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Items: 1 to 50 of 453

1.

N,N-bis-heteroaryl methylamines: Potent anti-mitotic and highly cytotoxic agents.

Khelifi I, Naret T, Hamze A, Bignon J, Levaique H, Garcia Alvarez MC, Dubois J, Provot O, Alami M.

Eur J Med Chem. 2019 Apr 15;168:176-188. doi: 10.1016/j.ejmech.2019.02.038. Epub 2019 Feb 16.

PMID:
30818177
2.

1,1-Diheterocyclic Ethylenes Derived from Quinaldine and Carbazole as New Tubulin-Polymerization Inhibitors: Synthesis, Metabolism, and Biological Evaluation.

Naret T, Khelifi I, Provot O, Bignon J, Levaique H, Dubois J, Souce M, Kasselouri A, Deroussent A, Paci A, Varela PF, Gigant B, Alami M, Hamze A.

J Med Chem. 2019 Feb 28;62(4):1902-1916. doi: 10.1021/acs.jmedchem.8b01386. Epub 2018 Dec 21.

PMID:
30525602
3.

One-Pot Synthesis of 2-Styrylindoles from Ortho-Substituted Chloroenynes.

Zhao G, Bignon J, Levaique H, Dubois J, Alami M, Provot O.

J Org Chem. 2018 Dec 21;83(24):15323-15332. doi: 10.1021/acs.joc.8b02563. Epub 2018 Dec 11.

PMID:
30520637
4.

N-myristoyltransferases inhibitory activity of ellagitannins from Terminalia bentzoë (L.) L. f. subsp. bentzoë.

Apel C, Bignon J, Garcia-Alvarez MC, Ciccone S, Clerc P, Grondin I, Girard-Valenciennes E, Smadja J, Lopes P, Frédérich M, Roussi F, Meinnel T, Giglione C, Litaudon M.

Fitoterapia. 2018 Nov;131:91-95. doi: 10.1016/j.fitote.2018.10.014. Epub 2018 Oct 17.

PMID:
30342177
5.

Inhibition of p53-Murine Double Minute 2 (MDM2) Interactions with 3,3'-Spirocyclopentene Oxindole Derivatives.

Gicquel M, Gomez C, Garcia Alvarez MC, Pamlard O, Guérineau V, Jacquet E, Bignon J, Voituriez A, Marinetti A.

J Med Chem. 2018 Oct 25;61(20):9386-9392. doi: 10.1021/acs.jmedchem.8b01137. Epub 2018 Oct 8.

PMID:
30221935
6.

mTOR Inhibition via Displacement of Phosphatidic Acid Induces Enhanced Cytotoxicity Specifically in Cancer Cells.

Nguyen TL, Nokin MJ, Egorov M, Tomé M, Bodineau C, Di Primo C, Minder L, Wdzieczak-Bakala J, Garcia-Alvarez MC, Bignon J, Thoison O, Delpech B, Surpateanu G, Frapart YM, Peyrot F, Abbas K, Terés S, Evrard S, Khatib AM, Soubeyran P, Iorga BI, Durán RV, Collin P.

Cancer Res. 2018 Sep 15;78(18):5384-5397. doi: 10.1158/0008-5472.CAN-18-0232. Epub 2018 Jul 27.

7.

Design and Synthesis of Tubulin and Histone Deacetylase Inhibitor Based on iso-Combretastatin A-4.

Lamaa D, Lin HP, Zig L, Bauvais C, Bollot G, Bignon J, Levaique H, Pamlard O, Dubois J, Ouaissi M, Souce M, Kasselouri A, Saller F, Borgel D, Jayat-Vignoles C, Al-Mouhammad H, Feuillard J, Benihoud K, Alami M, Hamze A.

J Med Chem. 2018 Aug 9;61(15):6574-6591. doi: 10.1021/acs.jmedchem.8b00050. Epub 2018 Jul 26.

PMID:
30004697
8.

Dual inhibitors of the pro-survival proteins Bcl-2 and Mcl-1 derived from natural compound meiogynin A.

Abou Samra A, Robert A, Gov C, Favre L, Eloy L, Jacquet E, Bignon J, Wiels J, Desrat S, Roussi F.

Eur J Med Chem. 2018 Mar 25;148:26-38. doi: 10.1016/j.ejmech.2018.01.100. Epub 2018 Feb 5.

PMID:
29453135
9.

Csp2-Csp2 and Csp2-N Bond Formation in a One-Pot Reaction between N-Tosylhydrazones and Bromonitrobenzenes: An Unexpected Cyclization to Substituted Indole Derivatives.

Bzeih T, Lamaa D, Frison G, Hachem A, Jaber N, Bignon J, Retailleau P, Alami M, Hamze A.

Org Lett. 2017 Dec 15;19(24):6700-6703. doi: 10.1021/acs.orglett.7b03422. Epub 2017 Dec 5.

PMID:
29206470
10.

A fluorine scan of a tubulin polymerization inhibitor isocombretastatin A-4: Design, synthesis, molecular modelling, and biological evaluation.

Naret T, Bignon J, Bernadat G, Benchekroun M, Levaique H, Lenoir C, Dubois J, Pruvost A, Saller F, Borgel D, Manoury B, Leblais V, Darrigrand R, Apcher S, Brion JD, Schmitt E, Leroux FR, Alami M, Hamze A.

Eur J Med Chem. 2018 Jan 1;143:473-490. doi: 10.1016/j.ejmech.2017.11.055. Epub 2017 Dec 2.

PMID:
29202409
11.

Cytotoxic Prenylated Stilbenes Isolated from Macaranga tanarius.

Péresse T, Jézéquel G, Allard PM, Pham VC, Huong DTM, Blanchard F, Bignon J, Lévaique H, Wolfender JL, Litaudon M, Roussi F.

J Nat Prod. 2017 Oct 27;80(10):2684-2691. doi: 10.1021/acs.jnatprod.7b00409. Epub 2017 Oct 3.

PMID:
28972755
12.

A New Series of Succinimido-ferrociphenols and Related Heterocyclic Species Induce Strong Antiproliferative Effects, Especially against Ovarian Cancer Cells Resistant to Cisplatin.

Pigeon P, Wang Y, Top S, Najlaoui F, Garcia Alvarez MC, Bignon J, McGlinchey MJ, Jaouen G.

J Med Chem. 2017 Oct 26;60(20):8358-8368. doi: 10.1021/acs.jmedchem.7b00743. Epub 2017 Sep 22.

PMID:
28895732
13.

Design, synthesis and anticancer properties of IsoCombretaQuinolines as potent tubulin assembly inhibitors.

Khelifi I, Naret T, Renko D, Hamze A, Bernadat G, Bignon J, Lenoir C, Dubois J, Brion JD, Provot O, Alami M.

Eur J Med Chem. 2017 Feb 15;127:1025-1034. doi: 10.1016/j.ejmech.2016.11.012. Epub 2016 Nov 9.

PMID:
28166995
14.

A general synthesis of arylindoles and (1-arylvinyl)carbazoles via a one-pot reaction from N-tosylhydrazones and 2-nitro-haloarenes and their potential application to colon cancer.

Bzeih T, Naret T, Hachem A, Jaber N, Khalaf A, Bignon J, Brion JD, Alami M, Hamze A.

Chem Commun (Camb). 2016 Oct 27;52(88):13027-13030.

PMID:
27752657
15.

Original Vinca Derivatives: From P-Glycoprotein Substrates to P-Glycoprotein Inhibitors.

Gherbovet O, García Alvarez MC, Bignon J, Roussi F.

J Med Chem. 2016 Dec 8;59(23):10774-10780. Epub 2016 Nov 23.

PMID:
27753480
16.

MetAP1 and MetAP2 drive cell selectivity for a potent anti-cancer agent in synergy, by controlling glutathione redox state.

Frottin F, Bienvenut WV, Bignon J, Jacquet E, Vaca Jacome AS, Van Dorsselaer A, Cianferani S, Carapito C, Meinnel T, Giglione C.

Oncotarget. 2016 Sep 27;7(39):63306-63323. doi: 10.18632/oncotarget.11216.

17.

Anacardic Acids from Knema hookeriana as Modulators of Bcl-xL/Bak and Mcl-1/Bid Interactions.

Gény C, Rivière G, Bignon J, Birlirakis N, Guittet E, Awang K, Litaudon M, Roussi F, Dumontet V.

J Nat Prod. 2016 Apr 22;79(4):838-44. doi: 10.1021/acs.jnatprod.5b00915. Epub 2016 Mar 23.

PMID:
27008174
18.

IsoCombretaQuinazolines: Potent Cytotoxic Agents with Antitubulin Activity.

Soussi MA, Provot O, Bernadat G, Bignon J, Desravines D, Dubois J, Brion JD, Messaoudi S, Alami M.

ChemMedChem. 2015 Aug;10(8):1392-402. doi: 10.1002/cmdc.201500069. Epub 2015 Jun 15.

PMID:
26076053
19.

Palladium-Catalyzed One-Pot Reaction of Hydrazones, Dihaloarenes, and Organoboron Reagents: Synthesis and Cytotoxic Activity of 1,1-Diarylethylene Derivatives.

Roche M, Salim SM, Bignon J, Levaique H, Brion JD, Alami M, Hamze A.

J Org Chem. 2015 Jul 2;80(13):6715-27. doi: 10.1021/acs.joc.5b00880. Epub 2015 Jun 12.

PMID:
26036279
20.

Antibacterial Labdane Diterpenoids from Vitex vestita.

Corlay N, Lecsö-Bornet M, Leborgne E, Blanchard F, Cachet X, Bignon J, Roussi F, Butel MJ, Awang K, Litaudon M.

J Nat Prod. 2015 Jun 26;78(6):1348-56. doi: 10.1021/acs.jnatprod.5b00206. Epub 2015 Jun 2.

PMID:
26034885
21.

Dynamics of MBD2 deposition across methylated DNA regions during malignant transformation of human mammary epithelial cells.

Devailly G, Grandin M, Perriaud L, Mathot P, Delcros JG, Bidet Y, Morel AP, Bignon JY, Puisieux A, Mehlen P, Dante R.

Nucleic Acids Res. 2015 Jul 13;43(12):5838-54. doi: 10.1093/nar/gkv508. Epub 2015 May 24.

22.

Synthesis and biological evaluation of C-13' substituted 7'-homo-anhydrovinblastine derivatives.

Gherbovet O, La Spisa F, Thoret S, Alvarez MCG, Levaique H, Bignon J, Roussi F.

Bioorg Med Chem Lett. 2015 Apr 15;25(8):1771-1773. doi: 10.1016/j.bmcl.2015.02.045. Epub 2015 Mar 7.

PMID:
25804719
23.

Synthesis and evaluation of hybrid molecules targeting the vinca domain of tubulin.

Gherbovet O, Sánchez-Murcia PA, García Alvarez MC, Bignon J, Thoret S, Gago F, Roussi F.

Org Biomol Chem. 2015 Mar 14;13(10):3144-54. doi: 10.1039/c4ob02114b.

PMID:
25634805
24.

Antiangiogenic-Like Properties of Fermented Extracts of Ayurvedic Medicinal Plants.

Rabhi C, Arcile G, Cariel L, Lenoir C, Bignon J, Wdzieczak-Bakala J, Ouazzani J.

J Med Food. 2015 Sep;18(9):1065-72. doi: 10.1089/jmf.2014.0128. Epub 2015 Jan 21.

PMID:
25608021
25.

Rapid synthesis of 4-arylchromenes from ortho-substituted alkynols: A versatile access to restricted isocombretastatin A-4 analogues as antitumor agents.

Renko D, Provot O, Rasolofonjatovo E, Bignon J, Rodrigo J, Dubois J, Brion JD, Hamze A, Alami M.

Eur J Med Chem. 2015 Jan 27;90:834-44. doi: 10.1016/j.ejmech.2014.12.024. Epub 2014 Dec 15.

PMID:
25528337
26.

Synthesis of a 3-(α-styryl)benzo[b]-thiophene library via bromocyclization of alkynes and palladium-catalyzed to sylhydrazones cross-couplings: evaluation as antitubulin agents.

Tréguier B, Lawson M, Bernadat G, Bignon J, Dubois J, Brion JD, Alami M, Hamze A.

ACS Comb Sci. 2014 Dec 8;16(12):702-10. doi: 10.1021/co500115b. Epub 2014 Sep 25.

PMID:
25229390
27.

Tandem one-pot palladium-catalyzed coupling of hydrazones, haloindoles, and amines: synthesis of amino-N-vinylindoles and their effect on human colon carcinoma cells.

Roche M, Bignon J, Brion JD, Hamze A, Alami M.

J Org Chem. 2014 Aug 15;79(16):7583-92. doi: 10.1021/jo501315q. Epub 2014 Jul 29.

PMID:
25029590
28.

One-pot synthesis of vinca alkaloids-phomopsin hybrids.

Gherbovet O, Coderch C, García Alvarez MC, Bignon J, Thoret S, Guéritte F, Gago F, Roussi F.

J Med Chem. 2014 Jun 26;57(12):5470-6. doi: 10.1021/jm500530v. Epub 2014 Jun 10.

PMID:
24871162
29.

Reduction-responsive cholesterol-based block copolymer vesicles for drug delivery.

Jia L, Cui D, Bignon J, Di Cicco A, Wdzieczak-Bakala J, Liu J, Li MH.

Biomacromolecules. 2014 Jun 9;15(6):2206-17. doi: 10.1021/bm5003569. Epub 2014 May 19.

PMID:
24801808
30.

Discovery of azaisoerianin derivatives as potential antitumors agents.

Soussi MA, Provot O, Bernadat G, Bignon J, Wdzieczak-Bakala J, Desravines D, Dubois J, Brion JD, Messaoudi S, Alami M.

Eur J Med Chem. 2014 May 6;78:178-89. doi: 10.1016/j.ejmech.2014.03.032. Epub 2014 Mar 13.

PMID:
24681982
31.

T-cell therapy using a bank of EBV-specific cytotoxic T cells: lessons from a phase I/II feasibility and safety study.

Gallot G, Vollant S, Saïagh S, Clémenceau B, Vivien R, Cerato E, Bignon JD, Ferrand C, Jaccard A, Vigouroux S, Choquet S, Dalle JH, Frachon I, Bruno B, Mothy M, Mechinaud F, Leblond V, Milpied N, Vié H.

J Immunother. 2014 Apr;37(3):170-9. doi: 10.1097/CJI.0000000000000031.

PMID:
24598452
32.

Synthesis and biological evaluation of a new series of highly functionalized 7'-homo-anhydrovinblastine derivatives.

Gherbovet O, Coderch C, García Alvarez MC, Bignon J, Thoret S, Martin MT, Guéritte F, Gago F, Roussi F.

J Med Chem. 2013 Aug 8;56(15):6088-100. doi: 10.1021/jm4004347. Epub 2013 Jul 18.

PMID:
23822556
33.

An efficient coupling of N-tosylhydrazones with 2-halopyridines: synthesis of 2-α-styrylpyridines endowed with antitumor activity.

Lawson M, Hamze A, Peyrat JF, Bignon J, Dubois J, Brion JD, Alami M.

Org Biomol Chem. 2013 Jun 14;11(22):3664-73. doi: 10.1039/c3ob40263k.

PMID:
23615719
34.

The regulatory role of the tetrapeptide AcSDKP in skin and hair physiology and the prevention of ageing effects in these tissues--a potential cosmetic role.

Hajem N, Chapelle A, Bignon J, Pinault A, Liu JM, Salah-Mohellibi N, Lati E, Wdzieczak-Bakala J.

Int J Cosmet Sci. 2013 Jun;35(3):286-98. doi: 10.1111/ics.12046. Epub 2013 Apr 18.

PMID:
23488645
35.

Design, synthesis and anticancer properties of 5-arylbenzoxepins as conformationally restricted isocombretastatin A-4 analogs.

Rasolofonjatovo E, Provot O, Hamze A, Rodrigo J, Bignon J, Wdzieczak-Bakala J, Lenoir C, Desravines D, Dubois J, Brion JD, Alami M.

Eur J Med Chem. 2013 Apr;62:28-39. doi: 10.1016/j.ejmech.2012.12.042. Epub 2013 Jan 4.

PMID:
23353744
36.

Synthesis, biological evaluation, and structure-activity relationships of tri- and tetrasubstituted olefins related to isocombretastatin A-4 as new tubulin inhibitors.

Aziz J, Brachet E, Hamze A, Peyrat JF, Bernadat G, Morvan E, Bignon J, Wdzieczak-Bakala J, Desravines D, Dubois J, Tueni M, Yassine A, Brion JD, Alami M.

Org Biomol Chem. 2013 Jan 21;11(3):430-42. doi: 10.1039/c2ob26253c. Epub 2012 Oct 9.

PMID:
23047722
37.

Conformationnally restricted naphthalene derivatives type isocombretastatin A-4 and isoerianin analogues: synthesis, cytotoxicity and antitubulin activity.

Rasolofonjatovo E, Provot O, Hamze A, Rodrigo J, Bignon J, Wdzieczak-Bakala J, Desravines D, Dubois J, Brion JD, Alami M.

Eur J Med Chem. 2012 Jun;52:22-32. doi: 10.1016/j.ejmech.2012.03.001. Epub 2012 Mar 9.

PMID:
22449653
38.

Effect of T-cell-epitope matching at HLA-DPB1 in recipients of unrelated-donor haemopoietic-cell transplantation: a retrospective study.

Fleischhauer K, Shaw BE, Gooley T, Malkki M, Bardy P, Bignon JD, Dubois V, Horowitz MM, Madrigal JA, Morishima Y, Oudshoorn M, Ringden O, Spellman S, Velardi A, Zino E, Petersdorf EW; International Histocompatibility Working Group in Hematopoietic Cell Transplantation.

Lancet Oncol. 2012 Apr;13(4):366-74. doi: 10.1016/S1470-2045(12)70004-9. Epub 2012 Feb 15. Erratum in: Lancet Oncol. 2012 Apr;13(4):e134-5.

39.

B-ring-modified isocombretastatin A-4 analogues endowed with interesting anticancer activities.

Hamze A, Rasolofonjatovo E, Provot O, Mousset C, Veau D, Rodrigo J, Bignon J, Liu JM, Wdzieczak-Bakala J, Thoret S, Dubois J, Brion JD, Alami M.

ChemMedChem. 2011 Dec 9;6(12):2179-91. doi: 10.1002/cmdc.201100325. Epub 2011 Oct 11.

PMID:
21990101
40.

The metabolic fate of isocombretastatin A-4 in human liver microsomes: identification, synthesis and biological evaluation of metabolites.

Soussi MA, Aprile S, Messaoudi S, Provot O, Del Grosso E, Bignon J, Dubois J, Brion JD, Grosa G, Alami M.

ChemMedChem. 2011 Oct 4;6(10):1781-8. doi: 10.1002/cmdc.201100193. Epub 2011 Jul 11. No abstract available.

PMID:
21748852
41.

Nitric oxide activates an Nrf2/sulfiredoxin antioxidant pathway in macrophages.

Abbas K, Breton J, Planson AG, Bouton C, Bignon J, Seguin C, Riquier S, Toledano MB, Drapier JC.

Free Radic Biol Med. 2011 Jul 1;51(1):107-14. doi: 10.1016/j.freeradbiomed.2011.03.039. Epub 2011 Apr 3.

PMID:
21466852
42.

Discovery of isoerianin analogues as promising anticancer agents.

Messaoudi S, Hamze A, Provot O, Tréguier B, Rodrigo De Losada J, Bignon J, Liu JM, Wdzieczak-Bakala J, Thoret S, Dubois J, Brion JD, Alami M.

ChemMedChem. 2011 Mar 7;6(3):488-97. doi: 10.1002/cmdc.201000456. Epub 2011 Jan 14. Erratum in: ChemMedChem. 2011 May 2;6(5):750.

PMID:
21360820
43.

HLA mismatches and hematopoietic cell transplantation: structural simulations assess the impact of changes in peptide binding specificity on transplant outcome.

Yanover C, Petersdorf EW, Malkki M, Gooley T, Spellman S, Velardi A, Bardy P, Madrigal A, Bignon JD, Bradley P.

Immunome Res. 2011;7(2):4.

44.

Cytotoxic 3,4-seco-Atisane Diterpenoids from Croton barorum and Croton goudotii.

Rakotonandrasana OL, Raharinjato FH, Rajaonarivelo M, Dumontet V, Martin MT, Bignon J, Rasoanaivo P.

J Nat Prod. 2010 Oct 22;73(10):1730-3. doi: 10.1021/np1005086. Epub 2010 Sep 17.

PMID:
20849074
45.

Regioselective hydrostannation of diarylalkynes directed by a labile ortho bromine atom: an easy access to stereodefined triarylolefins, hybrids of combretastatin A-4 and isocombretastatin A-4.

Rasolofonjatovo E, Provot O, Hamze A, Bignon J, Thoret S, Brion JD, Alami M.

Eur J Med Chem. 2010 Sep;45(9):3617-26. doi: 10.1016/j.ejmech.2010.05.007. Epub 2010 May 12.

PMID:
20627378
46.

Granulocyte antibody screening: evaluation of a bead-based assay in comparison with classical methods.

Fromont P, Prié N, Simon P, Cesbron-Gautier A, Quelvennec E, Bignon JD, Muller JY, Audrain M.

Transfusion. 2010 Dec;50(12):2643-8. doi: 10.1111/j.1537-2995.2010.02762.x.

PMID:
20576014
47.

Overexpression of the natural tetrapeptide acetyl-N-ser-asp-lys-pro derived from thymosin beta4 in neoplastic diseases.

Liu JM, Garcia-Alvarez MC, Bignon J, Kusinski M, Kuzdak K, Riches A, Wdzieczak-Bakala J.

Ann N Y Acad Sci. 2010 Apr;1194:53-9. doi: 10.1111/j.1749-6632.2010.05488.x. Review.

PMID:
20536450
48.

Improved KIR gene and HLA-C KIR ligand sequence-specific primer polymerase chain reaction genotyping using whole genome amplification.

Chainonthee W, Böttcher G, Gagne K, Füssel M, Bignon JD, Wassmuth R.

Tissue Antigens. 2010 Aug;76(2):135-43. doi: 10.1111/j.1399-0039.2010.01479.x. Epub 2010 Apr 8.

PMID:
20403144
49.

Variation in gene expression profiles of human monocytic U937 cells exposed to various fluxes of nitric oxide.

Turpaev K, Glatigny A, Bignon J, Delacroix H, Drapier JC.

Free Radic Biol Med. 2010 Jan 15;48(2):298-305. doi: 10.1016/j.freeradbiomed.2009.10.054. Epub 2009 Nov 3.

PMID:
19892011
50.

Elevated plasma levels of the angiogenic tetrapeptide acetyl-ser-asp-lys-pro are found in some patients with hematologic malignancies.

Liu JM, Gora-Tybor J, Grzybowska-Izydorczyk O, Bignon J, Robak T, Wdzieczak-Bakala J.

Leuk Lymphoma. 2009 Dec;50(12):2096-7. doi: 10.3109/10428190903331074. No abstract available.

PMID:
19863169

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