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Items: 1 to 50 of 83

1.

Enhanced hemato-endothelial specification during human embryonic differentiation through developmental cooperation between AF4-MLL and MLL-AF4 fusions.

Bueno C, Calero-Nieto FJ, Wang X, Valdés-Mas R, Gutiérrez-Agüera F, Roca-Ho H, Ayllon V, Real PJ, Arambilet D, Espinosa L, Torres-Ruiz R, Agraz-Doblas A, Varela I, de Boer J, Bigas A, Gottgens B, Marschalek R, Menendez P.

Haematologica. 2019 Jun;104(6):1189-1201. doi: 10.3324/haematol.2018.202044. Epub 2019 Jan 24.

2.

Manic Fringe deficiency imposes Jagged1 addiction to intestinal tumor cells.

López-Arribillaga E, Rodilla V, Colomer C, Vert A, Shelton A, Cheng JH, Yan B, Gonzalez-Perez A, Junttila MR, Iglesias M, Torres F, Albanell J, Villanueva A, Bigas A, Siebel CW, Espinosa L.

Nat Commun. 2018 Jul 31;9(1):2992. doi: 10.1038/s41467-018-05385-0.

3.

Notch and Stem Cells.

Bigas A, Porcheri C.

Adv Exp Med Biol. 2018;1066:235-263. doi: 10.1007/978-3-319-89512-3_12. Review.

PMID:
30030830
4.

The multiple usages of Notch signaling in development, cell differentiation and cancer.

Bigas A, Espinosa L.

Curr Opin Cell Biol. 2018 Dec;55:1-7. doi: 10.1016/j.ceb.2018.06.010. Epub 2018 Jul 10. Review.

PMID:
30006050
5.

Role of p27Kip1 as a transcriptional regulator.

Bachs O, Gallastegui E, Orlando S, Bigas A, Morante-Redolat JM, Serratosa J, Fariñas I, Aligué R, Pujol MJ.

Oncotarget. 2018 May 25;9(40):26259-26278. doi: 10.18632/oncotarget.25447. eCollection 2018 May 25. Review.

6.

Blood Development: Hematopoietic Stem Cell Dependence and Independence.

Dzierzak E, Bigas A.

Cell Stem Cell. 2018 May 3;22(5):639-651. doi: 10.1016/j.stem.2018.04.015. Review.

7.

Novel phosphorylated TAK1 species with functional impact on NF-κB and β-catenin signaling in human Cutaneous T-cell lymphoma.

Gallardo F, Bertran J, López-Arribillaga E, González J, Menéndez S, Sánchez I, Colomo L, Iglesias M, Garrido M, Santamaría-Babí LF, Torres F, Pujol RM, Bigas A, Espinosa L.

Leukemia. 2018 Oct;32(10):2211-2223. doi: 10.1038/s41375-018-0066-4. Epub 2018 Feb 22.

8.

IKKα is required in the intestinal epithelial cells for tumour stemness.

Colomer C, Margalef P, Gonzalez J, Vert A, Bigas A, Espinosa L.

Br J Cancer. 2018 Mar 20;118(6):839-846. doi: 10.1038/bjc.2017.459. Epub 2018 Feb 13.

9.

NOTCH2 Hajdu-Cheney Mutations Escape SCFFBW7-Dependent Proteolysis to Promote Osteoporosis.

Fukushima H, Shimizu K, Watahiki A, Hoshikawa S, Kosho T, Oba D, Sakano S, Arakaki M, Yamada A, Nagashima K, Okabe K, Fukumoto S, Jimi E, Bigas A, Nakayama KI, Nakayama K, Aoki Y, Wei W, Inuzuka H.

Mol Cell. 2017 Nov 16;68(4):645-658.e5. doi: 10.1016/j.molcel.2017.10.018.

10.

A Paradoxical Tumor-Suppressor Role for the Rac1 Exchange Factor Vav1 in T Cell Acute Lymphoblastic Leukemia.

Robles-Valero J, Lorenzo-Martín LF, Menacho-Márquez M, Fernández-Pisonero I, Abad A, Camós M, Toribio ML, Espinosa L, Bigas A, Bustelo XR.

Cancer Cell. 2017 Nov 13;32(5):608-623.e9. doi: 10.1016/j.ccell.2017.10.004.

11.

NF-κB Members Left Home: NF-κB-Independent Roles in Cancer.

Colomer C, Marruecos L, Vert A, Bigas A, Espinosa L.

Biomedicines. 2017 May 25;5(2). pii: E26. doi: 10.3390/biomedicines5020026. Review.

12.

p27Kip1, PCAF and PAX5 cooperate in the transcriptional regulation of specific target genes.

Perearnau A, Orlando S, Islam ABMMK, Gallastegui E, Martínez J, Jordan A, Bigas A, Aligué R, Pujol MJ, Bachs O.

Nucleic Acids Res. 2017 May 19;45(9):5086-5099. doi: 10.1093/nar/gkx075.

13.

Proinflammatory signals are insufficient to drive definitive hematopoietic specification of human HSCs in vitro.

Giorgetti A, Castaño J, Bueno C, Díaz de la Guardia R, Delgado M, Bigas A, Espinosa L, Menendez P.

Exp Hematol. 2017 Jan;45:85-93.e2. doi: 10.1016/j.exphem.2016.09.007. Epub 2016 Sep 28.

PMID:
27693385
14.

Blood stem cells: from beginning to end.

Bigas A, Waskow C.

Development. 2016 Oct 1;143(19):3429-3433. Review.

15.

Efficient nuclear export of p65-IκBα complexes requires 14-3-3 proteins.

Aguilera C, Fernández-Majada V, Inglés-Esteve J, Rodilla V, Bigas A, Espinosa L.

J Cell Sci. 2016 Jun 15;129(12):2472. doi: 10.1242/jcs.192641. No abstract available.

16.

β-Catenin is required for T-cell leukemia initiation and MYC transcription downstream of Notch1.

Gekas C, D'Altri T, Aligué R, González J, Espinosa L, Bigas A.

Leukemia. 2016 Oct;30(10):2002-2010. doi: 10.1038/leu.2016.106. Epub 2016 Apr 29.

PMID:
27125305
17.

NUMB inactivation confers resistance to imatinib in chronic myeloid leukemia cells.

García-Alegría E, Lafita-Navarro MC, Aguado R, García-Gutiérrez L, Sarnataro K, Ruiz-Herguido C, Martín F, Bigas A, Canelles M, León J.

Cancer Lett. 2016 May 28;375(1):92-99. doi: 10.1016/j.canlet.2016.02.037. Epub 2016 Mar 2.

PMID:
26944313
18.

Corrigendum: Notch signal strength controls cell fate in the haemogenic endothelium.

Gama-Norton L, Ferrando E, Ruiz-Herguido C, Liu Z, Guiu J, Islam AB, Lee SU, Yan M, Guidos CJ, López-Bigas N, Maeda T, Espinosa L, Kopan R, Bigas A.

Nat Commun. 2016 Mar 4;7:10978. doi: 10.1038/ncomms10978. No abstract available.

19.

Intra-Bone Marrow Transplantation Confers Superior Multilineage Engraftment of Murine Aorta-Gonad Mesonephros Cells Over Intravenous Transplantation.

Sanjuan-Pla A, Romero-Moya D, Prieto C, Bueno C, Bigas A, Menendez P.

Stem Cells Dev. 2016 Feb 1;25(3):259-65. doi: 10.1089/scd.2015.0309. Epub 2016 Jan 7.

PMID:
26603126
20.

Notch signal strength controls cell fate in the haemogenic endothelium.

Gama-Norton L, Ferrando E, Ruiz-Herguido C, Liu Z, Guiu J, Islam AB, Lee SU, Yan M, Guidos CJ, López-Bigas N, Maeda T, Espinosa L, Kopan R, Bigas A.

Nat Commun. 2015 Oct 14;6:8510. doi: 10.1038/ncomms9510. Erratum in: Nat Commun. 2016;7:10978. Liu, Zenhy [Corrected to Liu, Zhenyi].

21.

Notch1 Pathway Activation Results from the Epigenetic Abrogation of Notch-Related MicroRNAs in Mycosis Fungoides.

Gallardo F, Sandoval J, Díaz-Lagares A, Garcia R, D'Altri T, González J, Alegre V, Servitje O, Crujeiras AB, Stefánsson ÓA, Espinet B, Hernández MI, Bellosillo B, Esteller M, Pujol RM, Bigas A, Espinosa L.

J Invest Dermatol. 2015 Dec;135(12):3144-3152. doi: 10.1038/jid.2015.328. Epub 2015 Aug 24.

22.

PTEN mediates Notch-dependent stalk cell arrest in angiogenesis.

Serra H, Chivite I, Angulo-Urarte A, Soler A, Sutherland JD, Arruabarrena-Aristorena A, Ragab A, Lim R, Malumbres M, Fruttiger M, Potente M, Serrano M, Fabra À, Viñals F, Casanovas O, Pandolfi PP, Bigas A, Carracedo A, Gerhardt H, Graupera M.

Nat Commun. 2015 Jul 31;6:7935. doi: 10.1038/ncomms8935.

23.

Active nuclear IKK correlates with metastatic risk in cutaneous squamous cell carcinoma.

Toll A, Margalef P, Masferrer E, Ferrándiz-Pulido C, Gimeno J, Pujol RM, Bigas A, Espinosa L.

Arch Dermatol Res. 2015 Oct;307(8):721-9. doi: 10.1007/s00403-015-1579-6. Epub 2015 Jun 21.

PMID:
26094020
24.

Overlapping DNA methylation dynamics in mouse intestinal cell differentiation and early stages of malignant progression.

Forn M, Díez-Villanueva A, Merlos-Suárez A, Muñoz M, Lois S, Carriò E, Jordà M, Bigas A, Batlle E, Peinado MA.

PLoS One. 2015 May 1;10(5):e0123263. doi: 10.1371/journal.pone.0123263. eCollection 2015.

25.

BRAF-induced tumorigenesis is IKKα-dependent but NF-κB-independent.

Margalef P, Colomer C, Villanueva A, Montagut C, Iglesias M, Bellosillo B, Salazar R, Martínez-Iniesta M, Bigas A, Espinosa L.

Sci Signal. 2015 Apr 21;8(373):ra38. doi: 10.1126/scisignal.2005886.

PMID:
25900832
26.

Cytoplasmic accumulation of NCoR in malignant melanoma: consequences of altered gene repression and prognostic significance.

Gallardo F, Padrón A, Garcia-Carbonell R, Rius C, González-Perez A, Arumí-Uria M, Iglesias M, Nonell L, Bellosillo B, Segura S, Pujol RM, Lopez-Bigas N, Bertran J, Bigas A, Espinosa L.

Oncotarget. 2015 Apr 20;6(11):9284-94.

27.

The Notch ligand DLL4 specifically marks human hematoendothelial progenitors and regulates their hematopoietic fate.

Ayllón V, Bueno C, Ramos-Mejía V, Navarro-Montero O, Prieto C, Real PJ, Romero T, García-León MJ, Toribio ML, Bigas A, Menendez P.

Leukemia. 2015 Aug;29(8):1741-53. doi: 10.1038/leu.2015.74. Epub 2015 Mar 17.

PMID:
25778099
28.

Lysyl oxidase-like 2 represses Notch1 expression in the skin to promote squamous cell carcinoma progression.

Martin A, Salvador F, Moreno-Bueno G, Floristán A, Ruiz-Herguido C, Cuevas EP, Morales S, Santos V, Csiszar K, Dubus P, Haigh JJ, Bigas A, Portillo F, Cano A.

EMBO J. 2015 Apr 15;34(8):1090-109. doi: 10.15252/embj.201489975. Epub 2015 Mar 10.

29.

Notch1 acts via Foxc2 to promote definitive hematopoiesis via effects on hemogenic endothelium.

Jang IH, Lu YF, Zhao L, Wenzel PL, Kume T, Datta SM, Arora N, Guiu J, Lagha M, Kim PG, Do EK, Kim JH, Schlaeger TM, Zon LI, Bigas A, Burns CE, Daley GQ.

Blood. 2015 Feb 26;125(9):1418-26. doi: 10.1182/blood-2014-04-568170. Epub 2015 Jan 13.

30.

Bmi1 regulates murine intestinal stem cell proliferation and self-renewal downstream of Notch.

López-Arribillaga E, Rodilla V, Pellegrinet L, Guiu J, Iglesias M, Roman AC, Gutarra S, González S, Muñoz-Cánoves P, Fernández-Salguero P, Radtke F, Bigas A, Espinosa L.

Development. 2015 Jan 1;142(1):41-50. doi: 10.1242/dev.107714. Epub 2014 Dec 5.

31.

Identification of Cdca7 as a novel Notch transcriptional target involved in hematopoietic stem cell emergence.

Guiu J, Bergen DJ, De Pater E, Islam AB, Ayllón V, Gama-Norton L, Ruiz-Herguido C, González J, López-Bigas N, Menendez P, Dzierzak E, Espinosa L, Bigas A.

J Exp Med. 2014 Nov 17;211(12):2411-23. doi: 10.1084/jem.20131857. Epub 2014 Nov 10.

32.

Novel functions of chromatin-bound IκBα in oncogenic transformation.

Espinosa L, Bigas A, Mulero MC.

Br J Cancer. 2014 Oct 28;111(9):1688-92. doi: 10.1038/bjc.2014.84. Epub 2014 Sep 18. Review.

33.

Authors' response: Recognition sequence for DNA uptake in Haemophilus parasuis.

Bigas A, Garrido ME, Pérez de Rozas AM, Badiola I, Barbé J, Llagostera M.

Vet Microbiol. 2014 Oct 10;173(3-4):397. doi: 10.1016/j.vetmic.2014.08.001. Epub 2014 Aug 12. No abstract available.

PMID:
25201628
34.

Non-conventional functions for NF-κB members: the dark side of NF-κB.

Espinosa L, Margalef P, Bigas A.

Oncogene. 2015 Apr 30;34(18):2279-87. doi: 10.1038/onc.2014.188. Epub 2014 Jun 30. Review.

PMID:
24975576
35.

Prostate tumor OVerexpressed-1 (PTOV1) down-regulates HES1 and HEY1 notch targets genes and promotes prostate cancer progression.

Alaña L, Sesé M, Cánovas V, Punyal Y, Fernández Y, Abasolo I, de Torres I, Ruiz C, Espinosa L, Bigas A, Y Cajal SR, Fernández PL, Serras F, Corominas M, Thomson TM, Paciucci R.

Mol Cancer. 2014 Mar 31;13:74. doi: 10.1186/1476-4598-13-74.

36.

The Notch1 transcriptional activation domain is required for development and reveals a novel role for Notch1 signaling in fetal hematopoietic stem cells.

Gerhardt DM, Pajcini KV, D'altri T, Tu L, Jain R, Xu L, Chen MJ, Rentschler S, Shestova O, Wertheim GB, Tobias JW, Kluk M, Wood AW, Aster JC, Gimotty PA, Epstein JA, Speck N, Bigas A, Pear WS.

Genes Dev. 2014 Mar 15;28(6):576-93. doi: 10.1101/gad.227496.113.

37.

Deficiency in p53 is required for doxorubicin induced transcriptional activation of NF-кB target genes in human breast cancer.

Dalmases A, González I, Menendez S, Arpí O, Corominas JM, Servitja S, Tusquets I, Chamizo C, Rincón R, Espinosa L, Bigas A, Eroles P, Furriol J, Lluch A, Rovira A, Albanell J, Rojo F.

Oncotarget. 2014 Jan 15;5(1):196-210.

38.

IκBα beyond the NF-kB dogma.

Mulero MC, Bigas A, Espinosa L.

Oncotarget. 2013 Oct;4(10):1550-1. No abstract available.

39.

Mucus enhances gut homeostasis and oral tolerance by delivering immunoregulatory signals.

Shan M, Gentile M, Yeiser JR, Walland AC, Bornstein VU, Chen K, He B, Cassis L, Bigas A, Cols M, Comerma L, Huang B, Blander JM, Xiong H, Mayer L, Berin C, Augenlicht LH, Velcich A, Cerutti A.

Science. 2013 Oct 25;342(6157):447-53. doi: 10.1126/science.1237910. Epub 2013 Sep 26.

40.

Long range epigenetic silencing is a trans-species mechanism that results in cancer specific deregulation by overriding the chromatin domains of normal cells.

Forn M, Muñoz M, Tauriello DV, Merlos-Suárez A, Rodilla V, Bigas A, Batlle E, Jordà M, Peinado MA.

Mol Oncol. 2013 Dec;7(6):1129-41. doi: 10.1016/j.molonc.2013.08.008. Epub 2013 Aug 30.

41.

Notch and Wnt signaling in the emergence of hematopoietic stem cells.

Bigas A, Guiu J, Gama-Norton L.

Blood Cells Mol Dis. 2013 Dec;51(4):264-70. doi: 10.1016/j.bcmd.2013.07.005. Epub 2013 Aug 6. Review.

PMID:
23927968
42.

MiR-142-3p controls the specification of definitive hemangioblasts during ontogeny.

Nimmo R, Ciau-Uitz A, Ruiz-Herguido C, Soneji S, Bigas A, Patient R, Enver T.

Dev Cell. 2013 Aug 12;26(3):237-49. doi: 10.1016/j.devcel.2013.06.023. Epub 2013 Aug 1.

43.

Chromatin-bound IκBα regulates a subset of polycomb target genes in differentiation and cancer.

Mulero MC, Ferres-Marco D, Islam A, Margalef P, Pecoraro M, Toll A, Drechsel N, Charneco C, Davis S, Bellora N, Gallardo F, López-Arribillaga E, Asensio-Juan E, Rodilla V, González J, Iglesias M, Shih V, Mar Albà M, Di Croce L, Hoffmann A, Miyamoto S, Villà-Freixa J, López-Bigas N, Keyes WM, Domínguez M, Bigas A, Espinosa L.

Cancer Cell. 2013 Aug 12;24(2):151-66. doi: 10.1016/j.ccr.2013.06.003. Epub 2013 Jul 11.

44.

Parp-2 is required to maintain hematopoiesis following sublethal γ-irradiation in mice.

Farrés J, Martín-Caballero J, Martínez C, Lozano JJ, Llacuna L, Ampurdanés C, Ruiz-Herguido C, Dantzer F, Schreiber V, Villunger A, Bigas A, Yélamos J.

Blood. 2013 Jul 4;122(1):44-54. doi: 10.1182/blood-2012-12-472845. Epub 2013 May 15.

45.

Hes repressors are essential regulators of hematopoietic stem cell development downstream of Notch signaling.

Guiu J, Shimizu R, D'Altri T, Fraser ST, Hatakeyama J, Bresnick EH, Kageyama R, Dzierzak E, Yamamoto M, Espinosa L, Bigas A.

J Exp Med. 2013 Jan 14;210(1):71-84. doi: 10.1084/jem.20120993. Epub 2012 Dec 24.

46.

A truncated form of IKKα is responsible for specific nuclear IKK activity in colorectal cancer.

Margalef P, Fernández-Majada V, Villanueva A, Garcia-Carbonell R, Iglesias M, López L, Martínez-Iniesta M, Villà-Freixa J, Mulero MC, Andreu M, Torres F, Mayo MW, Bigas A, Espinosa L.

Cell Rep. 2012 Oct 25;2(4):840-54. doi: 10.1016/j.celrep.2012.08.028. Epub 2012 Oct 4.

47.

Hematopoietic stem cell development requires transient Wnt/β-catenin activity.

Ruiz-Herguido C, Guiu J, D'Altri T, Inglés-Esteve J, Dzierzak E, Espinosa L, Bigas A.

J Exp Med. 2012 Jul 30;209(8):1457-68. doi: 10.1084/jem.20120225. Epub 2012 Jul 16.

48.

The Notch pathway in hematopoietic stem cells.

Bigas A, D'Altri T, Espinosa L.

Curr Top Microbiol Immunol. 2012;360:1-18. doi: 10.1007/82_2012_229. Review.

PMID:
22692832
49.

Inhibition of specific NF-κB activity contributes to the tumor suppressor function of 14-3-3σ in breast cancer.

Inglés-Esteve J, Morales M, Dalmases A, Garcia-Carbonell R, Jené-Sanz A, López-Bigas N, Iglesias M, Ruiz-Herguido C, Rovira A, Rojo F, Albanell J, Gomis RR, Bigas A, Espinosa L.

PLoS One. 2012;7(5):e38347. doi: 10.1371/journal.pone.0038347. Epub 2012 May 31.

50.

Hematopoietic stem cells: to be or Notch to be.

Bigas A, Espinosa L.

Blood. 2012 Apr 5;119(14):3226-35. doi: 10.1182/blood-2011-10-355826. Epub 2012 Feb 3. Review.

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