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Items: 1 to 50 of 239

1.

Memory CD8+ T Cells Use Cell-Intrinsic Lipolysis to Support the Metabolic Programming Necessary for Development.

O'Sullivan D, van der Windt GJW, Huang SC, Curtis JD, Chang CH, Buck MD, Qiu J, Smith AM, Lam WY, DiPlato LM, Hsu FF, Birnbaum MJ, Pearce EJ, Pearce EL.

Immunity. 2018 Aug 21;49(2):375-376. doi: 10.1016/j.immuni.2018.07.018. No abstract available.

2.

Publisher Correction: Targeting hepatic glutaminase activity to ameliorate hyperglycemia.

Miller RA, Shi Y, Lu W, Pirman DA, Jatkar A, Blatnik M, Wu H, Cárdenas C, Wan M, Foskett JK, Park JO, Zhang Y, Holland WL, Rabinowitz JD, Birnbaum MJ.

Nat Med. 2018 Sep;24(9):1482. doi: 10.1038/s41591-018-0047-1.

PMID:
29895835
3.

Activation of Liver AMPK with PF-06409577 Corrects NAFLD and Lowers Cholesterol in Rodent and Primate Preclinical Models.

Esquejo RM, Salatto CT, Delmore J, Albuquerque B, Reyes A, Shi Y, Moccia R, Cokorinos E, Peloquin M, Monetti M, Barricklow J, Bollinger E, Smith BK, Day EA, Nguyen C, Geoghegan KF, Kreeger JM, Opsahl A, Ward J, Kalgutkar AS, Tess D, Butler L, Shirai N, Osborne TF, Steinberg GR, Birnbaum MJ, Cameron KO, Miller RA.

EBioMedicine. 2018 May;31:122-132. doi: 10.1016/j.ebiom.2018.04.009. Epub 2018 Apr 8.

4.

Targeting hepatic glutaminase activity to ameliorate hyperglycemia.

Miller RA, Shi Y, Lu W, Pirman DA, Jatkar A, Blatnik M, Wu H, Cárdenas C, Wan M, Foskett JK, Park JO, Zhang Y, Holland WL, Rabinowitz JD, Birnbaum MJ.

Nat Med. 2018 May;24(4):518-524. doi: 10.1038/nm.4514. Epub 2018 Mar 26. Erratum in: Nat Med. 2018 Jun 12;:.

5.

Innate Immune Signaling in Drosophila Blocks Insulin Signaling by Uncoupling PI(3,4,5)P3 Production and Akt Activation.

Roth SW, Bitterman MD, Birnbaum MJ, Bland ML.

Cell Rep. 2018 Mar 6;22(10):2550-2556. doi: 10.1016/j.celrep.2018.02.033.

6.

The Small Intestine Converts Dietary Fructose into Glucose and Organic Acids.

Jang C, Hui S, Lu W, Cowan AJ, Morscher RJ, Lee G, Liu W, Tesz GJ, Birnbaum MJ, Rabinowitz JD.

Cell Metab. 2018 Feb 6;27(2):351-361.e3. doi: 10.1016/j.cmet.2017.12.016.

PMID:
29414685
7.

Hepatic Gi signaling regulates whole-body glucose homeostasis.

Rossi M, Zhu L, McMillin SM, Pydi SP, Jain S, Wang L, Cui Y, Lee RJ, Cohen AH, Kaneto H, Birnbaum MJ, Ma Y, Rotman Y, Liu J, Cyphert TJ, Finkel T, McGuinness OP, Wess J.

J Clin Invest. 2018 Feb 1;128(2):746-759. doi: 10.1172/JCI94505. Epub 2018 Jan 16.

8.

mTORC1 stimulates phosphatidylcholine synthesis to promote triglyceride secretion.

Quinn WJ 3rd, Wan M, Shewale SV, Gelfer R, Rader DJ, Birnbaum MJ, Titchenell PM.

J Clin Invest. 2017 Nov 1;127(11):4207-4215. doi: 10.1172/JCI96036. Epub 2017 Oct 16.

9.

Selective Targeting of Bromodomains of the Bromodomain-PHD Fingers Family Impairs Osteoclast Differentiation.

Meier JC, Tallant C, Fedorov O, Witwicka H, Hwang SY, van Stiphout RG, Lambert JP, Rogers C, Yapp C, Gerstenberger BS, Fedele V, Savitsky P, Heidenreich D, Daniels DL, Owen DR, Fish PV, Igoe NM, Bayle ED, Haendler B, Oppermann UCT, Buffa F, Brennan PE, Müller S, Gingras AC, Odgren PR, Birnbaum MJ, Knapp S.

ACS Chem Biol. 2017 Oct 20;12(10):2619-2630. doi: 10.1021/acschembio.7b00481. Epub 2017 Sep 12.

10.

Unraveling the Regulation of Hepatic Metabolism by Insulin.

Titchenell PM, Lazar MA, Birnbaum MJ.

Trends Endocrinol Metab. 2017 Jul;28(7):497-505. doi: 10.1016/j.tem.2017.03.003. Epub 2017 Apr 14. Review.

11.

Selective Activation of AMPK β1-Containing Isoforms Improves Kidney Function in a Rat Model of Diabetic Nephropathy.

Salatto CT, Miller RA, Cameron KO, Cokorinos E, Reyes A, Ward J, Calabrese MF, Kurumbail RG, Rajamohan F, Kalgutkar AS, Tess DA, Shavnya A, Genung NE, Edmonds DJ, Jatkar A, Maciejewski BS, Amaro M, Gandhok H, Monetti M, Cialdea K, Bollinger E, Kreeger JM, Coskran TM, Opsahl AC, Boucher GG, Birnbaum MJ, DaSilva-Jardine P, Rolph T.

J Pharmacol Exp Ther. 2017 May;361(2):303-311. doi: 10.1124/jpet.116.237925. Epub 2017 Mar 13.

12.

Pharma and Academia: What We Have Here Is a Failure to Communicate.

Birnbaum MJ.

Cell Metab. 2016 Sep 13;24(3):365-367. doi: 10.1016/j.cmet.2016.08.026.

13.

SREBP1c-CRY1 signalling represses hepatic glucose production by promoting FOXO1 degradation during refeeding.

Jang H, Lee GY, Selby CP, Lee G, Jeon YG, Lee JH, Cheng KK, Titchenell P, Birnbaum MJ, Xu A, Sancar A, Kim JB.

Nat Commun. 2016 Jul 14;7:12180. doi: 10.1038/ncomms12180.

14.

Lack of AKT in adipocytes causes severe lipodystrophy.

Shearin AL, Monks BR, Seale P, Birnbaum MJ.

Mol Metab. 2016 May 13;5(7):472-479. doi: 10.1016/j.molmet.2016.05.006. eCollection 2016 Jul.

15.

Direct Hepatocyte Insulin Signaling Is Required for Lipogenesis but Is Dispensable for the Suppression of Glucose Production.

Titchenell PM, Quinn WJ, Lu M, Chu Q, Lu W, Li C, Chen H, Monks BR, Chen J, Rabinowitz JD, Birnbaum MJ.

Cell Metab. 2016 Jun 14;23(6):1154-1166. doi: 10.1016/j.cmet.2016.04.022. Epub 2016 May 26.

16.

Insulin-Dependent Regulation of mTORC2-Akt-FoxO Suppresses TLR4 Signaling in Human Leukocytes: Relevance to Type 2 Diabetes.

Zhang Z, Amorosa LF, Coyle SM, Macor MA, Birnbaum MJ, Lee LY, Haimovich B.

Diabetes. 2016 Aug;65(8):2224-34. doi: 10.2337/db16-0027. Epub 2016 May 10.

17.

Glucagon: acute actions on hepatic metabolism.

Miller RA, Birnbaum MJ.

Diabetologia. 2016 Jul;59(7):1376-1381. doi: 10.1007/s00125-016-3955-y. Epub 2016 Apr 26. Review.

PMID:
27115415
18.

Spontaneous Hepatocellular Carcinoma after the Combined Deletion of Akt Isoforms.

Wang Q, Yu WN, Chen X, Peng XD, Jeon SM, Birnbaum MJ, Guzman G, Hay N.

Cancer Cell. 2016 Apr 11;29(4):523-535. doi: 10.1016/j.ccell.2016.02.008. Epub 2016 Mar 17.

19.

Insulin Is Required to Maintain Albumin Expression by Inhibiting Forkhead Box O1 Protein.

Chen Q, Lu M, Monks BR, Birnbaum MJ.

J Biol Chem. 2016 Jan 29;291(5):2371-8. doi: 10.1074/jbc.M115.677351. Epub 2015 Dec 14.

20.

Akt-mediated foxo1 inhibition is required for liver regeneration.

Pauta M, Rotllan N, Fernández-Hernando A, Langhi C, Ribera J, Lu M, Boix L, Bruix J, Jimenez W, Suárez Y, Ford DA, Baldán A, Birnbaum MJ, Morales-Ruiz M, Fernández-Hernando C.

Hepatology. 2016 May;63(5):1660-74. doi: 10.1002/hep.28286. Epub 2015 Dec 18.

21.

Proteolytic Cleavage of AMPKα and Intracellular MMP9 Expression Are Both Required for TLR4-Mediated mTORC1 Activation and HIF-1α Expression in Leukocytes.

Zhang Z, Amorosa LF, Coyle SM, Macor MA, Lubitz SE, Carson JL, Birnbaum MJ, Lee LY, Haimovich B.

J Immunol. 2015 Sep 1;195(5):2452-60. doi: 10.4049/jimmunol.1500944. Epub 2015 Jul 31.

22.

mTORC1 Down-Regulates Cyclin-Dependent Kinase 8 (CDK8) and Cyclin C (CycC).

Feng D, Youn DY, Zhao X, Gao Y, Quinn WJ 3rd, Xiaoli AM, Sun Y, Birnbaum MJ, Pessin JE, Yang F.

PLoS One. 2015 Jun 4;10(6):e0126240. doi: 10.1371/journal.pone.0126240. eCollection 2015.

23.

Studies of OC-STAMP in Osteoclast Fusion: A New Knockout Mouse Model, Rescue of Cell Fusion, and Transmembrane Topology.

Witwicka H, Hwang SY, Reyes-Gutierrez P, Jia H, Odgren PE, Donahue LR, Birnbaum MJ, Odgren PR.

PLoS One. 2015 Jun 4;10(6):e0128275. doi: 10.1371/journal.pone.0128275. eCollection 2015.

24.

The Role of PDE3B Phosphorylation in the Inhibition of Lipolysis by Insulin.

DiPilato LM, Ahmad F, Harms M, Seale P, Manganiello V, Birnbaum MJ.

Mol Cell Biol. 2015 Aug;35(16):2752-60. doi: 10.1128/MCB.00422-15. Epub 2015 Jun 1.

25.

Phosphorylation of GATA-6 is required for vascular smooth muscle cell differentiation after mTORC1 inhibition.

Xie Y, Jin Y, Merenick BL, Ding M, Fetalvero KM, Wagner RJ, Mai A, Gleim S, Tucker DF, Birnbaum MJ, Ballif BA, Luciano AK, Sessa WC, Rzucidlo EM, Powell RJ, Hou L, Zhao H, Hwa J, Yu J, Martin KA.

Sci Signal. 2015 May 12;8(376):ra44. doi: 10.1126/scisignal.2005482.

26.

Hepatic insulin signalling is dispensable for suppression of glucose output by insulin in vivo.

Titchenell PM, Chu Q, Monks BR, Birnbaum MJ.

Nat Commun. 2015 May 12;6:7078. doi: 10.1038/ncomms8078.

27.

The role of mouse Akt2 in insulin-dependent suppression of adipocyte lipolysis in vivo.

Koren S, DiPilato LM, Emmett MJ, Shearin AL, Chu Q, Monks B, Birnbaum MJ.

Diabetologia. 2015 May;58(5):1063-70. doi: 10.1007/s00125-015-3532-9. Epub 2015 Mar 5.

28.

Oxalic acid and diacylglycerol 36:3 are cross-species markers of sleep debt.

Weljie AM, Meerlo P, Goel N, Sengupta A, Kayser MS, Abel T, Birnbaum MJ, Dinges DF, Sehgal A.

Proc Natl Acad Sci U S A. 2015 Feb 24;112(8):2569-74. doi: 10.1073/pnas.1417432112. Epub 2015 Feb 9.

29.

Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes.

Perry RJ, Camporez JG, Kursawe R, Titchenell PM, Zhang D, Perry CJ, Jurczak MJ, Abudukadier A, Han MS, Zhang XM, Ruan HB, Yang X, Caprio S, Kaech SM, Sul HS, Birnbaum MJ, Davis RJ, Cline GW, Petersen KF, Shulman GI.

Cell. 2015 Feb 12;160(4):745-758. doi: 10.1016/j.cell.2015.01.012. Epub 2015 Feb 5.

30.

The Polycomb protein, Bmi1, regulates insulin sensitivity.

Cannon CE, Titchenell PM, Groff DN, El Ouaamari A, Kulkarni RN, Birnbaum MJ, Stoffers DA.

Mol Metab. 2014 Aug 27;3(8):794-802. doi: 10.1016/j.molmet.2014.08.002. eCollection 2014 Nov.

31.

Akt recruits Dab2 to albumin endocytosis in the proximal tubule.

Koral K, Li H, Ganesh N, Birnbaum MJ, Hallows KR, Erkan E.

Am J Physiol Renal Physiol. 2014 Dec 15;307(12):F1380-9. doi: 10.1152/ajprenal.00454.2014. Epub 2014 Sep 24.

32.

Control of gluconeogenesis by metformin: does redox trump energy charge?

Baur JA, Birnbaum MJ.

Cell Metab. 2014 Aug 5;20(2):197-9. doi: 10.1016/j.cmet.2014.07.013.

33.

The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver.

Patel K, Foretz M, Marion A, Campbell DG, Gourlay R, Boudaba N, Tournier E, Titchenell P, Peggie M, Deak M, Wan M, Kaestner KH, Göransson O, Viollet B, Gray NS, Birnbaum MJ, Sutherland C, Sakamoto K.

Nat Commun. 2014 Aug 4;5:4535. doi: 10.1038/ncomms5535.

34.

Memory CD8(+) T cells use cell-intrinsic lipolysis to support the metabolic programming necessary for development.

O'Sullivan D, van der Windt GJ, Huang SC, Curtis JD, Chang CH, Buck MD, Qiu J, Smith AM, Lam WY, DiPlato LM, Hsu FF, Birnbaum MJ, Pearce EJ, Pearce EL.

Immunity. 2014 Jul 17;41(1):75-88. doi: 10.1016/j.immuni.2014.06.005. Epub 2014 Jul 4. Erratum in: Immunity. 2018 Aug 21;49(2):375-376.

35.

Rapamycin induces mitogen-activated protein (MAP) kinase phosphatase-1 (MKP-1) expression through activation of protein kinase B and mitogen-activated protein kinase kinase pathways.

Rastogi R, Jiang Z, Ahmad N, Rosati R, Liu Y, Beuret L, Monks R, Charron J, Birnbaum MJ, Samavati L.

J Biol Chem. 2013 Nov 22;288(47):33966-77. doi: 10.1074/jbc.M113.492702. Epub 2013 Oct 14.

36.

A noncanonical, GSK3-independent pathway controls postprandial hepatic glycogen deposition.

Wan M, Leavens KF, Hunter RW, Koren S, von Wilamowitz-Moellendorff A, Lu M, Satapati S, Chu Q, Sakamoto K, Burgess SC, Birnbaum MJ.

Cell Metab. 2013 Jul 2;18(1):99-105. doi: 10.1016/j.cmet.2013.06.001.

37.

Natural and inducible TH17 cells are regulated differently by Akt and mTOR pathways.

Kim JS, Sklarz T, Banks LB, Gohil M, Waickman AT, Skuli N, Krock BL, Luo CT, Hu W, Pollizzi KN, Li MO, Rathmell JC, Birnbaum MJ, Powell JD, Jordan MS, Koretzky GA.

Nat Immunol. 2013 Jun;14(6):611-8. doi: 10.1038/ni.2607. Epub 2013 May 5. Retraction in: Nat Immunol. 2014 Oct;15(10):996.

38.

Construction of human activity-based phosphorylation networks.

Newman RH, Hu J, Rho HS, Xie Z, Woodard C, Neiswinger J, Cooper C, Shirley M, Clark HM, Hu S, Hwang W, Jeong JS, Wu G, Lin J, Gao X, Ni Q, Goel R, Xia S, Ji H, Dalby KN, Birnbaum MJ, Cole PA, Knapp S, Ryazanov AG, Zack DJ, Blackshaw S, Pawson T, Gingras AC, Desiderio S, Pandey A, Turk BE, Zhang J, Zhu H, Qian J.

Mol Syst Biol. 2013;9:655. doi: 10.1038/msb.2013.12.

39.

Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP.

Miller RA, Chu Q, Xie J, Foretz M, Viollet B, Birnbaum MJ.

Nature. 2013 Feb 14;494(7436):256-60. doi: 10.1038/nature11808. Epub 2013 Jan 6.

40.

MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca(2+) uptake that regulates cell survival.

Mallilankaraman K, Doonan P, Cárdenas C, Chandramoorthy HC, Müller M, Miller R, Hoffman NE, Gandhirajan RK, Molgó J, Birnbaum MJ, Rothberg BS, Mak DO, Foskett JK, Madesh M.

Cell. 2012 Oct 26;151(3):630-44. doi: 10.1016/j.cell.2012.10.011.

41.

Distinct mTORC1 pathways for transcription and cleavage of SREBP-1c.

Quinn WJ 3rd, Birnbaum MJ.

Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):15974-5. doi: 10.1073/pnas.1214113109. Epub 2012 Sep 24. No abstract available.

42.

Mio/dChREBP coordinately increases fat mass by regulating lipid synthesis and feeding behavior in Drosophila.

Sassu ED, McDermott JE, Keys BJ, Esmaeili M, Keene AC, Birnbaum MJ, DiAngelo JR.

Biochem Biophys Res Commun. 2012 Sep 14;426(1):43-8. doi: 10.1016/j.bbrc.2012.08.028. Epub 2012 Aug 12.

43.

The combined deletion of S6K1 and Akt2 deteriorates glycemic control in a high-fat diet.

Treins C, Alliouachene S, Hassouna R, Xie Y, Birnbaum MJ, Pende M.

Mol Cell Biol. 2012 Oct;32(19):4001-11. doi: 10.1128/MCB.00514-12. Epub 2012 Jul 30.

44.

Physiology. De-meaning of metabolism.

Lazar MA, Birnbaum MJ.

Science. 2012 Jun 29;336(6089):1651-2. doi: 10.1126/science.1221834. No abstract available.

PMID:
22745413
45.

Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration.

Sun Z, Miller RA, Patel RT, Chen J, Dhir R, Wang H, Zhang D, Graham MJ, Unterman TG, Shulman GI, Sztalryd C, Bennett MJ, Ahima RS, Birnbaum MJ, Lazar MA.

Nat Med. 2012 Jun;18(6):934-42. doi: 10.1038/nm.2744.

46.

Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1.

Lu M, Wan M, Leavens KF, Chu Q, Monks BR, Fernandez S, Ahima RS, Ueki K, Kahn CR, Birnbaum MJ.

Nat Med. 2012 Feb 19;18(3):388-95. doi: 10.1038/nm.2686.

47.

PPARγ contributes to PKM2 and HK2 expression in fatty liver.

Panasyuk G, Espeillac C, Chauvin C, Pradelli LA, Horie Y, Suzuki A, Annicotte JS, Fajas L, Foretz M, Verdeguer F, Pontoglio M, Ferré P, Scoazec JY, Birnbaum MJ, Ricci JE, Pende M.

Nat Commun. 2012 Feb 14;3:672. doi: 10.1038/ncomms1667.

48.

TLR4-mediated AKT activation is MyD88/TRIF dependent and critical for induction of oxidative phosphorylation and mitochondrial transcription factor A in murine macrophages.

Bauerfeld CP, Rastogi R, Pirockinaite G, Lee I, Hüttemann M, Monks B, Birnbaum MJ, Franchi L, Nuñez G, Samavati L.

J Immunol. 2012 Mar 15;188(6):2847-57. doi: 10.4049/jimmunol.1102157. Epub 2012 Feb 6.

49.

Of mice and men: not ExAKTly the same?

Wan M, Birnbaum MJ.

Cell Metab. 2011 Dec 7;14(6):722-3. doi: 10.1016/j.cmet.2011.11.009.

50.

Loss of Akt1 in mice increases energy expenditure and protects against diet-induced obesity.

Wan M, Easton RM, Gleason CE, Monks BR, Ueki K, Kahn CR, Birnbaum MJ.

Mol Cell Biol. 2012 Jan;32(1):96-106. doi: 10.1128/MCB.05806-11. Epub 2011 Oct 28.

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