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Items: 1 to 50 of 61

1.

Lamotrigine pharmacokinetics following oral and stable-labeled intravenous administration in young and elderly adult epilepsy patients: Effect of age.

Polepally AR, Brundage RC, Remmel RP, Leppik IE, Pennell PB, White JR, Ramsay RE, Kistner BM, Birnbaum AK.

Epilepsia. 2018 Aug 12. doi: 10.1111/epi.14519. [Epub ahead of print]

PMID:
30101556
2.

Brain's compensatory response to drug-induced cognitive impairment.

Babu Henry Samuel I, Barkley C, Marino SE, Wang C, Han SM, Birnbaum AK, Cibula JE, Ding M.

J Clin Exp Neuropsychol. 2018 May 2:1-13. doi: 10.1080/13803395.2018.1458822. [Epub ahead of print]

PMID:
29720037
3.

Opioid Dose- and Route-Dependent Efficacy of Oxycodone and Heroin Vaccines in Rats.

Raleigh MD, Laudenbach M, Baruffaldi F, Peterson SJ, Roslawski MJ, Birnbaum AK, Carroll FI, Runyon SP, Winston S, Pentel PR, Pravetoni M.

J Pharmacol Exp Ther. 2018 May;365(2):346-353. doi: 10.1124/jpet.117.247049. Epub 2018 Mar 13.

PMID:
29535156
4.

Factors in Variability of Serial Gabapentin Concentrations in Elderly Patients with Epilepsy.

Conway JM, Eberly LE, Collins JF, Macias FM, Ramsay RE, Leppik IE, Birnbaum AK.

Pharmacotherapy. 2017 Oct;37(10):1197-1203. doi: 10.1002/phar.2012. Epub 2017 Sep 19.

PMID:
28801938
5.

The impact of exposure to antidepressant medications during pregnancy on neonatal outcomes: a review of retrospective database cohort studies.

Tak CR, Job KM, Schoen-Gentry K, Campbell SC, Carroll P, Costantine M, Brixner D, Birnbaum AK, Sherwin CMT.

Eur J Clin Pharmacol. 2017 Sep;73(9):1055-1069. doi: 10.1007/s00228-017-2269-4. Epub 2017 Jun 9. Review.

PMID:
28600701
6.

Phxnlme: An R package that facilitates pharmacometric workflow of Phoenix NLME analyses.

Lim CN, Liang S, Feng K, Chittenden J, Henry A, Mouksassi S, Birnbaum AK.

Comput Methods Programs Biomed. 2017 Mar;140:121-129. doi: 10.1016/j.cmpb.2016.12.002. Epub 2016 Dec 7.

PMID:
28254068
7.

Antiseizure, antidepressant, and antipsychotic medication prescribing in elderly nursing home residents.

Bathena SPR, Leppik IE, Kanner AM, Birnbaum AK.

Epilepsy Behav. 2017 Apr;69:116-120. doi: 10.1016/j.yebeh.2017.01.027. Epub 2017 Feb 24.

8.

Prevalence of epilepsy/seizures as a comorbidity of neurologic disorders in nursing homes.

Birnbaum AK, Leppik IE, Svensden K, Eberly LE.

Neurology. 2017 Feb 21;88(8):750-757. doi: 10.1212/WNL.0000000000003629. Epub 2017 Jan 20.

9.

Pharmacokinetics and Saturable Absorption of Gabapentin in Nursing Home Elderly Patients.

Ahmed GF, Bathena SP, Brundage RC, Leppik IE, Conway JM, Schwartz JB, Birnbaum AK.

AAPS J. 2017 Mar;19(2):551-556. doi: 10.1208/s12248-016-0022-z. Epub 2017 Jan 9.

PMID:
28070716
10.

Intravenous and Intramuscular Formulations of Antiseizure Drugs in the Treatment of Epilepsy.

Patel SI, Birnbaum AK, Cloyd JC, Leppik IE.

CNS Drugs. 2015 Dec;29(12):1009-22. doi: 10.1007/s40263-015-0289-0. Review.

PMID:
26603741
11.

Pharmacokinetic-Pharmacodynamic Modeling of Intravenous and Oral Topiramate and Its Effect on the Symbol-Digit Modalities Test in Adult Healthy Volunteers.

Lim CN, Birnbaum AK, Brundage RC, Leppik IE, Cloyd JC, Clark A, Marino SE.

J Clin Pharmacol. 2016 Jun;56(6):714-22. doi: 10.1002/jcph.646. Epub 2015 Dec 21.

12.

Steady-state pharmacokinetics and bioavailability of immediate-release and extended-release formulations of lamotrigine in elderly epilepsy patients: Use of stable isotope methodology.

Polepally AR, Remmel RP, Brundage RC, Leppik IE, Rarick JO, Ramsay RE, Birnbaum AK.

J Clin Pharmacol. 2015 Oct;55(10):1101-8. doi: 10.1002/jcph.522. Epub 2015 Aug 18.

13.

Pharmacokinetic-pharmacodynamic modelling of intravenous and oral topiramate and its effect on phonemic fluency in adult healthy volunteers.

Ahmed GF, Marino SE, Brundage RC, Pakhomov SV, Leppik IE, Cloyd JC, Clark A, Birnbaum AK.

Br J Clin Pharmacol. 2015 May;79(5):820-30. doi: 10.1111/bcp.12556.

14.

Treating epilepsy in the elderly: more art than science.

Leppik IE, Birnbaum AK.

Cleve Clin J Med. 2014 Aug;81(8):499-500. doi: 10.3949/ccjm.81a.14030. No abstract available.

PMID:
25085988
15.

MODEL-BASED LAMOTRIGINE CLEARANCE CHANGES DURING PREGNANCY: CLINICAL IMPLICATION.

Polepally AR, Pennell PB, Brundage RC, Stowe ZN, Newport DJ, Viguera AC, Ritchie JC, Birnbaum AK.

Ann Clin Transl Neurol. 2014 Feb;1(2):99-106.

16.

Safety of an intravenous formulation of lamotrigine.

Conway JM, Birnbaum AK, Leppik IE, Pennell PB, White JR, Rarick JO, Remmel RP.

Seizure. 2014 May;23(5):390-2. doi: 10.1016/j.seizure.2014.01.019. Epub 2014 Jan 31.

17.

Population pharmacokinetics of unbound and total drug concentrations following intravenously administered carbamazepine in elderly and younger adult patients with epilepsy.

Ahmed GF, Brundage RC, Marino SE, Cloyd JC, Leppik IE, Pennell PB, Ramsay RE, Birnbaum AK.

J Clin Pharmacol. 2013 Mar;53(3):276-84. doi: 10.1002/jcph.8. Epub 2013 Feb 13.

18.

Valproic acid pathway: pharmacokinetics and pharmacodynamics.

Ghodke-Puranik Y, Thorn CF, Lamba JK, Leeder JS, Song W, Birnbaum AK, Altman RB, Klein TE.

Pharmacogenet Genomics. 2013 Apr;23(4):236-41. doi: 10.1097/FPC.0b013e32835ea0b2. No abstract available.

19.

Association of carbamazepine major metabolism and transport pathway gene polymorphisms and pharmacokinetics in patients with epilepsy.

Puranik YG, Birnbaum AK, Marino SE, Ahmed G, Cloyd JC, Remmel RP, Leppik IE, Lamba JK.

Pharmacogenomics. 2013 Jan;14(1):35-45. doi: 10.2217/pgs.12.180.

20.

Stability of heroin, 6-monoacetylmorphine, and morphine in biological samples and validation of an LC-MS assay for delayed analyses of pharmacokinetic samples in rats.

Jones JM, Raleigh MD, Pentel PR, Harmon TM, Keyler DE, Remmel RP, Birnbaum AK.

J Pharm Biomed Anal. 2013 Feb 23;74:291-7. doi: 10.1016/j.jpba.2012.10.033. Epub 2012 Nov 15.

21.

Selective effects of a morphine conjugate vaccine on heroin and metabolite distribution and heroin-induced behaviors in rats.

Raleigh MD, Pravetoni M, Harris AC, Birnbaum AK, Pentel PR.

J Pharmacol Exp Ther. 2013 Feb;344(2):397-406. doi: 10.1124/jpet.112.201194. Epub 2012 Dec 7.

22.

Challenges of epilepsy in elderly people.

Leppik IE, Walczak TS, Birnbaum AK.

Lancet. 2012 Sep 29;380(9848):1128-30. doi: 10.1016/S0140-6736(12)61517-7. No abstract available.

PMID:
23021270
23.

Validation of tacrolimus equation to predict troughs using genetic and clinical factors.

Passey C, Birnbaum AK, Brundage RC, Schladt DP, Oetting WS, Leduc RE, Israni AK, Guan W, Matas AJ, Jacobson PA.

Pharmacogenomics. 2012 Jul;13(10):1141-7. doi: 10.2217/pgs.12.98.

24.

The effect of topiramate plasma concentration on linguistic behavior, verbal recall and working memory.

Marino SE, Pakhomov SV, Han S, Anderson KL, Ding M, Eberly LE, Loring DW, Hawkins-Taylor C, Rarick JO, Leppik IE, Cibula JE, Birnbaum AK.

Epilepsy Behav. 2012 Jul;24(3):365-72. doi: 10.1016/j.yebeh.2012.04.120. Epub 2012 May 30.

25.

Co-administration of morphine and oxycodone vaccines reduces the distribution of 6-monoacetylmorphine and oxycodone to brain in rats.

Pravetoni M, Raleigh MD, Le Naour M, Tucker AM, Harmon TM, Jones JM, Birnbaum AK, Portoghese PS, Pentel PR.

Vaccine. 2012 Jun 29;30(31):4617-24. doi: 10.1016/j.vaccine.2012.04.101. Epub 2012 May 11.

26.

Using PharmGKB to train text mining approaches for identifying potential gene targets for pharmacogenomic studies.

Pakhomov S, McInnes BT, Lamba J, Liu Y, Melton GB, Ghodke Y, Bhise N, Lamba V, Birnbaum AK.

J Biomed Inform. 2012 Oct;45(5):862-9. doi: 10.1016/j.jbi.2012.04.007. Epub 2012 May 4.

27.

Variability of carbamazepine and valproate concentrations in elderly nursing home residents.

Birnbaum AK, Conway JM, Strege MA, Leppik IE.

Epilepsy Res. 2012 Aug;101(1-2):22-7. doi: 10.1016/j.eplepsyres.2012.02.014. Epub 2012 Mar 30.

28.

Population pharmacokinetics of carbamazepine in elderly patients.

Punyawudho B, Ramsay ER, Brundage RC, Macias FM, Collins JF, Birnbaum AK.

Ther Drug Monit. 2012 Apr;34(2):176-81. doi: 10.1097/FTD.0b013e31824d6a4e.

29.

Steady-state carbamazepine pharmacokinetics following oral and stable-labeled intravenous administration in epilepsy patients: effects of race and sex.

Marino SE, Birnbaum AK, Leppik IE, Conway JM, Musib LC, Brundage RC, Ramsay RE, Pennell PB, White JR, Gross CR, Rarick JO, Mishra U, Cloyd JC.

Clin Pharmacol Ther. 2012 Mar;91(3):483-8. doi: 10.1038/clpt.2011.251. Epub 2012 Jan 25.

30.

A sensitive capillary GC-MS method for analysis of topiramate from plasma obtained from single-dose studies.

Conway JM, Birnbaum AK, Marino SE, Cloyd JC, Remmel RP.

Biomed Chromatogr. 2012 Sep;26(9):1071-6. doi: 10.1002/bmc.1749. Epub 2012 Jan 4.

31.

Genetic and environmental correlates of topiramate-induced cognitive impairment.

Cirulli ET, Urban TJ, Marino SE, Linney KN, Birnbaum AK, Depondt C, Attix DK, Radtke RA, Goldstein DB.

Epilepsia. 2012 Jan;53(1):e5-8. doi: 10.1111/j.1528-1167.2011.03322.x. Epub 2011 Nov 16.

32.

Effects of age and dementia on temporal cycles in spontaneous speech fluency.

Pakhomov SV, Kaiser EA, Boley DL, Marino SE, Knopman DS, Birnbaum AK.

J Neurolinguistics. 2011 Oct;24(6):619-635.

33.

Dosing equation for tacrolimus using genetic variants and clinical factors.

Passey C, Birnbaum AK, Brundage RC, Oetting WS, Israni AK, Jacobson PA.

Br J Clin Pharmacol. 2011 Dec;72(6):948-57. doi: 10.1111/j.1365-2125.2011.04039.x.

34.

Zonisamide discontinuation due to psychiatric and cognitive adverse events: a case-control study.

White JR, Walczak TS, Marino SE, Beniak TE, Leppik IE, Birnbaum AK.

Neurology. 2010 Aug 10;75(6):513-8. doi: 10.1212/WNL.0b013e3181eccfb5.

35.

Epilepsy in the elderly.

Leppik IE, Birnbaum AK.

Ann N Y Acad Sci. 2010 Jan;1184:208-24. doi: 10.1111/j.1749-6632.2009.05113.x. Review.

36.

CYP2C9*1B promoter polymorphisms, in linkage with CYP2C19*2, affect phenytoin autoinduction of clearance and maintenance dose.

Chaudhry AS, Urban TJ, Lamba JK, Birnbaum AK, Remmel RP, Subramanian M, Strom S, You JH, Kasperaviciute D, Catarino CB, Radtke RA, Sisodiya SM, Goldstein DB, Schuetz EG.

J Pharmacol Exp Ther. 2010 Feb;332(2):599-611. doi: 10.1124/jpet.109.161026. Epub 2009 Oct 23.

37.

Characterization of the time course of carbamazepine deinduction by an enzyme turnover model.

Punyawudho B, Cloyd JC, Leppik IE, Ramsay RE, Marino SE, Pennell PB, White JR, Birnbaum AK.

Clin Pharmacokinet. 2009;48(5):313-20. doi: 10.2165/00003088-200948050-00003.

38.

Safety of an IV formulation of carbamazepine.

Conway JM, White JR, Birnbaum AK, Eugene Ramsay R, Pennell PB, Rarick JO, Musib L, Leppik IE, Cloyd JC.

Epilepsy Res. 2009 Apr;84(2-3):242-4. doi: 10.1016/j.eplepsyres.2009.01.013. Epub 2009 Mar 18.

39.

Phenytoin half-life and clearance during maintenance therapy in adults and elderly patients with epilepsy.

Ahn JE, Cloyd JC, Brundage RC, Marino SE, Conway JM, Ramsay RE, White JR, Musib LC, Rarick JO, Birnbaum AK, Leppik IE.

Neurology. 2008 Jul 1;71(1):38-43. doi: 10.1212/01.wnl.0000316392.55784.57.

PMID:
18591503
40.

High-speed simultaneous determination of nine antiepileptic drugs using liquid chromatography-mass spectrometry.

Subramanian M, Birnbaum AK, Remmel RP.

Ther Drug Monit. 2008 Jun;30(3):347-56. doi: 10.1097/FTD.0b013e3181678ecb.

PMID:
18520607
41.

Population pharmacokinetics of lamotrigine in elderly patients.

Punyawudho B, Ramsay RE, Macias FM, Rowan AJ, Collins JF, Brundage RC, Birnbaum AK.

J Clin Pharmacol. 2008 Apr;48(4):455-63. doi: 10.1177/0091270007313391. Epub 2008 Feb 22.

PMID:
18296554
42.

Population pharmacokinetics of valproic acid concentrations in elderly nursing home residents.

Birnbaum AK, Ahn JE, Brundage RC, Hardie NA, Conway JM, Leppik IE.

Ther Drug Monit. 2007 Oct;29(5):571-5.

PMID:
17898646
43.

Carbamazepine dose-concentration relationship in elderly nursing home residents.

Birnbaum AK, Conway JM, Hardie NA, Lackner TE, Bowers SE, Leppik IE.

Epilepsy Res. 2007 Oct;77(1):31-5. Epub 2007 Sep 24.

PMID:
17890057
44.

Pharmacokinetics of antiepileptic drugs in elderly nursing home residents.

Birnbaum AK.

Int Rev Neurobiol. 2007;81:211-20. Review.

PMID:
17433926
45.

Factors affecting antiepileptic drug pharmacokinetics in community-dwelling elderly.

Cloyd JC, Marino S, Birnbaum AK.

Int Rev Neurobiol. 2007;81:201-10.

PMID:
17433925
46.

Paradoxical urinary phenytoin metabolite (S)/(R) ratios in CYP2C19*1/*2 patients.

Argikar UA, Cloyd JC, Birnbaum AK, Leppik IE, Conway J, Kshirsagar S, Oetting WS, Klein EC, Remmel RP.

Epilepsy Res. 2006 Sep;71(1):54-63. Epub 2006 Jul 3.

PMID:
16815679
47.
48.

The pharmacology of AEDs pertaining to the treatment of the elderly in chronic care facilities.

Birnbaum AK.

Geriatrics. 2005 May;Suppl:13-6, 19. Review. No abstract available.

PMID:
16025883
49.

Advances in antiepileptic drug treatments. A rational basis for selecting drugs for older patients with epilepsy.

Leppik IE, Bergey GK, Ramsay RE, Rowan AJ, Gidal BE, Birnbaum AK, Elliott MB.

Geriatrics. 2004 Dec;59(12):14-8, 22-4. Review.

PMID:
15667018
50.

Valproic acid doses, concentrations, and clearances in elderly nursing home residents.

Birnbaum AK, Hardie NA, Conway JM, Bowers SE, Lackner TE, Graves NM, Leppik IE.

Epilepsy Res. 2004 Dec;62(2-3):157-62.

PMID:
15579303

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