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Electrophysiological abnormalities in induced pluripotent stem cell-derived cardiomyocytes generated from Duchenne muscular dystrophy patients.

Eisen B, Ben Jehuda R, Cuttitta AJ, Mekies LN, Shemer Y, Baskin P, Reiter I, Willi L, Freimark D, Gherghiceanu M, Monserrat L, Scherr M, Hilfiker-Kleiner D, Arad M, Michele DE, Binah O.

J Cell Mol Med. 2019 Mar;23(3):2125-2135. doi: 10.1111/jcmm.14124. Epub 2019 Jan 8.


Functional abnormalities in induced Pluripotent Stem Cell-derived cardiomyocytes generated from titin-mutated patients with dilated cardiomyopathy.

Schick R, Mekies LN, Shemer Y, Eisen B, Hallas T, Ben Jehuda R, Ben-Ari M, Szantai A, Willi L, Shulman R, Gramlich M, Pane LS, My I, Freimark D, Murgia M, Santamaria G, Gherghiceanu M, Arad M, Moretti A, Binah O.

PLoS One. 2018 Oct 17;13(10):e0205719. doi: 10.1371/journal.pone.0205719. eCollection 2018. Erratum in: PLoS One. 2018 Nov 8;13(11):e0207548.


Generation of Duchenne muscular dystrophy patient-specific induced pluripotent stem cell line lacking exons 45-50 of the dystrophin gene (IITi001-A).

Eisen B, Ben Jehuda R, Cuttitta AJ, Mekies LN, Reiter I, Ramchandren S, Arad M, Michele DE, Binah O.

Stem Cell Res. 2018 May;29:111-114. doi: 10.1016/j.scr.2018.03.023. Epub 2018 Apr 3.


Genome Editing in Induced Pluripotent Stem Cells using CRISPR/Cas9.

Ben Jehuda R, Shemer Y, Binah O.

Stem Cell Rev Rep. 2018 Jun;14(3):323-336. doi: 10.1007/s12015-018-9811-3. Review.


Investigating the cardiac pathology of SCO2-mediated hypertrophic cardiomyopathy using patients induced pluripotent stem cell-derived cardiomyocytes.

Hallas T, Eisen B, Shemer Y, Ben Jehuda R, Mekies LN, Naor S, Schick R, Eliyahu S, Reiter I, Vlodavsky E, Katz YS, ├Ľunap K, Lorber A, Rodenburg R, Mandel H, Gherghiceanu M, Binah O.

J Cell Mol Med. 2018 Feb;22(2):913-925. doi: 10.1111/jcmm.13392. Epub 2017 Nov 28.


CRISPR correction of the PRKAG2 gene mutation in the patient's induced pluripotent stem cell-derived cardiomyocytes eliminates electrophysiological and structural abnormalities.

Ben Jehuda R, Eisen B, Shemer Y, Mekies LN, Szantai A, Reiter I, Cui H, Guan K, Haron-Khun S, Freimark D, Sperling SR, Gherghiceanu M, Arad M, Binah O.

Heart Rhythm. 2018 Feb;15(2):267-276. doi: 10.1016/j.hrthm.2017.09.024. Epub 2017 Sep 14.


A Method Sustaining the Bioelectric, Biophysical, and Bioenergetic Function of Cultured Rabbit Atrial Cells.

Kirschner Peretz N, Segal S, Arbel-Ganon L, Ben Jehuda R, Shemer Y, Eisen B, Davoodi M, Binah O, Yaniv Y.

Front Physiol. 2017 Aug 15;8:584. doi: 10.3389/fphys.2017.00584. eCollection 2017.


Induced Pluripotent Stem Cell-Derived Cardiomyocytes Provide In Vivo Biological Pacemaker Function.

Chauveau S, Anyukhovsky EP, Ben-Ari M, Naor S, Jiang YP, Danilo P Jr, Rahim T, Burke S, Qiu X, Potapova IA, Doronin SV, Brink PR, Binah O, Cohen IS, Rosen MR.

Circ Arrhythm Electrophysiol. 2017 May;10(5):e004508. doi: 10.1161/CIRCEP.116.004508.


SK4 K+ channels are therapeutic targets for the treatment of cardiac arrhythmias.

Haron-Khun S, Weisbrod D, Bueno H, Yadin D, Behar J, Peretz A, Binah O, Hochhauser E, Eldar M, Yaniv Y, Arad M, Attali B.

EMBO Mol Med. 2017 Apr;9(4):415-429. doi: 10.15252/emmm.201606937.


The cardioprotective efficacy of TVP1022 against ischemia/reperfusion injury and cardiac remodeling in rats.

Malka A, Ertracht O, Bachner-Hinenzon N, Reiter I, Binah O.

Pharmacol Res Perspect. 2016 Nov 22;4(6):e00272. doi: 10.1002/prp2.272. eCollection 2016 Dec.


Detection of small subendocardial infarction using speckle tracking echocardiography in a rat model.

Bachner-Hinenzon N, Shlomo L, Khamis H, Ertracht O, Vered Z, Malka A, Binah O, Adam D.

Echocardiography. 2016 Oct;33(10):1571-1578. doi: 10.1111/echo.13291. Epub 2016 Jul 11.


Developmental changes in electrophysiological characteristics of human-induced pluripotent stem cell-derived cardiomyocytes.

Ben-Ari M, Naor S, Zeevi-Levin N, Schick R, Ben Jehuda R, Reiter I, Raveh A, Grijnevitch I, Barak O, Rosen MR, Weissman A, Binah O.

Heart Rhythm. 2016 Dec;13(12):2379-2387. doi: 10.1016/j.hrthm.2016.08.045. Epub 2016 Sep 14.


Strain Analysis in the Detection of Myocardial Infarction at the Acute and Chronic Stages.

Bachner-Hinenzon N, Malka A, Barac Y, Meerkin D, Ertracht O, Carasso S, Shofti R, Leitman M, Vered Z, Adam D, Binah O.

Echocardiography. 2016 Mar;33(3):450-8. doi: 10.1111/echo.13079. Epub 2015 Sep 28.


Functional abnormalities in iPSC-derived cardiomyocytes generated from CPVT1 and CPVT2 patients carrying ryanodine or calsequestrin mutations.

Novak A, Barad L, Lorber A, Gherghiceanu M, Reiter I, Eisen B, Eldor L, Itskovitz-Eldor J, Eldar M, Arad M, Binah O.

J Cell Mol Med. 2015 Aug;19(8):2006-18. doi: 10.1111/jcmm.12581. Epub 2015 Jul 8.


TVP1022: A Novel Cardioprotective Drug Attenuates Left Ventricular Remodeling After Ischemia/Reperfusion in Pigs.

Malka A, Meerkin D, Barac YD, Malits E, Bachner-Hinenzon N, Carasso S, Ertracht O, Angel I, Shofti R, Youdim M, Abassi Z, Binah O.

J Cardiovasc Pharmacol. 2015 Aug;66(2):214-22. doi: 10.1097/FJC.0000000000000267.


Human embryonic stem cells vs human induced pluripotent stem cells for cardiac repair.

Barad L, Schick R, Zeevi-Levin N, Itskovitz-Eldor J, Binah O.

Can J Cardiol. 2014 Nov;30(11):1279-87. doi: 10.1016/j.cjca.2014.06.023. Epub 2014 Jul 2. Review.


From beat rate variability in induced pluripotent stem cell-derived pacemaker cells to heart rate variability in human subjects.

Ben-Ari M, Schick R, Barad L, Novak A, Ben-Ari E, Lorber A, Itskovitz-Eldor J, Rosen MR, Weissman A, Binah O.

Heart Rhythm. 2014 Oct;11(10):1808-1818. doi: 10.1016/j.hrthm.2014.05.037. Epub 2014 Jun 2.


The fractal nature of blood glucose fluctuations.

Weissman A, Binah O.

J Diabetes Complications. 2014 Sep-Oct;28(5):646-51. doi: 10.1016/j.jdiacomp.2014.05.009. Epub 2014 Jun 2.


Modeling of Friedreich ataxia-related iron overloading cardiomyopathy using patient-specific-induced pluripotent stem cells.

Lee YK, Ho PW, Schick R, Lau YM, Lai WH, Zhou T, Li Y, Ng KM, Ho SL, Esteban MA, Binah O, Tse HF, Siu CW.

Pflugers Arch. 2014 Sep;466(9):1831-44. doi: 10.1007/s00424-013-1414-x. Epub 2013 Dec 11.


The mitochondria as a target for cardioprotection in acute myocardial ischemia.

Ertracht O, Malka A, Atar S, Binah O.

Pharmacol Ther. 2014 Apr;142(1):33-40. doi: 10.1016/j.pharmthera.2013.11.003. Epub 2013 Nov 22. Review.


Modeling Catecholaminergic Polymorphic Ventricular Tachycardia using Induced Pluripotent Stem Cell-derived Cardiomyocytes.

Novak A, Lorber A, Itskovitz-Eldor J, Binah O.

Rambam Maimonides Med J. 2012 Jul 31;3(3):e0015. doi: 10.5041/RMMJ.10086. Print 2012 Jul.


SK4 Ca2+ activated K+ channel is a critical player in cardiac pacemaker derived from human embryonic stem cells.

Weisbrod D, Peretz A, Ziskind A, Menaker N, Oz S, Barad L, Eliyahu S, Itskovitz-Eldor J, Dascal N, Khananshvili D, Binah O, Attali B.

Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):E1685-94. doi: 10.1073/pnas.1221022110. Epub 2013 Apr 15.


Functional cardiomyocytes from human stem cells: a tool for determining the cardiotoxic potential of preclinical drugs.

Zeevi-Levin N, Itskovitz-Eldor J, Binah O.

Future Med Chem. 2013 Mar;5(4):363-6. doi: 10.4155/fmc.13.22. No abstract available.


Integrating beat rate variability: from single cells to hearts.

Binah O, Weissman A, Itskovitz-Eldor J, Rosen MR.

Heart Rhythm. 2013 Jun;10(6):928-932. doi: 10.1016/j.hrthm.2013.02.013. Epub 2013 Feb 13. No abstract available.


I1 imidazoline receptor: novel potential cytoprotective target of TVP1022, the S-enantiomer of rasagiline.

Barac YD, Bar-Am O, Liani E, Amit T, Frolov L, Ovcharenko E, Angel I, Youdim MB, Binah O.

PLoS One. 2012;7(11):e47890. doi: 10.1371/journal.pone.0047890. Epub 2012 Nov 15. Erratum in: PLoS One. 2013;8(6). doi: 10.1371/annotation/9dae97ef-4a68-47b2-a8f5-fb953ebe877c.


Layer-specific strain analysis: investigation of regional deformations in a rat model of acute versus chronic myocardial infarction.

Bachner-Hinenzon N, Ertracht O, Malka A, Leitman M, Vered Z, Binah O, Adam D.

Am J Physiol Heart Circ Physiol. 2012 Sep 1;303(5):H549-58. doi: 10.1152/ajpheart.00294.2012. Epub 2012 Jul 9.


Cardiomyocytes derived from human pluripotent stem cells for drug screening.

Zeevi-Levin N, Itskovitz-Eldor J, Binah O.

Pharmacol Ther. 2012 May;134(2):180-8. doi: 10.1016/j.pharmthera.2012.01.005. Epub 2012 Jan 16. Review.


Human embryonic and induced pluripotent stem cell-derived cardiomyocytes exhibit beat rate variability and power-law behavior.

Mandel Y, Weissman A, Schick R, Barad L, Novak A, Meiry G, Goldberg S, Lorber A, Rosen MR, Itskovitz-Eldor J, Binah O.

Circulation. 2012 Feb 21;125(7):883-93. doi: 10.1161/CIRCULATIONAHA.111.045146. Epub 2012 Jan 18.


Cardiomyocytes generated from CPVTD307H patients are arrhythmogenic in response to ╬▓-adrenergic stimulation.

Novak A, Barad L, Zeevi-Levin N, Shick R, Shtrichman R, Lorber A, Itskovitz-Eldor J, Binah O.

J Cell Mol Med. 2012 Mar;16(3):468-82. doi: 10.1111/j.1582-4934.2011.01476.x.


Cardiomyocytes derived from human embryonic and induced pluripotent stem cells: comparative ultrastructure.

Gherghiceanu M, Barad L, Novak A, Reiter I, Itskovitz-Eldor J, Binah O, Popescu LM.

J Cell Mol Med. 2011 Nov;15(11):2539-51. doi: 10.1111/j.1582-4934.2011.01417.x.


TVP1022 attenuates cardiac remodeling and kidney dysfunction in experimental volume overload-induced congestive heart failure.

Abassi ZA, Barac YD, Kostin S, Roguin A, Ovcharenko E, Awad H, Blank A, Bar-Am O, Amit T, Schaper J, Youdim M, Binah O.

Circ Heart Fail. 2011 Jul;4(4):463-73. doi: 10.1161/CIRCHEARTFAILURE.111.961037. Epub 2011 May 10.


The cardioprotective efficacy of TVP1022 in a rat model of ischaemia/reperfusion.

Ertracht O, Liani E, Bachner-Hinenzon N, Bar-Am O, Frolov L, Ovcharenko E, Awad H, Blum S, Barac Y, Amit T, Adam D, Youdim M, Binah O.

Br J Pharmacol. 2011 Jun;163(4):755-69. doi: 10.1111/j.1476-5381.2011.01274.x.


Enhanced reprogramming and cardiac differentiation of human keratinocytes derived from plucked hair follicles, using a single excisable lentivirus.

Novak A, Shtrichman R, Germanguz I, Segev H, Zeevi-Levin N, Fishman B, Mandel YE, Barad L, Domev H, Kotton D, Mostoslavsky G, Binah O, Itskovitz-Eldor J.

Cell Reprogram. 2010 Dec;12(6):665-78. doi: 10.1089/cell.2010.0027. Epub 2010 Oct 21.


Hypoxia causes connexin 43 internalization in neonatal rat ventricular myocytes.

Danon A, Zeevi-Levin N, Pinkovich DY, Michaeli T, Berkovich A, Flugelman M, Eldar YC, Rosen MR, Binah O.

Gen Physiol Biophys. 2010 Sep;29(3):222-33.


Layer-specific assessment of left ventricular function by utilizing wavelet de-noising: a validation study.

Bachner-Hinenzon N, Ertracht O, Lysiansky M, Binah O, Adam D.

Med Biol Eng Comput. 2011 Jan;49(1):3-13. doi: 10.1007/s11517-010-0662-6. Epub 2010 Jul 20.


Layer-specific strain analysis by speckle tracking echocardiography reveals differences in left ventricular function between rats and humans.

Bachner-Hinenzon N, Ertracht O, Leitman M, Vered Z, Shimoni S, Beeri R, Binah O, Adam D.

Am J Physiol Heart Circ Physiol. 2010 Sep;299(3):H664-72. doi: 10.1152/ajpheart.00017.2010. Epub 2010 Jul 2.


Functional properties of human embryonic stem cell-derived cardiomyocytes.

Zeevi-Levin N, Itskovitz-Eldor J, Binah O.

Crit Rev Eukaryot Gene Expr. 2010;20(1):51-9. Review.


Human embryonic stem cell-derived cardiomyocytes can mobilize 1,4,5-inositol trisphosphate-operated [Ca2+]i stores: the functionality of angiotensin-II/endothelin-1 signaling pathways.

Sedan O, Dolnikov K, Zeevi-Levin N, Fleishmann N, Spiegel I, Berdichevski S, Amit M, Itskovitz-Eldor J, Binah O.

Ann N Y Acad Sci. 2010 Feb;1188:68-77. doi: 10.1111/j.1749-6632.2009.05085.x.


Molecular characterization and functional properties of cardiomyocytes derived from human inducible pluripotent stem cells.

Germanguz I, Sedan O, Zeevi-Levin N, Shtrichman R, Barak E, Ziskind A, Eliyahu S, Meiry G, Amit M, Itskovitz-Eldor J, Binah O.

J Cell Mol Med. 2011 Jan;15(1):38-51. doi: 10.1111/j.1582-4934.2009.00996.x.


TVP1022 protects neonatal rat ventricular myocytes against doxorubicin-induced functional derangements.

Berdichevski A, Meiry G, Milman F, Reiter I, Sedan O, Eliyahu S, Duffy HS, Youdim MB, Binah O.

J Pharmacol Exp Ther. 2010 Feb;332(2):413-20. doi: 10.1124/jpet.109.161158. Epub 2009 Nov 13.


Impulse conduction and gap junctional remodelling by endothelin-1 in cultured neonatal rat ventricular myocytes.

Reisner Y, Meiry G, Zeevi-Levin N, Barac DY, Reiter I, Abassi Z, Ziv N, Kostin S, Schaper J, Rosen MR, Binah O.

J Cell Mol Med. 2009 Mar;13(3):562-73. doi: 10.1111/j.1582-4934.2008.00361.x.


Shear stress-induced transcriptional regulation via hybrid promoters as a potential tool for promoting angiogenesis.

Silberman M, Barac YD, Yahav H, Wolfovitz E, Einav S, Resnick N, Binah O.

Angiogenesis. 2009;12(3):231-42. doi: 10.1007/s10456-009-9143-7. Epub 2009 Mar 26.


Role of the Fas/Fas-L pathway-mediated apoptosis in inflammatory heart diseases and vasculature diseases.

Binah O.

J Cardiovasc Pharmacol. 2009 Feb;53(2):91-3. doi: 10.1097/FJC.0b013e31819aa304. No abstract available.


Mechanical load induced by glass microspheres releases angiogenic factors from neonatal rat ventricular myocytes cultures and causes arrhythmias.

Barac DY, Reisner Y, Silberman M, Zeevi-Levin N, Danon A, Salomon O, Shoham M, Shilkrut M, Kostin S, Schaper J, Binah O.

J Cell Mol Med. 2008 Oct;12(5B):2037-51. doi: 10.1111/j.1582-4934.2008.00193.x.


1,4,5-Inositol trisphosphate-operated intracellular Ca(2+) stores and angiotensin-II/endothelin-1 signaling pathway are functional in human embryonic stem cell-derived cardiomyocytes.

Sedan O, Dolnikov K, Zeevi-Levin N, Leibovich N, Amit M, Itskovitz-Eldor J, Binah O.

Stem Cells. 2008 Dec;26(12):3130-8. doi: 10.1634/stemcells.2008-0777. Epub 2008 Sep 25.


TVP1022 and propargylamine protect neonatal rat ventricular myocytes against doxorubicin-induced and serum starvation-induced cardiotoxicity.

Kleiner Y, Bar-Am O, Amit T, Berdichevski A, Liani E, Maor G, Reiter I, Youdim MB, Binah O.

J Cardiovasc Pharmacol. 2008 Sep;52(3):268-77. doi: 10.1097/FJC.0b013e3181862441.


Functional and developmental properties of human embryonic stem cells-derived cardiomyocytes.

Binah O, Dolnikov K, Sadan O, Shilkrut M, Zeevi-Levin N, Amit M, Danon A, Itskovitz-Eldor J.

J Electrocardiol. 2007 Nov-Dec;40(6 Suppl):S192-6.


Adaptive cardiac resynchronization therapy device based on spiking neurons architecture and reinforcement learning scheme.

Rom R, Erel J, Glikson M, Lieberman RA, Rosenblum K, Binah O, Ginosar R, Hayes DL.

IEEE Trans Neural Netw. 2007 Mar;18(2):542-50.


Autoantibodies to cardiac troponin I in patients with idiopathic dilated and ischemic cardiomyopathy.

Shmilovich H, Danon A, Binah O, Roth A, Chen G, Wexler D, Keren G, George J.

Int J Cardiol. 2007 Apr 25;117(2):198-203. Epub 2006 Aug 2.


Functional properties of human embryonic stem cell-derived cardiomyocytes: intracellular Ca2+ handling and the role of sarcoplasmic reticulum in the contraction.

Dolnikov K, Shilkrut M, Zeevi-Levin N, Gerecht-Nir S, Amit M, Danon A, Itskovitz-Eldor J, Binah O.

Stem Cells. 2006 Feb;24(2):236-45. Epub 2005 Dec 1.

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