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Items: 36

1.

Automated exploration of gene ontology term and pathway networks with ClueGO-REST.

Mlecnik B, Galon J, Bindea G.

Bioinformatics. 2019 Oct 1;35(19):3864-3866. doi: 10.1093/bioinformatics/btz163.

2.

The Link between the Multiverse of Immune Microenvironments in Metastases and the Survival of Colorectal Cancer Patients.

Van den Eynde M, Mlecnik B, Bindea G, Fredriksen T, Church SE, Lafontaine L, Haicheur N, Marliot F, Angelova M, Vasaturo A, Bruni D, Jouret-Mourin A, Baldin P, Huyghe N, Haustermans K, Debucquoy A, Van Cutsem E, Gigot JF, Hubert C, Kartheuser A, Remue C, Léonard D, Valge-Archer V, Pagès F, Machiels JP, Galon J.

Cancer Cell. 2018 Dec 10;34(6):1012-1026.e3. doi: 10.1016/j.ccell.2018.11.003.

PMID:
30537506
3.

Evolution of Metastases in Space and Time under Immune Selection.

Angelova M, Mlecnik B, Vasaturo A, Bindea G, Fredriksen T, Lafontaine L, Buttard B, Morgand E, Bruni D, Jouret-Mourin A, Hubert C, Kartheuser A, Humblet Y, Ceccarelli M, Syed N, Marincola FM, Bedognetti D, Van den Eynde M, Galon J.

Cell. 2018 Oct 18;175(3):751-765.e16. doi: 10.1016/j.cell.2018.09.018. Epub 2018 Oct 11.

4.

International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study.

Pagès F, Mlecnik B, Marliot F, Bindea G, Ou FS, Bifulco C, Lugli A, Zlobec I, Rau TT, Berger MD, Nagtegaal ID, Vink-Börger E, Hartmann A, Geppert C, Kolwelter J, Merkel S, Grützmann R, Van den Eynde M, Jouret-Mourin A, Kartheuser A, Léonard D, Remue C, Wang JY, Bavi P, Roehrl MHA, Ohashi PS, Nguyen LT, Han S, MacGregor HL, Hafezi-Bakhtiari S, Wouters BG, Masucci GV, Andersson EK, Zavadova E, Vocka M, Spacek J, Petruzelka L, Konopasek B, Dundr P, Skalova H, Nemejcova K, Botti G, Tatangelo F, Delrio P, Ciliberto G, Maio M, Laghi L, Grizzi F, Fredriksen T, Buttard B, Angelova M, Vasaturo A, Maby P, Church SE, Angell HK, Lafontaine L, Bruni D, El Sissy C, Haicheur N, Kirilovsky A, Berger A, Lagorce C, Meyers JP, Paustian C, Feng Z, Ballesteros-Merino C, Dijkstra J, van de Water C, van Lent-van Vliet S, Knijn N, Mușină AM, Scripcariu DV, Popivanova B, Xu M, Fujita T, Hazama S, Suzuki N, Nagano H, Okuno K, Torigoe T, Sato N, Furuhata T, Takemasa I, Itoh K, Patel PS, Vora HH, Shah B, Patel JB, Rajvik KN, Pandya SJ, Shukla SN, Wang Y, Zhang G, Kawakami Y, Marincola FM, Ascierto PA, Sargent DJ, Fox BA, Galon J.

Lancet. 2018 May 26;391(10135):2128-2139. doi: 10.1016/S0140-6736(18)30789-X. Epub 2018 May 10.

PMID:
29754777
5.

Comprehensive Intrametastatic Immune Quantification and Major Impact of Immunoscore on Survival.

Mlecnik B, Van den Eynde M, Bindea G, Church SE, Vasaturo A, Fredriksen T, Lafontaine L, Haicheur N, Marliot F, Debetancourt D, Pairet G, Jouret-Mourin A, Gigot JF, Hubert C, Danse E, Dragean C, Carrasco J, Humblet Y, Valge-Archer V, Berger A, Pagès F, Machiels JP, Galon J.

J Natl Cancer Inst. 2018 Jan 1;110(1). doi: 10.1093/jnci/djx123. Erratum in: J Natl Cancer Inst. 2018 Apr 1;110(4):438.

PMID:
28922789
6.

Comprehensive functional analysis of large lists of genes and proteins.

Mlecnik B, Galon J, Bindea G.

J Proteomics. 2018 Jan 16;171:2-10. doi: 10.1016/j.jprot.2017.03.016. Epub 2017 Mar 22.

PMID:
28343001
7.

T Cell Cancer Therapy Requires CD40-CD40L Activation of Tumor Necrosis Factor and Inducible Nitric-Oxide-Synthase-Producing Dendritic Cells.

Marigo I, Zilio S, Desantis G, Mlecnik B, Agnellini AH, Ugel S, Sasso MS, Qualls JE, Kratochvill F, Zanovello P, Molon B, Ries CH, Runza V, Hoves S, Bilocq AM, Bindea G, Mazza EM, Bicciato S, Galon J, Murray PJ, Bronte V.

Cancer Cell. 2016 Oct 10;30(4):651. doi: 10.1016/j.ccell.2016.09.009. No abstract available.

8.

T Cell Cancer Therapy Requires CD40-CD40L Activation of Tumor Necrosis Factor and Inducible Nitric-Oxide-Synthase-Producing Dendritic Cells.

Marigo I, Zilio S, Desantis G, Mlecnik B, Agnellini AHR, Ugel S, Sasso MS, Qualls JE, Kratochvill F, Zanovello P, Molon B, Ries CH, Runza V, Hoves S, Bilocq AM, Bindea G, Mazza EMC, Bicciato S, Galon J, Murray PJ, Bronte V.

Cancer Cell. 2016 Sep 12;30(3):377-390. doi: 10.1016/j.ccell.2016.08.004. Erratum in: Cancer Cell. 2016 Oct 10;30(4):651.

9.

Integrative Analyses of Colorectal Cancer Show Immunoscore Is a Stronger Predictor of Patient Survival Than Microsatellite Instability.

Mlecnik B, Bindea G, Angell HK, Maby P, Angelova M, Tougeron D, Church SE, Lafontaine L, Fischer M, Fredriksen T, Sasso M, Bilocq AM, Kirilovsky A, Obenauf AC, Hamieh M, Berger A, Bruneval P, Tuech JJ, Sabourin JC, Le Pessot F, Mauillon J, Rafii A, Laurent-Puig P, Speicher MR, Trajanoski Z, Michel P, Sesboüe R, Frebourg T, Pagès F, Valge-Archer V, Latouche JB, Galon J.

Immunity. 2016 Mar 15;44(3):698-711. doi: 10.1016/j.immuni.2016.02.025.

10.

Density of tumor-infiltrating lymphocytes correlates with extent of brain edema and overall survival time in patients with brain metastases.

Berghoff AS, Fuchs E, Ricken G, Mlecnik B, Bindea G, Spanberger T, Hackl M, Widhalm G, Dieckmann K, Prayer D, Bilocq A, Heinzl H, Zielinski C, Bartsch R, Birner P, Galon J, Preusser M.

Oncoimmunology. 2015 Jun 9;5(1):e1057388. eCollection 2016.

11.

The tumor microenvironment and Immunoscore are critical determinants of dissemination to distant metastasis.

Mlecnik B, Bindea G, Kirilovsky A, Angell HK, Obenauf AC, Tosolini M, Church SE, Maby P, Vasaturo A, Angelova M, Fredriksen T, Mauger S, Waldner M, Berger A, Speicher MR, Pagès F, Valge-Archer V, Galon J.

Sci Transl Med. 2016 Feb 24;8(327):327ra26. doi: 10.1126/scitranslmed.aad6352.

PMID:
26912905
12.

Cetuximab promotes epithelial to mesenchymal transition and cancer associated fibroblasts in patients with head and neck cancer.

Schmitz S, Bindea G, Albu RI, Mlecnik B, Machiels JP.

Oncotarget. 2015 Oct 27;6(33):34288-99. doi: 10.18632/oncotarget.5924.

13.

Correlation between Density of CD8+ T-cell Infiltrate in Microsatellite Unstable Colorectal Cancers and Frameshift Mutations: A Rationale for Personalized Immunotherapy.

Maby P, Tougeron D, Hamieh M, Mlecnik B, Kora H, Bindea G, Angell HK, Fredriksen T, Elie N, Fauquembergue E, Drouet A, Leprince J, Benichou J, Mauillon J, Le Pessot F, Sesboüé R, Tuech JJ, Sabourin JC, Michel P, Frébourg T, Galon J, Latouche JB.

Cancer Res. 2015 Sep 1;75(17):3446-55. doi: 10.1158/0008-5472.CAN-14-3051. Epub 2015 Jun 9.

14.

Meta-analysis of organ-specific differences in the structure of the immune infiltrate in major malignancies.

Stoll G, Bindea G, Mlecnik B, Galon J, Zitvogel L, Kroemer G.

Oncotarget. 2015 May 20;6(14):11894-909.

15.

Characterization of the immunophenotypes and antigenomes of colorectal cancers reveals distinct tumor escape mechanisms and novel targets for immunotherapy.

Angelova M, Charoentong P, Hackl H, Fischer ML, Snajder R, Krogsdam AM, Waldner MJ, Bindea G, Mlecnik B, Galon J, Trajanoski Z.

Genome Biol. 2015 Mar 31;16:64. doi: 10.1186/s13059-015-0620-6.

16.

[Intratumoral immune microenvironment and survival: the immunoscore].

Galon J, Bindea G, Mlecnik B, Angell H, Lagorce C, Todosi AM, Berger A, Pagès F.

Med Sci (Paris). 2014 Apr;30(4):439-44. doi: 10.1051/medsci/20143004020. Epub 2014 May 5. Review. French.

17.

The immune landscape of human tumors: Implications for cancer immunotherapy.

Bindea G, Mlecnik B, Angell HK, Galon J.

Oncoimmunology. 2014 Jan 1;3(1):e27456. Epub 2014 Jan 3.

18.

Prognostic and predictive values of the immunoscore in patients with rectal cancer.

Anitei MG, Zeitoun G, Mlecnik B, Marliot F, Haicheur N, Todosi AM, Kirilovsky A, Lagorce C, Bindea G, Ferariu D, Danciu M, Bruneval P, Scripcariu V, Chevallier JM, Zinzindohoué F, Berger A, Galon J, Pagès F.

Clin Cancer Res. 2014 Apr 1;20(7):1891-9. doi: 10.1158/1078-0432.CCR-13-2830.

19.

Functional network pipeline reveals genetic determinants associated with in situ lymphocyte proliferation and survival of cancer patients.

Mlecnik B, Bindea G, Angell HK, Sasso MS, Obenauf AC, Fredriksen T, Lafontaine L, Bilocq AM, Kirilovsky A, Tosolini M, Waldner M, Berger A, Fridman WH, Rafii A, Valge-Archer V, Pagès F, Speicher MR, Galon J.

Sci Transl Med. 2014 Mar 19;6(228):228ra37. doi: 10.1126/scitranslmed.3007240.

20.

Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer.

Bindea G, Mlecnik B, Tosolini M, Kirilovsky A, Waldner M, Obenauf AC, Angell H, Fredriksen T, Lafontaine L, Berger A, Bruneval P, Fridman WH, Becker C, Pagès F, Speicher MR, Trajanoski Z, Galon J.

Immunity. 2013 Oct 17;39(4):782-95. doi: 10.1016/j.immuni.2013.10.003.

21.

Towards the introduction of the 'Immunoscore' in the classification of malignant tumours.

Galon J, Mlecnik B, Bindea G, Angell HK, Berger A, Lagorce C, Lugli A, Zlobec I, Hartmann A, Bifulco C, Nagtegaal ID, Palmqvist R, Masucci GV, Botti G, Tatangelo F, Delrio P, Maio M, Laghi L, Grizzi F, Asslaber M, D'Arrigo C, Vidal-Vanaclocha F, Zavadova E, Chouchane L, Ohashi PS, Hafezi-Bakhtiari S, Wouters BG, Roehrl M, Nguyen L, Kawakami Y, Hazama S, Okuno K, Ogino S, Gibbs P, Waring P, Sato N, Torigoe T, Itoh K, Patel PS, Shukla SN, Wang Y, Kopetz S, Sinicrope FA, Scripcariu V, Ascierto PA, Marincola FM, Fox BA, Pagès F.

J Pathol. 2014 Jan;232(2):199-209. doi: 10.1002/path.4287. Review.

22.

CluePedia Cytoscape plugin: pathway insights using integrated experimental and in silico data.

Bindea G, Galon J, Mlecnik B.

Bioinformatics. 2013 Mar 1;29(5):661-3. doi: 10.1093/bioinformatics/btt019. Epub 2013 Jan 16.

23.

The prognostic impact of anti-cancer immune response: a novel classification of cancer patients.

Bindea G, Mlecnik B, Fridman WH, Galon J.

Semin Immunopathol. 2011 Jul;33(4):335-40. doi: 10.1007/s00281-011-0264-x. Epub 2011 Apr 5. Review.

24.

Clinical impact of different classes of infiltrating T cytotoxic and helper cells (Th1, th2, treg, th17) in patients with colorectal cancer.

Tosolini M, Kirilovsky A, Mlecnik B, Fredriksen T, Mauger S, Bindea G, Berger A, Bruneval P, Fridman WH, Pagès F, Galon J.

Cancer Res. 2011 Feb 15;71(4):1263-71. doi: 10.1158/0008-5472.CAN-10-2907. Epub 2011 Feb 8. Erratum in: Cancer Res. 2011 Jul 1;71(13):4732.

25.

Tumor immunosurveillance in human cancers.

Mlecnik B, Bindea G, Pagès F, Galon J.

Cancer Metastasis Rev. 2011 Mar;30(1):5-12. doi: 10.1007/s10555-011-9270-7. Review.

26.

Histopathologic-based prognostic factors of colorectal cancers are associated with the state of the local immune reaction.

Mlecnik B, Tosolini M, Kirilovsky A, Berger A, Bindea G, Meatchi T, Bruneval P, Trajanoski Z, Fridman WH, Pagès F, Galon J.

J Clin Oncol. 2011 Feb 20;29(6):610-8. doi: 10.1200/JCO.2010.30.5425. Epub 2011 Jan 18.

PMID:
21245428
27.

Immunosurveillance in human non-viral cancers.

Fridman WH, Mlecnik B, Bindea G, Pagès F, Galon J.

Curr Opin Immunol. 2011 Apr;23(2):272-8. doi: 10.1016/j.coi.2010.12.011. Epub 2011 Jan 14. Review.

PMID:
21237631
28.

Information technology solutions for integration of biomolecular and clinical data in the identification of new cancer biomarkers and targets for therapy.

Hackl H, Stocker G, Charoentong P, Mlecnik B, Bindea G, Galon J, Trajanoski Z.

Pharmacol Ther. 2010 Dec;128(3):488-98. doi: 10.1016/j.pharmthera.2010.08.012. Epub 2010 Sep 9. Review.

PMID:
20832425
29.

Natural immunity to cancer in humans.

Bindea G, Mlecnik B, Fridman WH, Pagès F, Galon J.

Curr Opin Immunol. 2010 Apr;22(2):215-22. doi: 10.1016/j.coi.2010.02.006. Epub 2010 Mar 6. Review.

PMID:
20207124
30.

Data integration and exploration for the identification of molecular mechanisms in tumor-immune cells interaction.

Mlecnik B, Sanchez-Cabo F, Charoentong P, Bindea G, Pagès F, Berger A, Galon J, Trajanoski Z.

BMC Genomics. 2010 Feb 10;11 Suppl 1:S7. doi: 10.1186/1471-2164-11-S1-S7.

31.

iLAP: a workflow-driven software for experimental protocol development, data acquisition and analysis.

Stocker G, Fischer M, Rieder D, Bindea G, Kainz S, Oberstolz M, McNally JG, Trajanoski Z.

BMC Bioinformatics. 2009 Nov 26;10:390. doi: 10.1186/1471-2105-10-390.

32.

Biomolecular network reconstruction identifies T-cell homing factors associated with survival in colorectal cancer.

Mlecnik B, Tosolini M, Charoentong P, Kirilovsky A, Bindea G, Berger A, Camus M, Gillard M, Bruneval P, Fridman WH, Pagès F, Trajanoski Z, Galon J.

Gastroenterology. 2010 Apr;138(4):1429-40. doi: 10.1053/j.gastro.2009.10.057. Epub 2009 Nov 10.

PMID:
19909745
33.

In situ cytotoxic and memory T cells predict outcome in patients with early-stage colorectal cancer.

Pagès F, Kirilovsky A, Mlecnik B, Asslaber M, Tosolini M, Bindea G, Lagorce C, Wind P, Marliot F, Bruneval P, Zatloukal K, Trajanoski Z, Berger A, Fridman WH, Galon J.

J Clin Oncol. 2009 Dec 10;27(35):5944-51. doi: 10.1200/JCO.2008.19.6147. Epub 2009 Oct 26.

PMID:
19858404
34.

Coordination of intratumoral immune reaction and human colorectal cancer recurrence.

Camus M, Tosolini M, Mlecnik B, Pagès F, Kirilovsky A, Berger A, Costes A, Bindea G, Charoentong P, Bruneval P, Trajanoski Z, Fridman WH, Galon J.

Cancer Res. 2009 Mar 15;69(6):2685-93. doi: 10.1158/0008-5472.CAN-08-2654. Epub 2009 Mar 3.

35.

ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks.

Bindea G, Mlecnik B, Hackl H, Charoentong P, Tosolini M, Kirilovsky A, Fridman WH, Pagès F, Trajanoski Z, Galon J.

Bioinformatics. 2009 Apr 15;25(8):1091-3. doi: 10.1093/bioinformatics/btp101. Epub 2009 Feb 23.

36.

A new platform linking chromosomal and sequence information.

Kowalska A, Bozsaky E, Ramsauer T, Rieder D, Bindea G, Lörch T, Trajanoski Z, Ambros PF.

Chromosome Res. 2007;15(3):327-39. Epub 2007 May 10.

PMID:
17406992

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