, Hoffmann B, Chong JA, Abramowitz J, Birnbaumer L, O'Connell K, Tryba AK, Greene AS, Chan CS, Kaczorowski CC.

Behav Brain Res. 2017 Aug 14;332:379. doi: 10.1016/j.bbr.2017.05.038. Epub 2017 May 30. No abstract available.


Major contribution of the 3/6/7 class of TRPC channels to myocardial ischemia/reperfusion and cellular hypoxia/reoxygenation injuries.

He X, Li S, Liu B, Susperreguy S, Formoso K, Yao J, Kang J, Shi A, Birnbaumer L, Liao Y.

Proc Natl Acad Sci U S A. 2017 Jun 6;114(23):E4582-E4591. doi: 10.1073/pnas.1621384114. Epub 2017 May 19.


Evidence that Orai1 does not contribute to store-operated TRPC1 channels in vascular smooth muscle cells.

Shi J, Miralles F, Kinet JP, Birnbaumer L, Large WA, Albert AP.

Channels (Austin). 2017 Jul 4;11(4):329-339. doi: 10.1080/19336950.2017.1303025. Epub 2017 Mar 16.


Does Erythropoietin Regulate TRPC Channels in Red Blood Cells?

Danielczok J, Hertz L, Ruppenthal S, Kaiser E, Petkova-Kirova P, Bogdanova A, Krause E, Lipp P, Freichel M, Kaestner L, Birnbaumer L.

Cell Physiol Biochem. 2017;41(3):1219-1228. doi: 10.1159/000464384. Epub 2017 Mar 6.


Inhibition of L-Type Ca2+ Channels by TRPC1-STIM1 Complex Is Essential for the Protection of Dopaminergic Neurons.

Sun Y, Zhang H, Selvaraj S, Sukumaran P, Lei S, Birnbaumer L, Singh BB.

J Neurosci. 2017 Mar 22;37(12):3364-3377. doi: 10.1523/JNEUROSCI.3010-16.2017. Epub 2017 Mar 3.


TRPC3 participates in angiotensin II type 1 receptor-dependent stress-induced slow increase in intracellular Ca2+ concentration in mouse cardiomyocytes.

Yamaguchi Y, Iribe G, Kaneko T, Takahashi K, Numaga-Tomita T, Nishida M, Birnbaumer L, Naruse K.

J Physiol Sci. 2018 Mar;68(2):153-164. doi: 10.1007/s12576-016-0519-3. Epub 2017 Jan 19.


Soluble klotho binds monosialoganglioside to regulate membrane microdomains and growth factor signaling.

Dalton G, An SW, Al-Juboori SI, Nischan N, Yoon J, Dobrinskikh E, Hilgemann DW, Xie J, Luby-Phelps K, Kohler JJ, Birnbaumer L, Huang CL.

Proc Natl Acad Sci U S A. 2017 Jan 24;114(4):752-757. doi: 10.1073/pnas.1620301114. Epub 2017 Jan 9.


Deep Transcriptomic Profiling of M1 Macrophages Lacking Trpc3.

Kumarasamy S, Solanki S, Atolagbe OT, Joe B, Birnbaumer L, Vazquez G.

Sci Rep. 2017 Jan 4;7:39867. doi: 10.1038/srep39867.


TRPC3 channels play a critical role in the theta component of pilocarpine-induced status epilepticus in mice.

Phelan KD, Shwe UT, Cozart MA, Wu H, Mock MM, Abramowitz J, Birnbaumer L, Zheng F.

Epilepsia. 2017 Feb;58(2):247-254. doi: 10.1111/epi.13648. Epub 2016 Dec 24.


TRPC3-GEF-H1 axis mediates pressure overload-induced cardiac fibrosis.

Numaga-Tomita T, Kitajima N, Kuroda T, Nishimura A, Miyano K, Yasuda S, Kuwahara K, Sato Y, Ide T, Birnbaumer L, Sumimoto H, Mori Y, Nishida M.

Sci Rep. 2016 Dec 19;6:39383. doi: 10.1038/srep39383.


Inhibition of TRPC6 channels ameliorates renal fibrosis and contributes to renal protection by soluble klotho.

Wu YL, Xie J, An SW, Oliver N, Barrezueta NX, Lin MH, Birnbaumer L, Huang CL.

Kidney Int. 2017 Apr;91(4):830-841. doi: 10.1016/j.kint.2016.09.039. Epub 2016 Dec 12.


Transient Receptor Potential Canonical 3 (TRPC3) Channels Are Required for Hypothalamic Glucose Detection and Energy Homeostasis.

Chrétien C, Fenech C, Liénard F, Grall S, Chevalier C, Chaudy S, Brenachot X, Berges R, Louche K, Stark R, Nédélec E, Laderrière A, Andrews ZB, Benani A, Flockerzi V, Gascuel J, Hartmann J, Moro C, Birnbaumer L, Leloup C, Pénicaud L, Fioramonti X.

Diabetes. 2017 Feb;66(2):314-324. doi: 10.2337/db16-1114. Epub 2016 Nov 29.


TRPC3 positively regulates reactive oxygen species driving maladaptive cardiac remodeling.

Kitajima N, Numaga-Tomita T, Watanabe M, Kuroda T, Nishimura A, Miyano K, Yasuda S, Kuwahara K, Sato Y, Ide T, Birnbaumer L, Sumimoto H, Mori Y, Nishida M.

Sci Rep. 2016 Nov 11;6:37001. doi: 10.1038/srep37001.


TRPC3/6/7 Knockdown Protects the Brain from Cerebral Ischemia Injury via Astrocyte Apoptosis Inhibition and Effects on NF-кB Translocation.

Chen X, Lu M, He X, Ma L, Birnbaumer L, Liao Y.

Mol Neurobiol. 2017 Dec;54(10):7555-7566. doi: 10.1007/s12035-016-0227-2. Epub 2016 Nov 8.


Store-operated interactions between plasmalemmal STIM1 and TRPC1 proteins stimulate PLCβ1 to induce TRPC1 channel activation in vascular smooth muscle cells.

Shi J, Miralles F, Birnbaumer L, Large WA, Albert AP.

J Physiol. 2017 Feb 15;595(4):1039-1058. doi: 10.1113/JP273302. Epub 2016 Dec 7.


Development of the main olfactory system and main olfactory epithelium-dependent male mating behavior are altered in Go-deficient mice.

Choi JM, Kim SS, Choi CI, Cha HL, Oh HH, Ghil S, Lee YD, Birnbaumer L, Suh-Kim H.

Proc Natl Acad Sci U S A. 2016 Sep 27;113(39):10974-9. doi: 10.1073/pnas.1613026113. Epub 2016 Sep 13.

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