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Items: 1 to 50 of 85

1.

Modulating eIF6 levels unveils the role of translation in ecdysone biosynthesis during Drosophila development.

Russo A, Gatti G, Alfieri R, Pesce E, Soanes K, Ricciardi S, Mancino M, Cheroni C, Vaccari T, Biffo S, Calamita P.

Dev Biol. 2019 Nov 1;455(1):100-111. doi: 10.1016/j.ydbio.2019.05.013. Epub 2019 Jul 5.

2.

Correction for Gallo et al., "RACK1 Specifically Regulates Translation through Its Binding to Ribosomes".

Gallo S, Ricciardi S, Manfrini N, Pesce E, Oliveto S, Calamita P, Mancino M, Maffioli E, Moro M, Crosti M, Berno V, Bombaci M, Tedeschi G, Biffo S.

Mol Cell Biol. 2019 Jan 16;39(3). pii: e00544-18. doi: 10.1128/MCB.00544-18. Print 2019 Feb 1. No abstract available.

3.

The Translational Machinery of Human CD4+ T Cells Is Poised for Activation and Controls the Switch from Quiescence to Metabolic Remodeling.

Ricciardi S, Manfrini N, Alfieri R, Calamita P, Crosti MC, Gallo S, Müller R, Pagani M, Abrignani S, Biffo S.

Cell Metab. 2018 Dec 4;28(6):961. doi: 10.1016/j.cmet.2018.09.010. No abstract available.

4.

Translating the Game: Ribosomes as Active Players.

Calamita P, Gatti G, Miluzio A, Scagliola A, Biffo S.

Front Genet. 2018 Nov 15;9:533. doi: 10.3389/fgene.2018.00533. eCollection 2018. Review.

5.

RACK1 Specifically Regulates Translation through Its Binding to Ribosomes.

Gallo S, Ricciardi S, Manfrini N, Pesce E, Oliveto S, Calamita P, Mancino M, Maffioli E, Moro M, Crosti M, Berno V, Bombaci M, Tedeschi G, Biffo S.

Mol Cell Biol. 2018 Nov 13;38(23). pii: e00230-18. doi: 10.1128/MCB.00230-18. Print 2018 Dec 1. Erratum in: Mol Cell Biol. 2019 Jan 16;39(3):.

6.

The Translational Machinery of Human CD4+ T Cells Is Poised for Activation and Controls the Switch from Quiescence to Metabolic Remodeling.

Ricciardi S, Manfrini N, Alfieri R, Calamita P, Crosti MC, Gallo S, Müller R, Pagani M, Abrignani S, Biffo S.

Cell Metab. 2018 Dec 4;28(6):895-906.e5. doi: 10.1016/j.cmet.2018.08.009. Epub 2018 Sep 6. Erratum in: Cell Metab. 2018 Dec 4;28(6):961.

7.

A Polysome-Based microRNA Screen Identifies miR-24-3p as a Novel Promigratory miRNA in Mesothelioma.

Oliveto S, Alfieri R, Miluzio A, Scagliola A, Secli RS, Gasparini P, Grosso S, Cascione L, Mutti L, Biffo S.

Cancer Res. 2018 Oct 15;78(20):5741-5753. doi: 10.1158/0008-5472.CAN-18-0655. Epub 2018 Aug 2.

8.

A Mad2-Mediated Translational Regulatory Mechanism Promoting S-Phase Cyclin Synthesis Controls Origin Firing and Survival to Replication Stress.

Gay S, Piccini D, Bruhn C, Ricciardi S, Soffientini P, Carotenuto W, Biffo S, Foiani M.

Mol Cell. 2018 May 17;70(4):628-638.e5. doi: 10.1016/j.molcel.2018.04.020.

9.

Crosstalks between translation and metabolism in cancer.

Biffo S, Manfrini N, Ricciardi S.

Curr Opin Genet Dev. 2018 Feb;48:75-81. doi: 10.1016/j.gde.2017.10.011. Epub 2017 Nov 15. Review.

PMID:
29153483
10.

The Role of Eif6 in Skeletal Muscle Homeostasis Revealed by Endurance Training Co-expression Networks.

Clarke K, Ricciardi S, Pearson T, Bharudin I, Davidsen PK, Bonomo M, Brina D, Scagliola A, Simpson DM, Beynon RJ, Khanim F, Ankers J, Sarzynski MA, Ghosh S, Pisconti A, Rozman J, Hrabe de Angelis M, Bunce C, Stewart C, Egginton S, Caddick M, Jackson M, Bouchard C, Biffo S, Falciani F.

Cell Rep. 2017 Nov 7;21(6):1507-1520. doi: 10.1016/j.celrep.2017.10.040.

11.

Data on the effects of eIF6 downmodulation on the proportions of innate and adaptive immune system cell subpopulations and on thymocyte maturation.

Manfrini N, Ricciardi S, Miluzio A, Fedeli M, Scagliola A, Gallo S, Adler T, Busch DH, Gailus-Durner V, Fuchs H, de Angelis MH, Biffo S.

Data Brief. 2017 Aug 30;14:653-658. doi: 10.1016/j.dib.2017.08.023. eCollection 2017 Oct.

12.

High levels of eukaryotic Initiation Factor 6 (eIF6) are required for immune system homeostasis and for steering the glycolytic flux of TCR-stimulated CD4+ T cells in both mice and humans.

Manfrini N, Ricciardi S, Miluzio A, Fedeli M, Scagliola A, Gallo S, Brina D, Adler T, Busch DH, Gailus-Durner V, Fuchs H, Hrabě de Angelis M, Biffo S.

Dev Comp Immunol. 2017 Dec;77:69-76. doi: 10.1016/j.dci.2017.07.022. Epub 2017 Jul 22.

PMID:
28743432
13.

Eukaryotic initiation factor eIF6 modulates the expression of Kermit 2/XGIPC in IGF- regulated eye development.

De Marco N, Tussellino M, Carotenuto R, Ronca R, Rizzolio S, Biffo S, Campanella C.

Dev Biol. 2017 Jul 1;427(1):148-154. doi: 10.1016/j.ydbio.2017.04.017. Epub 2017 May 1.

14.

Role of microRNAs in translation regulation and cancer.

Oliveto S, Mancino M, Manfrini N, Biffo S.

World J Biol Chem. 2017 Feb 26;8(1):45-56. doi: 10.4331/wjbc.v8.i1.45. Review.

15.

SBDS-Deficient Cells Have an Altered Homeostatic Equilibrium due to Translational Inefficiency Which Explains their Reduced Fitness and Provides a Logical Framework for Intervention.

Calamita P, Miluzio A, Russo A, Pesce E, Ricciardi S, Khanim F, Cheroni C, Alfieri R, Mancino M, Gorrini C, Rossetti G, Peluso I, Pagani M, Medina DL, Rommens J, Biffo S.

PLoS Genet. 2017 Jan 5;13(1):e1006552. doi: 10.1371/journal.pgen.1006552. eCollection 2017 Jan.

16.

Human macrophage ferroportin biology and the basis for the ferroportin disease.

Sabelli M, Montosi G, Garuti C, Caleffi A, Oliveto S, Biffo S, Pietrangelo A.

Hepatology. 2017 May;65(5):1512-1525. doi: 10.1002/hep.29007. Epub 2017 Mar 22.

17.

Translational control by mTOR-independent routes: how eIF6 organizes metabolism.

Miluzio A, Ricciardi S, Manfrini N, Alfieri R, Oliveto S, Brina D, Biffo S.

Biochem Soc Trans. 2016 Dec 15;44(6):1667-1673.

PMID:
27913676
18.

mTORC1-mediated inhibition of polycystin-1 expression drives renal cyst formation in tuberous sclerosis complex.

Pema M, Drusian L, Chiaravalli M, Castelli M, Yao Q, Ricciardi S, Somlo S, Qian F, Biffo S, Boletta A.

Nat Commun. 2016 Mar 2;7:10786. doi: 10.1038/ncomms10786.

19.

Direct and high throughput (HT) interactions on the ribosomal surface by iRIA.

Pesce E, Minici C, Baβler J, Hurt E, Degano M, Calamita P, Biffo S.

Sci Rep. 2015 Oct 21;5:15401. doi: 10.1038/srep15401.

20.

Expression and activity of eIF6 trigger malignant pleural mesothelioma growth in vivo.

Miluzio A, Oliveto S, Pesce E, Mutti L, Murer B, Grosso S, Ricciardi S, Brina D, Biffo S.

Oncotarget. 2015 Nov 10;6(35):37471-85. doi: 10.18632/oncotarget.5462.

21.

Eukaryotic translation initiation factor 6 is a novel regulator of reactive oxygen species-dependent megakaryocyte maturation.

Ricciardi S, Miluzio A, Brina D, Clarke K, Bonomo M, Aiolfi R, Guidotti LG, Falciani F, Biffo S.

J Thromb Haemost. 2015 Nov;13(11):2108-18. doi: 10.1111/jth.13150. Epub 2015 Oct 23.

22.

eIF6 coordinates insulin sensitivity and lipid metabolism by coupling translation to transcription.

Brina D, Miluzio A, Ricciardi S, Clarke K, Davidsen PK, Viero G, Tebaldi T, Offenhäuser N, Rozman J, Rathkolb B, Neschen S, Klingenspor M, Wolf E, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Quattrone A, Falciani F, Biffo S.

Nat Commun. 2015 Sep 18;6:8261. doi: 10.1038/ncomms9261.

23.

The ribonuclease DIS3 promotes let-7 miRNA maturation by degrading the pluripotency factor LIN28B mRNA.

Segalla S, Pivetti S, Todoerti K, Chudzik MA, Giuliani EC, Lazzaro F, Volta V, Lazarevic D, Musco G, Muzi-Falconi M, Neri A, Biffo S, Tonon G.

Nucleic Acids Res. 2015 May 26;43(10):5182-93. doi: 10.1093/nar/gkv387. Epub 2015 Apr 29.

24.

eIF6 anti-association activity is required for ribosome biogenesis, translational control and tumor progression.

Brina D, Miluzio A, Ricciardi S, Biffo S.

Biochim Biophys Acta. 2015 Jul;1849(7):830-5. doi: 10.1016/j.bbagrm.2014.09.010. Epub 2014 Sep 22. Review.

PMID:
25252159
25.

Cytoskeletal proteins associate with components of the ribosomal maturation and translation apparatus in Xenopus stage I oocytes.

Chierchia L, Tussellino M, Guarino D, Carotenuto R, DeMarco N, Campanella C, Biffo S, Vaccaro MC.

Zygote. 2015 Oct;23(5):669-82. doi: 10.1017/S0967199414000409. Epub 2014 Sep 17.

PMID:
25230050
26.

Translation factors and ribosomal proteins control tumor onset and progression: how?

Loreni F, Mancino M, Biffo S.

Oncogene. 2014 Apr 24;33(17):2145-56. doi: 10.1038/onc.2013.153. Epub 2013 May 6. Review.

PMID:
23644661
27.

Preclinical demonstration of synergistic Active Nutrients/Drug (AND) combination as a potential treatment for malignant pleural mesothelioma.

Volta V, Ranzato E, Martinotti S, Gallo S, Russo MV, Mutti L, Biffo S, Burlando B.

PLoS One. 2013;8(3):e58051. doi: 10.1371/journal.pone.0058051. Epub 2013 Mar 6.

28.

Cap dependent translation contributes to resistance of myeloma cells to bortezomib.

Mancino M, Grosso S, Terragna C, Borsi E, Cavo M, Biffo S.

Translation (Austin). 2013 Nov 18;1(2):e27245. doi: 10.4161/trla.27245. eCollection 2013.

29.

RACK1 depletion in a mouse model causes lethality, pigmentation deficits and reduction in protein synthesis efficiency.

Volta V, Beugnet A, Gallo S, Magri L, Brina D, Pesce E, Calamita P, Sanvito F, Biffo S.

Cell Mol Life Sci. 2013 Apr;70(8):1439-50. doi: 10.1007/s00018-012-1215-y. Epub 2012 Dec 2.

PMID:
23212600
30.

Long non-coding antisense RNA controls Uchl1 translation through an embedded SINEB2 repeat.

Carrieri C, Cimatti L, Biagioli M, Beugnet A, Zucchelli S, Fedele S, Pesce E, Ferrer I, Collavin L, Santoro C, Forrest AR, Carninci P, Biffo S, Stupka E, Gustincich S.

Nature. 2012 Nov 15;491(7424):454-7. doi: 10.1038/nature11508. Epub 2012 Oct 14.

PMID:
23064229
31.

Epigallocatechin-3-gallate induces mesothelioma cell death via H2 O2 -dependent T-type Ca2+ channel opening.

Ranzato E, Martinotti S, Magnelli V, Murer B, Biffo S, Mutti L, Burlando B.

J Cell Mol Med. 2012 Nov;16(11):2667-78. doi: 10.1111/j.1582-4934.2012.01584.x.

32.

Growth defects and impaired cognitive-behavioral abilities in mice with knockout for Eif4h, a gene located in the mouse homolog of the Williams-Beuren syndrome critical region.

Capossela S, Muzio L, Bertolo A, Bianchi V, Dati G, Chaabane L, Godi C, Politi LS, Biffo S, D'Adamo P, Mallamaci A, Pannese M.

Am J Pathol. 2012 Mar;180(3):1121-35. doi: 10.1016/j.ajpath.2011.12.008. Epub 2012 Jan 9.

PMID:
22234171
33.

Sensitivity of global translation to mTOR inhibition in REN cells depends on the equilibrium between eIF4E and 4E-BP1.

Grosso S, Pesce E, Brina D, Beugnet A, Loreni F, Biffo S.

PLoS One. 2011;6(12):e29136. doi: 10.1371/journal.pone.0029136. Epub 2011 Dec 22.

34.

Translational control by 80S formation and 60S availability: the central role of eIF6, a rate limiting factor in cell cycle progression and tumorigenesis.

Brina D, Grosso S, Miluzio A, Biffo S.

Cell Cycle. 2011 Oct 15;10(20):3441-6. doi: 10.4161/cc.10.20.17796. Epub 2011 Oct 15. Review.

PMID:
22031223
35.

Impairment of cytoplasmic eIF6 activity restricts lymphomagenesis and tumor progression without affecting normal growth.

Miluzio A, Beugnet A, Grosso S, Brina D, Mancino M, Campaner S, Amati B, de Marco A, Biffo S.

Cancer Cell. 2011 Jun 14;19(6):765-75. doi: 10.1016/j.ccr.2011.04.018.

36.

Reduced AKT/mTOR signaling and protein synthesis dysregulation in a Rett syndrome animal model.

Ricciardi S, Boggio EM, Grosso S, Lonetti G, Forlani G, Stefanelli G, Calcagno E, Morello N, Landsberger N, Biffo S, Pizzorusso T, Giustetto M, Broccoli V.

Hum Mol Genet. 2011 Mar 15;20(6):1182-96. doi: 10.1093/hmg/ddq563. Epub 2011 Jan 6.

PMID:
21212100
37.

Tagging of functional ribosomes in living cells by HaloTag® technology.

Gallo S, Beugnet A, Biffo S.

In Vitro Cell Dev Biol Anim. 2011 Feb;47(2):132-8. doi: 10.1007/s11626-010-9370-7. Epub 2010 Nov 17.

PMID:
21082278
38.

Deregulation of the PI3K and KRAS signaling pathways in human cancer cells determines their response to everolimus.

Di Nicolantonio F, Arena S, Tabernero J, Grosso S, Molinari F, Macarulla T, Russo M, Cancelliere C, Zecchin D, Mazzucchelli L, Sasazuki T, Shirasawa S, Geuna M, Frattini M, Baselga J, Gallicchio M, Biffo S, Bardelli A.

J Clin Invest. 2010 Aug;120(8):2858-66. doi: 10.1172/JCI37539. Epub 2010 Jul 26.

39.

JNK inhibition arrests cotranslational degradation.

Gandin V, Brina D, Marchisio PC, Biffo S.

Biochim Biophys Acta. 2010 Jul;1803(7):826-31. doi: 10.1016/j.bbamcr.2010.03.016. Epub 2010 Mar 30.

40.

Selective ascorbate toxicity in malignant mesothelioma: a redox Trojan mechanism.

Ranzato E, Biffo S, Burlando B.

Am J Respir Cell Mol Biol. 2011 Jan;44(1):108-17. doi: 10.1165/rcmb.2009-0340OC. Epub 2010 Mar 4.

PMID:
20203294
41.

p27(BBP)/eIF6 acts as an anti-apoptotic factor upstream of Bcl-2 during Xenopus laevis development.

De Marco N, Iannone L, Carotenuto R, Biffo S, Vitale A, Campanella C.

Cell Death Differ. 2010 Feb;17(2):360-72. doi: 10.1038/cdd.2009.128. Epub 2009 Sep 25.

42.

Spreading of mesothelioma cells is rapamycin-sensitive and requires continuing translation.

Ranzato E, Grosso S, Patrone M, Betta PG, Viarengo A, Biffo S.

J Cell Biochem. 2009 Nov 1;108(4):867-76. doi: 10.1002/jcb.22316.

PMID:
19718660
43.

Eukaryotic initiation factor 6 mediates a continuum between 60S ribosome biogenesis and translation.

Miluzio A, Beugnet A, Volta V, Biffo S.

EMBO Rep. 2009 May;10(5):459-65. doi: 10.1038/embor.2009.70. Epub 2009 Apr 17. Review.

44.

Eukaryotic initiation factor 6 is rate-limiting in translation, growth and transformation.

Gandin V, Miluzio A, Barbieri AM, Beugnet A, Kiyokawa H, Marchisio PC, Biffo S.

Nature. 2008 Oct 2;455(7213):684-8. doi: 10.1038/nature07267. Epub 2008 Sep 10.

45.

Eukaryotic ribosomes host PKC activity.

Grosso S, Volta V, Vietri M, Gorrini C, Marchisio PC, Biffo S.

Biochem Biophys Res Commun. 2008 Nov 7;376(1):65-9. doi: 10.1016/j.bbrc.2008.08.118. Epub 2008 Sep 1.

PMID:
18768137
46.

PKCbetaII modulates translation independently from mTOR and through RACK1.

Grosso S, Volta V, Sala LA, Vietri M, Marchisio PC, Ron D, Biffo S.

Biochem J. 2008 Oct 1;415(1):77-85. doi: 10.1042/BJ20080463.

PMID:
18557705
47.

Eukaryotic initiation factor 6 selectively regulates Wnt signaling and beta-catenin protein synthesis.

Ji Y, Shah S, Soanes K, Islam MN, Hoxter B, Biffo S, Heslip T, Byers S.

Oncogene. 2008 Jan 31;27(6):755-62. Epub 2007 Jul 30.

PMID:
17667944
48.

MicroRNA inhibition of translation initiation in vitro by targeting the cap-binding complex eIF4F.

Mathonnet G, Fabian MR, Svitkin YV, Parsyan A, Huck L, Murata T, Biffo S, Merrick WC, Darzynkiewicz E, Pillai RS, Filipowicz W, Duchaine TF, Sonenberg N.

Science. 2007 Sep 21;317(5845):1764-7. Epub 2007 Jul 26.

49.

Nuclear myosin VI enhances RNA polymerase II-dependent transcription.

Vreugde S, Ferrai C, Miluzio A, Hauben E, Marchisio PC, Crippa MP, Bussi M, Biffo S.

Mol Cell. 2006 Sep 1;23(5):749-55.

50.

GABP complex regulates transcription of eIF6 (p27BBP), an essential trans-acting factor in ribosome biogenesis.

Donadini A, Giacopelli F, Ravazzolo R, Gandin V, Marchisio PC, Biffo S.

FEBS Lett. 2006 Apr 3;580(8):1983-7. Epub 2006 Mar 6.

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