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Items: 37


A novel orally available seleno-purine molecule suppresses triple-negative breast cancer cell proliferation and progression to metastasis by inducing cytostatic autophagy.

Chang CH, Bijian K, Wernic D, Su J, da Silva SD, Yu H, Qiu D, Asslan M, Alaoui-Jamali MA.

Autophagy. 2019 Aug;15(8):1376-1390. doi: 10.1080/15548627.2019.1582951. Epub 2019 Mar 1.


MNK1/NODAL Signaling Promotes Invasive Progression of Breast Ductal Carcinoma In Situ.

Guo Q, Li VZ, Nichol JN, Huang F, Yang W, Preston SEJ, Talat Z, Lefrère H, Yu H, Zhang G, Basik M, Gonçalves C, Zhan Y, Plourde D, Su J, Torres J, Marques M, Habyan SA, Bijian K, Amant F, Witcher M, Behbod F, McCaffrey L, Alaoui-Jamali M, Giannakopoulos NV, Brackstone M, Postovit LM, Del Rincón SV, Miller WH Jr.

Cancer Res. 2019 Apr 1;79(7):1646-1657. doi: 10.1158/0008-5472.CAN-18-1602. Epub 2019 Jan 18.


TRAF2 Cooperates with Focal Adhesion Signaling to Regulate Cancer Cell Susceptibility to Anoikis.

da Silva SD, Xu B, Maschietto M, Marchi FA, Alkailani MI, Bijian K, Xiao D, Alaoui-Jamali MA.

Mol Cancer Ther. 2019 Jan;18(1):139-146. doi: 10.1158/1535-7163.MCT-17-1261. Epub 2018 Oct 29.


MNK1/2 inhibition limits oncogenicity and metastasis of KIT-mutant melanoma.

Zhan Y, Guo J, Yang W, Goncalves C, Rzymski T, Dreas A, Żyłkiewicz E, Mikulski M, Brzózka K, Golas A, Kong Y, Ma M, Huang F, Huor B, Guo Q, da Silva SD, Torres J, Cai Y, Topisirovic I, Su J, Bijian K, Alaoui-Jamali MA, Huang S, Journe F, Ghanem GE, Miller WH Jr, Del Rincón SV.

J Clin Invest. 2017 Nov 1;127(11):4179-4192. doi: 10.1172/JCI91258. Epub 2017 Oct 16.


Efficacy of hybrid vitamin D receptor agonist/histone deacetylase inhibitors in vitamin D-resistant triple-negative 4T1 breast cancer.

Bijian K, Kaldre D, Wang TT, Su J, Bouttier M, Boucher A, Alaoui-Jamali M, White JH, Gleason JL.

J Steroid Biochem Mol Biol. 2018 Mar;177:135-139. doi: 10.1016/j.jsbmb.2017.08.010. Epub 2017 Aug 25.


Endosomal sorting and c-Cbl targeting of paxillin to autophagosomes regulate cell-matrix adhesion turnover in human breast cancer cells.

Chang CH, Bijian K, Qiu D, Su J, Saad A, Dahabieh MS, Miller WH Jr, Alaoui-Jamali MA.

Oncotarget. 2017 May 9;8(19):31199-31214. doi: 10.18632/oncotarget.16105.


Insights into a novel nuclear function for Fascin in the regulation of the amino-acid transporter SLC3A2.

Saad A, Bijian K, Qiu D, da Silva SD, Marques M, Chang CH, Nassour H, Ramotar D, Damaraju S, Mackey J, Bismar T, Witcher M, Alaoui-Jamali MA.

Sci Rep. 2016 Nov 7;6:36699. doi: 10.1038/srep36699.


microRNA 338-3p exhibits tumor suppressor role and its down-regulation is associated with adverse clinical outcome in prostate cancer patients.

Bakkar A, Alshalalfa M, Petersen LF, Abou-Ouf H, Al-Mami A, Hegazy SA, Feng F, Alhajj R, Bijian K, Alaoui-Jamali MA, Bismar TA.

Mol Biol Rep. 2016 Apr;43(4):229-40. doi: 10.1007/s11033-016-3948-4. Epub 2016 Feb 23.


Predominant Rab-GTPase amplicons contributing to oral squamous cell carcinoma progression to metastasis.

da Silva SD, Marchi FA, Xu B, Bijian K, Alobaid F, Mlynarek A, Rogatto SR, Hier M, Kowalski LP, Alaoui-Jamali MA.

Oncotarget. 2015 Sep 8;6(26):21950-63.


Dynamin 2 interacts with connexin 26 to regulate its degradation and function in gap junction formation.

Xiao D, Chen S, Shao Q, Chen J, Bijian K, Laird DW, Alaoui-Jamali MA.

Int J Biochem Cell Biol. 2014 Oct;55:288-97. doi: 10.1016/j.biocel.2014.09.021. Epub 2014 Sep 28.


The significance of dynamin 2 expression for prostate cancer progression, prognostication, and therapeutic targeting.

Xu B, Teng LH, Silva SD, Bijian K, Al Bashir S, Jie S, Dolph M, Alaoui-Jamali MA, Bismar TA.

Cancer Med. 2014 Feb;3(1):14-24. doi: 10.1002/cam4.168. Epub 2013 Dec 18.


Targeting focal adhesion turnover in invasive breast cancer cells by the purine derivative reversine.

Bijian K, Lougheed C, Su J, Xu B, Yu H, Wu JH, Riccio K, Alaoui-Jamali MA.

Br J Cancer. 2013 Nov 26;109(11):2810-8. doi: 10.1038/bjc.2013.675. Epub 2013 Oct 29.


Total synthesis and biological activity of marine alkaloid Eudistomins Y1-Y7 and their analogues.

Jin H, Zhang P, Bijian K, Ren S, Wan S, Alaoui-Jamali MA, Jiang T.

Mar Drugs. 2013 Apr 29;11(5):1427-39. doi: 10.3390/md11051427.


Reduced in vivo lung metastasis of a breast cancer cell line after treatment with Herceptin mAb conjugated to chemotherapeutic drugs.

Garcia AG, Nedev H, Bijian K, Su J, Alaoui-Jamali MA, Saragovi HU.

Oncogene. 2013 May 16;32(20):2527-33. doi: 10.1038/onc.2012.283. Epub 2012 Jul 16.


Synthesis and biological activity of novel organoselenium derivatives targeting multiple kinases and capable of inhibiting cancer progression to metastases.

Bijian K, Zhang Z, Xu B, Jie S, Chen B, Wan S, Wu J, Jiang T, Alaoui-Jamali MA.

Eur J Med Chem. 2012 Feb;48:143-52. doi: 10.1016/j.ejmech.2011.12.006. Epub 2011 Dec 9.


Total synthesis and bioactivity of the marine alkaloid pityriacitrin and some of its derivatives.

Zhang P, Sun X, Xu B, Bijian K, Wan S, Li G, Alaoui-Jamali M, Jiang T.

Eur J Med Chem. 2011 Dec;46(12):6089-97. doi: 10.1016/j.ejmech.2011.10.036. Epub 2011 Oct 25.


PTEN deletion and heme oxygenase-1 overexpression cooperate in prostate cancer progression and are associated with adverse clinical outcome.

Li Y, Su J, DingZhang X, Zhang J, Yoshimoto M, Liu S, Bijian K, Gupta A, Squire JA, Alaoui Jamali MA, Bismar TA.

J Pathol. 2011 May;224(1):90-100. doi: 10.1002/path.2855. Epub 2011 Mar 7.


Endoplasmic reticulum stress in glomerular epithelial cell injury.

Cybulsky AV, Takano T, Papillon J, Kitzler TM, Bijian K.

Am J Physiol Renal Physiol. 2011 Sep;301(3):F496-508. doi: 10.1152/ajprenal.00728.2010. Epub 2010 Dec 15.


Glomerular epithelial cell injury associated with mutant alpha-actinin-4.

Cybulsky AV, Takano T, Papillon J, Bijian K, Guillemette J, Kennedy CR.

Am J Physiol Renal Physiol. 2009 Oct;297(4):F987-95. doi: 10.1152/ajprenal.00055.2009. Epub 2009 Jul 29.


CD45 recruits adapter protein DOK-1 and negatively regulates JAK-STAT signaling in hematopoietic cells.

Wu L, Bijian K, Shen SH.

Mol Immunol. 2009 Jul;46(11-12):2167-77. doi: 10.1016/j.molimm.2009.04.032. Epub 2009 May 28. Erratum in: Mol Immunol. 2010 Jan;47(4):41. Shen, Shi-Shiang [corrected to Shen, Shi-Hsiang].


Serum proteomic approach for the identification of serum biomarkers contributed by oral squamous cell carcinoma and host tissue microenvironment.

Bijian K, Mlynarek AM, Balys RL, Jie S, Xu Y, Hier MP, Black MJ, Di Falco MR, LaBoissiere S, Alaoui-Jamali MA.

J Proteome Res. 2009 May;8(5):2173-85. doi: 10.1021/pr800979e.


Fascin regulates prostate cancer cell invasion and is associated with metastasis and biochemical failure in prostate cancer.

Darnel AD, Behmoaram E, Vollmer RT, Corcos J, Bijian K, Sircar K, Su J, Jiao J, Alaoui-Jamali MA, Bismar TA.

Clin Cancer Res. 2009 Feb 15;15(4):1376-83. doi: 10.1158/1078-0432.CCR-08-1789.


Discovery of indoline-based, natural-product-like compounds as probes of focal adhesion kinase signaling pathways.

Poondra RR, Kumar NN, Bijian K, Prakesch M, Campagna-Slater V, Reayi A, Reddy PT, Choudhry A, Barnes ML, Leek DM, Daroszewska M, Lougheed C, Xu B, Schapira M, Alaoui-Jamali MA, Arya P.

J Comb Chem. 2009 Mar 9;11(2):303-9. doi: 10.1021/cc8001525.


Building skeletally diverse architectures on the Indoline Scaffold: the discovery of a chemical probe of focal adhesion kinase signaling networks.

Prakesch M, Bijian K, Campagna-Slater V, Quevillon S, Joseph R, Wei CQ, Sesmilo E, Reayi A, Poondra RR, Barnes ML, Leek DM, Xu B, Lougheed C, Schapira M, Alaoui-Jamali M, Arya P.

Bioorg Med Chem. 2008 Nov 1;16(21):9596-602. doi: 10.1016/j.bmc.2008.09.025. Epub 2008 Sep 12.


Early stage cancer cell invasion: signaling, biomarkers and therapeutic targeting.

Behmoaram E, Bijian K, Bismar TA, Alaoui-Jamali MA.

Front Biosci. 2008 May 1;13:6314-25. Review.


Role of apoptosis signal-regulating kinase 1 in complement-mediated glomerular epithelial cell injury.

Ren G, Huynh C, Bijian K, Cybulsky AV.

Mol Immunol. 2008 Apr;45(8):2236-46. doi: 10.1016/j.molimm.2007.11.013. Epub 2008 Feb 21.


Collagen-mediated survival signaling is modulated by CD45 in Jurkat T cells.

Bijian K, Zhang L, Shen SH.

Mol Immunol. 2007 Jul;44(15):3682-90. Epub 2007 May 23.


Actin cytoskeleton regulates extracellular matrix-dependent survival signals in glomerular epithelial cells.

Bijian K, Takano T, Papillon J, Le Berre L, Michaud JL, Kennedy CR, Cybulsky AV.

Am J Physiol Renal Physiol. 2005 Dec;289(6):F1313-23. Epub 2005 Jul 12.


Stress proteins in glomerular epithelial cell injury.

Bijian K, Cybulsky AV.

Contrib Nephrol. 2005;148:8-20. doi: 10.1159/000086039. Review.


Role of the endoplasmic reticulum unfolded protein response in glomerular epithelial cell injury.

Cybulsky AV, Takano T, Papillon J, Bijian K.

J Biol Chem. 2005 Jul 1;280(26):24396-403. Epub 2005 Apr 29.


Activation of the extracellular signal-regulated kinase by complement C5b-9.

Cybulsky AV, Takano T, Papillon J, Bijian K, Guillemette J.

Am J Physiol Renal Physiol. 2005 Sep;289(3):F593-603. Epub 2005 Apr 26.


The actin cytoskeleton facilitates complement-mediated activation of cytosolic phospholipase A2.

Cybulsky AV, Takano T, Papillon J, Khadir A, Bijian K, Le Berre L.

Am J Physiol Renal Physiol. 2004 Mar;286(3):F466-76. Epub 2003 Nov 25.


Extracellular matrix regulates glomerular epithelial cell survival and proliferation.

Bijian K, Takano T, Papillon J, Khadir A, Cybulsky AV.

Am J Physiol Renal Physiol. 2004 Feb;286(2):F255-66. Epub 2003 Oct 14.


Renal expression and activity of the germinal center kinase SK2.

Cybulsky AV, Takano T, Papillon J, Khadir A, Bijian K, Chien CC, Alpers CE, Rabb H.

Am J Physiol Renal Physiol. 2004 Jan;286(1):F16-25. Epub 2003 Sep 9.


Complement activates the c-Jun N-terminal kinase/stress-activated protein kinase in glomerular epithelial cells.

Peng H, Takano T, Papillon J, Bijian K, Khadir A, Cybulsky AV.

J Immunol. 2002 Sep 1;169(5):2594-601.

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