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Items: 10


Zinc finger E-box binding homeobox-1 (Zeb1) drives anterograde lysosome trafficking and tumor cell invasion via upregulation of Na+/H+ Exchanger-1 (NHE1).

Dykes SS, Gao C, Songock WK, Bigelow RL, Woude GV, Bodily JM, Cardelli JA.

Mol Carcinog. 2017 Feb;56(2):722-734. doi: 10.1002/mc.22528. Epub 2016 Aug 22.


The polyphenols (-)-epigallocatechin-3-gallate and luteolin synergistically inhibit TGF-β-induced myofibroblast phenotypes through RhoA and ERK inhibition.

Gray AL, Stephens CA, Bigelow RL, Coleman DT, Cardelli JA.

PLoS One. 2014 Oct 1;9(10):e109208. doi: 10.1371/journal.pone.0109208. eCollection 2014.


The polyphenol epigallocatechin-3-gallate affects lipid rafts to block activation of the c-Met receptor in prostate cancer cells.

Duhon D, Bigelow RL, Coleman DT, Steffan JJ, Yu C, Langston W, Kevil CG, Cardelli JA.

Mol Carcinog. 2010 Aug;49(8):739-49. doi: 10.1002/mc.20649.


The green tea polyphenol EGCG potentiates the antiproliferative activity of c-Met and epidermal growth factor receptor inhibitors in non-small cell lung cancer cells.

Milligan SA, Burke P, Coleman DT, Bigelow RL, Steffan JJ, Carroll JL, Williams BJ, Cardelli JA.

Clin Cancer Res. 2009 Aug 1;15(15):4885-94. doi: 10.1158/1078-0432.CCR-09-0109. Epub 2009 Jul 28.


Layer-by-Layer-Coated Gelatin Nanoparticles as a Vehicle for Delivery of Natural Polyphenols.

Shutava TG, Balkundi SS, Vangala P, Steffan JJ, Bigelow RL, Cardelli JA, O'Neal DP, Lvov YM.

ACS Nano. 2009 Jul 28;3(7):1877-85. doi: 10.1021/nn900451a. Epub 2009 Jun 17.


TIMP-1 overexpression promotes tumorigenesis of MDA-MB-231 breast cancer cells and alters expression of a subset of cancer promoting genes in vivo distinct from those observed in vitro.

Bigelow RL, Williams BJ, Carroll JL, Daves LK, Cardelli JA.

Breast Cancer Res Treat. 2009 Sep;117(1):31-44. doi: 10.1007/s10549-008-0170-7. Epub 2008 Sep 12.


Sonic hedgehog induces epidermal growth factor dependent matrix infiltration in HaCaT keratinocytes.

Bigelow RL, Jen EY, Delehedde M, Chari NS, McDonnell TJ.

J Invest Dermatol. 2005 Feb;124(2):457-65.


Transcriptional regulation of bcl-2 mediated by the sonic hedgehog signaling pathway through gli-1.

Bigelow RL, Chari NS, Unden AB, Spurgers KB, Lee S, Roop DR, Toftgard R, McDonnell TJ.

J Biol Chem. 2004 Jan 9;279(2):1197-205. Epub 2003 Oct 10.

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