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Diurnal Variation in Systemic Acute Inflammation and Clinical Outcomes Following Severe Blunt Trauma.

Zaaqoq AM, Namas RA, Abdul-Malak O, Almahmoud K, Barclay D, Yin J, Zamora R, Rosengart MR, Billiar TR, Vodovotz Y.

Front Immunol. 2019 Nov 20;10:2699. doi: 10.3389/fimmu.2019.02699. eCollection 2019.


MPPED2 Polymorphism Is Associated With Altered Systemic Inflammation and Adverse Trauma Outcomes.

Schimunek L, Namas RA, Yin J, Barclay D, Liu D, El-Dehaibi F, Abboud A, Cohen M, Zamora R, Billiar TR, Vodovotz Y.

Front Genet. 2019 Nov 8;10:1115. doi: 10.3389/fgene.2019.01115. eCollection 2019.


TSLP protects against liver I/R injury via activation of the PI3K/Akt pathway.

Li S, Yi Z, Deng M, Scott MJ, Yang C, Li W, Lei Z, Santerre NM, Loughran P, Billiar TR.

JCI Insight. 2019 Nov 14;4(22). pii: 129013. doi: 10.1172/jci.insight.129013.


EGFR signaling augments TLR4 cell surface expression and function in macrophages via regulation of Rab5a activation.

Tang J, Zhou B, Scott MJ, Chen L, Lai D, Fan EK, Li Y, Wu Q, Billiar TR, Wilson MA, Wang P, Fan J.

Protein Cell. 2019 Nov 8. doi: 10.1007/s13238-019-00668-8. [Epub ahead of print] No abstract available.


Caspase-11 signaling enhances graft-versus-host disease.

Lu Y, Meng R, Wang X, Xu Y, Tang Y, Wu J, Xue Q, Yu S, Duan M, Shan D, Wang Q, Wang H, Billiar TR, Xiao X, Chen F, Lu B.

Nat Commun. 2019 Sep 6;10(1):4044. doi: 10.1038/s41467-019-11895-2.


Nitric oxide and hepatocellular cancer.

Wang R, Geller DA, Wink DA, Cheng B, Billiar TR.

Br J Pharmacol. 2019 Aug 18. doi: 10.1111/bph.14838. [Epub ahead of print] Review.


Dichotomous Role of Plasmin in Regulation of Macrophage Function after Acetaminophen Overdose.

Roth K, Strickland J, Joshi N, Deng M, Kennedy RC, Rockwell CE, Luyendyk JP, Billiar TR, Copple BL.

Am J Pathol. 2019 Oct;189(10):1986-2001. doi: 10.1016/j.ajpath.2019.07.003. Epub 2019 Aug 2.


TLR9 signaling in fibroblastic reticular cells regulates peritoneal immunity.

Xu L, Li Y, Yang C, Loughran P, Liao H, Hoffman R, Billiar TR, Deng M.

J Clin Invest. 2019 Aug 5;130:3657-3669. doi: 10.1172/JCI127542. eCollection 2019 Aug 5.


Quality Control Measures and Validation in Gene Association Studies: Lessons for Acute Illness.

Cohen M, Lamparello AJ, Schimunek L, El-Dehaibi F, Namas RA, Xu Y, Kaynar AM, Billiar TR, Vodovotz Y.

Shock. 2019 Jul 30. doi: 10.1097/SHK.0000000000001409. [Epub ahead of print]


Innate-Like Lymphocytes Are Immediate Participants in the Hyper-Acute Immune Response to Trauma and Hemorrhagic Shock.

Manson J, Hoffman R, Chen S, Ramadan MH, Billiar TR.

Front Immunol. 2019 Jul 11;10:1501. doi: 10.3389/fimmu.2019.01501. eCollection 2019.


An Aging-Related Single-Nucleotide Polymorphism is Associated with Altered Clinical Outcomes and Distinct Inflammatory Profiles in Aged Blunt Trauma Patients.

Lamparello AJ, Namas RA, Schimunek L, Cohen M, El-Dehaibi F, Yin J, Barclay D, Zamora R, Billiar TR, Vodovotz Y.

Shock. 2019 Jul 16. doi: 10.1097/SHK.0000000000001411. [Epub ahead of print]


Elevations in Circulating sST2 Levels Are Associated With In-Hospital Mortality and Adverse Clinical Outcomes After Blunt Trauma.

Billiar IM, Guardado J, Abdul-Malak O, Vodovotz Y, Billiar TR, Namas RA.

J Surg Res. 2019 Dec;244:23-33. doi: 10.1016/j.jss.2019.05.057. Epub 2019 Jul 3.


Defining geographic emergency medical services coverage in trauma systems.

Brown JB, Rosengart MR, Peitzman AB, Billiar TR, Sperry JL.

J Trauma Acute Care Surg. 2019 Jul;87(1):92-99. doi: 10.1097/TA.0000000000002296.


Gasdermin D protects against noninfectious liver injury by regulating apoptosis and necroptosis.

Yang C, Sun P, Deng M, Loughran P, Li W, Yi Z, Li S, Zhang X, Fan J, Billiar TR, Scott MJ.

Cell Death Dis. 2019 Jun 17;10(7):481. doi: 10.1038/s41419-019-1719-6.


Computational evidence for an early, amplified systemic inflammation program in polytrauma patients with severe extremity injuries.

Almahmoud K, Abboud A, Namas RA, Zamora R, Sperry J, Peitzman AB, Truitt MS, Gaski GE, McKinley TO, Billiar TR, Vodovotz Y.

PLoS One. 2019 Jun 4;14(6):e0217577. doi: 10.1371/journal.pone.0217577. eCollection 2019.


cAMP metabolism controls caspase-11 inflammasome activation and pyroptosis in sepsis.

Chen R, Zeng L, Zhu S, Liu J, Zeh HJ, Kroemer G, Wang H, Billiar TR, Jiang J, Tang D, Kang R.

Sci Adv. 2019 May 22;5(5):eaav5562. doi: 10.1126/sciadv.aav5562. eCollection 2019 May.


Identifying patients with time-sensitive injuries: Association of mortality with increasing prehospital time.

Chen X, Guyette FX, Peitzman AB, Billiar TR, Sperry JL, Brown JB.

J Trauma Acute Care Surg. 2019 Jun;86(6):1015-1022. doi: 10.1097/TA.0000000000002251.


Activation of Pregnane X Receptor Sensitizes Mice to Hemorrhagic Shock-Induced Liver Injury.

Xie Y, Xu M, Deng M, Li Z, Wang P, Ren S, Guo Y, Ma X, Fan J, Billiar TR, Xie W.

Hepatology. 2019 Sep;70(3):995-1010. doi: 10.1002/hep.30691. Epub 2019 Jun 24.


Early Immunologic Response in Multiply Injured Patients With Orthopaedic Injuries Is Associated With Organ Dysfunction.

Gaski GE, Metzger C, McCarroll T, Wessel R, Adler J, Cutshall A, Brown K, Vodovotz Y, Billiar TR, McKinley TO.

J Orthop Trauma. 2019 May;33(5):220-228. doi: 10.1097/BOT.0000000000001437.


Prehospital Blood Product and Crystalloid Resuscitation in the Severely Injured Patient: A Secondary Analysis of the Prehospital Air Medical Plasma Trial.

Guyette FX, Sperry JL, Peitzman AB, Billiar TR, Daley BJ, Miller RS, Harbrecht BG, Claridge JA, Putnam T, Duane TM, Phelan HA, Brown JB.

Ann Surg. 2019 Apr 13. doi: 10.1097/SLA.0000000000003324. [Epub ahead of print]


HMGB1 is a Central Driver of Dynamic Pro-inflammatory Networks in Pediatric Acute Liver Failure induced by Acetaminophen.

Zamora R, Barclay D, Yin J, Alonso EM, Leonis MA, Mi Q, Billiar TR, Simmons RL, Squires RH, Vodovotz Y.

Sci Rep. 2019 Apr 12;9(1):5971. doi: 10.1038/s41598-019-42564-5.


Location is the key to function: HMGB1 in sepsis and trauma-induced inflammation.

Deng M, Scott MJ, Fan J, Billiar TR.

J Leukoc Biol. 2019 Jul;106(1):161-169. doi: 10.1002/JLB.3MIR1218-497R. Epub 2019 Apr 4. Review.


IL-33-mediated IL-13 secretion by ST2+ Tregs controls inflammation after lung injury.

Liu Q, Dwyer GK, Zhao Y, Li H, Mathews LR, Chakka AB, Chandran UR, Demetris JA, Alcorn JF, Robinson KM, Ortiz LA, Pitt BR, Thomson AW, Fan MH, Billiar TR, Turnquist HR.

JCI Insight. 2019 Mar 21;4(6). pii: 123919. doi: 10.1172/jci.insight.123919. eCollection 2019 Mar 21.


A conceptual time window-based model for the early stratification of trauma patients.

Lamparello AJ, Namas RA, Constantine G, McKinley TO, Elster E, Vodovotz Y, Billiar TR.

J Intern Med. 2019 Jul;286(1):2-15. doi: 10.1111/joim.12874. Epub 2019 Jan 9. Review.


TRIF signaling is required for caspase-11-dependent immune responses and lethality in sepsis.

Tang Y, Zhang R, Xue Q, Meng R, Wang X, Yang Y, Xie L, Xiao X, Billiar TR, Lu B.

Mol Med. 2018 Dec 27;24(1):66. doi: 10.1186/s10020-018-0065-y.


Intestinal Microbiota Mediates the Susceptibility to Polymicrobial Sepsis-Induced Liver Injury by Granisetron Generation in Mice.

Gong S, Yan Z, Liu Z, Niu M, Fang H, Li N, Huang C, Li L, Chen G, Luo H, Chen X, Zhou H, Hu J, Yang W, Huang Q, Schnabl B, Chang P, Billiar TR, Jiang Y, Chen P.

Hepatology. 2019 Apr;69(4):1751-1767. doi: 10.1002/hep.30361. Epub 2019 Mar 5.


Young and Aged Blunt Trauma Patients Display Major Differences in Circulating Inflammatory Mediator Profiles after Severe Injury.

Lamparello AJ, Namas RA, Abdul-Malak O, Vodovotz Y, Billiar TR.

J Am Coll Surg. 2019 Feb;228(2):148-160.e7. doi: 10.1016/j.jamcollsurg.2018.10.019. Epub 2018 Nov 16.


Mechanical ventilation enhances extrapulmonary sepsis-induced lung injury: role of WISP1-αvβ5 integrin pathway in TLR4-mediated inflammation and injury.

Ding X, Tong Y, Jin S, Chen Z, Li T, Billiar TR, Pitt BR, Li Q, Zhang LM.

Crit Care. 2018 Nov 16;22(1):302. doi: 10.1186/s13054-018-2237-0.


A computational analysis of dynamic, multi-organ inflammatory crosstalk induced by endotoxin in mice.

Zamora R, Korff S, Mi Q, Barclay D, Schimunek L, Zucca R, Arsiwalla XD, Simmons RL, Verschure P, Billiar TR, Vodovotz Y.

PLoS Comput Biol. 2018 Nov 6;14(11):e1006582. doi: 10.1371/journal.pcbi.1006582. eCollection 2018 Nov.


The Endotoxin Delivery Protein HMGB1 Mediates Caspase-11-Dependent Lethality in Sepsis.

Deng M, Tang Y, Li W, Wang X, Zhang R, Zhang X, Zhao X, Liu J, Tang C, Liu Z, Huang Y, Peng H, Xiao L, Tang D, Scott MJ, Wang Q, Liu J, Xiao X, Watkins S, Li J, Yang H, Wang H, Chen F, Tracey KJ, Billiar TR, Lu B.

Immunity. 2018 Oct 16;49(4):740-753.e7. doi: 10.1016/j.immuni.2018.08.016. Epub 2018 Oct 9.


iNOS promotes CD24+CD133+ liver cancer stem cell phenotype through a TACE/ADAM17-dependent Notch signaling pathway.

Wang R, Li Y, Tsung A, Huang H, Du Q, Yang M, Deng M, Xiong S, Wang X, Zhang L, Geller DA, Cheng B, Billiar TR.

Proc Natl Acad Sci U S A. 2018 Oct 23;115(43):E10127-E10136. doi: 10.1073/pnas.1722100115. Epub 2018 Oct 8.


The IL-33-ST2 Pathway Contributes to Ventilator-Induced Lung Injury in Septic Mice in a Tidal Volume-Dependent Manner.

Ding X, Jin S, Shao Z, Xu L, Yu Z, Tong Y, Chen Z, Turnquist H, Pitt BR, Billiar TR, Zhang LM, Li Q.

Shock. 2019 Sep;52(3):e1-e11. doi: 10.1097/SHK.0000000000001260.


Lung epithelial cell-derived IL-25 negatively regulates LPS-induced exosome release from macrophages.

Li ZG, Scott MJ, Brzóska T, Sundd P, Li YH, Billiar TR, Wilson MA, Wang P, Fan J.

Mil Med Res. 2018 Jul 30;5(1):24. doi: 10.1186/s40779-018-0173-6.


Lack of Benefit on Brain Edema, Blood-Brain Barrier Permeability, or Cognitive Outcome in Global Inducible High Mobility Group Box 1 Knockout Mice Despite Tissue Sparing after Experimental Traumatic Brain Injury.

Aneja RK, Alcamo AM, Cummings J, Vagni V, Feldman K, Wang Q, Dixon CE, Billiar TR, Kochanek PM.

J Neurotrauma. 2019 Jan 15;36(2):360-369. doi: 10.1089/neu.2018.5664. Epub 2018 Sep 5.


Prehospital Plasma during Air Medical Transport in Trauma Patients at Risk for Hemorrhagic Shock.

Sperry JL, Guyette FX, Brown JB, Yazer MH, Triulzi DJ, Early-Young BJ, Adams PW, Daley BJ, Miller RS, Harbrecht BG, Claridge JA, Phelan HA, Witham WR, Putnam AT, Duane TM, Alarcon LH, Callaway CW, Zuckerbraun BS, Neal MD, Rosengart MR, Forsythe RM, Billiar TR, Yealy DM, Peitzman AB, Zenati MS; PAMPer Study Group.

N Engl J Med. 2018 Jul 26;379(4):315-326. doi: 10.1056/NEJMoa1802345.


Blunt cerebrovascular injury in elderly fall patients: are we screening enough?

Anto VP, Brown JB, Peitzman AB, Zuckerbraun BS, Neal MD, Watson G, Forsythe R, Billiar TR, Sperry JL.

World J Emerg Surg. 2018 Jul 4;13:30. doi: 10.1186/s13017-018-0188-z. eCollection 2018.


The Circadian Clock Controls Immune Checkpoint Pathway in Sepsis.

Deng W, Zhu S, Zeng L, Liu J, Kang R, Yang M, Cao L, Wang H, Billiar TR, Jiang J, Xie M, Tang D.

Cell Rep. 2018 Jul 10;24(2):366-378. doi: 10.1016/j.celrep.2018.06.026.


Lipid Peroxidation Drives Gasdermin D-Mediated Pyroptosis in Lethal Polymicrobial Sepsis.

Kang R, Zeng L, Zhu S, Xie Y, Liu J, Wen Q, Cao L, Xie M, Ran Q, Kroemer G, Wang H, Billiar TR, Jiang J, Tang D.

Cell Host Microbe. 2018 Jul 11;24(1):97-108.e4. doi: 10.1016/j.chom.2018.05.009. Epub 2018 Jun 21.


Logistics of air medical transport: When and where does helicopter transport reduce prehospital time for trauma?

Chen X, Gestring ML, Rosengart MR, Peitzman AB, Billiar TR, Sperry JL, Brown JB.

J Trauma Acute Care Surg. 2018 Jul;85(1):174-181. doi: 10.1097/TA.0000000000001935.


Interleukin-33 contributes to ILC2 activation and early inflammation-associated lung injury during abdominal sepsis.

Xu H, Xu J, Xu L, Jin S, Turnquist HR, Hoffman R, Loughran P, Billiar TR, Deng M.

Immunol Cell Biol. 2018 Oct;96(9):935-947. doi: 10.1111/imcb.12159. Epub 2018 May 17.


Platelet HMGB1 is required for efficient bacterial clearance in intra-abdominal bacterial sepsis in mice.

Zhou H, Deng M, Liu Y, Yang C, Hoffman R, Zhou J, Loughran PA, Scott MJ, Neal MD, Billiar TR.

Blood Adv. 2018 Mar 27;2(6):638-648. doi: 10.1182/bloodadvances.2017011817.


REDD-1 aggravates endotoxin-induced inflammation via atypical NF-κB activation.

Lee DK, Kim JH, Kim J, Choi S, Park M, Park W, Kim S, Lee KS, Kim T, Jung J, Choi YK, Ha KS, Won MH, Billiar TR, Kwon YG, Kim YM.

FASEB J. 2018 Aug;32(8):4585-4599. doi: 10.1096/fj.201701436R. Epub 2018 Mar 16.


Group 2 innate lymphoid cells protect lung endothelial cells from pyroptosis in sepsis.

Lai D, Tang J, Chen L, Fan EK, Scott MJ, Li Y, Billiar TR, Wilson MA, Fang X, Shu Q, Fan J.

Cell Death Dis. 2018 Mar 6;9(3):369. doi: 10.1038/s41419-018-0412-5.


Characterizing injury severity in nonaccidental trauma: Does Injury Severity Score miss the mark?

Brown JB, Gestring ML, Leeper CM, Sperry JL, Peitzman AB, Billiar TR, Gaines BA.

J Trauma Acute Care Surg. 2018 Oct;85(4):668-673. doi: 10.1097/TA.0000000000001841.


Toll-Like Receptor 4 Signaling Licenses the Cytosolic Transport of Lipopolysaccharide From Bacterial Outer Membrane Vesicles.

Gu L, Meng R, Tang Y, Zhao K, Liang F, Zhang R, Xue Q, Chen F, Xiao X, Wang H, Wang H, Billiar TR, Lu B.

Shock. 2019 Feb;51(2):256-265. doi: 10.1097/SHK.0000000000001129.


Diagnosis and Management of Polytraumatized Patients With Severe Extremity Trauma.

McKinley TO, Gaski GE, Vodovotz Y, Corona BT, Billiar TR.

J Orthop Trauma. 2018 Mar;32 Suppl 1:S1-S6. doi: 10.1097/BOT.0000000000001114. Review.


cGAS-mediated autophagy protects the liver from ischemia-reperfusion injury independently of STING.

Lei Z, Deng M, Yi Z, Sun Q, Shapiro RA, Xu H, Li T, Loughran PA, Griepentrog JE, Huang H, Scott MJ, Huang F, Billiar TR.

Am J Physiol Gastrointest Liver Physiol. 2018 Jun 1;314(6):G655-G667. doi: 10.1152/ajpgi.00326.2017. Epub 2018 Feb 15.


Overresuscitation with plasma is associated with sustained fibrinolysis shutdown and death in pediatric traumatic brain injury.

Leeper CM, Neal MD, Billiar TR, Sperry JL, Gaines BA.

J Trauma Acute Care Surg. 2018 Jul;85(1):12-17. doi: 10.1097/TA.0000000000001836.


"Thinking" vs. "Talking": Differential Autocrine Inflammatory Networks in Isolated Primary Hepatic Stellate Cells and Hepatocytes under Hypoxic Stress.

Vodovotz Y, Simmons RL, Gandhi CR, Barclay D, Jefferson BS, Huang C, Namas R, El-Dehaibi F, Mi Q, Billiar TR, Zamora R.

Front Physiol. 2017 Dec 22;8:1104. doi: 10.3389/fphys.2017.01104. eCollection 2017.


Speed is not everything: Identifying patients who may benefit from helicopter transport despite faster ground transport.

Chen X, Gestring ML, Rosengart MR, Billiar TR, Peitzman AB, Sperry JL, Brown JB.

J Trauma Acute Care Surg. 2018 Apr;84(4):549-557. doi: 10.1097/TA.0000000000001769.


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