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Items: 1 to 50 of 140

1.

Epigenetics of gastrointestinal diseases: notes from a workshop.

Marks DL, Olson RL, Urrutia R, Billadeau DD, Roy N, Calin GA, Fabbri M, Koutsioumpa M, Iliopoulos D, Ordog T, Huebert R, Sarmento O, Bamidele AO, Faubion W, Lomberk GL, Siveke J, Ahuja N, Iovanna J, Hlady RA, Robertson K, Kisiel J, Pin CL, Fernandez-Zapico ME.

Epigenetics. 2018 Jul 30:1-9. doi: 10.1080/15592294.2018.1464351. [Epub ahead of print]

PMID:
30056798
2.

Vasodilator-stimulated phosphoprotein promotes liver metastasis of gastrointestinal cancer by activating a β1-integrin-FAK-YAP1/TAZ signaling pathway.

Xiang X, Wang Y, Zhang H, Piao J, Muthusamy S, Wang L, Deng Y, Zhang W, Kuang R, Billadeau DD, Huang S, Lai J, Urrutia R, Kang N.

NPJ Precis Oncol. 2018 Jan 23;2(1):2. doi: 10.1038/s41698-017-0045-7. eCollection 2018.

3.

Endosomal receptor trafficking: Retromer and beyond.

Wang J, Fedoseienko A, Chen B, Burstein E, Jia D, Billadeau DD.

Traffic. 2018 Aug;19(8):578-590. doi: 10.1111/tra.12574. Epub 2018 May 21. Review.

PMID:
29667289
4.

The COMMD Family Regulates Plasma LDL Levels and Attenuates Atherosclerosis Through Stabilizing the CCC Complex in Endosomal LDLR Trafficking.

Fedoseienko A, Wijers M, Wolters JC, Dekker D, Smit M, Huijkman N, Kloosterhuis N, Klug H, Schepers A, Willems van Dijk K, Levels JHM, Billadeau DD, Hofker MH, van Deursen J, Westerterp M, Burstein E, Kuivenhoven JA, van de Sluis B.

Circ Res. 2018 Jun 8;122(12):1648-1660. doi: 10.1161/CIRCRESAHA.117.312004. Epub 2018 Mar 15.

PMID:
29545368
5.

Macrogenomic engineering via modulation of the scaling of chromatin packing density.

Almassalha LM, Bauer GM, Wu W, Cherkezyan L, Zhang D, Kendra A, Gladstein S, Chandler JE, VanDerway D, Seagle BL, Ugolkov A, Billadeau DD, O'Halloran TV, Mazar AP, Roy HK, Szleifer I, Shahabi S, Backman V.

Nat Biomed Eng. 2017 Nov;1(11):902-913. doi: 10.1038/s41551-017-0153-2. Epub 2017 Nov 6.

6.

Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling.

McNally KE, Faulkner R, Steinberg F, Gallon M, Ghai R, Pim D, Langton P, Pearson N, Danson CM, Nägele H, Morris LL, Singla A, Overlee BL, Heesom KJ, Sessions R, Banks L, Collins BM, Berger I, Billadeau DD, Burstein E, Cullen PJ.

Nat Cell Biol. 2017 Oct;19(10):1214-1225. doi: 10.1038/ncb3610. Epub 2017 Sep 11.

7.

Fructose-1,6-bisphosphatase Inhibits ERK Activation and Bypasses Gemcitabine Resistance in Pancreatic Cancer by Blocking IQGAP1-MAPK Interaction.

Jin X, Pan Y, Wang L, Ma T, Zhang L, Tang AH, Billadeau DD, Wu H, Huang H.

Cancer Res. 2017 Aug 15;77(16):4328-4341. doi: 10.1158/0008-5472.CAN-16-3143. Epub 2017 Jul 18.

8.

Cellular functions of WASP family proteins at a glance.

Alekhina O, Burstein E, Billadeau DD.

J Cell Sci. 2017 Jul 15;130(14):2235-2241. doi: 10.1242/jcs.199570. Epub 2017 Jun 23. Review.

9.

Glycogen synthase kinase-3β ablation limits pancreatitis-induced acinar-to-ductal metaplasia.

Ding L, Liou GY, Schmitt DM, Storz P, Zhang JS, Billadeau DD.

J Pathol. 2017 Sep;243(1):65-77. doi: 10.1002/path.4928. Epub 2017 Jul 27.

10.

Molecular Pathways: Revisiting Glycogen Synthase Kinase-3β as a Target for the Treatment of Cancer.

Walz A, Ugolkov A, Chandra S, Kozikowski A, Carneiro BA, O'Halloran TV, Giles FJ, Billadeau DD, Mazar AP.

Clin Cancer Res. 2017 Apr 15;23(8):1891-1897. doi: 10.1158/1078-0432.CCR-15-2240. Epub 2017 Jan 4. Review.

11.

Structural and mechanistic insights into regulation of the retromer coat by TBC1d5.

Jia D, Zhang JS, Li F, Wang J, Deng Z, White MA, Osborne DG, Phillips-Krawczak C, Gomez TS, Li H, Singla A, Burstein E, Billadeau DD, Rosen MK.

Nat Commun. 2016 Nov 9;7:13305. doi: 10.1038/ncomms13305.

12.

GSK-3 inhibition overcomes chemoresistance in human breast cancer.

Ugolkov A, Gaisina I, Zhang JS, Billadeau DD, White K, Kozikowski A, Jain S, Cristofanilli M, Giles F, O'Halloran T, Cryns VL, Mazar AP.

Cancer Lett. 2016 Oct 1;380(2):384-92. doi: 10.1016/j.canlet.2016.07.006. Epub 2016 Jul 14.

13.

Integrated mate-pair and RNA sequencing identifies novel, targetable gene fusions in peripheral T-cell lymphoma.

Boddicker RL, Razidlo GL, Dasari S, Zeng Y, Hu G, Knudson RA, Greipp PT, Davila JI, Johnson SH, Porcher JC, Smadbeck JB, Eckloff BW, Billadeau DD, Kurtin PJ, McNiven MA, Link BK, Ansell SM, Cerhan JR, Asmann YW, Vasmatzis G, Feldman AL.

Blood. 2016 Sep 1;128(9):1234-45. doi: 10.1182/blood-2016-03-707141. Epub 2016 Jun 13.

14.

CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL.

Bartuzi P, Billadeau DD, Favier R, Rong S, Dekker D, Fedoseienko A, Fieten H, Wijers M, Levels JH, Huijkman N, Kloosterhuis N, van der Molen H, Brufau G, Groen AK, Elliott AM, Kuivenhoven JA, Plecko B, Grangl G, McGaughran J, Horton JD, Burstein E, Hofker MH, van de Sluis B.

Nat Commun. 2016 Mar 11;7:10961. doi: 10.1038/ncomms10961.

15.

GSK-3β Governs Inflammation-Induced NFATc2 Signaling Hubs to Promote Pancreatic Cancer Progression.

Baumgart S, Chen NM, Zhang JS, Billadeau DD, Gaisina IN, Kozikowski AP, Singh SK, Fink D, Ströbel P, Klindt C, Zhang L, Bamlet WR, Koenig A, Hessmann E, Gress TM, Ellenrieder V, Neesse A.

Mol Cancer Ther. 2016 Mar;15(3):491-502. doi: 10.1158/1535-7163.MCT-15-0309. Epub 2016 Jan 28.

16.

MMSET is dynamically regulated during cell-cycle progression and promotes normal DNA replication.

Evans DL, Zhang H, Ham H, Pei H, Lee S, Kim J, Billadeau DD, Lou Z.

Cell Cycle. 2016;15(1):95-105. doi: 10.1080/15384101.2015.1121323.

17.

NFATc4 Regulates Sox9 Gene Expression in Acinar Cell Plasticity and Pancreatic Cancer Initiation.

Hessmann E, Zhang JS, Chen NM, Hasselluhn M, Liou GY, Storz P, Ellenrieder V, Billadeau DD, Koenig A.

Stem Cells Int. 2016;2016:5272498. doi: 10.1155/2016/5272498. Epub 2015 Nov 30.

18.

SIRT1-Activating Compounds (STAC) Negatively Regulate Pancreatic Cancer Cell Growth and Viability Through a SIRT1 Lysosomal-Dependent Pathway.

Chini CC, Espindola-Netto JM, Mondal G, Guerrico AM, Nin V, Escande C, Sola-Penna M, Zhang JS, Billadeau DD, Chini EN.

Clin Cancer Res. 2016 May 15;22(10):2496-507. doi: 10.1158/1078-0432.CCR-15-1760. Epub 2015 Dec 11.

19.

Endosomal sorting of Notch receptors through COMMD9-dependent pathways modulates Notch signaling.

Li H, Koo Y, Mao X, Sifuentes-Dominguez L, Morris LL, Jia D, Miyata N, Faulkner RA, van Deursen JM, Vooijs M, Billadeau DD, van de Sluis B, Cleaver O, Burstein E.

J Cell Biol. 2015 Nov 9;211(3):605-17. doi: 10.1083/jcb.201505108.

20.

Parkin Regulates Mitosis and Genomic Stability through Cdc20/Cdh1.

Lee SB, Kim JJ, Nam HJ, Gao B, Yin P, Qin B, Yi SY, Ham H, Evans D, Kim SH, Zhang J, Deng M, Liu T, Zhang H, Billadeau DD, Wang L, Giaime E, Shen J, Pang YP, Jen J, van Deursen JM, Lou Z.

Mol Cell. 2015 Oct 1;60(1):21-34. doi: 10.1016/j.molcel.2015.08.011. Epub 2015 Sep 17.

21.

Monitoring receptor trafficking following retromer and WASH deregulation.

Osborne DG, Phillips-Krawczak CA, Billadeau DD.

Methods Cell Biol. 2015;130:199-213. doi: 10.1016/bs.mcb.2015.03.018. Epub 2015 Jun 11.

PMID:
26360036
22.

IQGAP1 promotes CXCR4 chemokine receptor function and trafficking via EEA-1+ endosomes.

Bamidele AO, Kremer KN, Hirsova P, Clift IC, Gores GJ, Billadeau DD, Hedin KE.

J Cell Biol. 2015 Jul 20;210(2):257-72. doi: 10.1083/jcb.201411045.

23.

SNX17 affects T cell activation by regulating TCR and integrin recycling.

Osborne DG, Piotrowski JT, Dick CJ, Zhang JS, Billadeau DD.

J Immunol. 2015 May 1;194(9):4555-66. doi: 10.4049/jimmunol.1402734. Epub 2015 Mar 30.

24.

HkRP3 is a microtubule-binding protein regulating lytic granule clustering and NK cell killing.

Ham H, Huynh W, Schoon RA, Vale RD, Billadeau DD.

J Immunol. 2015 Apr 15;194(8):3984-96. doi: 10.4049/jimmunol.1402897. Epub 2015 Mar 11.

25.

NFATc1 Links EGFR Signaling to Induction of Sox9 Transcription and Acinar-Ductal Transdifferentiation in the Pancreas.

Chen NM, Singh G, Koenig A, Liou GY, Storz P, Zhang JS, Regul L, Nagarajan S, Kühnemuth B, Johnsen SA, Hebrok M, Siveke J, Billadeau DD, Ellenrieder V, Hessmann E.

Gastroenterology. 2015 May;148(5):1024-1034.e9. doi: 10.1053/j.gastro.2015.01.033. Epub 2015 Jan 23.

26.

Antithetical NFATc1-Sox2 and p53-miR200 signaling networks govern pancreatic cancer cell plasticity.

Singh SK, Chen NM, Hessmann E, Siveke J, Lahmann M, Singh G, Voelker N, Vogt S, Esposito I, Schmidt A, Brendel C, Stiewe T, Gaedcke J, Mernberger M, Crawford HC, Bamlet WR, Zhang JS, Li XK, Smyrk TC, Billadeau DD, Hebrok M, Neesse A, Koenig A, Ellenrieder V.

EMBO J. 2015 Feb 12;34(4):517-30. doi: 10.15252/embj.201489574. Epub 2015 Jan 13.

27.

Neuronal and immune synapses on the move at traffic.

Billadeau DD, Faundez V.

Traffic. 2015 Mar;16(3):227-8. doi: 10.1111/tra.12251. No abstract available.

28.

Nuclear FAM21 participates in NF-κB-dependent gene regulation in pancreatic cancer cells.

Deng ZH, Gomez TS, Osborne DG, Phillips-Krawczak CA, Zhang JS, Billadeau DD.

J Cell Sci. 2015 Jan 15;128(2):373-84. doi: 10.1242/jcs.161513. Epub 2014 Nov 27.

29.

COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A.

Phillips-Krawczak CA, Singla A, Starokadomskyy P, Deng Z, Osborne DG, Li H, Dick CJ, Gomez TS, Koenecke M, Zhang JS, Dai H, Sifuentes-Dominguez LF, Geng LN, Kaufmann SH, Hein MY, Wallis M, McGaughran J, Gecz J, Sluis Bv, Billadeau DD, Burstein E.

Mol Biol Cell. 2015 Jan 1;26(1):91-103. doi: 10.1091/mbc.E14-06-1073. Epub 2014 Oct 29.

30.

Retromer Binding to FAM21 and the WASH Complex Is Perturbed by the Parkinson Disease-Linked VPS35(D620N) Mutation.

McGough IJ, Steinberg F, Jia D, Barbuti PA, McMillan KJ, Heesom KJ, Whone AL, Caldwell MA, Billadeau DD, Rosen MK, Cullen PJ.

Curr Biol. 2014 Jul 21;24(14):1678. doi: 10.1016/j.cub.2014.07.004. Epub 2014 Jul 21. No abstract available.

31.

Retromer binding to FAM21 and the WASH complex is perturbed by the Parkinson disease-linked VPS35(D620N) mutation.

McGough IJ, Steinberg F, Jia D, Barbuti PA, McMillan KJ, Heesom KJ, Whone AL, Caldwell MA, Billadeau DD, Rosen MK, Cullen PJ.

Curr Biol. 2014 Jul 21;24(14):1670-1676. doi: 10.1016/j.cub.2014.06.024. Epub 2014 Jul 3. Erratum in: Curr Biol. 2014 Jul 21;24(14):1678. Whone, Alan L [added].

32.

Vasodilator-stimulated phosphoprotein promotes activation of hepatic stellate cells by regulating Rab11-dependent plasma membrane targeting of transforming growth factor beta receptors.

Tu K, Li J, Verma VK, Liu C, Billadeau DD, Lamprecht G, Xiang X, Guo L, Dhanasekaran R, Roberts LR, Shah VH, Kang N.

Hepatology. 2015 Jan;61(1):361-74. doi: 10.1002/hep.27251. Epub 2014 Sep 19.

33.

Poly(ADP-ribose) polymerase inhibitors sensitize cancer cells to death receptor-mediated apoptosis by enhancing death receptor expression.

Meng XW, Koh BD, Zhang JS, Flatten KS, Schneider PA, Billadeau DD, Hess AD, Smith BD, Karp JE, Kaufmann SH.

J Biol Chem. 2014 Jul 25;289(30):20543-58.

34.

Dendritic cells utilize the evolutionarily conserved WASH and retromer complexes to promote MHCII recycling and helper T cell priming.

Graham DB, Osborne DG, Piotrowski JT, Gomez TS, Gmyrek GB, Akilesh HM, Dani A, Billadeau DD, Swat W.

PLoS One. 2014 Jun 2;9(6):e98606. doi: 10.1371/journal.pone.0098606. eCollection 2014.

35.

Inflammation-induced NFATc1-STAT3 transcription complex promotes pancreatic cancer initiation by KrasG12D.

Baumgart S, Chen NM, Siveke JT, König A, Zhang JS, Singh SK, Wolf E, Bartkuhn M, Esposito I, Heßmann E, Reinecke J, Nikorowitsch J, Brunner M, Singh G, Fernandez-Zapico ME, Smyrk T, Bamlet WR, Eilers M, Neesse A, Gress TM, Billadeau DD, Tuveson D, Urrutia R, Ellenrieder V.

Cancer Discov. 2014 Jun;4(6):688-701. doi: 10.1158/2159-8290.CD-13-0593. Epub 2014 Apr 2.

36.

Differential activity of GSK-3 isoforms regulates NF-κB and TRAIL- or TNFα induced apoptosis in pancreatic cancer cells.

Zhang JS, Herreros-Villanueva M, Koenig A, Deng Z, de Narvajas AA, Gomez TS, Meng X, Bujanda L, Ellenrieder V, Li XK, Kaufmann SH, Billadeau DD.

Cell Death Dis. 2014 Mar 27;5:e1142. doi: 10.1038/cddis.2014.102. Erratum in: Cell Death Dis. 2014 Aug;5:e1365. Herreros-Vilanueva, M [corrected to Herreros-Villanueva, M].

37.

Embryonic stem cell factors and pancreatic cancer.

Herreros-Villanueva M, Bujanda L, Billadeau DD, Zhang JS.

World J Gastroenterol. 2014 Mar 7;20(9):2247-54. doi: 10.3748/wjg.v20.i9.2247. Review.

38.

Human immunodeficiency syndromes affecting human natural killer cell cytolytic activity.

Ham H, Billadeau DD.

Front Immunol. 2014 Jan 21;5:2. doi: 10.3389/fimmu.2014.00002. eCollection 2014. Review.

39.

Coactosin-like 1 antagonizes cofilin to promote lamellipodial protrusion at the immune synapse.

Kim J, Shapiro MJ, Bamidele AO, Gurel P, Thapa P, Higgs HN, Hedin KE, Shapiro VS, Billadeau DD.

PLoS One. 2014 Jan 13;9(1):e85090. doi: 10.1371/journal.pone.0085090. eCollection 2014.

40.

Vav1 as a central regulator of invadopodia assembly.

Razidlo GL, Schroeder B, Chen J, Billadeau DD, McNiven MA.

Curr Biol. 2014 Jan 6;24(1):86-93. doi: 10.1016/j.cub.2013.11.013. Epub 2013 Dec 12.

41.

Inhibition of GSK-3 induces differentiation and impaired glucose metabolism in renal cancer.

Pal K, Cao Y, Gaisina IN, Bhattacharya S, Dutta SK, Wang E, Gunosewoyo H, Kozikowski AP, Billadeau DD, Mukhopadhyay D.

Mol Cancer Ther. 2014 Feb;13(2):285-96. doi: 10.1158/1535-7163.MCT-13-0681. Epub 2013 Dec 10.

42.

Response to letter by Insall.

Seaman MN, Gautreau A, Billadeau DD.

Trends Cell Biol. 2013 Nov;23(11):520-1. doi: 10.1016/j.tcb.2013.07.012. Epub 2013 Aug 26. No abstract available.

PMID:
23988428
43.

Epigenetic regulation of autophagy by the methyltransferase G9a.

Artal-Martinez de Narvajas A, Gomez TS, Zhang JS, Mann AO, Taoda Y, Gorman JA, Herreros-Villanueva M, Gress TM, Ellenrieder V, Bujanda L, Kim DH, Kozikowski AP, Koenig A, Billadeau DD.

Mol Cell Biol. 2013 Oct;33(20):3983-93. doi: 10.1128/MCB.00813-13. Epub 2013 Aug 5.

44.

SOX2 promotes dedifferentiation and imparts stem cell-like features to pancreatic cancer cells.

Herreros-Villanueva M, Zhang JS, Koenig A, Abel EV, Smyrk TC, Bamlet WR, de Narvajas AA, Gomez TS, Simeone DM, Bujanda L, Billadeau DD.

Oncogenesis. 2013 Aug 5;2:e61. doi: 10.1038/oncsis.2013.23.

45.

Retromer-mediated endosomal protein sorting: all WASHed up!

Seaman MN, Gautreau A, Billadeau DD.

Trends Cell Biol. 2013 Nov;23(11):522-8. doi: 10.1016/j.tcb.2013.04.010. Epub 2013 May 28. Review.

46.

Dynamin 2 potentiates invasive migration of pancreatic tumor cells through stabilization of the Rac1 GEF Vav1.

Razidlo GL, Wang Y, Chen J, Krueger EW, Billadeau DD, McNiven MA.

Dev Cell. 2013 Mar 25;24(6):573-85. doi: 10.1016/j.devcel.2013.02.010.

47.

Dedicator of cytokinesis 8 interacts with talin and Wiskott-Aldrich syndrome protein to regulate NK cell cytotoxicity.

Ham H, Guerrier S, Kim J, Schoon RA, Anderson EL, Hamann MJ, Lou Z, Billadeau DD.

J Immunol. 2013 Apr 1;190(7):3661-9. doi: 10.4049/jimmunol.1202792. Epub 2013 Mar 1.

48.

IQGAP1 suppresses TβRII-mediated myofibroblastic activation and metastatic growth in liver.

Liu C, Billadeau DD, Abdelhakim H, Leof E, Kaibuchi K, Bernabeu C, Bloom GS, Yang L, Boardman L, Shah VH, Kang N.

J Clin Invest. 2013 Mar;123(3):1138-56. doi: 10.1172/JCI63836. Epub 2013 Feb 1.

49.

Regulation of WASH-dependent actin polymerization and protein trafficking by ubiquitination.

Hao YH, Doyle JM, Ramanathan S, Gomez TS, Jia D, Xu M, Chen ZJ, Billadeau DD, Rosen MK, Potts PR.

Cell. 2013 Feb 28;152(5):1051-64. doi: 10.1016/j.cell.2013.01.051.

50.

WASH knockout T cells demonstrate defective receptor trafficking, proliferation, and effector function.

Piotrowski JT, Gomez TS, Schoon RA, Mangalam AK, Billadeau DD.

Mol Cell Biol. 2013 Mar;33(5):958-73. doi: 10.1128/MCB.01288-12. Epub 2012 Dec 28.

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