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Systemic silencing of PHD2 causes reversible immune regulatory dysfunction.

Yamamoto A, Hester J, Macklin PS, Kawai K, Uchiyama M, Biggs D, Bishop T, Bull K, Cheng X, Cawthorne E, Coleman ML, Crockford TL, Davies B, Dow LE, Goldin R, Kranc K, Kudo H, Lawson H, McAuliffe J, Milward K, Scudamore CL, Soilleux E, Issa F, Ratcliffe PJ, Pugh CW.

J Clin Invest. 2019 Jun 4;130. pii: 124099. doi: 10.1172/JCI124099.


How should we treat patients who wake up with a stroke? A review of recent advances in management of acute ischemic stroke.

Biggs D, Silverman ME, Chen F, Walsh B, Wynne P.

Am J Emerg Med. 2019 May;37(5):954-959. doi: 10.1016/j.ajem.2019.02.010. Epub 2019 Feb 21. Review.


Protect Catalonia's corals despite politics.

Arafeh-Dalmau N, Linares C, Hereu B, Caceres-Escobar H, Biggs D, Possingham H.

Science. 2019 Jan 11;363(6423):135-136. doi: 10.1126/science.aav8710. No abstract available.


China's reopened rhino horn trade.

Cheung H, Wang Y, Biggs D.

Science. 2018 Dec 21;362(6421):1369. doi: 10.1126/science.aav9392. Epub 2018 Dec 20. No abstract available.


Succinylcholine Use and Dantrolene Availability for Malignant Hyperthermia Treatment: Database Analyses and Systematic Review.

Larach MG, Klumpner TT, Brandom BW, Vaughn MT, Belani KG, Herlich A, Kim TW, Limoncelli J, Riazi S, Sivak EL, Capacchione J, Mashman D, Kheterpal S, Kooij F, Wilczak J, Soto R, Berris J, Price Z, Lins S, Coles P, Harris JM, Cummings KC 3rd, Berman MF, Nanamori M, Adelman BT, Wedeven C, LaGorio J, McCormick PJ, Tom S, Aziz MF, Coffman T, Ellis TA 2nd, Molina S, Peterson W, Mackey SC, van Klei WA, Ginde AA, Biggs DA, Neuman MD, Craft RM, Pace NL, Paganelli WC, Durieux ME, Nair BJ, Wanderer JP, Miller SA, Helsten DL, Turnbull ZA, Schonberger RB; Multicenter Perioperative Outcomes Group.

Anesthesiology. 2019 Jan;130(1):41-54. doi: 10.1097/ALN.0000000000002490.


An observational study of end-tidal carbon dioxide trends in general anesthesia.

Akkermans A, van Waes JAR, Thompson A, Shanks A, Peelen LM, Aziz MF, Biggs DA, Paganelli WC, Wanderer JP, Helsten DL, Kheterpal S, van Klei WA, Saager L.

Can J Anaesth. 2019 Feb;66(2):149-160. doi: 10.1007/s12630-018-1249-1. Epub 2018 Nov 14.


Age and the Risk of Paclitaxel-Induced Neuropathy in Women with Early-Stage Breast Cancer (Alliance A151411): Results from 1,881 Patients from Cancer and Leukemia Group B (CALGB) 40101.

Barginear M, Dueck AC, Allred JB, Bunnell C, Cohen HJ, Freedman RA, Hurria A, Kimmick G, Le-Rademacher JG, Lichtman S, Muss HB, Shulman LN, Copur MS, Biggs D, Ramaswamy B, Lafky JM, Jatoi A.

Oncologist. 2019 May;24(5):617-623. doi: 10.1634/theoncologist.2018-0298. Epub 2018 Nov 8.


First evidence of association between past environmental exposure to dioxin and DNA methylation of CYP1A1 and IGF2 genes in present day Vietnamese population.

Giuliani C, Biggs D, Nguyen TT, Marasco E, De Fanti S, Garagnani P, Le Phan MT, Nguyen VN, Luiselli D, Romeo G.

Environ Pollut. 2018 Nov;242(Pt A):976-985. doi: 10.1016/j.envpol.2018.07.015. Epub 2018 Jul 17.


Single-copy expression of an amyotrophic lateral sclerosis-linked TDP-43 mutation (M337V) in BAC transgenic mice leads to altered stress granule dynamics and progressive motor dysfunction.

Gordon D, Dafinca R, Scaber J, Alegre-Abarrategui J, Farrimond L, Scott C, Biggs D, Kent L, Oliver PL, Davies B, Ansorge O, Wade-Martins R, Talbot K.

Neurobiol Dis. 2019 Jan;121:148-162. doi: 10.1016/j.nbd.2018.09.024. Epub 2018 Oct 2.


Inequality in access to cultural ecosystem services from protected areas in the Chilean biodiversity hotspot.

Martinez-Harms MJ, Bryan BA, Wood SA, Fisher DM, Law E, Rhodes JR, Dobbs C, Biggs D, Wilson KA.

Sci Total Environ. 2018 Sep 15;636:1128-1138. doi: 10.1016/j.scitotenv.2018.04.353. Epub 2018 May 3.


Phase II study of carboplatin, pemetrexed, and bevacizumab in advanced nonsquamous non-small-cell lung cancer.

Laslett NF, Park S, Masters GA, Biggs DD, Schneider CJ, Misleh JG, Suppiah K, Simpson PS, Grubbs S, Wozniak TF, Guarino M.

Cancer Med. 2018 Jun 14. doi: 10.1002/cam4.1569. [Epub ahead of print]


Response-Ivory crisis.

Biggs D, Smith RJ, Adams VM, Brink H, Cook CN, Cooney R, Holden MH, Maron M, Phelps J, Possingham HP, Redford KH, Scholes RJ, Sutherland WJ, Underwood FM, Milner-Gulland EJ.

Science. 2018 Apr 20;360(6386):277-278. doi: 10.1126/science.aat1596. Epub 2018 Apr 19. No abstract available.


Reach and messages of the world's largest ivory burn.

Braczkowski A, Holden MH, O'Bryan C, Choi CY, Gan X, Beesley N, Gao Y, Allan J, Tyrrell P, Stiles D, Brehony P, Meney R, Brink H, Takashina N, Lin MC, Lin HY, Rust N, Salmo SG 3rd, Watson JEM, Kahumbu P, Maron M, Possingham HP, Biggs D.

Conserv Biol. 2018 Aug;32(4):765-773. doi: 10.1111/cobi.13097. Epub 2018 Jun 20.


Breaking the deadlock on ivory.

Biggs D, Holden MH, Braczkowski A, Cook CN, Milner-Gulland EJ, Phelps J, Scholes RJ, Smith RJ, Underwood FM, Adams VM, Allan J, Brink H, Cooney R, Gao Y, Hutton J, Macdonald-Madden E, Maron M, Redford KH, Sutherland WJ, Possingham HP.

Science. 2017 Dec 15;358(6369):1378-1381. doi: 10.1126/science.aan5215. No abstract available.


Multiple Myeloma Presenting as Acute Renal Failure in the Absence of Other Characteristic Features.

Gastelum ZN, Biggs DM, Scott A.

Cureus. 2017 Sep 20;9(9):e1703. doi: 10.7759/cureus.1703.


Long-Term Follow-Up of Cardiac Function and Quality of Life for Patients in NSABP Protocol B-31/NRG Oncology: A Randomized Trial Comparing the Safety and Efficacy of Doxorubicin and Cyclophosphamide (AC) Followed by Paclitaxel With AC Followed by Paclitaxel and Trastuzumab in Patients With Node-Positive Breast Cancer With Tumors Overexpressing Human Epidermal Growth Factor Receptor 2.

Ganz PA, Romond EH, Cecchini RS, Rastogi P, Geyer CE Jr, Swain SM, Jeong JH, Fehrenbacher L, Gross HM, Brufsky AM, Flynn PJ, Wahl TA, Seay TE, Wade JL 3rd, Biggs DD, Atkins JN, Polikoff J, Zapas JL, Mamounas EP, Wolmark N.

J Clin Oncol. 2017 Dec 10;35(35):3942-3948. doi: 10.1200/JCO.2017.74.1165. Epub 2017 Oct 26.


A point mutation in the ion conduction pore of AMPA receptor GRIA3 causes dramatically perturbed sleep patterns as well as intellectual disability.

Davies B, Brown LA, Cais O, Watson J, Clayton AJ, Chang VT, Biggs D, Preece C, Hernandez-Pliego P, Krohn J, Bhomra A, Twigg SRF, Rimmer A, Kanapin A; WGS500 Consortium, Sen A, Zaiwalla Z, McVean G, Foster R, Donnelly P, Taylor JC, Blair E, Nutt D, Aricescu AR, Greger IH, Peirson SN, Flint J, Martin HC.

Hum Mol Genet. 2017 Oct 15;26(20):3869-3882. doi: 10.1093/hmg/ddx270.


Retinal amyloid pathology and proof-of-concept imaging trial in Alzheimer's disease.

Koronyo Y, Biggs D, Barron E, Boyer DS, Pearlman JA, Au WJ, Kile SJ, Blanco A, Fuchs DT, Ashfaq A, Frautschy S, Cole GM, Miller CA, Hinton DR, Verdooner SR, Black KL, Koronyo-Hamaoui M.

JCI Insight. 2017 Aug 17;2(16). pii: 93621. doi: 10.1172/jci.insight.93621. eCollection 2017 Aug 17.


Tissue-specific CTCF-cohesin-mediated chromatin architecture delimits enhancer interactions and function in vivo.

Hanssen LLP, Kassouf MT, Oudelaar AM, Biggs D, Preece C, Downes DJ, Gosden M, Sharpe JA, Sloane-Stanley JA, Hughes JR, Davies B, Higgs DR.

Nat Cell Biol. 2017 Aug;19(8):952-961. doi: 10.1038/ncb3573. Epub 2017 Jul 24.


Application of an advanced maximum likelihood estimation restoration method for enhanced-resolution and contrast in second-harmonic generation microscopy.

Sivaguru M, Kabir MM, Gartia MR, Biggs DSC, Sivaguru BS, Sivaguru VA, Fried GA, Liu GL, Sadayappan S, Toussaint KC Jr.

J Microsc. 2017 Sep;267(3):397-408. doi: 10.1111/jmi.12579. Epub 2017 Jun 8.


Hydroceles-Not Just For Men.

Biggs D, Patwa A, Gohsler S.

J Emerg Med. 2017 Sep;53(3):388-390. doi: 10.1016/j.jemermed.2017.03.023. Epub 2017 Apr 14.


After Chile's fires, reforest private land.

Martinez-Harms MJ, Caceres H, Biggs D, Possingham HP.

Science. 2017 Apr 14;356(6334):147-148. doi: 10.1126/science.aan0701. No abstract available.


Ivory ban: Close Hong Kong's ivory-trade window.

Cheung H, Wong RW, Biggs D.

Nature. 2017 Apr 5;544(7648):35. doi: 10.1038/544035b. No abstract available.


Feasibility Assessment of Patient Reporting of Symptomatic Adverse Events in Multicenter Cancer Clinical Trials.

Basch E, Dueck AC, Rogak LJ, Minasian LM, Kelly WK, O'Mara AM, Denicoff AM, Seisler D, Atherton PJ, Paskett E, Carey L, Dickler M, Heist RS, Himelstein A, Rugo HS, Sikov WM, Socinski MA, Venook AP, Weckstein DJ, Lake DE, Biggs DD, Freedman RA, Kuzma C, Kirshner JJ, Schrag D.

JAMA Oncol. 2017 Aug 1;3(8):1043-1050. doi: 10.1001/jamaoncol.2016.6749.


Maternal Supply of Cas9 to Zygotes Facilitates the Efficient Generation of Site-Specific Mutant Mouse Models.

Cebrian-Serrano A, Zha S, Hanssen L, Biggs D, Preece C, Davies B.

PLoS One. 2017 Jan 12;12(1):e0169887. doi: 10.1371/journal.pone.0169887. eCollection 2017.


Mapping optical path length and image enhancement using quantitative orientation-independent differential interference contrast microscopy.

Shribak M, Larkin KG, Biggs D.

J Biomed Opt. 2017 Jan 1;22(1):16006. doi: 10.1117/1.JBO.22.1.016006.


Trump: time to seize environmental gains.

Biggs D.

Nature. 2016 Dec 14;540(7633):341. doi: 10.1038/540341c. No abstract available.


MEF2 transcription factors are key regulators of sprouting angiogenesis.

Sacilotto N, Chouliaras KM, Nikitenko LL, Lu YW, Fritzsche M, Wallace MD, Nornes S, García-Moreno F, Payne S, Bridges E, Liu K, Biggs D, Ratnayaka I, Herbert SP, Molnár Z, Harris AL, Davies B, Bond GL, Bou-Gharios G, Schwarz JJ, De Val S.

Genes Dev. 2016 Oct 15;30(20):2297-2309.


An essential cell-autonomous role for hepcidin in cardiac iron homeostasis.

Lakhal-Littleton S, Wolna M, Chung YJ, Christian HC, Heather LC, Brescia M, Ball V, Diaz R, Santos A, Biggs D, Clarke K, Davies B, Robbins PA.

Elife. 2016 Nov 29;5. pii: e19804. doi: 10.7554/eLife.19804.


Passport power: Entrenching inequality.

Wilson JW, Biggs D.

Science. 2016 Sep 16;353(6305):1216. doi: 10.1126/science.aajl1604. No abstract available.


Exploring Electronic Brachytherapy and the INTRABEAM.

Biggs D.

Radiol Technol. 2016 Sep;88(1):99-106. Review. No abstract available.


Effects of acute androstenedione supplementation on testosterone levels in older men.

Judge LW, Bellar DM, Hoover DL, Biggs D, Leitzelar BN, Craig BW.

Aging Male. 2016 Sep;19(3):161-167. Epub 2016 Aug 25.


Success of Intubation Rescue Techniques after Failed Direct Laryngoscopy in Adults: A Retrospective Comparative Analysis from the Multicenter Perioperative Outcomes Group.

Aziz MF, Brambrink AM, Healy DW, Willett AW, Shanks A, Tremper T, Jameson L, Ragheb J, Biggs DA, Paganelli WC, Rao J, Epps JL, Colquhoun DA, Bakke P, Kheterpal S.

Anesthesiology. 2016 Oct;125(4):656-66. doi: 10.1097/ALN.0000000000001267.


Induced Disruption of the Iron-Regulatory Hormone Hepcidin Inhibits Acute Inflammatory Hypoferraemia.

Armitage AE, Lim PJ, Frost JN, Pasricha SR, Soilleux EJ, Evans E, Morovat A, Santos A, Diaz R, Biggs D, Davies B, Gileadi U, Robbins PA, Lakhal-Littleton S, Drakesmith H.

J Innate Immun. 2016;8(5):517-28. doi: 10.1159/000447713. Epub 2016 Jul 16.


Developing a theory of change for a community-based response to illegal wildlife trade.

Biggs D, Cooney R, Roe D, Dublin HT, Allan JR, Challender DW, Skinner D.

Conserv Biol. 2017 Feb;31(1):5-12. doi: 10.1111/cobi.12796. Epub 2016 Nov 4.


Olanzapine for the Prevention of Chemotherapy-Induced Nausea and Vomiting.

Navari RM, Qin R, Ruddy KJ, Liu H, Powell SF, Bajaj M, Dietrich L, Biggs D, Lafky JM, Loprinzi CL.

N Engl J Med. 2016 Jul 14;375(2):134-42. doi: 10.1056/NEJMoa1515725.


Elephant poaching: Track the impact of Kenya's ivory burn.

Biggs D, Holden MH, Braczkowski AR, Possingham HP.

Nature. 2016 Jun 9;534(7606):179. doi: 10.1038/534179a. No abstract available.


Potential Synergies between Nature-Based Tourism and Sustainable Use of Marine Resources: Insights from Dive Tourism in Territorial User Rights for Fisheries in Chile.

Biggs D, Amar F, Valdebenito A, Gelcich S.

PLoS One. 2016 Mar 29;11(3):e0148862. doi: 10.1371/journal.pone.0148862. eCollection 2016.


Re-engineering the zinc fingers of PRDM9 reverses hybrid sterility in mice.

Davies B, Hatton E, Altemose N, Hussin JG, Pratto F, Zhang G, Hinch AG, Moralli D, Biggs D, Diaz R, Preece C, Li R, Bitoun E, Brick K, Green CM, Camerini-Otero RD, Myers SR, Donnelly P.

Nature. 2016 Feb 11;530(7589):171-176. doi: 10.1038/nature16931. Epub 2016 Feb 3.


Practitioner application.

Biggs DE.

J Healthc Manag. 2015 May-Jun;60(3):184-5. No abstract available.


A versatile transgenic allele for mouse overexpression studies.

Dolatshad H, Biggs D, Diaz R, Hortin N, Preece C, Davies B.

Mamm Genome. 2015 Dec;26(11-12):598-608. doi: 10.1007/s00335-015-9602-y. Epub 2015 Sep 14.


Effect of ArginMax on sexual functioning and quality of life among female cancer survivors: results of the WFU CCOP Research Base Protocol 97106.

Greven KM, Case LD, Nycum LR, Zekan PJ, Hurd DD, Balcueva EP, Mills GM, Zon R, Flynn PJ, Biggs D, Shaw EG, Lesser G, Naughton MJ.

J Community Support Oncol. 2015 Mar;13(3):87-94. doi: 10.12788/jcso.0114.


Understanding protected area resilience: a multi-scale, social-ecological approach.

Cumming GS, Allen CR, Ban NC, Biggs D, Biggs HC, Cumming DH, De Vos A, Epstein G, Etienne M, Maciejewski K, Mathevet R, Moore C, Nenadovic M, Schoon M.

Ecol Appl. 2015 Mar;25(2):299-319.


Cross-scale feedbacks and scale mismatches as influences on cultural services and the resilience of protected areas.

Maciejewski K, De Vos A, Cumming GS, Moore C, Biggs D.

Ecol Appl. 2015 Jan;25(1):11-23.


Elephant conservation and corruption beyond the ivory trade.

Smith RJ, Biggs D, St John FA, 't Sas-Rolfes M, Barrington R.

Conserv Biol. 2015 Jun;29(3):953-6. doi: 10.1111/cobi.12488. Epub 2015 Mar 31. No abstract available.


Cardiac ferroportin regulates cellular iron homeostasis and is important for cardiac function.

Lakhal-Littleton S, Wolna M, Carr CA, Miller JJ, Christian HC, Ball V, Santos A, Diaz R, Biggs D, Stillion R, Holdship P, Larner F, Tyler DJ, Clarke K, Davies B, Robbins PA.

Proc Natl Acad Sci U S A. 2015 Mar 10;112(10):3164-9. doi: 10.1073/pnas.1422373112. Epub 2015 Feb 23. Erratum in: Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):E1812.


A multidisciplinary conceptualization of conservation opportunity.

Moon K, Adams VM, Januchowski-Hartley SR, Polyakov M, Mills M, Biggs D, Knight AT, Game ET, Raymond CM.

Conserv Biol. 2014 Dec;28(6):1484-96. doi: 10.1111/cobi.12408. Epub 2014 Nov 7.


Comparison of isometric and anatomical graft placement in synthetic ACL reconstructions: a pilot study.

Dabirrahmani D, Christopher Hogg M, Walker P, Biggs D, Mark Gillies R.

Comput Biol Med. 2013 Dec;43(12):2287-96. doi: 10.1016/j.compbiomed.2013.10.008. Epub 2013 Oct 25.


Financing marine protected areas through visitor fees: insights from tourists willingness to pay in Chile.

Gelcich S, Amar F, Valdebenito A, Castilla JC, Fernandez M, Godoy C, Biggs D.

Ambio. 2013 Dec;42(8):975-84. doi: 10.1007/s13280-013-0453-z.


Conservation. Biodiversity risks from fossil fuel extraction.

Butt N, Beyer HL, Bennett JR, Biggs D, Maggini R, Mills M, Renwick AR, Seabrook LM, Possingham HP.

Science. 2013 Oct 25;342(6157):425-6. doi: 10.1126/science.1237261. No abstract available.


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