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Items: 1 to 50 of 224

1.

NMR for screening and a biochemical assay: Identification of new FPPS inhibitors exerting anticancer activity.

Grimaldi M, Randino R, Ciaglia E, Scrima M, Buonocore M, Stillitano I, Abate M, Covelli V, Tosco A, Gazzerro P, Bifulco M, Rodriquez M, D'Ursi AM.

Bioorg Chem. 2019 Nov 21:103449. doi: 10.1016/j.bioorg.2019.103449. [Epub ahead of print]

PMID:
32057422
2.

Headaches in the medieval Medical School of Salerno.

Bifulco M, Marasco G, Colucci-D'Amato L, Pisanti S.

Cephalalgia. 2020 Feb 4:333102420905317. doi: 10.1177/0333102420905317. [Epub ahead of print]

PMID:
32019328
3.

N6-Isopentenyladenosine Enhances the Radiosensitivity of Glioblastoma Cells by Inhibiting the Homologous Recombination Repair Protein RAD51 Expression.

Navarra G, Pagano C, Pacelli R, Crescenzi E, Longobardi E, Gazzerro P, Fiore D, Pastorino O, Pentimalli F, Laezza C, Bifulco M.

Front Oncol. 2020 Jan 14;9:1498. doi: 10.3389/fonc.2019.01498. eCollection 2019.

4.

The Endocannabinoid System: A Target for Cancer Treatment.

Laezza C, Pagano C, Navarra G, Pastorino O, Proto MC, Fiore D, Piscopo C, Gazzerro P, Bifulco M.

Int J Mol Sci. 2020 Jan 23;21(3). pii: E747. doi: 10.3390/ijms21030747. Review.

5.

Integrating Medical Humanities into medical school training.

Bifulco M, Pisanti S.

EMBO Rep. 2019 Dec 5;20(12):e48830. doi: 10.15252/embr.201948830. Epub 2019 Oct 30.

PMID:
31663234
6.

N6-Isopentenyladenosine Inhibits Colorectal Cancer and Improves Sensitivity to 5-Fluorouracil-Targeting FBXW7 Tumor Suppressor.

Fiore D, Piscopo C, Proto MC, Vasaturo M, Dal Piaz F, Fusco BM, Pagano C, Laezza C, Bifulco M, Gazzerro P.

Cancers (Basel). 2019 Sep 28;11(10). pii: E1456. doi: 10.3390/cancers11101456.

7.

HUVEC Tube-formation Assay to Evaluate the Impact of Natural Products on Angiogenesis.

Gentile MT, Pastorino O, Bifulco M, Colucci-D'Amato L.

J Vis Exp. 2019 Jun 24;(148). doi: 10.3791/58591.

PMID:
31282895
8.

Novel role for cannabidiol in circadian clock function.

Bifulco M, Navarra G, Laezza C, Pagano C.

Addict Biol. 2020 Mar;25(2):e12772. doi: 10.1111/adb.12772. Epub 2019 May 27. No abstract available.

PMID:
31132803
9.

Trotula de Ruggiero: The Magistra mulier sapiens and her medical dermatology treatises.

Bifulco M, De Falco DD, Aquino RP, Pisanti S.

J Cosmet Dermatol. 2019 Dec;18(6):1613-1616. doi: 10.1111/jocd.12882. Epub 2019 Feb 25.

PMID:
30803123
10.

The transition from adolescence to adulthood as a 'sensitive period' for developing cancer risk: the contribution of obesity and sociobehavioral mechanisms.

Bifulco M, Abate M.

Eur J Cancer Prev. 2019 Mar;28(2):142. doi: 10.1097/CEJ.0000000000000425. No abstract available.

PMID:
30707145
11.

Medical Cannabis: A plurimillennial history of an evergreen.

Pisanti S, Bifulco M.

J Cell Physiol. 2019 Jun;234(6):8342-8351. doi: 10.1002/jcp.27725. Epub 2018 Nov 11. Review.

PMID:
30417354
12.

PR/SET Domain Family and Cancer: Novel Insights from the Cancer Genome Atlas.

Sorrentino A, Federico A, Rienzo M, Gazzerro P, Bifulco M, Ciccodicola A, Casamassimi A, Abbondanza C.

Int J Mol Sci. 2018 Oct 19;19(10). pii: E3250. doi: 10.3390/ijms19103250.

13.

Symptoms of alcohol abuse: The first warning sign of cancer development risk.

Bifulco M, Citro M, Abate M.

Eur J Intern Med. 2018 Sep;55:e19-e20. doi: 10.1016/j.ejim.2018.07.003. Epub 2018 Jul 6. No abstract available.

PMID:
29983226
14.

Polypharmacological profile of 1,2-dihydro-2-oxo-pyridine-3-carboxamides in the endocannabinoid system.

Chicca A, Arena C, Bertini S, Gado F, Ciaglia E, Abate M, Digiacomo M, Lapillo M, Poli G, Bifulco M, Macchia M, Tuccinardi T, Gertsch J, Manera C.

Eur J Med Chem. 2018 Jun 25;154:155-171. doi: 10.1016/j.ejmech.2018.05.019. Epub 2018 May 14.

PMID:
29793210
15.

Colon Cancer Survival and Statins: What More Evidence Do We Need?

Bifulco M, Gazzerro P.

Gastroenterology. 2018 Apr;154(5):1545-1546. doi: 10.1053/j.gastro.2017.06.071. Epub 2018 Mar 8. No abstract available.

PMID:
29526725
16.

Rimonabant Kills Colon Cancer Stem Cells without Inducing Toxicity in Normal Colon Organoids.

Fiore D, Ramesh P, Proto MC, Piscopo C, Franceschelli S, Anzelmo S, Medema JP, Bifulco M, Gazzerro P.

Front Pharmacol. 2018 Jan 4;8:949. doi: 10.3389/fphar.2017.00949. eCollection 2017.

17.

The isoprenoid end product N6-isopentenyladenosine reduces inflammatory response through the inhibition of the NFκB and STAT3 pathways in cystic fibrosis cells.

Santoro A, Ciaglia E, Nicolin V, Pescatore A, Prota L, Capunzo M, Ursini MV, Nori SL, Bifulco M.

Inflamm Res. 2018 Apr;67(4):315-326. doi: 10.1007/s00011-017-1123-6. Epub 2017 Dec 11.

18.

Deregulated expression and activity of Farnesyl Diphosphate Synthase (FDPS) in Glioblastoma.

Abate M, Laezza C, Pisanti S, Torelli G, Seneca V, Catapano G, Montella F, Ranieri R, Notarnicola M, Gazzerro P, Bifulco M, Ciaglia E.

Sci Rep. 2017 Oct 26;7(1):14123. doi: 10.1038/s41598-017-14495-6.

19.

N6-isopentenyladenosine dual targeting of AMPK and Rab7 prenylation inhibits melanoma growth through the impairment of autophagic flux.

Ranieri R, Ciaglia E, Amodio G, Picardi P, Proto MC, Gazzerro P, Laezza C, Remondelli P, Bifulco M, Pisanti S.

Cell Death Differ. 2018 Feb;25(2):353-367. doi: 10.1038/cdd.2017.165. Epub 2017 Oct 13.

20.

Inhibition of Wnt/β-Catenin pathway and Histone acetyltransferase activity by Rimonabant: a therapeutic target for colon cancer.

Proto MC, Fiore D, Piscopo C, Franceschelli S, Bizzarro V, Laezza C, Lauro G, Feoli A, Tosco A, Bifulco G, Sbardella G, Bifulco M, Gazzerro P.

Sci Rep. 2017 Sep 15;7(1):11678. doi: 10.1038/s41598-017-11688-x.

21.

Recognition by natural killer cells of N6-isopentenyladenosine-treated human glioma cell lines.

Ciaglia E, Laezza C, Abate M, Pisanti S, Ranieri R, D'alessandro A, Picardi P, Gazzerro P, Bifulco M.

Int J Cancer. 2018 Jan 1;142(1):176-190. doi: 10.1002/ijc.31036. Epub 2017 Sep 21.

22.

Impact of drought on human health.

Bifulco M, Ranieri R.

Eur J Intern Med. 2017 Dec;46:e9-e10. doi: 10.1016/j.ejim.2017.08.009. Epub 2017 Aug 12. No abstract available.

PMID:
28807484
23.

Immuno-Modulatory and Anti-Inflammatory Effects of Dihydrogracilin A, a Terpene Derived from the Marine Sponge Dendrilla membranosa.

Ciaglia E, Malfitano AM, Laezza C, Fontana A, Nuzzo G, Cutignano A, Abate M, Pelin M, Sosa S, Bifulco M, Gazzerro P.

Int J Mol Sci. 2017 Jul 28;18(8). pii: E1643. doi: 10.3390/ijms18081643.

24.

Remembering Professor Gaetano "Nino" Salvatore.

Bifulco M.

Endocrine. 2018 Jul;61(1):173-174. doi: 10.1007/s12020-017-1376-4. Epub 2017 Aug 7. No abstract available.

PMID:
28786075
25.

The mystery of longevity in Cilento: a mix of a good dose of genetic predisposition and a balanced diet based on the Mediterranean model.

Bifulco M, Pisanti S.

Eur J Clin Nutr. 2017 Aug;71(8):1020-1021. doi: 10.1038/ejcn.2017.91. Epub 2017 May 31. No abstract available.

PMID:
28561040
26.

The isoprenoid derivative N6 -benzyladenosine CM223 exerts antitumor effects in glioma patient-derived primary cells through the mevalonate pathway.

Ciaglia E, Grimaldi M, Abate M, Scrima M, Rodriquez M, Laezza C, Ranieri R, Pisanti S, Ciuffreda P, Manera C, Gazzerro P, D'Ursi AM, Bifulco M.

Br J Pharmacol. 2017 Jul;174(14):2287-2301. doi: 10.1111/bph.13824. Epub 2017 Jun 11.

27.

Cannabidiol: State of the art and new challenges for therapeutic applications.

Pisanti S, Malfitano AM, Ciaglia E, Lamberti A, Ranieri R, Cuomo G, Abate M, Faggiana G, Proto MC, Fiore D, Laezza C, Bifulco M.

Pharmacol Ther. 2017 Jul;175:133-150. doi: 10.1016/j.pharmthera.2017.02.041. Epub 2017 Feb 22. Review.

PMID:
28232276
28.

Immunomodulatory properties of 1,2-dihydro-4-hydroxy-2-oxo-1,8-naphthyridine-3-carboxamide derivative VL15.

Malfitano AM, Laezza C, Bertini S, Marasco D, Tuccinardi T, Bifulco M, Manera C.

Biochimie. 2017 Apr;135:173-180. doi: 10.1016/j.biochi.2017.02.009. Epub 2017 Feb 20.

PMID:
28219703
29.

The complex interplay among hepatocytes and immune cells at the crossroad between inflammation and cholesterol metabolism in hyperglycemia.

Bifulco M, Pisanti S, Ciaglia E.

Endocrine. 2017 Oct;58(1):21-23. doi: 10.1007/s12020-017-1254-0. Epub 2017 Feb 8. Review.

PMID:
28181143
30.

Modern History of Medical Cannabis: From Widespread Use to Prohibitionism and Back.

Pisanti S, Bifulco M.

Trends Pharmacol Sci. 2017 Mar;38(3):195-198. doi: 10.1016/j.tips.2016.12.002. Epub 2017 Jan 14. No abstract available.

PMID:
28095988
31.

Updates on "adiponcosis": More new incoming evidence strengthening the obesity-cancer link.

Bifulco M, Ciaglia E.

Eur J Intern Med. 2017 Jun;41:e19-e20. doi: 10.1016/j.ejim.2016.12.016. Epub 2016 Dec 27. No abstract available.

PMID:
28038825
32.

Statins for inflammatory bowel disease: Can off-label drug help it?

Bifulco M, Ciaglia E.

Eur J Intern Med. 2017 Mar;38:e23. doi: 10.1016/j.ejim.2016.11.008. Epub 2016 Nov 14. No abstract available.

PMID:
27856092
33.

Brain cancer risk: the weight of obesity.

Bifulco M, Ranieri R, Ciaglia E.

J Neurooncol. 2017 Jan;131(2):421-422. doi: 10.1007/s11060-016-2315-6. Epub 2016 Nov 9. No abstract available.

PMID:
27830478
34.

Antiglioma effects of N6-isopentenyladenosine, an endogenous isoprenoid end product, through the downregulation of epidermal growth factor receptor.

Ciaglia E, Abate M, Laezza C, Pisanti S, Vitale M, Seneca V, Torelli G, Franceschelli S, Catapano G, Gazzerro P, Bifulco M.

Int J Cancer. 2017 Feb 15;140(4):959-972. doi: 10.1002/ijc.30505. Epub 2016 Nov 16.

35.

Dental care and dentistry practice in the Medieval Medical School of Salerno.

Bifulco M, Amato M, Gangemi G, Marasco M, Caggiano M, Amato A, Pisanti S.

Br Dent J. 2016 Jul 22;221(2):87-9. doi: 10.1038/sj.bdj.2016.528.

PMID:
27444600
36.

Endocannabinoid System in Neurological Disorders.

Ranieri R, Laezza C, Bifulco M, Marasco D, Malfitano AM.

Recent Pat CNS Drug Discov. 2016;10(2):90-112. Review.

PMID:
27364363
37.

Cannabimimetic Drugs: Recent Patents in Central Nervous System Disorders.

Ranieri R, Marasco D, Bifulco M, Malfitano AM.

Recent Pat CNS Drug Discov. 2016 Jun 19. [Epub ahead of print]

PMID:
27334611
38.

Cannabinoids and Neuro-Inflammation: Regulation of Brain Immune Response.

Ranieri R, Laezza C, Bifulco M, Marasco D, Malfitano AM.

Recent Pat CNS Drug Discov. 2016;10(2):178-203. Review.

PMID:
27334610
39.

Phytocannabinoids and Cannabimimetic Drugs: Recent Patents in Central Nervous System Disorders.

Ranieri R, Marasco D, Bifulco M, Malfitano AM.

Recent Pat CNS Drug Discov. 2016;10(2):157-177. Review.

PMID:
27184693
40.

Immuno-Modulatory Properties of a Quinolin-2-(1H)-on-3-Carboxamide Derivative: Relevance in Multiple Sclerosis.

Malfitano AM, Laezza C, Pisanti S, Manera C, Bifulco M.

Recent Pat CNS Drug Discov. 2016;10(2):113-121.

PMID:
27097974
41.

Molecular mechanisms responsible for neuroinflammation and neurological impairments in mevalonate kinase deficiency.

Bifulco M.

Mol Genet Metab Rep. 2015 Apr 2;3:42. doi: 10.1016/j.ymgmr.2015.03.006. eCollection 2015 Jun. No abstract available.

42.

Drug screening on Hutchinson Gilford progeria pluripotent stem cells reveals aminopyrimidines as new modulators of farnesylation.

Blondel S, Egesipe AL, Picardi P, Jaskowiak AL, Notarnicola M, Ragot J, Tournois J, Le Corf A, Brinon B, Poydenot P, Georges P, Navarro C, Pitrez PR, Ferreira L, Bollot G, Bauvais C, Laustriat D, Mejat A, De Sandre-Giovannoli A, Levy N, Bifulco M, Peschanski M, Nissan X.

Cell Death Dis. 2016 Feb 18;7:e2105. doi: 10.1038/cddis.2015.374.

43.

The new task for medical scientists.

Bifulco M.

Eur J Intern Med. 2016 Apr;29:e21. doi: 10.1016/j.ejim.2015.12.005. Epub 2016 Jan 5. No abstract available.

PMID:
26777105
44.

Breast adiponcosis: a call for further research.

Bifulco M, Malfitano AM.

Endocrine. 2017 Jan;55(1):326-327. doi: 10.1007/s12020-015-0839-8. Epub 2016 Jan 4. No abstract available.

PMID:
26725314
45.

p53 regulates the mevalonate pathway in human glioblastoma multiforme.

Laezza C, D'Alessandro A, Di Croce L, Picardi P, Ciaglia E, Pisanti S, Malfitano AM, Comegna M, Faraonio R, Gazzerro P, Bifulco M.

Cell Death Dis. 2015 Oct 15;6:e1909. doi: 10.1038/cddis.2015.279.

46.

Statin reduces orbitopathy risk in patients with Graves' disease by modulating apoptosis and autophagy activities.

Bifulco M, Ciaglia E.

Endocrine. 2016 Sep;53(3):649-50. doi: 10.1007/s12020-015-0762-z. Epub 2015 Oct 5.

PMID:
26438397
47.

Antitumor effect of pyrrolo-1,5-benzoxazepine-15 and its synergistic effect with Oxaliplatin and 5-FU in colorectal cancer cells.

Fiore D, Proto MC, Pisanti S, Picardi P, Pagano Zottola AC, Butini S, Gemma S, Casagni A, Laezza C, Vitale M, Ligresti A, Di Marzo V, Zisterer DM, Nathwani S, Williams DC, Campiani G, Gazzerro P, Bifulco M.

Cancer Biol Ther. 2016 Aug 2;17(8):849-58. doi: 10.1080/15384047.2015.1078028.

48.

How does the Mediterranean diet decrease the risk of a variety of cancers?

Bifulco M.

Eur J Clin Nutr. 2015 Dec;69(12):1372. doi: 10.1038/ejcn.2015.142. Epub 2015 Sep 16. No abstract available.

PMID:
26373965
49.

Lung and Nodal Involvement in Nontuberculous Mycobacterial Disease: PET/CT Role.

Del Giudice G, Bianco A, Cennamo A, Santoro G, Bifulco M, Marzo C, Mazzarella G.

Biomed Res Int. 2015;2015:353202. doi: 10.1155/2015/353202. Epub 2015 May 28.

50.

Mediterranean diet: the missing link between gut microbiota and inflammatory diseases.

Bifulco M.

Eur J Clin Nutr. 2015 Sep;69(9):1078. doi: 10.1038/ejcn.2015.81. Epub 2015 May 27. No abstract available.

PMID:
26014263

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