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Items: 26


Precision medicine screening using whole-genome sequencing and advanced imaging to identify disease risk in adults.

Perkins BA, Caskey CT, Brar P, Dec E, Karow DS, Kahn AM, Hou YC, Shah N, Boeldt D, Coughlin E, Hands G, Lavrenko V, Yu J, Procko A, Appis J, Dale AM, Guo L, Jönsson TJ, Wittmann BM, Bartha I, Ramakrishnan S, Bernal A, Brewer JB, Brewerton S, Biggs WH, Turpaz Y, Venter JC.

Proc Natl Acad Sci U S A. 2018 Apr 3;115(14):3686-3691. doi: 10.1073/pnas.1706096114. Epub 2018 Mar 19.


The human noncoding genome defined by genetic diversity.

di Iulio J, Bartha I, Wong EHM, Yu HC, Lavrenko V, Yang D, Jung I, Hicks MA, Shah N, Kirkness EF, Fabani MM, Biggs WH, Ren B, Venter JC, Telenti A.

Nat Genet. 2018 Mar;50(3):333-337. doi: 10.1038/s41588-018-0062-7. Epub 2018 Feb 26.


Profiling of Short-Tandem-Repeat Disease Alleles in 12,632 Human Whole Genomes.

Tang H, Kirkness EF, Lippert C, Biggs WH, Fabani M, Guzman E, Ramakrishnan S, Lavrenko V, Kakaradov B, Hou C, Hicks B, Heckerman D, Och FJ, Caskey CT, Venter JC, Telenti A.

Am J Hum Genet. 2017 Nov 2;101(5):700-715. doi: 10.1016/j.ajhg.2017.09.013.


Fast and accurate HLA typing from short-read next-generation sequence data with xHLA.

Xie C, Yeo ZX, Wong M, Piper J, Long T, Kirkness EF, Biggs WH, Bloom K, Spellman S, Vierra-Green C, Brady C, Scheuermann RH, Telenti A, Howard S, Brewerton S, Turpaz Y, Venter JC.

Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):8059-8064. doi: 10.1073/pnas.1707945114. Epub 2017 Jul 3.


Whole-genome sequencing identifies common-to-rare variants associated with human blood metabolites.

Long T, Hicks M, Yu HC, Biggs WH, Kirkness EF, Menni C, Zierer J, Small KS, Mangino M, Messier H, Brewerton S, Turpaz Y, Perkins BA, Evans AM, Miller LA, Guo L, Caskey CT, Schork NJ, Garner C, Spector TD, Venter JC, Telenti A.

Nat Genet. 2017 Apr;49(4):568-578. doi: 10.1038/ng.3809. Epub 2017 Mar 6.


Deep sequencing of 10,000 human genomes.

Telenti A, Pierce LC, Biggs WH, di Iulio J, Wong EH, Fabani MM, Kirkness EF, Moustafa A, Shah N, Xie C, Brewerton SC, Bulsara N, Garner C, Metzker G, Sandoval E, Perkins BA, Och FJ, Turpaz Y, Venter JC.

Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):11901-11906. Epub 2016 Oct 4.


Analytical performance validation of a coronary heart disease risk assessment multi-analyte proteomic test.

Nolan N, Tee L, Vijayakumar S, Burazor I, Hytopoulos E, Biggs WH 3rd, Beggs M, French C, Harrington DS.

Expert Opin Med Diagn. 2013 Mar;7(2):127-36. doi: 10.1517/17530059.2013.753055. Epub 2012 Dec 11.


Company profile: Aviir, Inc.

Beggs M, Biggs WH 3rd, French C.

Pharmacogenomics. 2013 Feb;14(3):245-8. doi: 10.2217/pgs.13.4.


Tuning a three-component reaction for trapping kinase substrate complexes.

Statsuk AV, Maly DJ, Seeliger MA, Fabian MA, Biggs WH 3rd, Lockhart DJ, Zarrinkar PP, Kuriyan J, Shokat KM.

J Am Chem Soc. 2008 Dec 24;130(51):17568-74. doi: 10.1021/ja807066f.


Structure of the kinase domain of an imatinib-resistant Abl mutant in complex with the Aurora kinase inhibitor VX-680.

Young MA, Shah NP, Chao LH, Seeliger M, Milanov ZV, Biggs WH 3rd, Treiber DK, Patel HK, Zarrinkar PP, Lockhart DJ, Sawyers CL, Kuriyan J.

Cancer Res. 2006 Jan 15;66(2):1007-14.


Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases.

Carter TA, Wodicka LM, Shah NP, Velasco AM, Fabian MA, Treiber DK, Milanov ZV, Atteridge CE, Biggs WH 3rd, Edeen PT, Floyd M, Ford JM, Grotzfeld RM, Herrgard S, Insko DE, Mehta SA, Patel HK, Pao W, Sawyers CL, Varmus H, Zarrinkar PP, Lockhart DJ.

Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):11011-6. Epub 2005 Jul 26.


A small molecule-kinase interaction map for clinical kinase inhibitors.

Fabian MA, Biggs WH 3rd, Treiber DK, Atteridge CE, Azimioara MD, Benedetti MG, Carter TA, Ciceri P, Edeen PT, Floyd M, Ford JM, Galvin M, Gerlach JL, Grotzfeld RM, Herrgard S, Insko DE, Insko MA, Lai AG, Lélias JM, Mehta SA, Milanov ZV, Velasco AM, Wodicka LM, Patel HK, Zarrinkar PP, Lockhart DJ.

Nat Biotechnol. 2005 Mar;23(3):329-36. Epub 2005 Feb 13.


Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification.

Hosaka T, Biggs WH 3rd, Tieu D, Boyer AD, Varki NM, Cavenee WK, Arden KC.

Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):2975-80. Epub 2004 Feb 20.


Identification and characterization of mouse SSX genes: a multigene family on the X chromosome with restricted cancer/testis expression.

Chen YT, Alpen B, Ono T, Gure AO, Scanlan MA, Biggs WH 3rd, Arden K, Nakayama E, Old LJ.

Genomics. 2003 Dec;82(6):628-36.


The forkhead transcription factor Foxo1 regulates adipocyte differentiation.

Nakae J, Kitamura T, Kitamura Y, Biggs WH 3rd, Arden KC, Accili D.

Dev Cell. 2003 Jan;4(1):119-29.


The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth.

Kitamura T, Nakae J, Kitamura Y, Kido Y, Biggs WH 3rd, Wright CV, White MF, Arden KC, Accili D.

J Clin Invest. 2002 Dec;110(12):1839-47.


Regulation of insulin action and pancreatic beta-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1.

Nakae J, Biggs WH 3rd, Kitamura T, Cavenee WK, Wright CV, Arden KC, Accili D.

Nat Genet. 2002 Oct;32(2):245-53. Epub 2002 Sep 3.


Regulation of the FoxO family of transcription factors by phosphatidylinositol-3 kinase-activated signaling.

Arden KC, Biggs WH 3rd.

Arch Biochem Biophys. 2002 Jul 15;403(2):292-8. Review. No abstract available.


Analysis of the regulation of the A33 antigen gene reveals intestine-specific mechanisms of gene expression.

Johnstone CN, White SJ, Tebbutt NC, Clay FJ, Ernst M, Biggs WH, Viars CS, Czekay S, Arden KC, Heath JK.

J Biol Chem. 2002 Sep 13;277(37):34531-9. Epub 2002 Jul 11.


Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1.

Biggs WH 3rd, Meisenhelder J, Hunter T, Cavenee WK, Arden KC.

Proc Natl Acad Sci U S A. 1999 Jun 22;96(13):7421-6.


The Drosophila rolled locus encodes a MAP kinase required in the sevenless signal transduction pathway.

Biggs WH 3rd, Zavitz KH, Dickson B, van der Straten A, Brunner D, Hafen E, Zipursky SL.

EMBO J. 1994 Apr 1;13(7):1628-35.


A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways.

Brunner D, Oellers N, Szabad J, Biggs WH 3rd, Zipursky SL, Hafen E.

Cell. 1994 Mar 11;76(5):875-88.


Primary structure, expression, and signal-dependent tyrosine phosphorylation of a Drosophila homolog of extracellular signal-regulated kinase.

Biggs WH 3rd, Zipursky SL.

Proc Natl Acad Sci U S A. 1992 Jul 15;89(14):6295-9. Erratum in: Proc Natl Acad Sci U S A 1993 Jul 1;90(13):6377.


Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB.

Yamamoto KK, Gonzalez GA, Biggs WH 3rd, Montminy MR.

Nature. 1988 Aug 11;334(6182):494-8.


Effects of penicillinase on bactericidal and complement activities in normal human serum.

Biggs WH 3rd, Wunderlich AC, Corbeil LC, Davis CE, Curd JG.

Antimicrob Agents Chemother. 1983 May;23(5):738-41.

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