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Items: 34

1.

DNA Methylation Changes Are Associated With an Incremental Ascent to High Altitude.

Childebayeva A, Harman T, Weinstein J, Goodrich JM, Dolinoy DC, Day TA, Bigham AW, Brutsaert TD.

Front Genet. 2019 Oct 29;10:1062. doi: 10.3389/fgene.2019.01062. eCollection 2019.

2.

Association of EGLN1 gene with high aerobic capacity of Peruvian Quechua at high altitude.

Brutsaert TD, Kiyamu M, Elias Revollendo G, Isherwood JL, Lee FS, Rivera-Ch M, Leon-Velarde F, Ghosh S, Bigham AW.

Proc Natl Acad Sci U S A. 2019 Nov 26;116(48):24006-24011. doi: 10.1073/pnas.1906171116. Epub 2019 Nov 11.

PMID:
31712437
3.

LINE-1 and EPAS1 DNA methylation associations with high-altitude exposure.

Childebayeva A, Jones TR, Goodrich JM, Leon-Velarde F, Rivera-Chira M, Kiyamu M, Brutsaert TD, Dolinoy DC, Bigham AW.

Epigenetics. 2019 Jan;14(1):1-15. doi: 10.1080/15592294.2018.1561117. Epub 2019 Jan 9.

4.

Complex signatures of natural selection at GYPA.

Bigham AW, Magnaye K, Dunn DM, Weiss RB, Bamshad M.

Hum Genet. 2018 Feb;137(2):151-160. doi: 10.1007/s00439-018-1866-3. Epub 2018 Jan 23.

5.

The Genetic Anthropologist's Contribution to Understanding Race and Racial Health Disparities.

Bigham AW, Non A.

Hum Biol. 2015 Oct;87(4):291-293. No abstract available.

PMID:
27737593
6.

Genetics of human origin and evolution: high-altitude adaptations.

Bigham AW.

Curr Opin Genet Dev. 2016 Dec;41:8-13. doi: 10.1016/j.gde.2016.06.018. Epub 2016 Aug 6. Review.

7.

Toll-like receptor gene variants and bacterial vaginosis among HIV-1 infected and uninfected African women.

Mackelprang RD, Scoville CW, Cohen CR, Ondondo RO, Bigham AW, Celum C, Campbell MS, Essex M, Wald A, Kiarie J, Ronald A, Gray G, Lingappa JR; Partners in Prevention HSV/HIV Transmission Study Team.

Genes Immun. 2015 Jul-Aug;16(5):362-365. doi: 10.1038/gene.2015.13. Epub 2015 Apr 30.

8.

Estimates of continental ancestry vary widely among individuals with the same mtDNA haplogroup.

Emery LS, Magnaye KM, Bigham AW, Akey JM, Bamshad MJ.

Am J Hum Genet. 2015 Feb 5;96(2):183-93. doi: 10.1016/j.ajhg.2014.12.015. Epub 2015 Jan 22.

9.

Human high-altitude adaptation: forward genetics meets the HIF pathway.

Bigham AW, Lee FS.

Genes Dev. 2014 Oct 15;28(20):2189-204. doi: 10.1101/gad.250167.114. Review.

10.

Maternal PRKAA1 and EDNRA genotypes are associated with birth weight, and PRKAA1 with uterine artery diameter and metabolic homeostasis at high altitude.

Bigham AW, Julian CG, Wilson MJ, Vargas E, Browne VA, Shriver MD, Moore LG.

Physiol Genomics. 2014 Sep 15;46(18):687-97. doi: 10.1152/physiolgenomics.00063.2014. Epub 2014 Jul 15.

11.

Defective Tibetan PHD2 binding to p23 links high altitude adaption to altered oxygen sensing.

Song D, Li LS, Arsenault PR, Tan Q, Bigham AW, Heaton-Johnson KJ, Master SR, Lee FS.

J Biol Chem. 2014 May 23;289(21):14656-65. doi: 10.1074/jbc.M113.541227. Epub 2014 Apr 7.

12.

Variants in host viral replication cycle genes are associated with heterosexual HIV-1 acquisition in Africans.

Bigham AW, Mackelprang RD, Celum C, De Bruyn G, Beima-Sofie K, John-Stewart G, Ronald A, Mugo NR, Buckingham K, Bamshad MJ, Mullins JI, McElrath MJ, Lingappa JR.

J Acquir Immune Defic Syndr. 2014 Jun 1;66(2):127-34. doi: 10.1097/QAI.0000000000000113.

13.

Toll-like receptor polymorphism associations with HIV-1 outcomes among sub-Saharan Africans.

Mackelprang RD, Bigham AW, Celum C, de Bruyn G, Beima-Sofie K, John-Stewart G, Ronald A, Mugo NR, Buckingham KJ, Bamshad MJ, Mullins JI, McElrath MJ, Lingappa JR.

J Infect Dis. 2014 May 15;209(10):1623-7. doi: 10.1093/infdis/jit807. Epub 2013 Dec 10.

14.

Toll-like receptor variants are associated with infant HIV-1 acquisition and peak plasma HIV-1 RNA level.

Beima-Sofie KM, Bigham AW, Lingappa JR, Wamalwa D, Mackelprang RD, Bamshad MJ, Maleche-Obimbo E, Richardson BA, John-Stewart GC.

AIDS. 2013 Sep 24;27(15):2431-9. doi: 10.1097/QAD.0b013e3283629117.

15.

Andean and Tibetan patterns of adaptation to high altitude.

Bigham AW, Wilson MJ, Julian CG, Kiyamu M, Vargas E, Leon-Velarde F, Rivera-Chira M, Rodriquez C, Browne VA, Parra E, Brutsaert TD, Moore LG, Shriver MD.

Am J Hum Biol. 2013 Mar-Apr;25(2):190-7. doi: 10.1002/ajhb.22358. Epub 2013 Jan 24.

16.

Evolution and functional impact of rare coding variation from deep sequencing of human exomes.

Tennessen JA, Bigham AW, O'Connor TD, Fu W, Kenny EE, Gravel S, McGee S, Do R, Liu X, Jun G, Kang HM, Jordan D, Leal SM, Gabriel S, Rieder MJ, Abecasis G, Altshuler D, Nickerson DA, Boerwinkle E, Sunyaev S, Bustamante CD, Bamshad MJ, Akey JM; Broad GO; Seattle GO; NHLBI Exome Sequencing Project.

Science. 2012 Jul 6;337(6090):64-9. doi: 10.1126/science.1219240. Epub 2012 May 17.

17.

OPRM1 and EGFR contribute to skin pigmentation differences between Indigenous Americans and Europeans.

Quillen EE, Bauchet M, Bigham AW, Delgado-Burbano ME, Faust FX, Klimentidis YC, Mao X, Stoneking M, Shriver MD.

Hum Genet. 2012 Jul;131(7):1073-80. doi: 10.1007/s00439-011-1135-1. Epub 2011 Dec 24.

PMID:
22198722
18.

Potential role for elevated maternal enzymatic antioxidant status in Andean protection against altitude-associated SGA.

Julian CG, Vargas E, Browne VA, Wilson MJ, Bigham AW, Rodriguez C, McCord JM, Moore LG.

J Matern Fetal Neonatal Med. 2012 Aug;25(8):1233-40. doi: 10.3109/14767058.2011.636102. Epub 2011 Nov 30.

PMID:
22082238
19.

Exome sequencing as a tool for Mendelian disease gene discovery.

Bamshad MJ, Ng SB, Bigham AW, Tabor HK, Emond MJ, Nickerson DA, Shendure J.

Nat Rev Genet. 2011 Sep 27;12(11):745-55. doi: 10.1038/nrg3031. Review.

PMID:
21946919
20.

Host genetic risk factors for West Nile virus infection and disease progression.

Bigham AW, Buckingham KJ, Husain S, Emond MJ, Bofferding KM, Gildersleeve H, Rutherford A, Astakhova NM, Perelygin AA, Busch MP, Murray KO, Sejvar JJ, Green S, Kriesel J, Brinton MA, Bamshad M.

PLoS One. 2011;6(9):e24745. doi: 10.1371/journal.pone.0024745. Epub 2011 Sep 15.

21.

Spectrum of MLL2 (ALR) mutations in 110 cases of Kabuki syndrome.

Hannibal MC, Buckingham KJ, Ng SB, Ming JE, Beck AE, McMillin MJ, Gildersleeve HI, Bigham AW, Tabor HK, Mefford HC, Cook J, Yoshiura K, Matsumoto T, Matsumoto N, Miyake N, Tonoki H, Naritomi K, Kaname T, Nagai T, Ohashi H, Kurosawa K, Hou JW, Ohta T, Liang D, Sudo A, Morris CA, Banka S, Black GC, Clayton-Smith J, Nickerson DA, Zackai EH, Shaikh TH, Donnai D, Niikawa N, Shendure J, Bamshad MJ.

Am J Med Genet A. 2011 Jul;155A(7):1511-6. doi: 10.1002/ajmg.a.34074. Epub 2011 Jun 10.

22.

High-end arteriolar resistance limits uterine artery blood flow and restricts fetal growth in preeclampsia and gestational hypertension at high altitude.

Browne VA, Toledo-Jaldin L, Davila RD, Lopez LP, Yamashiro H, Cioffi-Ragan D, Julian CG, Wilson MJ, Bigham AW, Shriver MD, Honigman B, Vargas E, Roach R, Moore LG.

Am J Physiol Regul Integr Comp Physiol. 2011 May;300(5):R1221-9. doi: 10.1152/ajpregu.91046.2008. Epub 2011 Feb 16.

23.

Identity-by-descent filtering of exome sequence data for disease-gene identification in autosomal recessive disorders.

Rödelsperger C, Krawitz P, Bauer S, Hecht J, Bigham AW, Bamshad M, de Condor BJ, Schweiger MR, Robinson PN.

Bioinformatics. 2011 Mar 15;27(6):829-36. doi: 10.1093/bioinformatics/btr022. Epub 2011 Jan 28.

24.

Do cytokines contribute to the Andean-associated protection from reduced fetal growth at high altitude?

Dávila RD, Julian CG, Wilson MJ, Browne VA, Rodriguez C, Bigham AW, Shriver MD, Vargas E, Moore LG.

Reprod Sci. 2011 Jan;18(1):79-87. doi: 10.1177/1933719110380061. Epub 2010 Sep 14.

25.

Exome sequencing identifies MLL2 mutations as a cause of Kabuki syndrome.

Ng SB, Bigham AW, Buckingham KJ, Hannibal MC, McMillin MJ, Gildersleeve HI, Beck AE, Tabor HK, Cooper GM, Mefford HC, Lee C, Turner EH, Smith JD, Rieder MJ, Yoshiura K, Matsumoto N, Ohta T, Niikawa N, Nickerson DA, Bamshad MJ, Shendure J.

Nat Genet. 2010 Sep;42(9):790-3. doi: 10.1038/ng.646. Epub 2010 Aug 15.

26.

Do anti-angiogenic or angiogenic factors contribute to the protection of birth weight at high altitude afforded by Andean ancestry?

Dávila RD, Julian CG, Wilson MJ, Browne VA, Rodriguez C, Bigham AW, Shriver MD, Vargas E, Moore LG.

Reprod Sci. 2010 Sep;17(9):861-70. doi: 10.1177/1933719110372418. Epub 2010 Jul 2.

27.

Worldwide allele frequency distribution of four polymorphisms associated with warfarin dose requirements.

Ross KA, Bigham AW, Edwards M, Gozdzik A, Suarez-Kurtz G, Parra EJ.

J Hum Genet. 2010 Sep;55(9):582-9. doi: 10.1038/jhg.2010.73. Epub 2010 Jun 17.

PMID:
20555338
28.

Identifying positive selection candidate loci for high-altitude adaptation in Andean populations.

Bigham AW, Mao X, Mei R, Brutsaert T, Wilson MJ, Julian CG, Parra EJ, Akey JM, Moore LG, Shriver MD.

Hum Genomics. 2009 Dec;4(2):79-90.

29.

Exome sequencing identifies the cause of a mendelian disorder.

Ng SB, Buckingham KJ, Lee C, Bigham AW, Tabor HK, Dent KM, Huff CD, Shannon PT, Jabs EW, Nickerson DA, Shendure J, Bamshad MJ.

Nat Genet. 2010 Jan;42(1):30-5. doi: 10.1038/ng.499. Epub 2009 Nov 13.

30.

Targeted capture and massively parallel sequencing of 12 human exomes.

Ng SB, Turner EH, Robertson PD, Flygare SD, Bigham AW, Lee C, Shaffer T, Wong M, Bhattacharjee A, Eichler EE, Bamshad M, Nickerson DA, Shendure J.

Nature. 2009 Sep 10;461(7261):272-6. doi: 10.1038/nature08250. Epub 2009 Aug 16.

31.

Uncoupling protein 2 Ala55Val polymorphism is associated with a higher acute insulin response to glucose.

Willig AL, Casazza KR, Divers J, Bigham AW, Gower BA, Hunter GR, Fernandez JR.

Metabolism. 2009 Jun;58(6):877-81. doi: 10.1016/j.metabol.2009.02.016.

32.

Augmented uterine artery blood flow and oxygen delivery protect Andeans from altitude-associated reductions in fetal growth.

Julian CG, Wilson MJ, Lopez M, Yamashiro H, Tellez W, Rodriguez A, Bigham AW, Shriver MD, Rodriguez C, Vargas E, Moore LG.

Am J Physiol Regul Integr Comp Physiol. 2009 May;296(5):R1564-75. doi: 10.1152/ajpregu.90945.2008. Epub 2009 Feb 25.

33.

Angiotensin-converting enzyme genotype and arterial oxygen saturation at high altitude in Peruvian Quechua.

Bigham AW, Kiyamu M, León-Velarde F, Parra EJ, Rivera-Ch M, Shriver MD, Brutsaert TD.

High Alt Med Biol. 2008 Summer;9(2):167-78. doi: 10.1089/ham.2007.1066.

34.

A genomewide admixture mapping panel for Hispanic/Latino populations.

Mao X, Bigham AW, Mei R, Gutierrez G, Weiss KM, Brutsaert TD, Leon-Velarde F, Moore LG, Vargas E, McKeigue PM, Shriver MD, Parra EJ.

Am J Hum Genet. 2007 Jun;80(6):1171-8. Epub 2007 Apr 20.

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