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Items: 11


Cryo-EM structure of the activated RET signaling complex reveals the importance of its cysteine-rich domain.

Bigalke JM, Aibara S, Roth R, Dahl G, Gordon E, Dorbéus S, Amunts A, Sandmark J.

Sci Adv. 2019 Jul 31;5(7):eaau4202. doi: 10.1126/sciadv.aau4202. eCollection 2019 Jul.


Structure and biophysical characterization of the human full-length neurturin-GFRa2 complex: A role for heparan sulfate in signaling.

Sandmark J, Dahl G, Öster L, Xu B, Johansson P, Akerud T, Aagaard A, Davidsson P, Bigalke JM, Winzell MS, Rainey GJ, Roth RG.

J Biol Chem. 2018 Apr 13;293(15):5492-5508. doi: 10.1074/jbc.RA117.000820. Epub 2018 Feb 2.


Have NEC Coat, Will Travel: Structural Basis of Membrane Budding During Nuclear Egress in Herpesviruses.

Bigalke JM, Heldwein EE.

Adv Virus Res. 2017;97:107-141. doi: 10.1016/bs.aivir.2016.07.002. Epub 2016 Sep 1. Review.


Expression, Purification and Crystallization of the Herpesvirus Nuclear Egress Complex (NEC).

Bigalke JM, Heldwein EE.

Bio Protoc. 2016 Jul 20;6(14). pii: e1872. doi: 10.21769/BioProtoc.1872.


Nuclear Exodus: Herpesviruses Lead the Way.

Bigalke JM, Heldwein EE.

Annu Rev Virol. 2016 Sep 29;3(1):387-409. Epub 2016 Jul 22.


Structural basis of membrane budding by the nuclear egress complex of herpesviruses.

Bigalke JM, Heldwein EE.

EMBO J. 2015 Dec 2;34(23):2921-36. doi: 10.15252/embj.201592359. Epub 2015 Oct 28.


The Great (Nuclear) Escape: New Insights into the Role of the Nuclear Egress Complex of Herpesviruses.

Bigalke JM, Heldwein EE.

J Virol. 2015 Sep;89(18):9150-3. doi: 10.1128/JVI.02530-14. Epub 2015 Jun 24. Review.


Membrane deformation and scission by the HSV-1 nuclear egress complex.

Bigalke JM, Heuser T, Nicastro D, Heldwein EE.

Nat Commun. 2014 Jun 11;5:4131. doi: 10.1038/ncomms5131.


Structure and dynamics of a stabilized coiled-coil domain in the P-TEFb regulator Hexim1.

Bigalke JM, Dames SA, Blankenfeldt W, Grzesiek S, Geyer M.

J Mol Biol. 2011 Dec 16;414(5):639-53. doi: 10.1016/j.jmb.2011.10.022. Epub 2011 Oct 18.


Formation of Tat-TAR containing ribonucleoprotein complexes for biochemical and structural analyses.

Bigalke JM, Czudnochowski N, Vollmuth F, Vogel-Bachmayr K, Anand K, Geyer M.

Methods. 2011 Jan;53(1):78-84. doi: 10.1016/j.ymeth.2010.04.001. Epub 2010 Apr 10.


A flexible bipartite coiled coil structure is required for the interaction of Hexim1 with the P-TEFB subunit cyclin T1.

Schönichen A, Bigalke JM, Urbanke C, Grzesiek S, Dames SA, Geyer M.

Biochemistry. 2010 Apr 13;49(14):3083-91. doi: 10.1021/bi902072f.


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