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Items: 9

1.

Design and synthesis of a series of bioavailable fatty acid synthase (FASN) KR domain inhibitors for cancer therapy.

Lu T, Schubert C, Cummings MD, Bignan G, Connolly PJ, Smans K, Ludovici D, Parker MH, Meyer C, Rocaboy C, Alexander R, Grasberger B, De Breucker S, Esser N, Fraiponts E, Gilissen R, Janssens B, Peeters D, Van Nuffel L, Vermeulen P, Bischoff J, Meerpoel L.

Bioorg Med Chem Lett. 2018 Jul 1;28(12):2159-2164. doi: 10.1016/j.bmcl.2018.05.014. Epub 2018 May 8.

PMID:
29779975
2.

A selective small molecule NOP (ORL-1 receptor) partial agonist for the treatment of anxiety.

Ross TM, Battista K, Bignan GC, Brenneman DE, Connolly PJ, Liu J, Middleton SA, Orsini M, Reitz AB, Rosenthal DI, Scott MK, Vaidya AH.

Bioorg Med Chem Lett. 2015 Feb 1;25(3):602-6. doi: 10.1016/j.bmcl.2014.12.015. Epub 2014 Dec 17.

PMID:
25556095
3.

3-(4-Piperidinyl)indoles and 3-(4-piperidinyl)pyrrolo-[2,3-b]pyridines as ligands for the ORL-1 receptor.

Bignan GC, Battista K, Connolly PJ, Orsini MJ, Liu J, Middleton SA, Reitz AB.

Bioorg Med Chem Lett. 2006 Jul 1;16(13):3524-8. Epub 2006 Apr 24.

PMID:
16632355
4.

Preparation of 3-spirocyclic indolin-2-ones as ligands for the ORL-1 receptor.

Bignan GC, Battista K, Connolly PJ, Orsini MJ, Liu J, Middleton SA, Reitz AB.

Bioorg Med Chem Lett. 2005 Nov 15;15(22):5022-6.

PMID:
16153834
5.

A vascular endothelial growth factor receptor-2 kinase inhibitor potentiates the activity of the conventional chemotherapeutic agents paclitaxel and doxorubicin in tumor xenograft models.

Emanuel S, Gruninger RH, Fuentes-Pesquera A, Connolly PJ, Seamon JA, Hazel S, Tominovich R, Hollister B, Napier C, D'Andrea MR, Reuman M, Bignan G, Tuman R, Johnson D, Moffatt D, Batchelor M, Foley A, O'Connell J, Allen R, Perry M, Jolliffe L, Middleton SA.

Mol Pharmacol. 2004 Sep;66(3):635-47.

PMID:
15322256
6.

Synthesis of an Epimer of a 16-Membered Ring Model for Teicoplanin: Confirmation of Epimerization during Cycloamidation.

Pearson AJ, Zhang P, Bignan G.

J Org Chem. 1997 Jun 27;62(13):4536-4538. No abstract available.

PMID:
11671792
7.

Cycloetherification Reactions of Areneruthenium Complexes: Construction of a 16-Membered Cyclic Peptide Model for Teicoplanin.

Pearson AJ, Bignan G, Zhang P, Chelliah M.

J Org Chem. 1996 Jun 14;61(12):3940-3941. No abstract available.

PMID:
11667263
8.

Biological studies of analogues of glucose iodinated in positions 1, 2, or 3.

Koumanov F, Henry C, Ghezzi C, Bignan G, Morin C, Mathieu JP, Hamant S, Vidal M, de Leiris J, Comet M.

Nucl Med Biol. 1996 Jan;23(1):53-60.

PMID:
9004915
9.

Synthesis of 3-O-(iodoethyl)-D-glucose, a stable iodo derivative of D-glucose for medical imaging.

Bignan G, Morin C, Vidal M.

Carbohydr Res. 1993 Oct 4;248:371-5. No abstract available.

PMID:
8252545

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