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Pseudomonas aeruginosa-Derived Volatile Sulfur Compounds Promote Distal Aspergillus fumigatus Growth and a Synergistic Pathogen-Pathogen Interaction That Increases Pathogenicity in Co-infection.

Scott J, Sueiro-Olivares M, Ahmed W, Heddergott C, Zhao C, Thomas R, Bromley M, Latgé JP, Krappmann S, Fowler S, Bignell E, Amich J.

Front Microbiol. 2019 Oct 9;10:2311. doi: 10.3389/fmicb.2019.02311. eCollection 2019.


Bayesian Detection of Piecewise Linear Trends in Replicated Time-Series with Application to Growth Data Modelling.

Papastamoulis P, Furukawa T, van Rhijn N, Bromley M, Bignell E, Rattray M.

Int J Biostat. 2019 Jul 25. pii: /j/ijb.ahead-of-print/ijb-2018-0052/ijb-2018-0052.xml. doi: 10.1515/ijb-2018-0052. [Epub ahead of print]


Microbial uptake by the respiratory epithelium: outcomes for host and pathogen.

Bertuzzi M, Hayes GE, Bignell EM.

FEMS Microbiol Rev. 2019 Mar 1;43(2):145-161. doi: 10.1093/femsre/fuy045. Review.


Mechanistic Basis of pH-Dependent 5-Flucytosine Resistance in Aspergillus fumigatus.

Gsaller F, Furukawa T, Carr PD, Rash B, Jöchl C, Bertuzzi M, Bignell EM, Bromley MJ.

Antimicrob Agents Chemother. 2018 May 25;62(6). pii: e02593-17. doi: 10.1128/AAC.02593-17. Print 2018 Jun.


Anti-Aspergillus Activities of the Respiratory Epithelium in Health and Disease.

Bertuzzi M, Hayes GE, Icheoku UJ, van Rhijn N, Denning DW, Osherov N, Bignell EM.

J Fungi (Basel). 2018 Jan 8;4(1). pii: E8. doi: 10.3390/jof4010008. Review.


Mutual independence of alkaline- and calcium-mediated signalling in Aspergillus fumigatus refutes the existence of a conserved druggable signalling nexus.

Loss O, Bertuzzi M, Yan Y, Fedorova N, McCann BL, Armstrong-James D, Espeso EA, Read ND, Nierman WC, Bignell EM.

Mol Microbiol. 2017 Dec;106(6):861-875. doi: 10.1111/mmi.13840. Epub 2017 Nov 14.


A Nonredundant Phosphopantetheinyl Transferase, PptA, Is a Novel Antifungal Target That Directs Secondary Metabolite, Siderophore, and Lysine Biosynthesis in Aspergillus fumigatus and Is Critical for Pathogenicity.

Johns A, Scharf DH, Gsaller F, Schmidt H, Heinekamp T, Straßburger M, Oliver JD, Birch M, Beckmann N, Dobb KS, Gilsenan J, Rash B, Bignell E, Brakhage AA, Bromley MJ.

MBio. 2017 Jul 18;8(4). pii: e01504-16. doi: 10.1128/mBio.01504-16.


Secondary metabolite arsenal of an opportunistic pathogenic fungus.

Bignell E, Cairns TC, Throckmorton K, Nierman WC, Keller NP.

Philos Trans R Soc Lond B Biol Sci. 2016 Dec 5;371(1709). pii: 20160023. doi: 10.1098/rstb.2016.0023.


Amino acid biosynthetic routes as drug targets for pulmonary fungal pathogens: what is known and why do we need to know more?

Amich J, Bignell E.

Curr Opin Microbiol. 2016 Aug;32:151-158. doi: 10.1016/j.mib.2016.06.003. Epub 2016 Jul 22. Review.


Editorial overview: The fungal infection arena in animal and plant hosts: dynamics at the interface.

Thomma BP, Bignell E.

Curr Opin Microbiol. 2016 Aug;32:v-vii. doi: 10.1016/j.mib.2016.07.001. Epub 2016 Jul 12. No abstract available.


Different Stress-Induced Calcium Signatures Are Reported by Aequorin-Mediated Calcium Measurements in Living Cells of Aspergillus fumigatus.

Muñoz A, Bertuzzi M, Bettgenhaeuser J, Iakobachvili N, Bignell EM, Read ND.

PLoS One. 2015 Sep 24;10(9):e0138008. doi: 10.1371/journal.pone.0138008. eCollection 2015.


In silico modeling of spore inhalation reveals fungal persistence following low dose exposure.

Tanaka RJ, Boon NJ, Vrcelj K, Nguyen A, Vinci C, Armstrong-James D, Bignell E.

Sci Rep. 2015 Sep 14;5:13958. doi: 10.1038/srep13958.


Refining the pH response in Aspergillus nidulans: a modulatory triad involving PacX, a novel zinc binuclear cluster protein.

Bussink HJ, Bignell EM, Múnera-Huertas T, Lucena-Agell D, Scazzocchio C, Espeso EA, Bertuzzi M, Rudnicka J, Negrete-Urtasun S, Peñas-Parilla MM, Rainbow L, Peñalva MÁ, Arst HN Jr, Tilburn J.

Mol Microbiol. 2015 Dec;98(6):1051-72. doi: 10.1111/mmi.13173. Epub 2015 Oct 16.


Correction: The pH-Responsive PacC Transcription Factor of Aspergillus fumigatus Governs Epithelial Entry and Tissue Invasion during Pulmonary Aspergillosis.

Bertuzzi M, Schrettl M, Alcazar-Fuoli L, Cairns TC, Muñoz A, Walker LA, Herbst S, Safari M, Cheverton AM, Chen D, Liu H, Saijo S, Fedorova ND, Armstrong-James D, Munro CA, Read ND, Filler SG, Espeso EA, Nierman WC, Haas H, Bignell EM.

PLoS Pathog. 2015 Jun 18;11(6):e1004943. doi: 10.1371/journal.ppat.1004943. eCollection 2015 Jun. No abstract available.


A modified recombineering protocol for the genetic manipulation of gene clusters in Aspergillus fumigatus.

Alcazar-Fuoli L, Cairns T, Lopez JF, Zonja B, Pérez S, Barceló D, Igarashi Y, Bowyer P, Bignell E.

PLoS One. 2014 Nov 5;9(11):e111875. doi: 10.1371/journal.pone.0111875. eCollection 2014.


The pH-responsive PacC transcription factor of Aspergillus fumigatus governs epithelial entry and tissue invasion during pulmonary aspergillosis.

Bertuzzi M, Schrettl M, Alcazar-Fuoli L, Cairns TC, Muñoz A, Walker LA, Herbst S, Safari M, Cheverton AM, Chen D, Liu H, Saijo S, Fedorova ND, Armstrong-James D, Munro CA, Read ND, Filler SG, Espeso EA, Nierman WC, Haas H, Bignell EM.

PLoS Pathog. 2014 Oct 16;10(10):e1004413. doi: 10.1371/journal.ppat.1004413. eCollection 2014 Oct. Erratum in: PLoS Pathog. 2015 Apr;11(4):e1004802. PLoS Pathog. 2015 Jun 18;11(6):e1004943.


Distribution, expression and expansion of Aspergillus fumigatus LINE-like retrotransposon populations in clinical and environmental isolates.

Huber F, Bignell E.

Fungal Genet Biol. 2014 Mar;64:36-44. doi: 10.1016/j.fgb.2014.01.002. Epub 2014 Jan 15. Erratum in: Fungal Genet Biol. 2014 Sep;70:32.


On the histone lysine methyltransferase activity of fungal metabolite chaetocin.

Cherblanc FL, Chapman KL, Reid J, Borg AJ, Sundriyal S, Alcazar-Fuoli L, Bignell E, Demetriades M, Schofield CJ, DiMaggio PA Jr, Brown R, Fuchter MJ.

J Med Chem. 2013 Nov 14;56(21):8616-25. doi: 10.1021/jm401063r. Epub 2013 Oct 25.


Genetic bypass of Aspergillus nidulans crzA function in calcium homeostasis.

Almeida RS, Loss O, Colabardini AC, Brown NA, Bignell E, Savoldi M, Pantano S, Goldman MH, Arst HN Jr, Goldman GH.

G3 (Bethesda). 2013 Jul 8;3(7):1129-41. doi: 10.1534/g3.113.005983.


Receptor-mediated signaling in Aspergillus fumigatus.

Grice CM, Bertuzzi M, Bignell EM.

Front Microbiol. 2013 Feb 20;4:26. doi: 10.3389/fmicb.2013.00026. eCollection 2013.


A new and clinically relevant murine model of solid-organ transplant aspergillosis.

Herbst S, Shah A, Carby M, Chusney G, Kikkeri N, Dorling A, Bignell E, Shaunak S, Armstrong-James D.

Dis Model Mech. 2013 May;6(3):643-51. doi: 10.1242/dmm.010330. Epub 2012 Dec 20.


Conservation in Aspergillus fumigatus of pH-signaling seven transmembrane domain and arrestin proteins, and implications for drug discovery.

Bignell EM.

Ann N Y Acad Sci. 2012 Dec;1273:35-43. doi: 10.1111/j.1749-6632.2012.06814.x.


Clonality despite sex: the evolution of host-associated sexual neighborhoods in the pathogenic fungus Penicillium marneffei.

Henk DA, Shahar-Golan R, Devi KR, Boyce KJ, Zhan N, Fedorova ND, Nierman WC, Hsueh PR, Yuen KY, Sieu TP, Kinh NV, Wertheim H, Baker SG, Day JN, Vanittanakom N, Bignell EM, Andrianopoulos A, Fisher MC.

PLoS Pathog. 2012;8(10):e1002851. doi: 10.1371/journal.ppat.1002851. Epub 2012 Oct 4.


Incidence of dsRNA mycoviruses in a collection of Aspergillus fumigatus isolates.

Bhatti MF, Jamal A, Bignell EM, Petrou MA, Coutts RH.

Mycopathologia. 2012 Oct;174(4):323-6. doi: 10.1007/s11046-012-9556-5. Epub 2012 May 20.


The Molecular Basis of pH Sensing, Signaling, and Homeostasis in Fungi.

Bignell E.

Adv Appl Microbiol. 2012;79:1-18. doi: 10.1016/B978-0-12-394318-7.00001-2. Review.


Host-fungal interactions: key players of antifungal immunity.

Salek-Ardakani S, Cota E, Bignell E.

Expert Rev Anti Infect Ther. 2012 Feb;10(2):149-51. doi: 10.1586/eri.11.169.


Mevalonate governs interdependency of ergosterol and siderophore biosyntheses in the fungal pathogen Aspergillus fumigatus.

Yasmin S, Alcazar-Fuoli L, Gründlinger M, Puempel T, Cairns T, Blatzer M, Lopez JF, Grimalt JO, Bignell E, Haas H.

Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):E497-504. doi: 10.1073/pnas.1106399108. Epub 2011 Nov 21.


Oligopeptide transport and regulation of extracellular proteolysis are required for growth of Aspergillus fumigatus on complex substrates but not for virulence.

Hartmann T, Cairns TC, Olbermann P, Morschhäuser J, Bignell EM, Krappmann S.

Mol Microbiol. 2011 Nov;82(4):917-35. doi: 10.1111/j.1365-2958.2011.07868.x. Epub 2011 Oct 24.


On the determination of the stereochemistry of semisynthetic natural product analogues using chiroptical spectroscopy: desulfurization of epidithiodioxopiperazine fungal metabolites.

Cherblanc F, Lo YP, De Gussem E, Alcazar-Fuoli L, Bignell E, He Y, Chapman-Rothe N, Bultinck P, Herrebout WA, Brown R, Rzepa HS, Fuchter MJ.

Chemistry. 2011 Oct 10;17(42):11868-75. doi: 10.1002/chem.201101129. Epub 2011 Sep 5.


The effects of dsRNA mycoviruses on growth and murine virulence of Aspergillus fumigatus.

Bhatti MF, Jamal A, Petrou MA, Cairns TC, Bignell EM, Coutts RH.

Fungal Genet Biol. 2011 Nov;48(11):1071-5. doi: 10.1016/j.fgb.2011.07.008. Epub 2011 Aug 5.


Targeted disruption of nonribosomal peptide synthetase pes3 augments the virulence of Aspergillus fumigatus.

O'Hanlon KA, Cairns T, Stack D, Schrettl M, Bignell EM, Kavanagh K, Miggin SM, O'Keeffe G, Larsen TO, Doyle S.

Infect Immun. 2011 Oct;79(10):3978-92. doi: 10.1128/IAI.00192-11. Epub 2011 Jul 11.


Complete nucleotide sequences of two dsRNAs associated with a new partitivirus infecting Aspergillus fumigatus.

Bhatti MF, Bignell EM, Coutts RH.

Arch Virol. 2011 Sep;156(9):1677-80. doi: 10.1007/s00705-011-1045-5. Epub 2011 Jun 12. No abstract available.


Therapeutic jackpots lie within the reach of multiscale and integrated mycological research.

Bignell E.

Expert Rev Anti Infect Ther. 2010 Dec;8(12):1333-5. doi: 10.1586/eri.10.113.


Complete nucleotide sequences of four dsRNAs associated with a new chrysovirus infecting Aspergillus fumigatus.

Jamal A, Bignell EM, Coutts RH.

Virus Res. 2010 Oct;153(1):64-70. doi: 10.1016/j.virusres.2010.07.008. Epub 2010 Jul 17.


The host-infecting fungal transcriptome.

Cairns T, Minuzzi F, Bignell E.

FEMS Microbiol Lett. 2010 Jun;307(1):1-11. doi: 10.1111/j.1574-6968.2010.01961.x. Review.


Exploring the concordance of Aspergillus fumigatus pathogenicity in mice and Toll-deficient flies.

Chamilos G, Bignell EM, Schrettl M, Lewis RE, Leventakos K, May GS, Haas H, Kontoyiannis DP.

Med Mycol. 2010 May;48(3):506-10. doi: 10.3109/13693780903225813.


The conserved and divergent roles of carbonic anhydrases in the filamentous fungi Aspergillus fumigatus and Aspergillus nidulans.

Han KH, Chun YH, Figueiredo Bde C, Soriani FM, Savoldi M, Almeida A, Rodrigues F, Cairns CT, Bignell E, Tobal JM, Goldman MH, Kim JH, Bahn YS, Goldman GH, Ferreira ME.

Mol Microbiol. 2010 Mar;75(6):1372-88. doi: 10.1111/j.1365-2958.2010.07058.x. Epub 2010 Feb 8. Erratum in: Mol Microbiol. 2010 May;76(3):802.


Impaired interferon-gamma responses, increased interleukin-17 expression, and a tumor necrosis factor-alpha transcriptional program in invasive aspergillosis.

Armstrong-James DP, Turnbull SA, Teo I, Stark J, Rogers NJ, Rogers TR, Bignell E, Haynes K.

J Infect Dis. 2009 Oct 15;200(8):1341-51. doi: 10.1086/605931.


A regulator of Aspergillus fumigatus extracellular proteolytic activity is dispensable for virulence.

Bergmann A, Hartmann T, Cairns T, Bignell EM, Krappmann S.

Infect Immun. 2009 Sep;77(9):4041-50. doi: 10.1128/IAI.00425-09. Epub 2009 Jun 29.


Sub-telomere directed gene expression during initiation of invasive aspergillosis.

McDonagh A, Fedorova ND, Crabtree J, Yu Y, Kim S, Chen D, Loss O, Cairns T, Goldman G, Armstrong-James D, Haynes K, Haas H, Schrettl M, May G, Nierman WC, Bignell E.

PLoS Pathog. 2008 Sep 12;4(9):e1000154. doi: 10.1371/journal.ppat.1000154.


Functional characterization of the Aspergillus fumigatusPHO80 homologue.

de Gouvêa PF, Soriani FM, Malavazi I, Savoldi M, Goldman MH, Loss O, Bignell E, da Silva Ferreira ME, Goldman GH.

Fungal Genet Biol. 2008 Jul;45(7):1135-46. doi: 10.1016/j.fgb.2008.04.001. Epub 2008 Apr 8.


Ambient pH gene regulation in fungi: making connections.

Peñalva MA, Tilburn J, Bignell E, Arst HN Jr.

Trends Microbiol. 2008 Jun;16(6):291-300. doi: 10.1016/j.tim.2008.03.006. Epub 2008 May 3. Review.


Functional characterization of the Aspergillus fumigatus CRZ1 homologue, CrzA.

Soriani FM, Malavazi I, da Silva Ferreira ME, Savoldi M, Von Zeska Kress MR, de Souza Goldman MH, Loss O, Bignell E, Goldman GH.

Mol Microbiol. 2008 Mar;67(6):1274-91. doi: 10.1111/j.1365-2958.2008.06122.x. Epub 2008 Feb 20.


Basal expression of the Aspergillus fumigatus transcriptional activator CpcA is sufficient to support pulmonary aspergillosis.

Sasse C, Bignell EM, Hasenberg M, Haynes K, Gunzer M, Braus GH, Krappmann S.

Fungal Genet Biol. 2008 May;45(5):693-704. doi: 10.1016/j.fgb.2007.12.008. Epub 2008 Jan 3.


Distinct roles for intra- and extracellular siderophores during Aspergillus fumigatus infection.

Schrettl M, Bignell E, Kragl C, Sabiha Y, Loss O, Eisendle M, Wallner A, Arst HN Jr, Haynes K, Haas H.

PLoS Pathog. 2007 Sep 28;3(9):1195-207.


Candida glabrata Ste11 is involved in adaptation to hypertonic stress, maintenance of wild-type levels of filamentation and plays a role in virulence.

Calcagno AM, Bignell E, Rogers TR, Jones MD, Mühlschlegel FA, Haynes K.

Med Mycol. 2005 Jun;43(4):355-64.


Virulence comparisons of Aspergillus nidulans mutants are confounded by the inflammatory response of p47phox-/- mice.

Bignell E, Negrete-Urtasun S, Calcagno AM, Arst HN Jr, Rogers T, Haynes K.

Infect Immun. 2005 Aug;73(8):5204-7.


The Aspergillus pH-responsive transcription factor PacC regulates virulence.

Bignell E, Negrete-Urtasun S, Calcagno AM, Haynes K, Arst HN Jr, Rogers T.

Mol Microbiol. 2005 Feb;55(4):1072-84.


Siderophore biosynthesis but not reductive iron assimilation is essential for Aspergillus fumigatus virulence.

Schrettl M, Bignell E, Kragl C, Joechl C, Rogers T, Arst HN Jr, Haynes K, Haas H.

J Exp Med. 2004 Nov 1;200(9):1213-9. Epub 2004 Oct 25.

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