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Hair cortisol concentration in clinically healthy slaughter calves with and -without chronic bronchopneumonic -lesions.

Braun U, Wiest A, Lutz T, Riond B, Hilbe M, Baumgartner M, Binz T.

Schweiz Arch Tierheilkd. 2019 Oct;161(10):639-647. doi: 10.17236/sat00226.


Nocturnal gamma-hydroxybutyrate reduces cortisol awakening response and morning kynurenine pathway metabolites in healthy volunteers.

Dornbierer DA, Boxler M, Voegel CD, Stucky B, Steuer AE, Binz TM, Baumgartner MR, Baur DM, Quednow BB, Kraemer T, Seifritz E, Landolt HP, Bosch OG.

Int J Neuropsychopharmacol. 2019 Sep 3. pii: pyz047. doi: 10.1093/ijnp/pyz047. [Epub ahead of print]


(Un)targeted hair metabolomics: first considerations and systematic evaluation on the impact of sample preparation.

Eisenbeiss L, Steuer AE, Binz TM, Baumgartner MR, Kraemer T.

Anal Bioanal Chem. 2019 Jul;411(17):3963-3977. doi: 10.1007/s00216-019-01873-4. Epub 2019 May 23.


Hair cortisol concentration in veal calves reared under two different welfare production labels.

Braun U, Wiest A, Lutz T, Riond B, Stirn M, Hilbe M, Baumgartner MR, Binz TM.

Res Vet Sci. 2019 Apr;123:286-292. doi: 10.1016/j.rvsc.2019.01.027. Epub 2019 Jan 28.


Non-medical prescription opioid users exhibit dysfunctional physiological stress responses to social rejection.

Kroll SL, Williams DP, Thoma M, Staib M, Binz TM, Baumgartner MR, Kirschbaum C, Thayer JF, Quednow BB.

Psychoneuroendocrinology. 2019 Feb;100:264-275. doi: 10.1016/j.psyneuen.2018.09.023. Epub 2018 Sep 19.


Steroid profiling in nails using liquid chromatography-tandem mass spectrometry.

Voegel CD, La Marca-Ghaemmaghami P, Ehlert U, Baumgartner MR, Kraemer T, Binz TM.

Steroids. 2018 Dec;140:144-150. doi: 10.1016/j.steroids.2018.09.015. Epub 2018 Oct 5.


Botulinum Neurotoxin F Subtypes Cleaving the VAMP-2 Q58⁻K59 Peptide Bond Exhibit Unique Catalytic Properties and Substrate Specificities.

Sikorra S, Skiba M, Dorner MB, Weisemann J, Weil M, Valdezate S, Davletov B, Rummel A, Dorner BG, Binz T.

Toxins (Basel). 2018 Aug 1;10(8). pii: E311. doi: 10.3390/toxins10080311.


Systematic investigations of endogenous cortisol and cortisone in nails by LC-MS/MS and correlation to hair.

Binz TM, Gaehler F, Voegel CD, Hofmann M, Baumgartner MR, Kraemer T.

Anal Bioanal Chem. 2018 Aug;410(20):4895-4903. doi: 10.1007/s00216-018-1131-6. Epub 2018 May 17.


Structural and biochemical characterization of the protease domain of the mosaic botulinum neurotoxin type HA.

Lam KH, Sikorra S, Weisemann J, Maatsch H, Perry K, Rummel A, Binz T, Jin R.

Pathog Dis. 2018 Jun 1;76(4). doi: 10.1093/femspd/fty044.


Endogenous cortisol in keratinized matrices: Systematic determination of baseline cortisol levels in hair and the influence of sex, age and hair color.

Binz TM, Rietschel L, Streit F, Hofmann M, Gehrke J, Herdener M, Quednow BB, Martin NG, Rietschel M, Kraemer T, Baumgartner MR.

Forensic Sci Int. 2018 Mar;284:33-38. doi: 10.1016/j.forsciint.2017.12.032. Epub 2017 Dec 24.


Contact to Nature Benefits Health: Mixed Effectiveness of Different Mechanisms.

Hofmann M, Young C, Binz TM, Baumgartner MR, Bauer N.

Int J Environ Res Public Health. 2017 Dec 25;15(1). pii: E31. doi: 10.3390/ijerph15010031.


A Cell Line for Detection of Botulinum Neurotoxin Type B.

Rust A, Doran C, Hart R, Binz T, Stickings P, Sesardic D, Peden AA, Davletov B.

Front Pharmacol. 2017 Nov 9;8:796. doi: 10.3389/fphar.2017.00796. eCollection 2017.


Biosynthesis of methyl-proline containing griselimycins, natural products with anti-tuberculosis activity.

Lukat P, Katsuyama Y, Wenzel S, Binz T, König C, Blankenfeldt W, Brönstrup M, Müller R.

Chem Sci. 2017 Nov 1;8(11):7521-7527. doi: 10.1039/c7sc02622f. Epub 2017 Aug 3.


Hair Cortisol in Twins: Heritability and Genetic Overlap with Psychological Variables and Stress-System Genes.

Rietschel L, Streit F, Zhu G, McAloney K, Frank J, Couvy-Duchesne B, Witt SH, Binz TM; CORtisolNETwork (CORNET) Consortium; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (PGC), McGrath J, Hickie IB, Hansell NK, Wright MJ, Gillespie NA, Forstner AJ, Schulze TG, Wüst S, Nöthen MM, Baumgartner MR, Walker BR, Crawford AA, Colodro-Conde L, Medland SE, Martin NG, Rietschel M.

Sci Rep. 2017 Nov 10;7(1):15351. doi: 10.1038/s41598-017-11852-3.


Hair cortisol concentration and adrenal gland weight in healthy and ill cows.

Braun U, Clavadetscher G, Baumgartner M, Riond B, Binz T.

Schweiz Arch Tierheilkd. 2017 Sep;159(9):493-495. doi: 10.17236/sat00128. No abstract available.


Botulinum neurotoxin C mutants reveal different effects of syntaxin or SNAP-25 proteolysis on neuromuscular transmission.

Zanetti G, Sikorra S, Rummel A, Krez N, Duregotti E, Negro S, Henke T, Rossetto O, Binz T, Pirazzini M.

PLoS Pathog. 2017 Aug 11;13(8):e1006567. doi: 10.1371/journal.ppat.1006567. eCollection 2017 Aug.


Cortisol concentration of regrown hair and hair from a previously unshorn area in dairy cows.

Braun U, Michel N, Baumgartner MR, Hässig M, Binz TM.

Res Vet Sci. 2017 Oct;114:412-415. doi: 10.1016/j.rvsc.2017.07.005. Epub 2017 Jul 9.


Screening for Hazardous Drinking in Nursing Home Residents: Evaluating the Validity of the Current Cutoffs of the Alcohol Use Disorder Identification Test-Consumption Questions by Using Ethyl Glucuronide in Hair.

Dreher-Weber M, Laireiter AR, Kühberger A, Kunz I, Yegles M, Binz T, Rumpf HJ, Hoffmann R, Praxenthaler V, Lang S, Wurst FM.

Alcohol Clin Exp Res. 2017 Sep;41(9):1593-1601. doi: 10.1111/acer.13449. Epub 2017 Aug 14.


Chiral analysis of amphetamines in hair by liquid chromatography-tandem mass spectrometry: compliance-monitoring of attention deficit hyperactivity disorder (ADHD) patients under Elvanse® therapy and identification after controlled low-dose application.

Binz TM, Williner E, Strajhar P, Dolder PC, Liechti ME, Baumgartner MR, Kraemer T, Steuer AE.

Drug Test Anal. 2018 Feb;10(2):254-261. doi: 10.1002/dta.2208. Epub 2017 Jul 5.


Development of an LC-MS/MS method for the determination of endogenous cortisol in hair using (13)C3-labeled cortisol as surrogate analyte.

Binz TM, Braun U, Baumgartner MR, Kraemer T.

J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Oct 15;1033-1034:65-72. doi: 10.1016/j.jchromb.2016.07.041. Epub 2016 Jul 22.


Erratum to "Inhibition of botulinum neurotoxins interchain disulfide bond reduction prevents the peripheral neuroparalysis of botulism" [Biochem. Pharmacol. 98 (2015) 522-530].

Zanetti G, Azarnia Tehran D, Pirazzini M, Binz T, Shone CC, Fillo S, Lista F, Rossetto O, Montecucco C.

Biochem Pharmacol. 2016 Sep 1;115:152. doi: 10.1016/j.bcp.2016.07.006. Epub 2016 Jul 12. No abstract available.


The first non Clostridial botulinum-like toxin cleaves VAMP within the juxtamembrane domain.

Zornetta I, Azarnia Tehran D, Arrigoni G, Anniballi F, Bano L, Leka O, Zanotti G, Binz T, Montecucco C.

Sci Rep. 2016 Jul 22;6:30257. doi: 10.1038/srep30257.


Hsp90 is involved in the entry of clostridial neurotoxins into the cytosol of nerve terminals.

Azarnia Tehran D, Pirazzini M, Leka O, Mattarei A, Lista F, Binz T, Rossetto O, Montecucco C.

Cell Microbiol. 2017 Feb;19(2). doi: 10.1111/cmi.12647. Epub 2016 Aug 4.


Botulinum neurotoxin type C protease induces apoptosis in differentiated human neuroblastoma cells.

Rust A, Leese C, Binz T, Davletov B.

Oncotarget. 2016 May 31;7(22):33220-8. doi: 10.18632/oncotarget.8903.


[Hair Analysis for the Retrospective and Prospective Consume-Monitoring: Substance Abuse, Abstinence- and Compliance Control].

Binz TM, Baumgartner MR.

Praxis (Bern 1994). 2016 Jan 6;105(1):17-21. doi: 10.1024/1661-8157/a002238. Review. German.


A Novel Inhibitor Prevents the Peripheral Neuroparalysis of Botulinum Neurotoxins.

Azarnia Tehran D, Zanetti G, Leka O, Lista F, Fillo S, Binz T, Shone CC, Rossetto O, Montecucco C, Paradisi C, Mattarei A, Pirazzini M.

Sci Rep. 2015 Dec 16;5:17513. doi: 10.1038/srep17513.


Identification and Characterization of Botulinum Neurotoxin A Substrate Binding Pockets and Their Re-Engineering for Human SNAP-23.

Sikorra S, Litschko C, Müller C, Thiel N, Galli T, Eichner T, Binz T.

J Mol Biol. 2016 Jan 29;428(2 Pt A):372-384. doi: 10.1016/j.jmb.2015.10.024. Epub 2015 Oct 30.


Inhibition of botulinum neurotoxins interchain disulfide bond reduction prevents the peripheral neuroparalysis of botulism.

Zanetti G, Azarnia Tehran D, Pirazzini M, Binz T, Shone CC, Fillo S, Lista F, Rossetto O, Montecucco C.

Biochem Pharmacol. 2015 Dec 1;98(3):522-30. doi: 10.1016/j.bcp.2015.09.023. Epub 2015 Oct 9.


Two complementary approaches for intracellular delivery of exogenous enzymes.

Rust A, Hassan HH, Sedelnikova S, Niranjan D, Hautbergue G, Abbas SA, Partridge L, Rice D, Binz T, Davletov B.

Sci Rep. 2015 Jul 24;5:12444. doi: 10.1038/srep12444.


The thioredoxin reductase--Thioredoxin redox system cleaves the interchain disulphide bond of botulinum neurotoxins on the cytosolic surface of synaptic vesicles.

Pirazzini M, Azarnia Tehran D, Zanetti G, Lista F, Binz T, Shone CC, Rossetto O, Montecucco C.

Toxicon. 2015 Dec 1;107(Pt A):32-6. doi: 10.1016/j.toxicon.2015.06.019. Epub 2015 Jun 27.


The mouse brain metabolome: region-specific signatures and response to excitotoxic neuronal injury.

Jaeger C, Glaab E, Michelucci A, Binz TM, Koeglsberger S, Garcia P, Trezzi JP, Ghelfi J, Balling R, Buttini M.

Am J Pathol. 2015 Jun;185(6):1699-712. doi: 10.1016/j.ajpath.2015.02.016. Epub 2015 Apr 28.


Glucose substitution prolongs maintenance of energy homeostasis and lifespan of telomere dysfunctional mice.

Missios P, Zhou Y, Guachalla LM, von Figura G, Wegner A, Chakkarappan SR, Binz T, Gompf A, Hartleben G, Burkhalter MD, Wulff V, Günes C, Sattler RW, Song Z, Illig T, Klaus S, Böhm BO, Wenz T, Hiller K, Rudolph KL.

Nat Commun. 2014 Sep 18;5:4924. doi: 10.1038/ncomms5924.


Thioredoxin and its reductase are present on synaptic vesicles, and their inhibition prevents the paralysis induced by botulinum neurotoxins.

Pirazzini M, Azarnia Tehran D, Zanetti G, Megighian A, Scorzeto M, Fillo S, Shone CC, Binz T, Rossetto O, Lista F, Montecucco C.

Cell Rep. 2014 Sep 25;8(6):1870-1878. doi: 10.1016/j.celrep.2014.08.017. Epub 2014 Sep 15.


The influence of cleansing shampoos on ethyl glucuronide concentration in hair analyzed with an optimized and validated LC-MS/MS method.

Binz TM, Baumgartner MR, Kraemer T.

Forensic Sci Int. 2014 Nov;244:20-4. doi: 10.1016/j.forsciint.2014.07.021. Epub 2014 Jul 25.


Time resolved analysis of quetiapine and 7-OH-quetiapine in hair using LC/MS-MS.

Binz TM, Yegles M, Schneider S, Neels H, Crunelle CL.

Forensic Sci Int. 2014 Sep;242:200-203. doi: 10.1016/j.forsciint.2014.07.002. Epub 2014 Jul 11.


Identification of the synaptic vesicle glycoprotein 2 receptor binding site in botulinum neurotoxin A.

Strotmeier J, Mahrhold S, Krez N, Janzen C, Lou J, Marks JD, Binz T, Rummel A.

FEBS Lett. 2014 Apr 2;588(7):1087-93. doi: 10.1016/j.febslet.2014.02.034. Epub 2014 Feb 25.


Botulinum protease-cleaved SNARE fragments induce cytotoxicity in neuroblastoma cells.

Arsenault J, Cuijpers SA, Ferrari E, Niranjan D, Rust A, Leese C, O'Brien JA, Binz T, Davletov B.

J Neurochem. 2014 Jun;129(5):781-91. doi: 10.1111/jnc.12645. Epub 2014 Jan 23.


Neutralisation of specific surface carboxylates speeds up translocation of botulinum neurotoxin type B enzymatic domain.

Pirazzini M, Henke T, Rossetto O, Mahrhold S, Krez N, Rummel A, Montecucco C, Binz T.

FEBS Lett. 2013 Nov 29;587(23):3831-6. doi: 10.1016/j.febslet.2013.10.010. Epub 2013 Oct 21.


Systematic investigation of the incorporation mechanisms of zolpidem in fingernails.

Madry MM, Steuer AE, Binz TM, Baumgartner MR, Kraemer T.

Drug Test Anal. 2014 Jun;6(6):533-41. doi: 10.1002/dta.1558. Epub 2013 Oct 7.


Exchanging the minimal cell binding fragments of tetanus neurotoxin in botulinum neurotoxin A and B impacts their toxicity at the neuromuscular junction and central neurons.

Höltje M, Schulze S, Strotmeier J, Mahrhold S, Richter K, Binz T, Bigalke H, Ahnert-Hilger G, Rummel A.

Toxicon. 2013 Dec 1;75:108-21. doi: 10.1016/j.toxicon.2013.06.010. Epub 2013 Jun 29.


Botulinum neurotoxin G binds synaptotagmin-II in a mode similar to that of serotype B: tyrosine 1186 and lysine 1191 cause its lower affinity.

Willjes G, Mahrhold S, Strotmeier J, Eichner T, Rummel A, Binz T.

Biochemistry. 2013 Jun 4;52(22):3930-8. doi: 10.1021/bi4003502. Epub 2013 May 17.


Identification of the SV2 protein receptor-binding site of botulinum neurotoxin type E.

Mahrhold S, Strotmeier J, Garcia-Rodriguez C, Lou J, Marks JD, Rummel A, Binz T.

Biochem J. 2013 Jul 1;453(1):37-47. doi: 10.1042/BJ20130391.


Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production.

Michelucci A, Cordes T, Ghelfi J, Pailot A, Reiling N, Goldmann O, Binz T, Wegner A, Tallam A, Rausell A, Buttini M, Linster CL, Medina E, Balling R, Hiller K.

Proc Natl Acad Sci U S A. 2013 May 7;110(19):7820-5. doi: 10.1073/pnas.1218599110. Epub 2013 Apr 22.


Clostridial neurotoxin light chains: devices for SNARE cleavage mediated blockade of neurotransmission.

Binz T.

Curr Top Microbiol Immunol. 2013;364:139-57. doi: 10.1007/978-3-642-33570-9_7.


Time course and temperature dependence of the membrane translocation of tetanus and botulinum neurotoxins C and D in neurons.

Pirazzini M, Rossetto O, Bertasio C, Bordin F, Shone CC, Binz T, Montecucco C.

Biochem Biophys Res Commun. 2013 Jan 4;430(1):38-42. doi: 10.1016/j.bbrc.2012.11.048. Epub 2012 Nov 27.


The thioredoxin reductase-thioredoxin system is involved in the entry of tetanus and botulinum neurotoxins in the cytosol of nerve terminals.

Pirazzini M, Bordin F, Rossetto O, Shone CC, Binz T, Montecucco C.

FEBS Lett. 2013 Jan 16;587(2):150-5. doi: 10.1016/j.febslet.2012.11.007. Epub 2012 Nov 21.


Rapid extraction, identification and quantification of oral hypoglycaemic drugs in serum and hair using LC-MS/MS.

Binz TM, Villani N, Neels H, Schneider S.

Forensic Sci Int. 2012 Nov 30;223(1-3):119-24. doi: 10.1016/j.forsciint.2012.08.014. Epub 2012 Aug 30.


Human synaptotagmin-II is not a high affinity receptor for botulinum neurotoxin B and G: increased therapeutic dosage and immunogenicity.

Strotmeier J, Willjes G, Binz T, Rummel A.

FEBS Lett. 2012 Feb 17;586(4):310-3. doi: 10.1016/j.febslet.2011.12.037. Epub 2012 Jan 16.


The vesicular SNARE Synaptobrevin is required for Semaphorin 3A axonal repulsion.

Zylbersztejn K, Petkovic M, Burgo A, Deck M, Garel S, Marcos S, Bloch-Gallego E, Nothias F, Serini G, Bagnard D, Binz T, Galli T.

J Cell Biol. 2012 Jan 9;196(1):37-46. doi: 10.1083/jcb.201106113. Epub 2012 Jan 2.


The influence of ethanol containing cosmetics on ethyl glucuronide concentration in hair.

Martins Ferreira L, Binz T, Yegles M.

Forensic Sci Int. 2012 May 10;218(1-3):123-5. doi: 10.1016/j.forsciint.2011.10.015. Epub 2011 Nov 1.


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