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Old Mice Demonstrate Organ Dysfunction as well as Prolonged Inflammation, Immunosuppression, and Weight Loss in a Modified Surgical Sepsis Model.

Stortz JA, Hollen MK, Nacionales DC, Horiguchi H, Ungaro R, Dirain ML, Wang Z, Wu Q, Wu KK, Kumar A, Foster TC, Stewart BD, Ross JA, Segal M, Bihorac A, Brakenridge S, Moore FA, Wohlgemuth SE, Leeuwenburgh C, Mohr AM, Moldawer LL, Efron PA.

Crit Care Med. 2019 Aug 5. doi: 10.1097/CCM.0000000000003926. [Epub ahead of print]


Use of Artificial Intelligence to Represent Emergent Systems and Augment Surgical Decision-making.

Loftus TJ, Upchurch GR Jr, Bihorac A.

JAMA Surg. 2019 Jun 19. doi: 10.1001/jamasurg.2019.1510. [Epub ahead of print] No abstract available.


Intelligent ICU for Autonomous Patient Monitoring Using Pervasive Sensing and Deep Learning.

Davoudi A, Malhotra KR, Shickel B, Siegel S, Williams S, Ruppert M, Bihorac E, Ozrazgat-Baslanti T, Tighe PJ, Bihorac A, Rashidi P.

Sci Rep. 2019 May 29;9(1):8020. doi: 10.1038/s41598-019-44004-w.


Quality Improvement Goals for Acute Kidney Injury.

Kashani K, Rosner MH, Haase M, Lewington AJP, O'Donoghue DJ, Wilson FP, Nadim MK, Silver SA, Zarbock A, Ostermann M, Mehta RL, Kane-Gill SL, Ding X, Pickkers P, Bihorac A, Siew ED, Barreto EF, Macedo E, Kellum JA, Palevsky PM, Tolwani AJ, Ronco C, Juncos LA, Rewa OG, Bagshaw SM, Mottes TA, Koyner JL, Liu KD, Forni LG, Heung M, Wu VC.

Clin J Am Soc Nephrol. 2019 Jun 7;14(6):941-953. doi: 10.2215/CJN.01250119. Epub 2019 May 17.


Response to Comment on "MySurgeryRisk: Development and Validation of a Machine-learning Risk Algorithm for Major Complications and Death After Surgery".

Bihorac A.

Ann Surg. 2019 Jun;269(6):e74. doi: 10.1097/SLA.0000000000002884. No abstract available.


Improved predictive models for acute kidney injury with IDEA: Intraoperative Data Embedded Analytics.

Adhikari L, Ozrazgat-Baslanti T, Ruppert M, Madushani RWMA, Paliwal S, Hashemighouchani H, Zheng F, Tao M, Lopes JM, Li X, Rashidi P, Bihorac A.

PLoS One. 2019 Apr 4;14(4):e0214904. doi: 10.1371/journal.pone.0214904. eCollection 2019.


Autonomous detection of disruptions in the intensive care unit using deep mask RCNN.

Malhotra KR, Davoudi A, Siegel S, Bihorac A, Rashidi P.

Conf Comput Vis Pattern Recognit Workshops. 2018 Jun;2018:1944-1946. doi: 10.1109/CVPRW.2018.00241. Epub 2018 Dec 17.


Comparing clinical judgment with the MySurgeryRisk algorithm for preoperative risk assessment: A pilot usability study.

Brennan M, Puri S, Ozrazgat-Baslanti T, Feng Z, Ruppert M, Hashemighouchani H, Momcilovic P, Li X, Wang DZ, Bihorac A.

Surgery. 2019 May;165(5):1035-1045. doi: 10.1016/j.surg.2019.01.002. Epub 2019 Feb 18.


DeepSOFA: A Continuous Acuity Score for Critically Ill Patients using Clinically Interpretable Deep Learning.

Shickel B, Loftus TJ, Adhikari L, Ozrazgat-Baslanti T, Bihorac A, Rashidi P.

Sci Rep. 2019 Feb 12;9(1):1879. doi: 10.1038/s41598-019-38491-0.


The Development of Chronic Critical Illness Determines Physical Function, Quality of Life, and Long-Term Survival Among Early Survivors of Sepsis in Surgical ICUs.

Gardner AK, Ghita GL, Wang Z, Ozrazgat-Baslanti T, Raymond SL, Mankowski RT, Brumback BA, Efron PA, Bihorac A, Moore FA, Anton SD, Brakenridge SC.

Crit Care Med. 2019 Apr;47(4):566-573. doi: 10.1097/CCM.0000000000003655.


Persistent inflammation and anemia among critically ill septic patients.

Loftus TJ, Mira JC, Stortz JA, Ozrazgat-Baslanti T, Ghita GL, Wang Z, Brumback BA, Ungaro RF, Bihorac A, Leeuwenburgh C, Moore FA, Moldawer LL, Brakenridge SC, Efron PA, Mohr AM.

J Trauma Acute Care Surg. 2019 Feb;86(2):260-267. doi: 10.1097/TA.0000000000002147.


Comparison of Gaussian Processes Methods to Linear methods for Imputation of Sparse Physiological Time Series.

Nickerson P, Baharloo R, Davoudi A, Bihorac A, Rashidi P.

Conf Proc IEEE Eng Med Biol Soc. 2018 Jul;2018:4106-4109. doi: 10.1109/EMBC.2018.8513303.


Activity and Circadian Rhythm of Sepsis Patients in the Intensive Care Unit.

Davoudi A, Corbett DB, Ozrazgat-Baslanti T, Bihorac A, Brakenridge SC, Manini TM, Rashidi P.

IEEE EMBS Int Conf Biomed Health Inform. 2018 Mar;2018:17-20. doi: 10.1109/BHI.2018.8333359. Epub 2018 Apr 9.


Delirium Prediction using Machine Learning Models on Preoperative Electronic Health Records Data.

Davoudi A, Ebadi A, Rashidi P, Ozrazgat-Baslanti T, Bihorac A, Bursian AC.

Proc IEEE Int Symp Bioinformatics Bioeng. 2017 Oct;2017:568-573. doi: 10.1109/BIBE.2017.00014. Epub 2018 Jan 11.


Intelligent Perioperative System: Towards Real-time Big Data Analytics in Surgery Risk Assessment.

Feng Z, Bhat RR, Yuan X, Freeman D, Baslanti T, Bihorac A, Li X.

DASC PICom DataCom CyberSciTech 2017 (2017). 2017 Nov;2017:1254-1259. doi: 10.1109/DASC-PICom-DataCom-CyberSciTec.2017.201.


Role of Transglutaminase 2 in Migration of Tumor Cells and How Mouse Models Fit.

Bihorac A.

Med Sci (Basel). 2018 Aug 30;6(3). pii: E70. doi: 10.3390/medsci6030070. Review.


Epidemiology, outcomes, and management of acute kidney injury in the vascular surgery patient.

Hobson C, Lysak N, Huber M, Scali S, Bihorac A.

J Vasc Surg. 2018 Sep;68(3):916-928. doi: 10.1016/j.jvs.2018.05.017. Epub 2018 Jun 28. Review.


Chronic Critical Illness and the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome.

Hawkins RB, Raymond SL, Stortz JA, Horiguchi H, Brakenridge SC, Gardner A, Efron PA, Bihorac A, Segal M, Moore FA, Moldawer LL.

Front Immunol. 2018 Jul 2;9:1511. doi: 10.3389/fimmu.2018.01511. eCollection 2018. Review.


Deep EHR: A Survey of Recent Advances in Deep Learning Techniques for Electronic Health Record (EHR) Analysis.

Shickel B, Tighe PJ, Bihorac A, Rashidi P.

IEEE J Biomed Health Inform. 2018 Sep;22(5):1589-1604. doi: 10.1109/JBHI.2017.2767063. Epub 2017 Oct 27. Review.


Response to: "MySurgeryRisk: Development and Validation of a Machine-learning Risk Algorithm for Major Complications and Death After Surgery".

Bihorac A.

Ann Surg. 2018 Jul 2. doi: 10.1097/SLA.0000000000002884. [Epub ahead of print] No abstract available.


Cardiac and Vascular Surgery-Associated Acute Kidney Injury: The 20th International Consensus Conference of the ADQI (Acute Disease Quality Initiative) Group.

Nadim MK, Forni LG, Bihorac A, Hobson C, Koyner JL, Shaw A, Arnaoutakis GJ, Ding X, Engelman DT, Gasparovic H, Gasparovic V, Herzog CA, Kashani K, Katz N, Liu KD, Mehta RL, Ostermann M, Pannu N, Pickkers P, Price S, Ricci Z, Rich JB, Sajja LR, Weaver FA, Zarbock A, Ronco C, Kellum JA.

J Am Heart Assoc. 2018 Jun 1;7(11). pii: e008834. doi: 10.1161/JAHA.118.008834. No abstract available.


Persistent inflammation, immunosuppression, and catabolism and the development of chronic critical illness after surgery.

Efron PA, Mohr AM, Bihorac A, Horiguchi H, Hollen MK, Segal MS, Baker HV, Leeuwenburgh C, Moldawer LL, Moore FA, Brakenridge SC.

Surgery. 2018 Aug;164(2):178-184. doi: 10.1016/j.surg.2018.04.011. Epub 2018 May 26. Review.


Innate Immunity in the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome and Its Implications for Therapy.

Horiguchi H, Loftus TJ, Hawkins RB, Raymond SL, Stortz JA, Hollen MK, Weiss BP, Miller ES, Bihorac A, Larson SD, Mohr AM, Brakenridge SC, Tsujimoto H, Ueno H, Moore FA, Moldawer LL, Efron PA; Sepsis and Critical Illness Research Center Investigators.

Front Immunol. 2018 Apr 4;9:595. doi: 10.3389/fimmu.2018.00595. eCollection 2018. Review.


The impact of age on the innate immune response and outcomes after severe sepsis/septic shock in trauma and surgical intensive care unit patients.

Brakenridge SC, Efron PA, Stortz JA, Ozrazgat-Baslanti T, Ghita G, Wang Z, Bihorac A, Mohr AM, Brumback BA, Moldawer LL, Moore FA.

J Trauma Acute Care Surg. 2018 Aug;85(2):247-255. doi: 10.1097/TA.0000000000001921.


Outcomes in Patients with Vasodilatory Shock and Renal Replacement Therapy Treated with Intravenous Angiotensin II.

Tumlin JA, Murugan R, Deane AM, Ostermann M, Busse LW, Ham KR, Kashani K, Szerlip HM, Prowle JR, Bihorac A, Finkel KW, Zarbock A, Forni LG, Lynch SJ, Jensen J, Kroll S, Chawla LS, Tidmarsh GF, Bellomo R; Angiotensin II for the Treatment of High-Output Shock 3 (ATHOS-3) Investigators.

Crit Care Med. 2018 Jun;46(6):949-957. doi: 10.1097/CCM.0000000000003092.


MySurgeryRisk: Development and Validation of a Machine-learning Risk Algorithm for Major Complications and Death After Surgery.

Bihorac A, Ozrazgat-Baslanti T, Ebadi A, Motaei A, Madkour M, Pardalos PM, Lipori G, Hogan WR, Efron PA, Moore F, Moldawer LL, Wang DZ, Hobson CE, Rashidi P, Li X, Momcilovic P.

Ann Surg. 2019 Apr;269(4):652-662. doi: 10.1097/SLA.0000000000002706.


Benchmarking clinical outcomes and the immunocatabolic phenotype of chronic critical illness after sepsis in surgical intensive care unit patients.

Stortz JA, Mira JC, Raymond SL, Loftus TJ, Ozrazgat-Baslanti T, Wang Z, Ghita GL, Leeuwenburgh C, Segal MS, Bihorac A, Brumback BA, Mohr AM, Efron PA, Moldawer LL, Moore FA, Brakenridge SC.

J Trauma Acute Care Surg. 2018 Feb;84(2):342-349. doi: 10.1097/TA.0000000000001758.


Acute kidney injury: Precision perioperative care protects the kidneys.

Bihorac A, Hobson CE.

Nat Rev Nephrol. 2017 Dec 13;14(1):8-10. doi: 10.1038/nrneph.2017.170. No abstract available.


The Impact of Changes in Medicare's Physician Payment System on Critical Care.

Hobson CE, Bihorac A, Hadian M, Herr DL, Rainey TG, Cerra FB, Napolitano LM, Hoyt JW.

Crit Connect. 2017 Feb;15:18-19.


Evidence for Persistent Immune Suppression in Patients Who Develop Chronic Critical Illness After Sepsis.

Stortz JA, Murphy TJ, Raymond SL, Mira JC, Ungaro R, Dirain ML, Nacionales DC, Loftus TJ, Wang Z, Ozrazgat-Baslanti T, Ghita GL, Brumback BA, Mohr AM, Bihorac A, Efron PA, Moldawer LL, Moore FA, Brakenridge SC.

Shock. 2018 Mar;49(3):249-258. doi: 10.1097/SHK.0000000000000981.


Sepsis and Critical Illness Research Center investigators: protocols and standard operating procedures for a prospective cohort study of sepsis in critically ill surgical patients.

Loftus TJ, Mira JC, Ozrazgat-Baslanti T, Ghita GL, Wang Z, Stortz JA, Brumback BA, Bihorac A, Segal MS, Anton SD, Leeuwenburgh C, Mohr AM, Efron PA, Moldawer LL, Moore FA, Brakenridge SC.

BMJ Open. 2017 Aug 1;7(7):e015136. doi: 10.1136/bmjopen-2016-015136.


Kidney and Brain, an Unbroken Chain.

Bihorac A, Hobson C.

Am J Respir Crit Care Med. 2017 Jun 15;195(12):1546-1548. doi: 10.1164/rccm.201611-2371ED. No abstract available.


Tissue transglutaminase expression is necessary for adhesion, metastatic potential and cancer stemness of renal cell carcinoma.

Bagatur Y, Ilter Akulke AZ, Bihorac A, Erdem M, Telci D.

Cell Adh Migr. 2018 Mar 4;12(2):138-151. doi: 10.1080/19336918.2017.1322255. Epub 2017 Jul 14.


D.R.E.A.M.S: (Digital Rehabilitation Environment-Altering Medical System).

Suvajdzic M, Bihorac A, Rashidi P.

SeGAH IEEE Int Conf Serious Games Appl Health. 2017 Apr;2017. doi: 10.1109/SeGAH.2017.7939293. Epub 2017 Jun 8.


Perioperative Acute Kidney Injury: Risk Factors and Predictive Strategies.

Hobson C, Ruchi R, Bihorac A.

Crit Care Clin. 2017 Apr;33(2):379-396. doi: 10.1016/j.ccc.2016.12.008. Review.


Acute kidney disease and renal recovery: consensus report of the Acute Disease Quality Initiative (ADQI) 16 Workgroup.

Chawla LS, Bellomo R, Bihorac A, Goldstein SL, Siew ED, Bagshaw SM, Bittleman D, Cruz D, Endre Z, Fitzgerald RL, Forni L, Kane-Gill SL, Hoste E, Koyner J, Liu KD, Macedo E, Mehta R, Murray P, Nadim M, Ostermann M, Palevsky PM, Pannu N, Rosner M, Wald R, Zarbock A, Ronco C, Kellum JA; Acute Disease Quality Initiative Workgroup 16.

Nat Rev Nephrol. 2017 Apr;13(4):241-257. doi: 10.1038/nrneph.2017.2. Epub 2017 Feb 27.


Acute Kidney Injury Following Exploratory Laparotomy and Temporary Abdominal Closure.

Loftus TJ, Bihorac A, Ozrazgat-Baslanti T, Jordan JR, Croft CA, Smith RS, Efron PA, Moore FA, Mohr AM, Brakenridge SC.

Shock. 2017 Jul;48(1):5-10. doi: 10.1097/SHK.0000000000000825.


Optimal Role of the Nephrologist in the Intensive Care Unit.

Askenazi DJ, Heung M, Connor MJ Jr, Basu RK, Cerdá J, Doi K, Koyner JL, Bihorac A, Golestaneh L, Vijayan A, Okusa MD, Faubel S; American Society of Nephrology Acute Kidney Injury Advisory Group.

Blood Purif. 2017;43(1-3):68-77. doi: 10.1159/000452317. Epub 2016 Dec 3.


Mortality and cost of acute and chronic kidney disease after cardiac surgery.

Lysak N, Bihorac A, Hobson C.

Curr Opin Anaesthesiol. 2017 Feb;30(1):113-117. doi: 10.1097/ACO.0000000000000422. Review.


Recovery after Acute Kidney Injury.

Kellum JA, Sileanu FE, Bihorac A, Hoste EA, Chawla LS.

Am J Respir Crit Care Med. 2017 Mar 15;195(6):784-791. doi: 10.1164/rccm.201604-0799OC.


Preoperative assessment of the risk for multiple complications after surgery.

Ozrazgat-Baslanti T, Blanc P, Thottakkara P, Ruppert M, Rashidi P, Momcilovic P, Hobson C, Efron PA, Moore FA, Bihorac A.

Surgery. 2016 Aug;160(2):463-72. doi: 10.1016/j.surg.2016.04.013. Epub 2016 May 26.


Application of Machine Learning Techniques to High-Dimensional Clinical Data to Forecast Postoperative Complications.

Thottakkara P, Ozrazgat-Baslanti T, Hupf BB, Rashidi P, Pardalos P, Momcilovic P, Bihorac A.

PLoS One. 2016 May 27;11(5):e0155705. doi: 10.1371/journal.pone.0155705. eCollection 2016.


Authors' reply re:Acute kidney injury in major gynaecological surgery: an observational study.

Bihorac A, J Vaught A, Ozrazgat-Baslanti T, E Hobson C.

BJOG. 2016 Jun;123(7):1235. doi: 10.1111/1471-0528.13936. No abstract available.


Perioperative Acute Kidney Injury-Reply.

Hobson C, Huber M, Bihorac A.

JAMA Surg. 2016 Aug 1;151(8):783. doi: 10.1001/jamasurg.2016.0470. No abstract available.


Long-Term Outcomes for Different Forms of Stress Cardiomyopathy After Surgical Treatment for Subarachnoid Hemorrhage.

Bihorac A, Ozrazgat-Baslanti T, Mahanna E, Malik S, White P, Sorensen M, Fahy BG, Petersen JW.

Anesth Analg. 2016 May;122(5):1594-602. doi: 10.1213/ANE.0000000000001231.


Clinical Use of the Urine Biomarker [TIMP-2] × [IGFBP7] for Acute Kidney Injury Risk Assessment.

Vijayan A, Faubel S, Askenazi DJ, Cerda J, Fissell WH, Heung M, Humphreys BD, Koyner JL, Liu KD, Mour G, Nolin TD, Bihorac A; American Society of Nephrology Acute Kidney Injury Advisory Group.

Am J Kidney Dis. 2016 Jul;68(1):19-28. doi: 10.1053/j.ajkd.2015.12.033. Epub 2016 Mar 4.


Establishing a continuum of acute kidney injury - tracing AKI using data source linkage and long-term follow-up: Workgroup Statements from the 15th ADQI Consensus Conference.

Mehta R, Bihorac A, Selby NM, Quan H, Goldstein SL, Kellum JA, Ronco C, Bagshaw SM; Acute Dialysis Quality Initiative (ADQI) Consensus Group.

Can J Kidney Health Dis. 2016 Feb 26;3:13. doi: 10.1186/s40697-016-0102-0. eCollection 2016.


TIMP2•IGFBP7 biomarker panel accurately predicts acute kidney injury in high-risk surgical patients.

Gunnerson KJ, Shaw AD, Chawla LS, Bihorac A, Al-Khafaji A, Kashani K, Lissauer M, Shi J, Walker MG, Kellum JA; Sapphire Topaz investigators.

J Trauma Acute Care Surg. 2016 Feb;80(2):243-9. doi: 10.1097/TA.0000000000000912.


Acute and Chronic Kidney Disease and Cardiovascular Mortality After Major Surgery.

Ozrazgat-Baslanti T, Thottakkara P, Huber M, Berg K, Gravenstein N, Tighe P, Lipori G, Segal MS, Hobson C, Bihorac A.

Ann Surg. 2016 Dec;264(6):987-996.


Cardiovascular-Specific Mortality and Kidney Disease in Patients Undergoing Vascular Surgery.

Huber M, Ozrazgat-Baslanti T, Thottakkara P, Scali S, Bihorac A, Hobson C.

JAMA Surg. 2016 May 1;151(5):441-50. doi: 10.1001/jamasurg.2015.4526.

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