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Items: 39


Class-A penicillin binding proteins do not contribute to cell shape but repair cell-wall defects.

Vigouroux A, Cordier B, Aristov A, Alvarez L, Özbaykal G, Chaze T, Oldewurtel ER, Matondo M, Cava F, Bikard D, van Teeffelen S.

Elife. 2020 Jan 6;9. pii: e51998. doi: 10.7554/eLife.51998.


Atypical organizations and epistatic interactions of CRISPRs and cas clusters in genomes and their mobile genetic elements.

Bernheim A, Bikard D, Touchon M, Rocha EPC.

Nucleic Acids Res. 2020 Jan 24;48(2):748-760. doi: 10.1093/nar/gkz1091.


Learning from Antibodies: Phage Host-Range Engineering.

Russell J, Bikard D.

Cell Host Microbe. 2019 Oct 9;26(4):445-446. doi: 10.1016/j.chom.2019.09.010.


Methods for the Analysis and Characterization of Defense Mechanisms Against Horizontal Gene Transfer: CRISPR Systems.

Calvo-Villamañán A, Bernheim A, Bikard D.

Methods Mol Biol. 2020;2075:235-249. doi: 10.1007/978-1-4939-9877-7_17.


Gene silencing with CRISPRi in bacteria and optimization of dCas9 expression levels.

Depardieu F, Bikard D.

Methods. 2019 Aug 1. pii: S1046-2023(18)30497-3. doi: 10.1016/j.ymeth.2019.07.024. [Epub ahead of print]


Editing the microbiome the CRISPR way.

Ramachandran G, Bikard D.

Philos Trans R Soc Lond B Biol Sci. 2019 May 13;374(1772):20180103. doi: 10.1098/rstb.2018.0103.


A matter of background: DNA repair pathways as a possible cause for the sparse distribution of CRISPR-Cas systems in bacteria.

Bernheim A, Bikard D, Touchon M, Rocha EPC.

Philos Trans R Soc Lond B Biol Sci. 2019 May 13;374(1772):20180088. doi: 10.1098/rstb.2018.0088.


Genome-wide CRISPR-dCas9 screens in E. coli identify essential genes and phage host factors.

Rousset F, Cui L, Siouve E, Becavin C, Depardieu F, Bikard D.

PLoS Genet. 2018 Nov 7;14(11):e1007749. doi: 10.1371/journal.pgen.1007749. eCollection 2018 Nov.


Microbial-derived products as potential new antimicrobials.

Seal BS, Drider D, Oakley BB, Brüssow H, Bikard D, Rich JO, Miller S, Devillard E, Kwan J, Bertin G, Reeves S, Swift SM, Raicek M, Gay CG.

Vet Res. 2018 Jul 31;49(1):66. doi: 10.1186/s13567-018-0563-5. Review.


A CRISPRi screen in E. coli reveals sequence-specific toxicity of dCas9.

Cui L, Vigouroux A, Rousset F, Varet H, Khanna V, Bikard D.

Nat Commun. 2018 May 15;9(1):1912. doi: 10.1038/s41467-018-04209-5.


Tuning dCas9's ability to block transcription enables robust, noiseless knockdown of bacterial genes.

Vigouroux A, Oldewurtel E, Cui L, Bikard D, van Teeffelen S.

Mol Syst Biol. 2018 Mar 8;14(3):e7899. doi: 10.15252/msb.20177899.


Inhibition of NHEJ repair by type II-A CRISPR-Cas systems in bacteria.

Bernheim A, Calvo-Villamañán A, Basier C, Cui L, Rocha EPC, Touchon M, Bikard D.

Nat Commun. 2017 Dec 12;8(1):2094. doi: 10.1038/s41467-017-02350-1.


Guest editorial: CRISPRcas9: CRISPR-Cas systems: at the cutting edge of microbiology.

Barrangou R, Bikard D.

Curr Opin Microbiol. 2017 Jun;37:vii-viii. doi: 10.1016/j.mib.2017.09.015. No abstract available.


Using CRISPR-Cas systems as antimicrobials.

Bikard D, Barrangou R.

Curr Opin Microbiol. 2017 Jun;37:155-160. doi: 10.1016/j.mib.2017.08.005. Epub 2017 Sep 6. Review.


PhageTerm: a tool for fast and accurate determination of phage termini and packaging mechanism using next-generation sequencing data.

Garneau JR, Depardieu F, Fortier LC, Bikard D, Monot M.

Sci Rep. 2017 Aug 15;7(1):8292. doi: 10.1038/s41598-017-07910-5.


Differences in Integron Cassette Excision Dynamics Shape a Trade-Off between Evolvability and Genetic Capacitance.

Loot C, Nivina A, Cury J, Escudero JA, Ducos-Galand M, Bikard D, Rocha EP, Mazel D.

mBio. 2017 Mar 28;8(2). pii: e02296-16. doi: 10.1128/mBio.02296-16.


[CRISPR-Cas systems as weapons against pathogenic bacteria].

Bikard D, Barrangou R.

Biol Aujourdhui. 2017;211(4):265-270. doi: 10.1051/jbio/2018004. Epub 2018 Jun 29. Review. French.


Mutations in Cas9 Enhance the Rate of Acquisition of Viral Spacer Sequences during the CRISPR-Cas Immune Response.

Heler R, Wright AV, Vucelja M, Bikard D, Doudna JA, Marraffini LA.

Mol Cell. 2017 Jan 5;65(1):168-175. doi: 10.1016/j.molcel.2016.11.031. Epub 2016 Dec 22.


A Eukaryotic-like Serine/Threonine Kinase Protects Staphylococci against Phages.

Depardieu F, Didier JP, Bernheim A, Sherlock A, Molina H, Duclos B, Bikard D.

Cell Host Microbe. 2016 Oct 12;20(4):471-481. doi: 10.1016/j.chom.2016.08.010. Epub 2016 Sep 22.


Consequences of Cas9 cleavage in the chromosome of Escherichia coli.

Cui L, Bikard D.

Nucleic Acids Res. 2016 May 19;44(9):4243-51. doi: 10.1093/nar/gkw223. Epub 2016 Apr 8.


Impact of Different Target Sequences on Type III CRISPR-Cas Immunity.

Maniv I, Jiang W, Bikard D, Marraffini LA.

J Bacteriol. 2016 Jan 11;198(6):941-50. doi: 10.1128/JB.00897-15.


Cas9 specifies functional viral targets during CRISPR-Cas adaptation.

Heler R, Samai P, Modell JW, Weiner C, Goldberg GW, Bikard D, Marraffini LA.

Nature. 2015 Mar 12;519(7542):199-202. doi: 10.1038/nature14245. Epub 2015 Feb 18.


Exploiting CRISPR-Cas nucleases to produce sequence-specific antimicrobials.

Bikard D, Euler CW, Jiang W, Nussenzweig PM, Goldberg GW, Duportet X, Fischetti VA, Marraffini LA.

Nat Biotechnol. 2014 Nov;32(11):1146-50. doi: 10.1038/nbt.3043. Epub 2014 Oct 5.


Conditional tolerance of temperate phages via transcription-dependent CRISPR-Cas targeting.

Goldberg GW, Jiang W, Bikard D, Marraffini LA.

Nature. 2014 Oct 30;514(7524):633-7. doi: 10.1038/nature13637. Epub 2014 Aug 31.


Adapting to new threats: the generation of memory by CRISPR-Cas immune systems.

Heler R, Marraffini LA, Bikard D.

Mol Microbiol. 2014 Jul;93(1):1-9. doi: 10.1111/mmi.12640. Epub 2014 Jun 4. Review.


The integron integrase efficiently prevents the melting effect of Escherichia coli single-stranded DNA-binding protein on folded attC sites.

Loot C, Parissi V, Escudero JA, Amarir-Bouhram J, Bikard D, Mazel D.

J Bacteriol. 2014 Feb;196(4):762-71. doi: 10.1128/JB.01109-13. Epub 2013 Dec 2.


Control of gene expression by CRISPR-Cas systems.

Bikard D, Marraffini LA.

F1000Prime Rep. 2013 Nov 1;5:47. doi: 10.12703/P5-47. eCollection 2013. Review.


Shuffling of DNA cassettes in a synthetic integron.

Bikard D, Mazel D.

Methods Mol Biol. 2013;1073:169-74. doi: 10.1007/978-1-62703-625-2_14.


Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system.

Bikard D, Jiang W, Samai P, Hochschild A, Zhang F, Marraffini LA.

Nucleic Acids Res. 2013 Aug;41(15):7429-37. doi: 10.1093/nar/gkt520. Epub 2013 Jun 12.


RNA-guided editing of bacterial genomes using CRISPR-Cas systems.

Jiang W, Bikard D, Cox D, Zhang F, Marraffini LA.

Nat Biotechnol. 2013 Mar;31(3):233-9. doi: 10.1038/nbt.2508. Epub 2013 Jan 29.


CRISPR interference can prevent natural transformation and virulence acquisition during in vivo bacterial infection.

Bikard D, Hatoum-Aslan A, Mucida D, Marraffini LA.

Cell Host Microbe. 2012 Aug 16;12(2):177-86. doi: 10.1016/j.chom.2012.06.003.


Innate and adaptive immunity in bacteria: mechanisms of programmed genetic variation to fight bacteriophages.

Bikard D, Marraffini LA.

Curr Opin Immunol. 2012 Feb;24(1):15-20. doi: 10.1016/j.coi.2011.10.005. Epub 2011 Nov 11. Review.


Folded DNA in action: hairpin formation and biological functions in prokaryotes.

Bikard D, Loot C, Baharoglu Z, Mazel D.

Microbiol Mol Biol Rev. 2010 Dec;74(4):570-88. doi: 10.1128/MMBR.00026-10. Review.


Conjugative DNA transfer induces the bacterial SOS response and promotes antibiotic resistance development through integron activation.

Baharoglu Z, Bikard D, Mazel D.

PLoS Genet. 2010 Oct 21;6(10):e1001165. doi: 10.1371/journal.pgen.1001165.


Cellular pathways controlling integron cassette site folding.

Loot C, Bikard D, Rachlin A, Mazel D.

EMBO J. 2010 Aug 4;29(15):2623-34. doi: 10.1038/emboj.2010.151. Epub 2010 Jul 13. Erratum in: EMBO J. 2010 Nov 3;29(21):3745.


The synthetic integron: an in vivo genetic shuffling device.

Bikard D, Julié-Galau S, Cambray G, Mazel D.

Nucleic Acids Res. 2010 Aug;38(15):e153. doi: 10.1093/nar/gkq511. Epub 2010 Jun 9.


Structural features of single-stranded integron cassette attC sites and their role in strand selection.

Bouvier M, Ducos-Galand M, Loot C, Bikard D, Mazel D.

PLoS Genet. 2009 Sep;5(9):e1000632. doi: 10.1371/journal.pgen.1000632. Epub 2009 Sep 4.


Divergent evolution of duplicate genes leads to genetic incompatibilities within A. thaliana.

Bikard D, Patel D, Le Metté C, Giorgi V, Camilleri C, Bennett MJ, Loudet O.

Science. 2009 Jan 30;323(5914):623-6. doi: 10.1126/science.1165917.


[First French team success during iGEM synthetic biology competition].

Bikard D, Képès F; L'Equipe iGEM Paris.

Med Sci (Paris). 2008 May;24(5):541-4. doi: 10.1051/medsci/2008245541. French. No abstract available.

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