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Items: 23

1.

Discovery of Potent, Selective, and Peripherally Restricted Pan-Trk Kinase Inhibitors for the Treatment of Pain.

Bagal SK, Andrews M, Bechle BM, Bian J, Bilsland J, Blakemore DC, Braganza JF, Bungay PJ, Corbett MS, Cronin CN, Cui JJ, Dias R, Flanagan NJ, Greasley SE, Grimley R, James K, Johnson E, Kitching L, Kraus ML, McAlpine I, Nagata A, Ninkovic S, Omoto K, Scales S, Skerratt SE, Sun J, Tran-Dubé M, Waldron GJ, Wang F, Warmus JS.

J Med Chem. 2018 Aug 9;61(15):6779-6800. doi: 10.1021/acs.jmedchem.8b00633. Epub 2018 Jul 27.

PMID:
29944371
2.

Discovery of Allosteric, Potent, Subtype Selective, and Peripherally Restricted TrkA Kinase Inhibitors.

Bagal SK, Omoto K, Blakemore DC, Bungay PJ, Bilsland JG, Clarke PJ, Corbett MS, Cronin CN, Cui JJ, Dias R, Flanagan NJ, Greasley SE, Grimley R, Johnson E, Fengas D, Kitching L, Kraus ML, McAlpine I, Nagata A, Waldron GJ, Warmus JS.

J Med Chem. 2018 May 3. doi: 10.1021/acs.jmedchem.8b00280. [Epub ahead of print]

PMID:
29672039
3.

The Discovery of a Potent, Selective, and Peripherally Restricted Pan-Trk Inhibitor (PF-06273340) for the Treatment of Pain.

Skerratt SE, Andrews M, Bagal SK, Bilsland J, Brown D, Bungay PJ, Cole S, Gibson KR, Jones R, Morao I, Nedderman A, Omoto K, Robinson C, Ryckmans T, Skinner K, Stupple P, Waldron G.

J Med Chem. 2016 Nov 23;59(22):10084-10099. Epub 2016 Nov 4.

PMID:
27766865
4.

Genome-wide association analysis of pain severity in dysmenorrhea identifies association at chromosome 1p13.2, near the nerve growth factor locus.

Jones AV, Hockley JR, Hyde C, Gorman D, Sredic-Rhodes A, Bilsland J, McMurray G, Furlotte NA, Hu Y, Hinds DA, Cox PJ, Scollen S.

Pain. 2016 Nov;157(11):2571-2581.

5.

Pharmacological reversal of a pain phenotype in iPSC-derived sensory neurons and patients with inherited erythromelalgia.

Cao L, McDonnell A, Nitzsche A, Alexandrou A, Saintot PP, Loucif AJ, Brown AR, Young G, Mis M, Randall A, Waxman SG, Stanley P, Kirby S, Tarabar S, Gutteridge A, Butt R, McKernan RM, Whiting P, Ali Z, Bilsland J, Stevens EB.

Sci Transl Med. 2016 Apr 20;8(335):335ra56. doi: 10.1126/scitranslmed.aad7653.

PMID:
27099175
6.

Characterizing human stem cell-derived sensory neurons at the single-cell level reveals their ion channel expression and utility in pain research.

Young GT, Gutteridge A, Fox H, Wilbrey AL, Cao L, Cho LT, Brown AR, Benn CL, Kammonen LR, Friedman JH, Bictash M, Whiting P, Bilsland JG, Stevens EB.

Mol Ther. 2014 Aug;22(8):1530-1543. doi: 10.1038/mt.2014.86. Epub 2014 May 15.

7.

Combined small-molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors.

Chambers SM, Qi Y, Mica Y, Lee G, Zhang XJ, Niu L, Bilsland J, Cao L, Stevens E, Whiting P, Shi SH, Studer L.

Nat Biotechnol. 2012 Jul 1;30(7):715-20. doi: 10.1038/nbt.2249.

8.

Behavioral and neurochemical alterations in mice deficient in anaplastic lymphoma kinase suggest therapeutic potential for psychiatric indications.

Bilsland JG, Wheeldon A, Mead A, Znamenskiy P, Almond S, Waters KA, Thakur M, Beaumont V, Bonnert TP, Heavens R, Whiting P, McAllister G, Munoz-Sanjuan I.

Neuropsychopharmacology. 2008 Feb;33(3):685-700. Epub 2007 May 9.

9.

Identification of proteomic changes during differentiation of adult mouse subventricular zone progenitor cells.

Salim K, Guest PC, Skynner HA, Bilsland JG, Bonnert TP, McAllister G, Munoz-Sanjuan I.

Stem Cells Dev. 2007 Feb;16(1):143-65.

PMID:
17233554
10.

Molecular characterization of adult mouse subventricular zone progenitor cells during the onset of differentiation.

Bonnert TP, Bilsland JG, Guest PC, Heavens R, McLaren D, Dale C, Thakur M, McAllister G, Munoz-Sanjuan I.

Eur J Neurosci. 2006 Aug;24(3):661-75.

PMID:
16930398
11.

A rapid method for the quantification of mouse hippocampal neurogenesis in vivo by flow cytometry. Validation with conventional and enhanced immunohistochemical methods.

Bilsland JG, Haldon C, Goddard J, Oliver K, Murray F, Wheeldon A, Cumberbatch J, McAllister G, Munoz-Sanjuan I.

J Neurosci Methods. 2006 Oct 15;157(1):54-63. Epub 2006 Jul 31.

PMID:
16876875
12.

Identification of differentiating neural progenitor cell markers using shotgun isobaric tagging mass spectrometry.

Salim K, Kehoe L, Minkoff MS, Bilsland JG, Munoz-Sanjuan I, Guest PC.

Stem Cells Dev. 2006 Jun;15(3):461-70.

PMID:
16846381
13.

CEP-1347 promotes survival of NGF responsive neurones in primary DRG explants.

Bilsland JG, Harper SJ.

Neuroreport. 2003 May 23;14(7):995-9.

PMID:
12802190
14.

Caspases and neuroprotection.

Bilsland J, Harper S.

Curr Opin Investig Drugs. 2002 Dec;3(12):1745-52. Review.

PMID:
12528311
15.

Caspase inhibitors attenuate 1-methyl-4-phenylpyridinium toxicity in primary cultures of mesencephalic dopaminergic neurons.

Bilsland J, Roy S, Xanthoudakis S, Nicholson DW, Han Y, Grimm E, Hefti F, Harper SJ.

J Neurosci. 2002 Apr 1;22(7):2637-49.

16.

The non-peptidyl fungal metabolite L-783,281 activates TRK neurotrophin receptors.

Wilkie N, Wingrove PB, Bilsland JG, Young L, Harper SJ, Hefti F, Ellis S, Pollack SJ.

J Neurochem. 2001 Sep;78(5):1135-45.

17.

A rapid method for determination of cell survival in primary neuronal DRG cultures.

Young L, Bilsland J, Harper S.

J Neurosci Methods. 1999 Oct 30;93(1):81-9.

PMID:
10598867
18.

A rapid method for semi-quantitative analysis of neurite outgrowth from chick DRG explants using image analysis.

Bilsland J, Rigby M, Young L, Harper S.

J Neurosci Methods. 1999 Oct 15;92(1-2):75-85.

PMID:
10595705
19.

The staurosporine-like compound L-753,000 (NB-506) potentiates the neurotrophic effects of neurotrophin-3 by acting selectively at the TrkA receptor.

Pollack S, Young L, Bilsland J, Wilkie N, Ellis S, Hefti F, Broughton H, Harper S.

Mol Pharmacol. 1999 Jul;56(1):185-95.

20.

Analysis of the neurotrophic effects of GPI-1046 on neuron survival and regeneration in culture and in vivo.

Harper S, Bilsland J, Young L, Bristow L, Boyce S, Mason G, Rigby M, Hewson L, Smith D, O'Donnell R, O'Connor D, Hill RG, Evans D, Swain C, Williams B, Hefti F.

Neuroscience. 1999 Jan;88(1):257-67.

PMID:
10051205
21.

Quantification of Fos immunoreactivity in cortical cultures treated with growth factors.

Bilsland JG, Harper SJ.

J Neurosci Methods. 1998 Oct 1;84(1-2):121-30.

PMID:
9821643
22.

Mouse cortical neurones lacking APP show normal neurite outgrowth and survival responses in vitro.

Harper SJ, Bilsland JG, Shearman MS, Zheng H, Van der Ploeg L, Sirinathsinghji DJ.

Neuroreport. 1998 Sep 14;9(13):3053-8.

PMID:
9804315
23.

De Quincey's opium experiences.

Bilsland JW.

Dalhousie Rev. 1975;55(3):419-30. No abstract available.

PMID:
11619649

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