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Genetic dissection of Nodal and Bmp signalling requirements during primordial germ cell development in mouse.

Senft AD, Bikoff EK, Robertson EJ, Costello I.

Nat Commun. 2019 Mar 6;10(1):1089. doi: 10.1038/s41467-019-09052-w.


Publisher Correction: Single-cell RNA-seq reveals cell type-specific transcriptional signatures at the maternal-foetal interface during pregnancy.

Nelson AC, Mould AW, Bikoff EK, Robertson EJ.

Nat Commun. 2018 Nov 19;9:16219. doi: 10.1038/ncomms16219.


Combinatorial Smad2/3 Activities Downstream of Nodal Signaling Maintain Embryonic/Extra-Embryonic Cell Identities during Lineage Priming.

Senft AD, Costello I, King HW, Mould AW, Bikoff EK, Robertson EJ.

Cell Rep. 2018 Aug 21;24(8):1977-1985.e7. doi: 10.1016/j.celrep.2018.07.077.


Blimp-1/PRDM1 is a critical regulator of Type III Interferon responses in mammary epithelial cells.

Elias S, Robertson EJ, Bikoff EK, Mould AW.

Sci Rep. 2018 Jan 10;8(1):237. doi: 10.1038/s41598-017-18652-9.


Long-lived unipotent Blimp1-positive luminal stem cells drive mammary gland organogenesis throughout adult life.

Elias S, Morgan MA, Bikoff EK, Robertson EJ.

Nat Commun. 2017 Nov 20;8(1):1714. doi: 10.1038/s41467-017-01971-w.


Mapping the chromatin landscape and Blimp1 transcriptional targets that regulate trophoblast differentiation.

Nelson AC, Mould AW, Bikoff EK, Robertson EJ.

Sci Rep. 2017 Jul 28;7(1):6793. doi: 10.1038/s41598-017-06859-9.


Functional characterisation of cis-regulatory elements governing dynamic Eomes expression in the early mouse embryo.

Simon CS, Downes DJ, Gosden ME, Telenius J, Higgs DR, Hughes JR, Costello I, Bikoff EK, Robertson EJ.

Development. 2017 Apr 1;144(7):1249-1260. doi: 10.1242/dev.147322. Epub 2017 Feb 7.


The transcriptional repressor Blimp1 is expressed in rare luminal progenitors and is essential for mammary gland development.

Ahmed MI, Elias S, Mould AW, Bikoff EK, Robertson EJ.

Development. 2016 May 15;143(10):1663-73. doi: 10.1242/dev.136358.


Single-cell RNA-seq reveals cell type-specific transcriptional signatures at the maternal-foetal interface during pregnancy.

Nelson AC, Mould AW, Bikoff EK, Robertson EJ.

Nat Commun. 2016 Apr 25;7:11414. doi: 10.1038/ncomms11414. Erratum in: Nat Commun. 2018 Nov 19;9:16219.


Lhx1 functions together with Otx2, Foxa2, and Ldb1 to govern anterior mesendoderm, node, and midline development.

Costello I, Nowotschin S, Sun X, Mould AW, Hadjantonakis AK, Bikoff EK, Robertson EJ.

Genes Dev. 2015 Oct 15;29(20):2108-22. doi: 10.1101/gad.268979.115.


Blimp1/Prdm1 Functions in Opposition to Irf1 to Maintain Neonatal Tolerance during Postnatal Intestinal Maturation.

Mould AW, Morgan MA, Nelson AC, Bikoff EK, Robertson EJ.

PLoS Genet. 2015 Jul 9;11(7):e1005375. doi: 10.1371/journal.pgen.1005375. eCollection 2015 Jul.


The PR/SET domain zinc finger protein Prdm4 regulates gene expression in embryonic stem cells but plays a nonessential role in the developing mouse embryo.

Bogani D, Morgan MA, Nelson AC, Costello I, McGouran JF, Kessler BM, Robertson EJ, Bikoff EK.

Mol Cell Biol. 2013 Oct;33(19):3936-50. doi: 10.1128/MCB.00498-13. Epub 2013 Aug 5.


The nonconventional MHC class II molecule DM governs diabetes susceptibility in NOD mice.

Morgan MA, Muller PS, Mould A, Newland SA, Nichols J, Robertson EJ, Cooke A, Bikoff EK.

PLoS One. 2013;8(2):e56738. doi: 10.1371/journal.pone.0056738. Epub 2013 Feb 13.


Progenitor and terminal subsets of CD8+ T cells cooperate to contain chronic viral infection.

Paley MA, Kroy DC, Odorizzi PM, Johnnidis JB, Dolfi DV, Barnett BE, Bikoff EK, Robertson EJ, Lauer GM, Reiner SL, Wherry EJ.

Science. 2012 Nov 30;338(6111):1220-5. doi: 10.1126/science.1229620.


Technical Advance: Fluorescent reporter reveals insights into eomesodermin biology in cytotoxic lymphocytes.

Paley MA, Gordon SM, Bikoff EK, Robertson EJ, Wherry EJ, Reiner SL.

J Leukoc Biol. 2013 Feb;93(2):307-15. doi: 10.1189/jlb.0812400. Epub 2012 Nov 27.


Blimp1/Prdm1 governs terminal differentiation of endovascular trophoblast giant cells and defines multipotent progenitors in the developing placenta.

Mould A, Morgan MA, Li L, Bikoff EK, Robertson EJ.

Genes Dev. 2012 Sep 15;26(18):2063-74. doi: 10.1101/gad.199828.112.


Alternative splicing regulates Prdm1/Blimp-1 DNA binding activities and corepressor interactions.

Morgan MA, Mould AW, Li L, Robertson EJ, Bikoff EK.

Mol Cell Biol. 2012 Sep;32(17):3403-13. doi: 10.1128/MCB.00174-12. Epub 2012 Jun 25.


The T-box transcription factor Eomesodermin acts upstream of Mesp1 to specify cardiac mesoderm during mouse gastrulation.

Costello I, Pimeisl IM, Dräger S, Bikoff EK, Robertson EJ, Arnold SJ.

Nat Cell Biol. 2011 Aug 7;13(9):1084-91. doi: 10.1038/ncb2304.


The transcriptional repressor Blimp1/Prdm1 regulates postnatal reprogramming of intestinal enterocytes.

Harper J, Mould A, Andrews RM, Bikoff EK, Robertson EJ.

Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10585-90. doi: 10.1073/pnas.1105852108. Epub 2011 Jun 13.


The fibronectin leucine-rich repeat transmembrane protein Flrt2 is required in the epicardium to promote heart morphogenesis.

Müller PS, Schulz R, Maretto S, Costello I, Srinivas S, Bikoff E, Robertson E.

Development. 2011 Apr;138(7):1297-308. doi: 10.1242/dev.059386. Epub 2011 Feb 24.


Smad4-dependent pathways control basement membrane deposition and endodermal cell migration at early stages of mouse development.

Costello I, Biondi CA, Taylor JM, Bikoff EK, Robertson EJ.

BMC Dev Biol. 2009 Oct 22;9:54. doi: 10.1186/1471-213X-9-54.


Blimp-1/Prdm1 alternative promoter usage during mouse development and plasma cell differentiation.

Morgan MA, Magnusdottir E, Kuo TC, Tunyaplin C, Harper J, Arnold SJ, Calame K, Robertson EJ, Bikoff EK.

Mol Cell Biol. 2009 Nov;29(21):5813-27. doi: 10.1128/MCB.00670-09. Epub 2009 Sep 8.


An expanding job description for Blimp-1/PRDM1.

Bikoff EK, Morgan MA, Robertson EJ.

Curr Opin Genet Dev. 2009 Aug;19(4):379-85. doi: 10.1016/j.gde.2009.05.005. Epub 2009 Jul 9. Review.


The T-box transcription factor Eomes/Tbr2 regulates neurogenesis in the cortical subventricular zone.

Arnold SJ, Huang GJ, Cheung AF, Era T, Nishikawa S, Bikoff EK, Molnár Z, Robertson EJ, Groszer M.

Genes Dev. 2008 Sep 15;22(18):2479-84. doi: 10.1101/gad.475408.


One PRDM is not enough for germ cell development.

Bikoff EK, Robertson EJ.

Nat Genet. 2008 Aug;40(8):934-5. doi: 10.1038/ng0808-934. No abstract available.


Ventral closure, headfold fusion and definitive endoderm migration defects in mouse embryos lacking the fibronectin leucine-rich transmembrane protein FLRT3.

Maretto S, Müller PS, Aricescu AR, Cho KW, Bikoff EK, Robertson EJ.

Dev Biol. 2008 Jun 1;318(1):184-93. doi: 10.1016/j.ydbio.2008.03.021. Epub 2008 Mar 26.


An MHC class II restriction bias in CD4 T cell responses toward I-A is altered to I-E in DM-deficient mice.

Menges PR, Jenks SA, Bikoff EK, Friedmann DR, Knowlden ZA, Sant AJ.

J Immunol. 2008 Feb 1;180(3):1619-33.


Pivotal roles for eomesodermin during axis formation, epithelium-to-mesenchyme transition and endoderm specification in the mouse.

Arnold SJ, Hofmann UK, Bikoff EK, Robertson EJ.

Development. 2008 Feb;135(3):501-11. doi: 10.1242/dev.014357. Epub 2008 Jan 2.


Blimp1 regulates development of the posterior forelimb, caudal pharyngeal arches, heart and sensory vibrissae in mice.

Robertson EJ, Charatsi I, Joyner CJ, Koonce CH, Morgan M, Islam A, Paterson C, Lejsek E, Arnold SJ, Kallies A, Nutt SL, Bikoff EK.

Development. 2007 Dec;134(24):4335-45.


Mice develop normally in the absence of Smad4 nucleocytoplasmic shuttling.

Biondi CA, Das D, Howell M, Islam A, Bikoff EK, Hill CS, Robertson EJ.

Biochem J. 2007 Jun 1;404(2):235-45.


Loss of invariant chain protects nonobese diabetic mice against type 1 diabetes.

Mellanby RJ, Koonce CH, Monti A, Phillips JM, Cooke A, Bikoff EK.

J Immunol. 2006 Dec 1;177(11):7588-98.


Dose-dependent Smad1, Smad5 and Smad8 signaling in the early mouse embryo.

Arnold SJ, Maretto S, Islam A, Bikoff EK, Robertson EJ.

Dev Biol. 2006 Aug 1;296(1):104-18.


BMP4 substitutes for loss of BMP7 during kidney development.

Oxburgh L, Dudley AT, Godin RE, Koonce CH, Islam A, Anderson DC, Bikoff EK, Robertson EJ.

Dev Biol. 2005 Oct 15;286(2):637-46. Epub 2005 Sep 8.


The zinc finger transcriptional repressor Blimp1/Prdm1 is dispensable for early axis formation but is required for specification of primordial germ cells in the mouse.

Vincent SD, Dunn NR, Sciammas R, Shapiro-Shalef M, Davis MM, Calame K, Bikoff EK, Robertson EJ.

Development. 2005 Mar;132(6):1315-25.


Mice exclusively expressing the short isoform of Smad2 develop normally and are viable and fertile.

Dunn NR, Koonce CH, Anderson DC, Islam A, Bikoff EK, Robertson EJ.

Genes Dev. 2005 Jan 1;19(1):152-63.


Combinatorial activities of Smad2 and Smad3 regulate mesoderm formation and patterning in the mouse embryo.

Dunn NR, Vincent SD, Oxburgh L, Robertson EJ, Bikoff EK.

Development. 2004 Apr;131(8):1717-28. Epub 2004 Mar 17.


T cells distinguish MHC-peptide complexes formed in separate vesicles and edited by H2-DM.

Pu Z, Lovitch SB, Bikoff EK, Unanue ER.

Immunity. 2004 Apr;20(4):467-76.


Control of early anterior-posterior patterning in the mouse embryo by TGF-beta signalling.

Robertson EJ, Norris DP, Brennan J, Bikoff EK.

Philos Trans R Soc Lond B Biol Sci. 2003 Aug 29;358(1436):1351-7; discussion 1357.


DM loss in k haplotype mice reveals isotype-specific chaperone requirements.

Koonce CH, Wutz G, Robertson EJ, Vogt AB, Kropshofer H, Bikoff EK.

J Immunol. 2003 Apr 1;170(7):3751-61.


MHC class II-associated invariant chain isoforms regulate pulmonary immune responses.

Ye Q, Finn PW, Sweeney R, Bikoff EK, Riese RJ.

J Immunol. 2003 Feb 1;170(3):1473-80.


Invariant chain controls the activity of extracellular cathepsin L.

Fiebiger E, Maehr R, Villadangos J, Weber E, Erickson A, Bikoff E, Ploegh HL, Lennon-Duménil AM.

J Exp Med. 2002 Nov 4;196(9):1263-9.


The Foxh1-dependent autoregulatory enhancer controls the level of Nodal signals in the mouse embryo.

Norris DP, Brennan J, Bikoff EK, Robertson EJ.

Development. 2002 Jul;129(14):3455-68.


Requirement for endocytic antigen processing and influence of invariant chain and H-2M deficiencies in CNS autoimmunity.

Slavin AJ, Soos JM, Stuve O, Patarroyo JC, Weiner HL, Fontana A, Bikoff EK, Zamvil SS.

J Clin Invest. 2001 Oct;108(8):1133-9.


The p41 isoform of invariant chain is a chaperone for cathepsin L.

Lennon-Duménil AM, Roberts RA, Valentijn K, Driessen C, Overkleeft HS, Erickson A, Peters PJ, Bikoff E, Ploegh HL, Wolf Bryant P.

EMBO J. 2001 Aug 1;20(15):4055-64.


Relaxed DM requirements during class II peptide loading and CD4+ T cell maturation in BALB/c mice.

Bikoff EK, Wutz G, Kenty GA, Koonce CH, Robertson EJ.

J Immunol. 2001 Apr 15;166(8):5087-98.


Formation of the definitive endoderm in mouse is a Smad2-dependent process.

Tremblay KD, Hoodless PA, Bikoff EK, Robertson EJ.

Development. 2000 Jul;127(14):3079-90.


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