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Items: 13


The Nlrp6 inflammasome is not required for baseline colonic inner mucus layer formation or function.

Volk JK, Nyström EEL, van der Post S, Abad BM, Schroeder BO, Johansson Å, Svensson F, Jäverfelt S, Johansson MEV, Hansson GC, Birchenough GMH.

J Exp Med. 2019 Nov 4;216(11):2602-2618. doi: 10.1084/jem.20190679. Epub 2019 Aug 16.


Loss of Trefoil Factor 2 Sensitizes Rat Pups to Systemic Infection with the Neonatal Pathogen Escherichia coli K1.

McCarthy AJ, Birchenough GMH, Taylor PW.

Infect Immun. 2019 Apr 23;87(5). pii: e00878-18. doi: 10.1128/IAI.00878-18. Print 2019 Mar.


Calcium-activated Chloride Channel Regulator 1 (CLCA1) Controls Mucus Expansion in Colon by Proteolytic Activity.

Nyström EEL, Birchenough GMH, van der Post S, Arike L, Gruber AD, Hansson GC, Johansson MEV.

EBioMedicine. 2018 Jul;33:134-143. doi: 10.1016/j.ebiom.2018.05.031. Epub 2018 Jun 7.


Bifidobacteria or Fiber Protects against Diet-Induced Microbiota-Mediated Colonic Mucus Deterioration.

Schroeder BO, Birchenough GMH, Ståhlman M, Arike L, Johansson MEV, Hansson GC, Bäckhed F.

Cell Host Microbe. 2018 Jan 10;23(1):27-40.e7. doi: 10.1016/j.chom.2017.11.004. Epub 2017 Dec 21.


Postnatal development of the small intestinal mucosa drives age-dependent, regio-selective susceptibility to Escherichia coli K1 infection.

Birchenough GM, Dalgakiran F, Witcomb LA, Johansson ME, McCarthy AJ, Hansson GC, Taylor PW.

Sci Rep. 2017 Mar 6;7(1):83. doi: 10.1038/s41598-017-00123-w.


Functional mucous layer and healing of proximal colonic anastomoses in an experimental model.

Bosmans JW, Jongen AC, Birchenough GM, Nyström EE, Gijbels MJ, Derikx JP, Bouvy ND, Hansson GC.

Br J Surg. 2017 Apr;104(5):619-630. doi: 10.1002/bjs.10456. Epub 2017 Feb 13.


Gram-positive bacteria are held at a distance in the colon mucus by the lectin-like protein ZG16.

Bergström JH, Birchenough GM, Katona G, Schroeder BO, Schütte A, Ermund A, Johansson ME, Hansson GC.

Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):13833-13838. Epub 2016 Nov 14.


A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion.

Birchenough GM, Nyström EE, Johansson ME, Hansson GC.

Science. 2016 Jun 24;352(6293):1535-42. doi: 10.1126/science.aaf7419.


The Goblet Cell Protein Clca1 (Alias mClca3 or Gob-5) Is Not Required for Intestinal Mucus Synthesis, Structure and Barrier Function in Naive or DSS-Challenged Mice.

Erickson NA, Nyström EE, Mundhenk L, Arike L, Glauben R, Heimesaat MM, Fischer A, Bereswill S, Birchenough GM, Gruber AD, Johansson ME.

PLoS One. 2015 Jul 10;10(7):e0131991. doi: 10.1371/journal.pone.0131991. eCollection 2015.


New developments in goblet cell mucus secretion and function.

Birchenough GM, Johansson ME, Gustafsson JK, Bergström JH, Hansson GC.

Mucosal Immunol. 2015 Jul;8(4):712-9. doi: 10.1038/mi.2015.32. Epub 2015 Apr 15. Review.


Non-invasive model of neuropathogenic Escherichia coli infection in the neonatal rat.

Dalgakiran F, Witcomb LA, McCarthy AJ, Birchenough GM, Taylor PW.

J Vis Exp. 2014 Oct 29;(92):e52018. doi: 10.3791/52018.


The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system.

Pelaseyed T, Bergström JH, Gustafsson JK, Ermund A, Birchenough GM, Schütte A, van der Post S, Svensson F, Rodríguez-Piñeiro AM, Nyström EE, Wising C, Johansson ME, Hansson GC.

Immunol Rev. 2014 Jul;260(1):8-20. doi: 10.1111/imr.12182. Review.


Altered innate defenses in the neonatal gastrointestinal tract in response to colonization by neuropathogenic Escherichia coli.

Birchenough GM, Johansson ME, Stabler RA, Dalgakiran F, Hansson GC, Wren BW, Luzio JP, Taylor PW.

Infect Immun. 2013 Sep;81(9):3264-75. doi: 10.1128/IAI.00268-13. Epub 2013 Jun 24.

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