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Items: 1 to 50 of 678

1.

Gasdermin D protects against noninfectious liver injury by regulating apoptosis and necroptosis.

Yang C, Sun P, Deng M, Loughran P, Li W, Yi Z, Li S, Zhang X, Fan J, Billiar TR, Scott MJ.

Cell Death Dis. 2019 Jun 17;10(7):481. doi: 10.1038/s41419-019-1719-6.

PMID:
31209224
2.

Computational evidence for an early, amplified systemic inflammation program in polytrauma patients with severe extremity injuries.

Almahmoud K, Abboud A, Namas RA, Zamora R, Sperry J, Peitzman AB, Truitt MS, Gaski GE, McKinley TO, Billiar TR, Vodovotz Y.

PLoS One. 2019 Jun 4;14(6):e0217577. doi: 10.1371/journal.pone.0217577. eCollection 2019.

3.

cAMP metabolism controls caspase-11 inflammasome activation and pyroptosis in sepsis.

Chen R, Zeng L, Zhu S, Liu J, Zeh HJ, Kroemer G, Wang H, Billiar TR, Jiang J, Tang D, Kang R.

Sci Adv. 2019 May 22;5(5):eaav5562. doi: 10.1126/sciadv.aav5562. eCollection 2019 May.

4.

Identifying patients with time-sensitive injuries: Association of mortality with increasing prehospital time.

Chen X, Guyette FX, Peitzman AB, Billiar TR, Sperry JL, Brown JB.

J Trauma Acute Care Surg. 2019 Jun;86(6):1015-1022. doi: 10.1097/TA.0000000000002251.

PMID:
31124900
5.

Activation of Pregnane X Receptor Sensitizes Mice to Hemorrhagic Shock Induced Liver Injury.

Xie Y, Xu M, Deng M, Li Z, Wang P, Ren S, Guo Y, Ma X, Fan J, Billiar TR, Xie W.

Hepatology. 2019 Apr 30. doi: 10.1002/hep.30691. [Epub ahead of print]

PMID:
31038762
6.

Early Immunologic Response in Multiply Injured Patients With Orthopaedic Injuries Is Associated With Organ Dysfunction.

Gaski GE, Metzger C, McCarroll T, Wessel R, Adler J, Cutshall A, Brown K, Vodovotz Y, Billiar TR, McKinley TO.

J Orthop Trauma. 2019 May;33(5):220-228. doi: 10.1097/BOT.0000000000001437.

PMID:
31008819
7.

Prehospital Blood Product and Crystalloid Resuscitation in the Severely Injured Patient: A Secondary Analysis of the Prehospital Air Medical Plasma Trial.

Guyette FX, Sperry JL, Peitzman AB, Billiar TR, Daley BJ, Miller RS, Harbrecht BG, Claridge JA, Putnam T, Duane TM, Phelan HA, Brown JB.

Ann Surg. 2019 Apr 13. doi: 10.1097/SLA.0000000000003324. [Epub ahead of print]

PMID:
30998533
8.

HMGB1 is a Central Driver of Dynamic Pro-inflammatory Networks in Pediatric Acute Liver Failure induced by Acetaminophen.

Zamora R, Barclay D, Yin J, Alonso EM, Leonis MA, Mi Q, Billiar TR, Simmons RL, Squires RH, Vodovotz Y.

Sci Rep. 2019 Apr 12;9(1):5971. doi: 10.1038/s41598-019-42564-5.

9.

Location is the key to function: HMGB1 in sepsis and trauma-induced inflammation.

Deng M, Scott MJ, Fan J, Billiar TR.

J Leukoc Biol. 2019 Apr 4. doi: 10.1002/JLB.3MIR1218-497R. [Epub ahead of print] Review.

PMID:
30946496
10.

IL-33-mediated IL-13 secretion by ST2+ Tregs controls inflammation after lung injury.

Liu Q, Dwyer GK, Zhao Y, Li H, Mathews LR, Chakka AB, Chandran UR, Demetris JA, Alcorn JF, Robinson KM, Ortiz LA, Pitt BR, Thomson AW, Fan MH, Billiar TR, Turnquist HR.

JCI Insight. 2019 Mar 21;4(6). pii: 123919. doi: 10.1172/jci.insight.123919. eCollection 2019 Mar 21.

11.

A conceptual time window-based model for the early stratification of trauma patients.

Lamparello AJ, Namas RA, Constantine G, McKinley TO, Elster E, Vodovotz Y, Billiar TR.

J Intern Med. 2019 Jan 9. doi: 10.1111/joim.12874. [Epub ahead of print] Review.

PMID:
30623510
12.

TRIF signaling is required for caspase-11-dependent immune responses and lethality in sepsis.

Tang Y, Zhang R, Xue Q, Meng R, Wang X, Yang Y, Xie L, Xiao X, Billiar TR, Lu B.

Mol Med. 2018 Dec 27;24(1):66. doi: 10.1186/s10020-018-0065-y.

13.

Intestinal Microbiota Mediates the Susceptibility to Polymicrobial Sepsis-Induced Liver Injury by Granisetron Generation in Mice.

Gong S, Yan Z, Liu Z, Niu M, Fang H, Li N, Huang C, Li L, Chen G, Luo H, Chen X, Zhou H, Hu J, Yang W, Huang Q, Schnabl B, Chang P, Billiar TR, Jiang Y, Chen P.

Hepatology. 2019 Apr;69(4):1751-1767. doi: 10.1002/hep.30361. Epub 2019 Mar 5.

PMID:
30506577
14.

Young and Aged Blunt Trauma Patients Display Major Differences in Circulating Inflammatory Mediator Profiles after Severe Injury.

Lamparello AJ, Namas RA, Abdul-Malak O, Vodovotz Y, Billiar TR.

J Am Coll Surg. 2019 Feb;228(2):148-160.e7. doi: 10.1016/j.jamcollsurg.2018.10.019. Epub 2018 Nov 16.

PMID:
30448299
15.

Mechanical ventilation enhances extrapulmonary sepsis-induced lung injury: role of WISP1-αvβ5 integrin pathway in TLR4-mediated inflammation and injury.

Ding X, Tong Y, Jin S, Chen Z, Li T, Billiar TR, Pitt BR, Li Q, Zhang LM.

Crit Care. 2018 Nov 16;22(1):302. doi: 10.1186/s13054-018-2237-0.

16.

A computational analysis of dynamic, multi-organ inflammatory crosstalk induced by endotoxin in mice.

Zamora R, Korff S, Mi Q, Barclay D, Schimunek L, Zucca R, Arsiwalla XD, Simmons RL, Verschure P, Billiar TR, Vodovotz Y.

PLoS Comput Biol. 2018 Nov 6;14(11):e1006582. doi: 10.1371/journal.pcbi.1006582. eCollection 2018 Nov.

17.

The Endotoxin Delivery Protein HMGB1 Mediates Caspase-11-Dependent Lethality in Sepsis.

Deng M, Tang Y, Li W, Wang X, Zhang R, Zhang X, Zhao X, Liu J, Tang C, Liu Z, Huang Y, Peng H, Xiao L, Tang D, Scott MJ, Wang Q, Liu J, Xiao X, Watkins S, Li J, Yang H, Wang H, Chen F, Tracey KJ, Billiar TR, Lu B.

Immunity. 2018 Oct 16;49(4):740-753.e7. doi: 10.1016/j.immuni.2018.08.016. Epub 2018 Oct 9.

PMID:
30314759
18.

iNOS promotes CD24+CD133+ liver cancer stem cell phenotype through a TACE/ADAM17-dependent Notch signaling pathway.

Wang R, Li Y, Tsung A, Huang H, Du Q, Yang M, Deng M, Xiong S, Wang X, Zhang L, Geller DA, Cheng B, Billiar TR.

Proc Natl Acad Sci U S A. 2018 Oct 23;115(43):E10127-E10136. doi: 10.1073/pnas.1722100115. Epub 2018 Oct 8.

19.

The IL-33-ST2 Pathway Contributes to Ventilator-Induced Lung Injury in Septic Mice in a Tidal Volume-Dependent Manner.

Ding X, Jin S, Shao Z, Xu L, Yu Z, Tong Y, Chen Z, Turnquist H, Pitt BR, Billiar TR, Zhang LM, Li Q.

Shock. 2018 Sep 5. doi: 10.1097/SHK.0000000000001260. [Epub ahead of print]

PMID:
30192340
20.

Lung epithelial cell-derived IL-25 negatively regulates LPS-induced exosome release from macrophages.

Li ZG, Scott MJ, Brzóska T, Sundd P, Li YH, Billiar TR, Wilson MA, Wang P, Fan J.

Mil Med Res. 2018 Jul 30;5(1):24. doi: 10.1186/s40779-018-0173-6.

21.

Lack of Benefit on Brain Edema, Blood-Brain Barrier Permeability, or Cognitive Outcome in Global Inducible High Mobility Group Box 1 Knockout Mice Despite Tissue Sparing after Experimental Traumatic Brain Injury.

Aneja RK, Alcamo AM, Cummings J, Vagni V, Feldman K, Wang Q, Dixon CE, Billiar TR, Kochanek PM.

J Neurotrauma. 2019 Jan 15;36(2):360-369. doi: 10.1089/neu.2018.5664. Epub 2018 Sep 5.

PMID:
30045665
22.

Prehospital Plasma during Air Medical Transport in Trauma Patients at Risk for Hemorrhagic Shock.

Sperry JL, Guyette FX, Brown JB, Yazer MH, Triulzi DJ, Early-Young BJ, Adams PW, Daley BJ, Miller RS, Harbrecht BG, Claridge JA, Phelan HA, Witham WR, Putnam AT, Duane TM, Alarcon LH, Callaway CW, Zuckerbraun BS, Neal MD, Rosengart MR, Forsythe RM, Billiar TR, Yealy DM, Peitzman AB, Zenati MS; PAMPer Study Group.

N Engl J Med. 2018 Jul 26;379(4):315-326. doi: 10.1056/NEJMoa1802345.

23.

Blunt cerebrovascular injury in elderly fall patients: are we screening enough?

Anto VP, Brown JB, Peitzman AB, Zuckerbraun BS, Neal MD, Watson G, Forsythe R, Billiar TR, Sperry JL.

World J Emerg Surg. 2018 Jul 4;13:30. doi: 10.1186/s13017-018-0188-z. eCollection 2018.

24.

The Circadian Clock Controls Immune Checkpoint Pathway in Sepsis.

Deng W, Zhu S, Zeng L, Liu J, Kang R, Yang M, Cao L, Wang H, Billiar TR, Jiang J, Xie M, Tang D.

Cell Rep. 2018 Jul 10;24(2):366-378. doi: 10.1016/j.celrep.2018.06.026.

25.

Lipid Peroxidation Drives Gasdermin D-Mediated Pyroptosis in Lethal Polymicrobial Sepsis.

Kang R, Zeng L, Zhu S, Xie Y, Liu J, Wen Q, Cao L, Xie M, Ran Q, Kroemer G, Wang H, Billiar TR, Jiang J, Tang D.

Cell Host Microbe. 2018 Jul 11;24(1):97-108.e4. doi: 10.1016/j.chom.2018.05.009. Epub 2018 Jun 21.

PMID:
29937272
26.

Logistics of air medical transport: When and where does helicopter transport reduce prehospital time for trauma?

Chen X, Gestring ML, Rosengart MR, Peitzman AB, Billiar TR, Sperry JL, Brown JB.

J Trauma Acute Care Surg. 2018 Jul;85(1):174-181. doi: 10.1097/TA.0000000000001935.

PMID:
29787553
27.

Interleukin-33 contributes to ILC2 activation and early inflammation-associated lung injury during abdominal sepsis.

Xu H, Xu J, Xu L, Jin S, Turnquist HR, Hoffman R, Loughran P, Billiar TR, Deng M.

Immunol Cell Biol. 2018 Oct;96(9):935-947. doi: 10.1111/imcb.12159. Epub 2018 May 17.

PMID:
29672927
28.

Platelet HMGB1 is required for efficient bacterial clearance in intra-abdominal bacterial sepsis in mice.

Zhou H, Deng M, Liu Y, Yang C, Hoffman R, Zhou J, Loughran PA, Scott MJ, Neal MD, Billiar TR.

Blood Adv. 2018 Mar 27;2(6):638-648. doi: 10.1182/bloodadvances.2017011817.

29.

REDD-1 aggravates endotoxin-induced inflammation via atypical NF-κB activation.

Lee DK, Kim JH, Kim J, Choi S, Park M, Park W, Kim S, Lee KS, Kim T, Jung J, Choi YK, Ha KS, Won MH, Billiar TR, Kwon YG, Kim YM.

FASEB J. 2018 Aug;32(8):4585-4599. doi: 10.1096/fj.201701436R. Epub 2018 Mar 16.

PMID:
29547704
30.

Group 2 innate lymphoid cells protect lung endothelial cells from pyroptosis in sepsis.

Lai D, Tang J, Chen L, Fan EK, Scott MJ, Li Y, Billiar TR, Wilson MA, Fang X, Shu Q, Fan J.

Cell Death Dis. 2018 Mar 6;9(3):369. doi: 10.1038/s41419-018-0412-5.

31.

Characterizing injury severity in nonaccidental trauma: Does Injury Severity Score miss the mark?

Brown JB, Gestring ML, Leeper CM, Sperry JL, Peitzman AB, Billiar TR, Gaines BA.

J Trauma Acute Care Surg. 2018 Oct;85(4):668-673. doi: 10.1097/TA.0000000000001841.

PMID:
29462080
32.

Toll-Like Receptor 4 Signaling Licenses the Cytosolic Transport of Lipopolysaccharide From Bacterial Outer Membrane Vesicles.

Gu L, Meng R, Tang Y, Zhao K, Liang F, Zhang R, Xue Q, Chen F, Xiao X, Wang H, Wang H, Billiar TR, Lu B.

Shock. 2019 Feb;51(2):256-265. doi: 10.1097/SHK.0000000000001129.

PMID:
29462003
33.

Diagnosis and Management of Polytraumatized Patients With Severe Extremity Trauma.

McKinley TO, Gaski GE, Vodovotz Y, Corona BT, Billiar TR.

J Orthop Trauma. 2018 Mar;32 Suppl 1:S1-S6. doi: 10.1097/BOT.0000000000001114.

PMID:
29461394
34.

cGAS-mediated autophagy protects the liver from ischemia-reperfusion injury independently of STING.

Lei Z, Deng M, Yi Z, Sun Q, Shapiro RA, Xu H, Li T, Loughran PA, Griepentrog JE, Huang H, Scott MJ, Huang F, Billiar TR.

Am J Physiol Gastrointest Liver Physiol. 2018 Jun 1;314(6):G655-G667. doi: 10.1152/ajpgi.00326.2017. Epub 2018 Feb 15.

35.

Overresuscitation with plasma is associated with sustained fibrinolysis shutdown and death in pediatric traumatic brain injury.

Leeper CM, Neal MD, Billiar TR, Sperry JL, Gaines BA.

J Trauma Acute Care Surg. 2018 Jul;85(1):12-17. doi: 10.1097/TA.0000000000001836.

PMID:
29443859
36.

"Thinking" vs. "Talking": Differential Autocrine Inflammatory Networks in Isolated Primary Hepatic Stellate Cells and Hepatocytes under Hypoxic Stress.

Vodovotz Y, Simmons RL, Gandhi CR, Barclay D, Jefferson BS, Huang C, Namas R, El-Dehaibi F, Mi Q, Billiar TR, Zamora R.

Front Physiol. 2017 Dec 22;8:1104. doi: 10.3389/fphys.2017.01104. eCollection 2017.

37.

Speed is not everything: Identifying patients who may benefit from helicopter transport despite faster ground transport.

Chen X, Gestring ML, Rosengart MR, Billiar TR, Peitzman AB, Sperry JL, Brown JB.

J Trauma Acute Care Surg. 2018 Apr;84(4):549-557. doi: 10.1097/TA.0000000000001769.

PMID:
29251708
38.

JTC801 Induces pH-dependent Death Specifically in Cancer Cells and Slows Growth of Tumors in Mice.

Song X, Zhu S, Xie Y, Liu J, Sun L, Zeng D, Wang P, Ma X, Kroemer G, Bartlett DL, Billiar TR, Lotze MT, Zeh HJ, Kang R, Tang D.

Gastroenterology. 2018 Apr;154(5):1480-1493. doi: 10.1053/j.gastro.2017.12.004. Epub 2017 Dec 14.

39.

NO and COX2: Dual targeting for aggressive cancers.

Davila-Gonzalez D, Chang JC, Billiar TR.

Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):13591-13593. doi: 10.1073/pnas.1717440114. Epub 2017 Dec 13. No abstract available.

40.

Toll-Like Receptor 4 on both Myeloid Cells and Dendritic Cells Is Required for Systemic Inflammation and Organ Damage after Hemorrhagic Shock with Tissue Trauma in Mice.

Zettel K, Korff S, Zamora R, Morelli AE, Darwiche S, Loughran PA, Elson G, Shang L, Salgado-Pires S, Scott MJ, Vodovotz Y, Billiar TR.

Front Immunol. 2017 Nov 28;8:1672. doi: 10.3389/fimmu.2017.01672. eCollection 2017.

41.

High mobility group protein B1 controls liver cancer initiation through yes-associated protein -dependent aerobic glycolysis.

Chen R, Zhu S, Fan XG, Wang H, Lotze MT, Zeh HJ 3rd, Billiar TR, Kang R, Tang D.

Hepatology. 2018 May;67(5):1823-1841. doi: 10.1002/hep.29663. Epub 2018 Apr 1.

42.

Comparing the Air Medical Prehospital Triage Score With Current Practice for Triage of Injured Patients to Helicopter Emergency Medical Services: A Cost-effectiveness Analysis.

Brown JB, Smith KJ, Gestring ML, Rosengart MR, Billiar TR, Peitzman AB, Sperry JL, Weissman JS.

JAMA Surg. 2018 Mar 1;153(3):261-268. doi: 10.1001/jamasurg.2017.4485. No abstract available.

43.

Interferon regulatory factor 1-Rab27a regulated extracellular vesicles promote liver ischemia/reperfusion injury.

Yang MQ, Du Q, Goswami J, Varley PR, Chen B, Wang RH, Morelli AE, Stolz DB, Billiar TR, Li J, Geller DA.

Hepatology. 2018 Mar;67(3):1056-1070. doi: 10.1002/hep.29605. Epub 2018 Jan 24.

44.

ALK is a therapeutic target for lethal sepsis.

Zeng L, Kang R, Zhu S, Wang X, Cao L, Wang H, Billiar TR, Jiang J, Tang D.

Sci Transl Med. 2017 Oct 18;9(412). pii: eaan5689. doi: 10.1126/scitranslmed.aan5689.

45.

Stearoyl Lysophosphatidylcholine Inhibits Endotoxin-Induced Caspase-11 Activation.

Li W, Zhang W, Deng M, Loughran P, Tang Y, Liao H, Zhang X, Liu J, Billiar TR, Lu B.

Shock. 2018 Sep;50(3):339-345. doi: 10.1097/SHK.0000000000001012.

PMID:
28991049
46.

High-mobility group box 1 protein is involved in the protective effect of Saquinavir on ventilation-induced lung injury in mice.

Wang X, Zhang R, Tong Y, Ding X, Jin S, Zhao X, Zong J, Chen Z, Billiar TR, Li Q.

Acta Biochim Biophys Sin (Shanghai). 2017 Oct 1;49(10):907-915. doi: 10.1093/abbs/gmx085.

PMID:
28981603
47.

Extracellular Cyclophilin A Augments Platelet-Dependent Thrombosis and Thromboinflammation.

von Ungern-Sternberg SNI, Vogel S, Walker-Allgaier B, Geue S, Maurer A, Wild AM, Münzer P, Chatterjee M, Heinzmann D, Kremmer E, Borst O, Loughran P, Zernecke A, Neal MD, Billiar TR, Gawaz M, Seizer P.

Thromb Haemost. 2017 Nov;117(11):2063-2078. doi: 10.1160/TH17-01-0067. Epub 2017 Nov 30.

48.

Aging-Impaired Filamentous Actin Polymerization Signaling Reduces Alveolar Macrophage Phagocytosis of Bacteria.

Li Z, Jiao Y, Fan EK, Scott MJ, Li Y, Li S, Billiar TR, Wilson MA, Shi X, Fan J.

J Immunol. 2017 Nov 1;199(9):3176-3186. doi: 10.4049/jimmunol.1700140. Epub 2017 Sep 25.

49.

An Enrichment Strategy Yields Seven Novel Single Nucleotide Polymorphisms Associated With Mortality and Altered Th17 Responses Following Blunt Trauma.

Schimunek L, Namas RA, Yin J, Liu D, Barclay D, El-Dehaibi F, Abboud A, Lindberg H, Zamora R, Billiar TR, Vodovotz Y.

Shock. 2018 Mar;49(3):259-268. doi: 10.1097/SHK.0000000000000987.

50.

Cyclic stretch induced IL-33 production through HMGB1/TLR-4 signaling pathway in murine respiratory epithelial cells.

Chang J, Xia Y, Wasserloos K, Deng M, Blose KJ, Vorp DA, Turnquist HR, Billiar TR, Pitt BA, Zhang MZ, Zhang LM.

PLoS One. 2017 Sep 12;12(9):e0184770. doi: 10.1371/journal.pone.0184770. eCollection 2017.

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