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Items: 1 to 50 of 145

1.

Conservation of the structure and function of bacterial tryptophan synthases.

Michalska K, Gale J, Joachimiak G, Chang C, Hatzos-Skintges C, Nocek B, Johnston SE, Bigelow L, Bajrami B, Jedrzejczak RP, Wellington S, Hung DT, Nag PP, Fisher SL, Endres M, Joachimiak A.

IUCrJ. 2019 May 29;6(Pt 4):649-664. doi: 10.1107/S2052252519005955. eCollection 2019 Jul 1.

2.

Brucella Periplasmic Protein EipB Is a Molecular Determinant of Cell Envelope Integrity and Virulence.

Herrou J, Willett JW, Fiebig A, Czyż DM, Cheng JX, Ultee E, Briegel A, Bigelow L, Babnigg G, Kim Y, Crosson S.

J Bacteriol. 2019 May 22;201(12). pii: e00134-19. doi: 10.1128/JB.00134-19. Print 2019 Jun 15.

PMID:
30936371
3.

Structure of Calcarisporiella thermophila Hsp104 Disaggregase that Antagonizes Diverse Proteotoxic Misfolding Events.

Michalska K, Zhang K, March ZM, Hatzos-Skintges C, Pintilie G, Bigelow L, Castellano LM, Miles LJ, Jackrel ME, Chuang E, Jedrzejczak R, Shorter J, Chiu W, Joachimiak A.

Structure. 2019 Mar 5;27(3):449-463.e7. doi: 10.1016/j.str.2018.11.001. Epub 2018 Dec 27.

PMID:
30595457
4.

Periplasmic protein EipA determines envelope stress resistance and virulence in Brucella abortus.

Herrou J, Willett JW, Fiebig A, Varesio LM, Czyż DM, Cheng JX, Ultee E, Briegel A, Bigelow L, Babnigg G, Kim Y, Crosson S.

Mol Microbiol. 2019 Mar;111(3):637-661. doi: 10.1111/mmi.14178. Epub 2019 Jan 21.

PMID:
30536925
5.

Structural Insights into the Free-Standing Condensation Enzyme SgcC5 Catalyzing Ester-Bond Formation in the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027.

Chang CY, Lohman JR, Huang T, Michalska K, Bigelow L, Rudolf JD, Jedrzejczak R, Yan X, Ma M, Babnigg G, Joachimiak A, Phillips GN Jr, Shen B.

Biochemistry. 2018 Jun 12;57(23):3278-3288. doi: 10.1021/acs.biochem.8b00174. Epub 2018 Mar 21.

6.

Crystal Structure of Thioesterase SgcE10 Supporting Common Polyene Intermediates in 9- and 10-Membered Enediyne Core Biosynthesis.

Annaval T, Rudolf JD, Chang CY, Lohman JR, Kim Y, Bigelow L, Jedrzejczak R, Babnigg G, Joachimiak A, Phillips GN Jr, Shen B.

ACS Omega. 2017 Aug 31;2(8):5159-5169. doi: 10.1021/acsomega.7b00933. Epub 2017 Aug 30.

7.

Erratum: The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex.

He Y, Selvaraju S, Curtin ML, Jakob CG, Zhu H, Comess KM, Shaw B, The J, Lima-Fernandes E, Szewczyk MM, Cheng D, Klinge KL, Li HQ, Pliushchev M, Algire MA, Maag D, Guo J, Dietrich J, Panchal SC, Petros AM, Sweis RF, Torrent M, Bigelow LJ, Senisterra G, Li F, Kennedy S, Wu Q, Osterling DJ, Lindley DJ, Gao W, Galasinski S, Barsyte-Lovejoy D, Vedadi M, Buchanan FG, Arrowsmith CH, Chiang GG, Sun C, Pappano WN.

Nat Chem Biol. 2017 Jul 18;13(8):922. doi: 10.1038/nchembio0817-922b. No abstract available.

PMID:
28853738
8.

Insights into PG-binding, conformational change, and dimerization of the OmpA C-terminal domains from Salmonella enterica serovar Typhimurium and Borrelia burgdorferi.

Tan K, Deatherage Kaiser BL, Wu R, Cuff M, Fan Y, Bigelow L, Jedrzejczak RP, Adkins JN, Cort JR, Babnigg G, Joachimiak A.

Protein Sci. 2017 Sep;26(9):1738-1748. doi: 10.1002/pro.3209. Epub 2017 Jun 19.

9.

The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex.

He Y, Selvaraju S, Curtin ML, Jakob CG, Zhu H, Comess KM, Shaw B, The J, Lima-Fernandes E, Szewczyk MM, Cheng D, Klinge KL, Li HQ, Pliushchev M, Algire MA, Maag D, Guo J, Dietrich J, Panchal SC, Petros AM, Sweis RF, Torrent M, Bigelow LJ, Senisterra G, Li F, Kennedy S, Wu Q, Osterling DJ, Lindley DJ, Gao W, Galasinski S, Barsyte-Lovejoy D, Vedadi M, Buchanan FG, Arrowsmith CH, Chiang GG, Sun C, Pappano WN.

Nat Chem Biol. 2017 Apr;13(4):389-395. doi: 10.1038/nchembio.2306. Epub 2017 Jan 30. Erratum in: Nat Chem Biol. 2017 Jul 18;13(8):922.

PMID:
28135237
10.

Crystal structure of SgcJ, an NTF2-like superfamily protein involved in biosynthesis of the nine-membered enediyne antitumor antibiotic C-1027.

Huang T, Chang CY, Lohman JR, Rudolf JD, Kim Y, Chang C, Yang D, Ma M, Yan X, Crnovcic I, Bigelow L, Clancy S, Bingman CA, Yennamalli RM, Babnigg G, Joachimiak A, Phillips GN, Shen B.

J Antibiot (Tokyo). 2016 Oct;69(10):731-740. doi: 10.1038/ja.2016.88. Epub 2016 Jul 13.

11.

Crystal Structures of SgcE6 and SgcC, the Two-Component Monooxygenase That Catalyzes Hydroxylation of a Carrier Protein-Tethered Substrate during the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027 in Streptomyces globisporus.

Chang CY, Lohman JR, Cao H, Tan K, Rudolf JD, Ma M, Xu W, Bingman CA, Yennamalli RM, Bigelow L, Babnigg G, Yan X, Joachimiak A, Phillips GN Jr, Shen B.

Biochemistry. 2016 Sep 13;55(36):5142-54. doi: 10.1021/acs.biochem.6b00713. Epub 2016 Sep 1.

12.

Structural dynamics of a methionine γ-lyase for calicheamicin biosynthesis: Rotation of the conserved tyrosine stacking with pyridoxal phosphate.

Cao H, Tan K, Wang F, Bigelow L, Yennamalli RM, Jedrzejczak R, Babnigg G, Bingman CA, Joachimiak A, Kharel MK, Singh S, Thorson JS, Phillips GN Jr.

Struct Dyn. 2016 Apr 29;3(3):034702. doi: 10.1063/1.4948539. eCollection 2016 May.

13.

How Aromatic Compounds Block DNA Binding of HcaR Catabolite Regulator.

Kim Y, Joachimiak G, Bigelow L, Babnigg G, Joachimiak A.

J Biol Chem. 2016 Jun 17;291(25):13243-56. doi: 10.1074/jbc.M115.712067. Epub 2016 Apr 25.

14.

Crystal Structure of the Zorbamycin-Binding Protein ZbmA, the Primary Self-Resistance Element in Streptomyces flavoviridis ATCC21892.

Rudolf JD, Bigelow L, Chang C, Cuff ME, Lohman JR, Chang CY, Ma M, Yang D, Clancy S, Babnigg G, Joachimiak A, Phillips GN Jr, Shen B.

Biochemistry. 2015 Nov 17;54(45):6842-51. doi: 10.1021/acs.biochem.5b01008. Epub 2015 Nov 5.

15.

Structural and evolutionary relationships of "AT-less" type I polyketide synthase ketosynthases.

Lohman JR, Ma M, Osipiuk J, Nocek B, Kim Y, Chang C, Cuff M, Mack J, Bigelow L, Li H, Endres M, Babnigg G, Joachimiak A, Phillips GN Jr, Shen B.

Proc Natl Acad Sci U S A. 2015 Oct 13;112(41):12693-8. doi: 10.1073/pnas.1515460112. Epub 2015 Sep 29.

16.

Structural Characterization of CalS8, a TDP-α-D-Glucose Dehydrogenase Involved in Calicheamicin Aminodideoxypentose Biosynthesis.

Singh S, Michalska K, Bigelow L, Endres M, Kharel MK, Babnigg G, Yennamalli RM, Bingman CA, Joachimiak A, Thorson JS, Phillips GN Jr.

J Biol Chem. 2015 Oct 23;290(43):26249-58. doi: 10.1074/jbc.M115.673459. Epub 2015 Aug 3.

17.

Structural characterization of AtmS13, a putative sugar aminotransferase involved in indolocarbazole AT2433 aminopentose biosynthesis.

Singh S, Kim Y, Wang F, Bigelow L, Endres M, Kharel MK, Babnigg G, Bingman CA, Joachimiak A, Thorson JS, Phillips GN Jr.

Proteins. 2015 Aug;83(8):1547-54. doi: 10.1002/prot.24844. Epub 2015 Jul 1.

18.

The crystal structure of BlmI as a model for nonribosomal peptide synthetase peptidyl carrier proteins.

Lohman JR, Ma M, Cuff ME, Bigelow L, Bearden J, Babnigg G, Joachimiak A, Phillips GN Jr, Shen B.

Proteins. 2014 Jul;82(7):1210-8.

19.

Salvage of failed protein targets by reductive alkylation.

Tan K, Kim Y, Hatzos-Skintges C, Chang C, Cuff M, Chhor G, Osipiuk J, Michalska K, Nocek B, An H, Babnigg G, Bigelow L, Joachimiak G, Li H, Mack J, Makowska-Grzyska M, Maltseva N, Mulligan R, Tesar C, Zhou M, Joachimiak A.

Methods Mol Biol. 2014;1140:189-200. doi: 10.1007/978-1-4939-0354-2_15.

20.

Perceptual Category Judgment Deficits are Related to Prefrontal Decision Making Abnormalities in Schizophrenia.

Weickert TW, Terrazas A, Bigelow LB, Apud JA, Egan MF, Weinberger DR.

Front Psychiatry. 2014 Jan 6;4:184. doi: 10.3389/fpsyt.2013.00184. eCollection 2014 Jan 6.

21.

Dopaminergic therapy removal differentially effects learning in schizophrenia and Parkinson's disease.

Weickert TW, Mattay VS, Das S, Bigelow LB, Apud JA, Egan MF, Weinberger DR, Goldberg TE.

Schizophr Res. 2013 Sep;149(1-3):162-6. doi: 10.1016/j.schres.2013.06.028. Epub 2013 Jul 3.

22.

The interplay between online and offline explorations of identity, relationships, and sex: a mixed-methods study with LGBT youth.

DeHaan S, Kuper LE, Magee JC, Bigelow L, Mustanski BS.

J Sex Res. 2013;50(5):421-34. doi: 10.1080/00224499.2012.661489. Epub 2012 Apr 10.

PMID:
22489658
23.

Interaction of J-protein co-chaperone Jac1 with Fe-S scaffold Isu is indispensable in vivo and conserved in evolution.

Ciesielski SJ, Schilke BA, Osipiuk J, Bigelow L, Mulligan R, Majewska J, Joachimiak A, Marszalek J, Craig EA, Dutkiewicz R.

J Mol Biol. 2012 Mar 16;417(1-2):1-12. doi: 10.1016/j.jmb.2012.01.022. Epub 2012 Jan 27.

24.

Expression of GABA signaling molecules KCC2, NKCC1, and GAD1 in cortical development and schizophrenia.

Hyde TM, Lipska BK, Ali T, Mathew SV, Law AJ, Metitiri OE, Straub RE, Ye T, Colantuoni C, Herman MM, Bigelow LB, Weinberger DR, Kleinman JE.

J Neurosci. 2011 Jul 27;31(30):11088-95. doi: 10.1523/JNEUROSCI.1234-11.2011.

25.

Sexual health information seeking online: a mixed-methods study among lesbian, gay, bisexual, and transgender young people.

Magee JC, Bigelow L, Dehaan S, Mustanski BS.

Health Educ Behav. 2012 Jun;39(3):276-89. doi: 10.1177/1090198111401384. Epub 2011 Apr 13.

PMID:
21490310
26.

Evidence of sex-modulated association of ZNF804A with schizophrenia.

Zhang F, Chen Q, Ye T, Lipska BK, Straub RE, Vakkalanka R, Rujescu D, St Clair D, Hyde TM, Bigelow L, Kleinman JE, Weinberger DR.

Biol Psychiatry. 2011 May 15;69(10):914-7. doi: 10.1016/j.biopsych.2011.01.003. Epub 2011 Feb 24.

PMID:
21349497
27.

Evaluation of tissue collection for postmortem studies of bipolar disorder.

Deep-Soboslay A, Iglesias B, Hyde TM, Bigelow LB, Imamovic V, Herman MM, Kleinman JE.

Bipolar Disord. 2008 Nov;10(7):822-8. doi: 10.1111/j.1399-5618.2008.00607.x.

28.

Large-scale evaluation of protein reductive methylation for improving protein crystallization.

Kim Y, Quartey P, Li H, Volkart L, Hatzos C, Chang C, Nocek B, Cuff M, Osipiuk J, Tan K, Fan Y, Bigelow L, Maltseva N, Wu R, Borovilos M, Duggan E, Zhou M, Binkowski TA, Zhang RG, Joachimiak A.

Nat Methods. 2008 Oct;5(10):853-4. doi: 10.1038/nmeth1008-853. No abstract available.

29.

Enuresis as a premorbid developmental marker of schizophrenia.

Hyde TM, Deep-Soboslay A, Iglesias B, Callicott JH, Gold JM, Meyer-Lindenberg A, Honea RA, Bigelow LB, Egan MF, Emsellem EM, Weinberger DR.

Brain. 2008 Sep;131(Pt 9):2489-98. doi: 10.1093/brain/awn167. Epub 2008 Jul 31.

30.

Structure of SO2946 orphan from Shewanella oneidensis shows "jelly-roll" fold with carbohydrate-binding module.

Nocek B, Bigelow L, Abdullah J, Joachimiak A.

J Struct Funct Genomics. 2008 Dec;9(1-4):1-6. doi: 10.1007/s10969-008-9040-0. Epub 2008 Jun 20.

31.

Chapter 3. High-throughput protein purification for x-ray crystallography and NMR.

Kim Y, Bigelow L, Borovilos M, Dementieva I, Duggan E, Eschenfeldt W, Hatzos C, Joachimiak G, Li H, Maltseva N, Mulligan R, Quartey P, Sather A, Stols L, Volkart L, Wu R, Zhou M, Joachimiak A.

Adv Protein Chem Struct Biol. 2008;75:85-105. doi: 10.1016/S0065-3233(07)75003-9. Epub 2009 Feb 26. Review.

32.

The G72/G30 gene complex and cognitive abnormalities in schizophrenia.

Goldberg TE, Straub RE, Callicott JH, Hariri A, Mattay VS, Bigelow L, Coppola R, Egan MF, Weinberger DR.

Neuropsychopharmacology. 2006 Sep;31(9):2022-32. Epub 2006 Mar 22.

33.

Reliability of psychiatric diagnosis in postmortem research.

Deep-Soboslay A, Akil M, Martin CE, Bigelow LB, Herman MM, Hyde TM, Kleinman JE.

Biol Psychiatry. 2005 Jan 1;57(1):96-101.

PMID:
15607306
34.

Comparison of cognitive performances during a placebo period and an atypical antipsychotic treatment period in schizophrenia: critical examination of confounds.

Weickert TW, Goldberg TE, Marenco S, Bigelow LB, Egan MF, Weinberger DR.

Neuropsychopharmacology. 2003 Aug;28(8):1491-500. Epub 2003 Jun 11. Erratum in: Neuropsychopharmacology. 2003 Dec;28(12):2217.

35.

Habit and skill learning in schizophrenia: evidence of normal striatal processing with abnormal cortical input.

Weickert TW, Terrazas A, Bigelow LB, Malley JD, Hyde T, Egan MF, Weinberger DR, Goldberg TE.

Learn Mem. 2002 Nov-Dec;9(6):430-42.

36.

Identification of Listeria monocytogenes genes expressed in response to growth at low temperature.

Liu S, Graham JE, Bigelow L, Morse PD 2nd, Wilkinson BJ.

Appl Environ Microbiol. 2002 Apr;68(4):1697-705.

37.

Relative risk of neurological signs in siblings of patients with schizophrenia.

Egan MF, Hyde TM, Bonomo JB, Mattay VS, Bigelow LB, Goldberg TE, Weinberger DR.

Am J Psychiatry. 2001 Nov;158(11):1827-34.

PMID:
11691688
38.

A quantitative immunohistochemical study of astrocytes in the entorhinal cortex in schizophrenia, bipolar disorder and major depression: absence of significant astrocytosis.

Damadzic R, Bigelow LB, Krimer LS, Goldenson DA, Saunders RC, Kleinman JE, Herman MM.

Brain Res Bull. 2001 Jul 15;55(5):611-8.

PMID:
11576757
39.

Relative risk for cognitive impairments in siblings of patients with schizophrenia.

Egan MF, Goldberg TE, Gscheidle T, Weirich M, Rawlings R, Hyde TM, Bigelow L, Weinberger DR.

Biol Psychiatry. 2001 Jul 15;50(2):98-107.

PMID:
11527000
40.

Cognitive impairments in patients with schizophrenia displaying preserved and compromised intellect.

Weickert TW, Goldberg TE, Gold JM, Bigelow LB, Egan MF, Weinberger DR.

Arch Gen Psychiatry. 2000 Sep;57(9):907-13. Erratum in: Arch Gen Psychiatry 2000 Dec;57(12):1122.

PMID:
10986554
41.

Relative risk of attention deficits in siblings of patients with schizophrenia.

Egan MF, Goldberg TE, Gscheidle T, Weirich M, Bigelow LB, Weinberger DR.

Am J Psychiatry. 2000 Aug;157(8):1309-16.

PMID:
10910796
42.

Evaluation of superior vermal Purkinje cell placement in mental illness.

Helmkamp CE, Bigelow LB, Paltán-Ortiz JD, Torrey EF, Kleinman JE, Herman MM.

Biol Psychiatry. 1999 May 15;45(10):1370-5.

PMID:
10349043
43.

Clonidine does not potentiate the antipsychotic effects of neuroleptics in chronically ill patients.

Hedges S, El-Mallakh RS, Issa F, Elkashef A, Bigelow LB, Wyatt RJ.

Ann Clin Psychiatry. 1998 Mar;10(1):3-7.

PMID:
9622044
44.

Prodynorphin mRNA expression is increased in the patch vs matrix compartment of the caudate nucleus in suicide subjects.

Hurd YL, Herman MM, Hyde TM, Bigelow LB, Weinberger DR, Kleinman JE.

Mol Psychiatry. 1997 Oct-Nov;2(6):495-500.

45.

Perinatal transport casebook. Maternal transport: a protocol for ambulance transfer from rural to regional facility.

Bigelow LK, Anderson KC, Camp J.

J Perinatol. 1997 Sep-Oct;17(5):411-5. No abstract available.

PMID:
9373851
46.

Glutamate receptors in the postmortem striatum of schizophrenic, suicide, and control brains.

Noga JT, Hyde TM, Herman MM, Spurney CF, Bigelow LB, Weinberger DR, Kleinman JE.

Synapse. 1997 Nov;27(3):168-76.

PMID:
9329152
47.

Dextroamphetamine enhances "neural network-specific" physiological signals: a positron-emission tomography rCBF study.

Mattay VS, Berman KF, Ostrem JL, Esposito G, Van Horn JD, Bigelow LB, Weinberger DR.

J Neurosci. 1996 Aug 1;16(15):4816-22.

48.

Possible relationship between conditions associated with chronic hypoxia and brain mitochondrial DNA deletions.

Merril CR, Zullo S, Ghanbari H, Herman MM, Kleinman JE, Bigelow LB, Bartko JJ, Sabourin DJ.

Arch Biochem Biophys. 1996 Feb 1;326(1):172-7.

PMID:
8579367
49.

Genetic risk of neuropsychological impairment in schizophrenia: a study of monozygotic twins discordant and concordant for the disorder.

Goldberg TE, Torrey EF, Gold JM, Bigelow LB, Ragland RD, Taylor E, Weinberger DR.

Schizophr Res. 1995 Sep;17(1):77-84.

PMID:
8541253
50.

Distribution of putative D4 dopamine receptors in postmortem striatum from patients with schizophrenia.

Murray AM, Hyde TM, Knable MB, Herman MM, Bigelow LB, Carter JM, Weinberger DR, Kleinman JE.

J Neurosci. 1995 Mar;15(3 Pt 2):2186-91.

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