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Items: 1 to 50 of 225

1.

Spatially Restricted Stromal Wnt Signaling Restrains Prostate Epithelial Progenitor Growth through Direct and Indirect Mechanisms.

Wei X, Zhang L, Zhou Z, Kwon OJ, Zhang Y, Nguyen H, Dumpit R, True L, Nelson P, Dong B, Xue W, Birchmeier W, Taketo MM, Xu F, Creighton CJ, Ittmann MM, Xin L.

Cell Stem Cell. 2019 May 2;24(5):753-768.e6. doi: 10.1016/j.stem.2019.03.010. Epub 2019 Apr 11.

PMID:
30982770
2.

Shp-2 is critical for ERK and metabolic engagement downstream of IL-15 receptor in NK cells.

Niogret C, Miah SMS, Rota G, Fonta NP, Wang H, Held W, Birchmeier W, Sexl V, Yang W, Vivier E, Ho PC, Brossay L, Guarda G.

Nat Commun. 2019 Mar 29;10(1):1444. doi: 10.1038/s41467-019-09431-3.

3.

The Wnt-Driven Mll1 Epigenome Regulates Salivary Gland and Head and Neck Cancer.

Zhu Q, Fang L, Heuberger J, Kranz A, Schipper J, Scheckenbach K, Vidal RO, Sunaga-Franze DY, Müller M, Wulf-Goldenberg A, Sauer S, Birchmeier W.

Cell Rep. 2019 Jan 8;26(2):415-428.e5. doi: 10.1016/j.celrep.2018.12.059.

4.

A C/EBPα-Wnt connection in gut homeostasis and carcinogenesis.

Heuberger J, Hill U, Förster S, Zimmermann K, Malchin V, Kühl AA, Stein U, Vieth M, Birchmeier W, Leutz A.

Life Sci Alliance. 2018 Dec 26;2(1):e201800173. doi: 10.26508/lsa.201800173. eCollection 2019 Feb.

5.

The tyrosine phosphatase SHP2 controls TGFβ-induced STAT3 signaling to regulate fibroblast activation and fibrosis.

Zehender A, Huang J, Györfi AH, Matei AE, Trinh-Minh T, Xu X, Li YN, Chen CW, Lin J, Dees C, Beyer C, Gelse K, Zhang ZY, Bergmann C, Ramming A, Birchmeier W, Distler O, Schett G, Distler JHW.

Nat Commun. 2018 Aug 14;9(1):3259. doi: 10.1038/s41467-018-05768-3.

6.

Keratinocyte-specific ablation of protease-activated receptor 2 prevents gingival inflammation and bone loss in a mouse model of periodontal disease.

Francis N, Ayodele BA, O'Brien-Simpson NM, Birchmeier W, Pike RN, Pagel CN, Mackie EJ.

Cell Microbiol. 2018 Nov;20(11):e12891. doi: 10.1111/cmi.12891. Epub 2018 Jul 31.

PMID:
30009515
7.

Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase.

Ruess DA, Heynen GJ, Ciecielski KJ, Ai J, Berninger A, Kabacaoglu D, Görgülü K, Dantes Z, Wörmann SM, Diakopoulos KN, Karpathaki AF, Kowalska M, Kaya-Aksoy E, Song L, van der Laan EAZ, López-Alberca MP, Nazaré M, Reichert M, Saur D, Erkan MM, Hopt UT, Sainz B Jr, Birchmeier W, Schmid RM, Lesina M, Algül H.

Nat Med. 2018 Jul;24(7):954-960. doi: 10.1038/s41591-018-0024-8. Epub 2018 May 28.

PMID:
29808009
8.

Shp-2 Is Dispensable for Establishing T Cell Exhaustion and for PD-1 Signaling In Vivo.

Rota G, Niogret C, Dang AT, Barros CR, Fonta NP, Alfei F, Morgado L, Zehn D, Birchmeier W, Vivier E, Guarda G.

Cell Rep. 2018 Apr 3;23(1):39-49. doi: 10.1016/j.celrep.2018.03.026.

9.

Characterization and structural determination of a new anti-MET function-blocking antibody with binding epitope distinct from the ligand binding domain.

DiCara DM, Chirgadze DY, Pope AR, Karatt-Vellatt A, Winter A, Slavny P, van den Heuvel J, Parthiban K, Holland J, Packman LC, Mavria G, Hoffmann J, Birchmeier W, Gherardi E, McCafferty J.

Sci Rep. 2017 Aug 21;7(1):9000. doi: 10.1038/s41598-017-09460-2.

10.

Cancer Stem Cells Regulate Cancer-Associated Fibroblasts via Activation of Hedgehog Signaling in Mammary Gland Tumors.

Valenti G, Quinn HM, Heynen GJJE, Lan L, Holland JD, Vogel R, Wulf-Goldenberg A, Birchmeier W.

Cancer Res. 2017 Apr 15;77(8):2134-2147. doi: 10.1158/0008-5472.CAN-15-3490. Epub 2017 Feb 15.

11.

RNF4-Dependent Oncogene Activation by Protein Stabilization.

Thomas JJ, Abed M, Heuberger J, Novak R, Zohar Y, Beltran Lopez AP, Trausch-Azar JS, Ilagan MXG, Benhamou D, Dittmar G, Kopan R, Birchmeier W, Schwartz AL, Orian A.

Cell Rep. 2016 Sep 20;16(12):3388-3400. doi: 10.1016/j.celrep.2016.08.024.

12.

The A-Kinase Anchoring Protein (AKAP) Glycogen Synthase Kinase 3β Interaction Protein (GSKIP) Regulates β-Catenin through Its Interactions with Both Protein Kinase A (PKA) and GSK3β.

Dema A, Schröter MF, Perets E, Skroblin P, Moutty MC, Deàk VA, Birchmeier W, Klussmann E.

J Biol Chem. 2016 Sep 9;291(37):19618-30. doi: 10.1074/jbc.M116.738047. Epub 2016 Aug 2.

13.

Orchestrating Wnt signalling for metabolic liver zonation.

Birchmeier W.

Nat Cell Biol. 2016 Apr 27;18(5):463-5. doi: 10.1038/ncb3349.

PMID:
27117330
14.

A Small-Molecule Antagonist of the β-Catenin/TCF4 Interaction Blocks the Self-Renewal of Cancer Stem Cells and Suppresses Tumorigenesis.

Fang L, Zhu Q, Neuenschwander M, Specker E, Wulf-Goldenberg A, Weis WI, von Kries JP, Birchmeier W.

Cancer Res. 2016 Feb 15;76(4):891-901. doi: 10.1158/0008-5472.CAN-15-1519. Epub 2015 Dec 8.

15.

Gab1 and Mapk Signaling Are Essential in the Hair Cycle and Hair Follicle Stem Cell Quiescence.

Akilli Öztürk Ö, Pakula H, Chmielowiec J, Qi J, Stein S, Lan L, Sasaki Y, Rajewsky K, Birchmeier W.

Cell Rep. 2015 Oct 20;13(3):561-572. doi: 10.1016/j.celrep.2015.09.015. Epub 2015 Oct 8.

16.

Shp2 signaling suppresses senescence in PyMT-induced mammary gland cancer in mice.

Lan L, Holland JD, Qi J, Grosskopf S, Vogel R, Györffy B, Wulf-Goldenberg A, Birchmeier W.

EMBO J. 2015 Sep 14;34(18):2383. doi: 10.15252/embj.201592508. No abstract available.

17.

New Wnt/β-catenin target genes promote experimental metastasis and migration of colorectal cancer cells through different signals.

Qi J, Yu Y, Akilli Öztürk Ö, Holland JD, Besser D, Fritzmann J, Wulf-Goldenberg A, Eckert K, Fichtner I, Birchmeier W.

Gut. 2016 Oct;65(10):1690-701. doi: 10.1136/gutjnl-2014-307900. Epub 2015 Jul 8.

PMID:
26156959
18.

Selective inhibitors of the protein tyrosine phosphatase SHP2 block cellular motility and growth of cancer cells in vitro and in vivo.

Grosskopf S, Eckert C, Arkona C, Radetzki S, Böhm K, Heinemann U, Wolber G, von Kries JP, Birchmeier W, Rademann J.

ChemMedChem. 2015 May;10(5):815-26. doi: 10.1002/cmdc.201500015. Epub 2015 Apr 15.

PMID:
25877780
19.

Shp2 signaling suppresses senescence in PyMT-induced mammary gland cancer in mice.

Lan L, Holland JD, Qi J, Grosskopf S, Rademann J, Vogel R, Györffy B, Wulf-Goldenberg A, Birchmeier W.

EMBO J. 2015 Jun 3;34(11):1493-508. doi: 10.15252/embj.201489004. Epub 2015 Mar 3. Erratum in: EMBO J. 2015 Sep 14;34(18):2383. Rademann, Jörg [added].

20.

Molecular signaling mechanisms of axon-glia communication in the peripheral nervous system.

Grigoryan T, Birchmeier W.

Bioessays. 2015 May;37(5):502-13. doi: 10.1002/bies.201400172. Epub 2015 Feb 23. Review.

PMID:
25707700
21.

Afadin requirement for cytokine expressions in keratinocytes during chemically induced inflammation in mice.

Yoshida T, Iwata T, Takai Y, Birchmeier W, Yamato M, Okano T.

Genes Cells. 2014 Nov;19(11):842-52. doi: 10.1111/gtc.12184. Epub 2014 Oct 9.

22.

Global increase of p16INK4a in APC-deficient mouse liver drives clonal growth of p16INK4a-negative tumors.

Ueberham E, Glöckner P, Göhler C, Straub BK, Teupser D, Schönig K, Braeuning A, Höhn AK, Jerchow B, Birchmeier W, Gaunitz F, Arendt T, Sansom O, Gebhardt R, Ueberham U.

Mol Cancer Res. 2015 Feb;13(2):239-49. doi: 10.1158/1541-7786.MCR-14-0278-T. Epub 2014 Sep 30.

23.

The BCL9-2 proto-oncogene governs estrogen receptor alpha expression in breast tumorigenesis.

Zatula N, Wiese M, Bunzendahl J, Birchmeier W, Perske C, Bleckmann A, Brembeck FH.

Oncotarget. 2014 Aug 30;5(16):6770-87.

24.

Wnt-Fzd signaling sensitizes peripheral sensory neurons via distinct noncanonical pathways.

Simonetti M, Agarwal N, Stösser S, Bali KK, Karaulanov E, Kamble R, Pospisilova B, Kurejova M, Birchmeier W, Niehrs C, Heppenstall P, Kuner R.

Neuron. 2014 Jul 2;83(1):104-21. doi: 10.1016/j.neuron.2014.05.037.

25.

Shp2/MAPK signaling controls goblet/paneth cell fate decisions in the intestine.

Heuberger J, Kosel F, Qi J, Grossmann KS, Rajewsky K, Birchmeier W.

Proc Natl Acad Sci U S A. 2014 Mar 4;111(9):3472-7. doi: 10.1073/pnas.1309342111. Epub 2014 Feb 18.

26.

Activation of MAPK overrides the termination of myelin growth and replaces Nrg1/ErbB3 signals during Schwann cell development and myelination.

Sheean ME, McShane E, Cheret C, Walcher J, Müller T, Wulf-Goldenberg A, Hoelper S, Garratt AN, Krüger M, Rajewsky K, Meijer D, Birchmeier W, Lewin GR, Selbach M, Birchmeier C.

Genes Dev. 2014 Feb 1;28(3):290-303. doi: 10.1101/gad.230045.113.

27.

Combined Wnt/β-catenin, Met, and CXCL12/CXCR4 signals characterize basal breast cancer and predict disease outcome.

Holland JD, Györffy B, Vogel R, Eckert K, Valenti G, Fang L, Lohneis P, Elezkurtaj S, Ziebold U, Birchmeier W.

Cell Rep. 2013 Dec 12;5(5):1214-27. doi: 10.1016/j.celrep.2013.11.001. Epub 2013 Nov 27.

28.

Wnt/Rspondin/β-catenin signals control axonal sorting and lineage progression in Schwann cell development.

Grigoryan T, Stein S, Qi J, Wende H, Garratt AN, Nave KA, Birchmeier C, Birchmeier W.

Proc Natl Acad Sci U S A. 2013 Nov 5;110(45):18174-9. doi: 10.1073/pnas.1310490110. Epub 2013 Oct 22.

29.

Loss of epidermal Evi/Wls results in a phenotype resembling psoriasiform dermatitis.

Augustin I, Gross J, Baumann D, Korn C, Kerr G, Grigoryan T, Mauch C, Birchmeier W, Boutros M.

J Exp Med. 2013 Aug 26;210(9):1761-77. doi: 10.1084/jem.20121871. Epub 2013 Aug 5.

30.

Wnt/β-catenin signalling induces MLL to create epigenetic changes in salivary gland tumours.

Wend P, Fang L, Zhu Q, Schipper JH, Loddenkemper C, Kosel F, Brinkmann V, Eckert K, Hindersin S, Holland JD, Lehr S, Kahn M, Ziebold U, Birchmeier W.

EMBO J. 2013 Jul 17;32(14):1977-89. doi: 10.1038/emboj.2013.127. Epub 2013 Jun 4.

31.

Wnt signaling in stem and cancer stem cells.

Holland JD, Klaus A, Garratt AN, Birchmeier W.

Curr Opin Cell Biol. 2013 Apr;25(2):254-64. doi: 10.1016/j.ceb.2013.01.004. Epub 2013 Jan 21. Review.

PMID:
23347562
32.

Neocortical dendritic complexity is controlled during development by NOMA-GAP-dependent inhibition of Cdc42 and activation of cofilin.

Rosário M, Schuster S, Jüttner R, Parthasarathy S, Tarabykin V, Birchmeier W.

Genes Dev. 2012 Aug 1;26(15):1743-57. doi: 10.1101/gad.191593.112. Epub 2012 Jul 18.

33.

Sodium current deficit and arrhythmogenesis in a murine model of plakophilin-2 haploinsufficiency.

Cerrone M, Noorman M, Lin X, Chkourko H, Liang FX, van der Nagel R, Hund T, Birchmeier W, Mohler P, van Veen TA, van Rijen HV, Delmar M.

Cardiovasc Res. 2012 Sep 1;95(4):460-8. doi: 10.1093/cvr/cvs218. Epub 2012 Jul 3.

34.

Wnt/β-catenin and Bmp signals control distinct sets of transcription factors in cardiac progenitor cells.

Klaus A, Müller M, Schulz H, Saga Y, Martin JF, Birchmeier W.

Proc Natl Acad Sci U S A. 2012 Jul 3;109(27):10921-6. doi: 10.1073/pnas.1121236109. Epub 2012 Jun 18.

35.

The role of Irf6 in tooth epithelial invagination.

Blackburn J, Ohazama A, Kawasaki K, Otsuka-Tanaka Y, Liu B, Honda K, Rountree RB, Hu Y, Kawasaki M, Birchmeier W, Schmidt-Ullrich R, Kinoshita A, Schutte BC, Hammond NL, Dixon MJ, Sharpe PT.

Dev Biol. 2012 May 1;365(1):61-70. doi: 10.1016/j.ydbio.2012.02.009. Epub 2012 Feb 14.

36.

Targeting MET in cancer: rationale and progress.

Gherardi E, Birchmeier W, Birchmeier C, Vande Woude G.

Nat Rev Cancer. 2012 Jan 24;12(2):89-103. doi: 10.1038/nrc3205. Review. Erratum in: Nat Rev Cancer. 2012 Sep;12(9):637.

PMID:
22270953
37.

The tyrosine phosphatase Shp2 acts downstream of GDNF/Ret in branching morphogenesis of the developing mouse kidney.

Willecke R, Heuberger J, Grossmann K, Michos O, Schmidt-Ott K, Walentin K, Costantini F, Birchmeier W.

Dev Biol. 2011 Dec 15;360(2):310-7. doi: 10.1016/j.ydbio.2011.09.029. Epub 2011 Oct 8.

38.

Stem cells: Orphan receptors find a home.

Birchmeier W.

Nature. 2011 Aug 17;476(7360):287-8. doi: 10.1038/476287a. No abstract available.

PMID:
21850098
39.

BCL9-2 promotes early stages of intestinal tumor progression.

Brembeck FH, Wiese M, Zatula N, Grigoryan T, Dai Y, Fritzmann J, Birchmeier W.

Gastroenterology. 2011 Oct;141(4):1359-70, 1370.e1-3. doi: 10.1053/j.gastro.2011.06.039. Epub 2011 Jun 23.

PMID:
21703997
40.

E-cadherin is crucial for embryonic stem cell pluripotency and can replace OCT4 during somatic cell reprogramming.

Redmer T, Diecke S, Grigoryan T, Quiroga-Negreira A, Birchmeier W, Besser D.

EMBO Rep. 2011 Jul 1;12(7):720-6. doi: 10.1038/embor.2011.88.

41.

Identification of Y-box binding protein 1 as a core regulator of MEK/ERK pathway-dependent gene signatures in colorectal cancer cells.

Jürchott K, Kuban RJ, Krech T, Blüthgen N, Stein U, Walther W, Friese C, Kiełbasa SM, Ungethüm U, Lund P, Knösel T, Kemmner W, Morkel M, Fritzmann J, Schlag PM, Birchmeier W, Krueger T, Sperling S, Sers C, Royer HD, Herzel H, Schäfer R.

PLoS Genet. 2010 Dec 2;6(12):e1001231. doi: 10.1371/journal.pgen.1001231.

42.

Wnt signaling in stem and cancer stem cells.

Wend P, Holland JD, Ziebold U, Birchmeier W.

Semin Cell Dev Biol. 2010 Oct;21(8):855-63. doi: 10.1016/j.semcdb.2010.09.004. Epub 2010 Sep 15. Review.

PMID:
20837152
43.

The tyrosine phosphatase Shp2 in development and cancer.

Grossmann KS, Rosário M, Birchmeier C, Birchmeier W.

Adv Cancer Res. 2010;106:53-89. doi: 10.1016/S0065-230X(10)06002-1. Review.

PMID:
20399956
44.

Interplay of cadherin-mediated cell adhesion and canonical Wnt signaling.

Heuberger J, Birchmeier W.

Cold Spring Harb Perspect Biol. 2010 Feb;2(2):a002915. doi: 10.1101/cshperspect.a002915. Review.

45.

Wnt/β-catenin activity is essential to turn the epigenetic state to "ON" in salivary gland stem cells to create cancer stem cells.

Wend P, Loddenkemper C, Brinkmann V, Eckert K, Taketo MM, Kahn M, Birchmeier W, Ziebold U.

J Stem Cells Regen Med. 2010 Oct 23;6(2):134. eCollection 2010. No abstract available.

PMID:
24693143
46.

Role of Epiprofin, a zinc-finger transcription factor, in limb development.

Talamillo A, Delgado I, Nakamura T, de-Vega S, Yoshitomi Y, Unda F, Birchmeier W, Yamada Y, Ros MA.

Dev Biol. 2010 Jan 15;337(2):363-74. doi: 10.1016/j.ydbio.2009.11.007. Epub 2009 Nov 10.

47.

The tyrosine phosphatase Shp2 (PTPN11) directs Neuregulin-1/ErbB signaling throughout Schwann cell development.

Grossmann KS, Wende H, Paul FE, Cheret C, Garratt AN, Zurborg S, Feinberg K, Besser D, Schulz H, Peles E, Selbach M, Birchmeier W, Birchmeier C.

Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16704-9. doi: 10.1073/pnas.0904336106. Epub 2009 Sep 11.

48.

The LIM domain protein Wtip interacts with the receptor tyrosine kinase Ror2 and inhibits canonical Wnt signalling.

van Wijk NV, Witte F, Feike AC, Schambony A, Birchmeier W, Mundlos S, Stricker S.

Biochem Biophys Res Commun. 2009 Dec 11;390(2):211-6. doi: 10.1016/j.bbrc.2009.09.086. Epub 2009 Sep 26.

PMID:
19785987
49.

Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-catenin signaling pathways in hair follicle induction.

Zhang Y, Tomann P, Andl T, Gallant NM, Huelsken J, Jerchow B, Birchmeier W, Paus R, Piccolo S, Mikkola ML, Morrisey EE, Overbeek PA, Scheidereit C, Millar SE, Schmidt-Ullrich R.

Dev Cell. 2009 Jul;17(1):49-61. doi: 10.1016/j.devcel.2009.05.011.

50.

A colorectal cancer expression profile that includes transforming growth factor beta inhibitor BAMBI predicts metastatic potential.

Fritzmann J, Morkel M, Besser D, Budczies J, Kosel F, Brembeck FH, Stein U, Fichtner I, Schlag PM, Birchmeier W.

Gastroenterology. 2009 Jul;137(1):165-75. doi: 10.1053/j.gastro.2009.03.041. Epub 2009 Mar 26.

PMID:
19328798

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