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Items: 37


Acquisition of a hybrid E/M state is essential for tumorigenicity of basal breast cancer cells.

Kröger C, Afeyan A, Mraz J, Eaton EN, Reinhardt F, Khodor YL, Thiru P, Bierie B, Ye X, Burge CB, Weinberg RA.

Proc Natl Acad Sci U S A. 2019 Apr 9;116(15):7353-7362. doi: 10.1073/pnas.1812876116. Epub 2019 Mar 25. Erratum in: Proc Natl Acad Sci U S A. 2019 Jun 4;116(23):11553-11554.


Recovering Gene Interactions from Single-Cell Data Using Data Diffusion.

van Dijk D, Sharma R, Nainys J, Yim K, Kathail P, Carr AJ, Burdziak C, Moon KR, Chaffer CL, Pattabiraman D, Bierie B, Mazutis L, Wolf G, Krishnaswamy S, Pe'er D.

Cell. 2018 Jul 26;174(3):716-729.e27. doi: 10.1016/j.cell.2018.05.061. Epub 2018 Jun 28.


The systemic response to surgery triggers the outgrowth of distant immune-controlled tumors in mouse models of dormancy.

Krall JA, Reinhardt F, Mercury OA, Pattabiraman DR, Brooks MW, Dougan M, Lambert AW, Bierie B, Ploegh HL, Dougan SK, Weinberg RA.

Sci Transl Med. 2018 Apr 11;10(436). pii: eaan3464. doi: 10.1126/scitranslmed.aan3464.


Predicting the response to CTLA-4 blockade by longitudinal noninvasive monitoring of CD8 T cells.

Rashidian M, Ingram JR, Dougan M, Dongre A, Whang KA, LeGall C, Cragnolini JJ, Bierie B, Gostissa M, Gorman J, Grotenbreg GM, Bhan A, Weinberg RA, Ploegh HL.

J Exp Med. 2017 Aug 7;214(8):2243-2255. doi: 10.1084/jem.20161950. Epub 2017 Jun 30.


LACTB is a tumour suppressor that modulates lipid metabolism and cell state.

Keckesova Z, Donaher JL, De Cock J, Freinkman E, Lingrell S, Bachovchin DA, Bierie B, Tischler V, Noske A, Okondo MC, Reinhardt F, Thiru P, Golub TR, Vance JE, Weinberg RA.

Nature. 2017 Mar 30;543(7647):681-686. doi: 10.1038/nature21408. Epub 2017 Mar 22.


Integrin-β4 identifies cancer stem cell-enriched populations of partially mesenchymal carcinoma cells.

Bierie B, Pierce SE, Kroeger C, Stover DG, Pattabiraman DR, Thiru P, Liu Donaher J, Reinhardt F, Chaffer CL, Keckesova Z, Weinberg RA.

Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):E2337-E2346. doi: 10.1073/pnas.1618298114. Epub 2017 Mar 7.


BRCA1/FANCD2/BRG1-Driven DNA Repair Stabilizes the Differentiation State of Human Mammary Epithelial Cells.

Wang H, Bierie B, Li AG, Pathania S, Toomire K, Dimitrov SD, Liu B, Gelman R, Giobbie-Hurder A, Feunteun J, Polyak K, Livingston DM.

Mol Cell. 2016 Jul 21;63(2):277-292. doi: 10.1016/j.molcel.2016.05.038. Epub 2016 Jun 30.


Activation of PKA leads to mesenchymal-to-epithelial transition and loss of tumor-initiating ability.

Pattabiraman DR, Bierie B, Kober KI, Thiru P, Krall JA, Zill C, Reinhardt F, Tam WL, Weinberg RA.

Science. 2016 Mar 4;351(6277):aad3680. doi: 10.1126/science.aad3680.


Dihydropyrimidine accumulation is required for the epithelial-mesenchymal transition.

Shaul YD, Freinkman E, Comb WC, Cantor JR, Tam WL, Thiru P, Kim D, Kanarek N, Pacold ME, Chen WW, Bierie B, Possemato R, Reinhardt F, Weinberg RA, Yaffe MB, Sabatini DM.

Cell. 2014 Aug 28;158(5):1094-1109. doi: 10.1016/j.cell.2014.07.032.


Protein kinase C α is a central signaling node and therapeutic target for breast cancer stem cells.

Tam WL, Lu H, Buikhuisen J, Soh BS, Lim E, Reinhardt F, Wu ZJ, Krall JA, Bierie B, Guo W, Chen X, Liu XS, Brown M, Lim B, Weinberg RA.

Cancer Cell. 2013 Sep 9;24(3):347-64. doi: 10.1016/j.ccr.2013.08.005.


The role of adipocyte XBP1 in metabolic regulation during lactation.

Gregor MF, Misch ES, Yang L, Hummasti S, Inouye KE, Lee AH, Bierie B, Hotamisligil GS.

Cell Rep. 2013 May 30;3(5):1430-9. doi: 10.1016/j.celrep.2013.03.042. Epub 2013 Apr 25.


p120-catenin is essential for terminal end bud function and mammary morphogenesis.

Kurley SJ, Bierie B, Carnahan RH, Lobdell NA, Davis MA, Hofmann I, Moses HL, Muller WJ, Reynolds AB.

Development. 2012 May;139(10):1754-64. doi: 10.1242/dev.072769. Epub 2012 Mar 29.


Inhibiting Cxcr2 disrupts tumor-stromal interactions and improves survival in a mouse model of pancreatic ductal adenocarcinoma.

Ijichi H, Chytil A, Gorska AE, Aakre ME, Bierie B, Tada M, Mohri D, Miyabayashi K, Asaoka Y, Maeda S, Ikenoue T, Tateishi K, Wright CV, Koike K, Omata M, Moses HL.

J Clin Invest. 2011 Oct;121(10):4106-17. doi: 10.1172/JCI42754. Epub 2011 Sep 19.


Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state.

Chaffer CL, Brueckmann I, Scheel C, Kaestli AJ, Wiggins PA, Rodrigues LO, Brooks M, Reinhardt F, Su Y, Polyak K, Arendt LM, Kuperwasser C, Bierie B, Weinberg RA.

Proc Natl Acad Sci U S A. 2011 May 10;108(19):7950-5. doi: 10.1073/pnas.1102454108. Epub 2011 Apr 15.


Transforming growth factor beta (TGF-beta) and inflammation in cancer.

Bierie B, Moses HL.

Cytokine Growth Factor Rev. 2010 Feb;21(1):49-59. doi: 10.1016/j.cytogfr.2009.11.008. Epub 2009 Dec 16. Review.


Gain or loss of TGFbeta signaling in mammary carcinoma cells can promote metastasis.

Bierie B, Moses HL.

Cell Cycle. 2009 Oct 15;8(20):3319-27. Epub 2009 Oct 4. Review.


Abrogation of TGF-beta signaling enhances chemokine production and correlates with prognosis in human breast cancer.

Bierie B, Chung CH, Parker JS, Stover DG, Cheng N, Chytil A, Aakre M, Shyr Y, Moses HL.

J Clin Invest. 2009 Jun;119(6):1571-82. doi: 10.1172/JCI37480. Epub 2009 May 18.


GFAP-Cre-mediated activation of oncogenic K-ras results in expansion of the subventricular zone and infiltrating glioma.

Abel TW, Clark C, Bierie B, Chytil A, Aakre M, Gorska A, Moses HL.

Mol Cancer Res. 2009 May;7(5):645-53. doi: 10.1158/1541-7786.MCR-08-0477. Epub 2009 May 12.


TGF-beta promotes cell death and suppresses lactation during the second stage of mammary involution.

Bierie B, Gorska AE, Stover DG, Moses HL.

J Cell Physiol. 2009 Apr;219(1):57-68. doi: 10.1002/jcp.21646.


Activation of beta-Catenin in mouse prostate causes HGPIN and continuous prostate growth after castration.

Yu X, Wang Y, Jiang M, Bierie B, Roy-Burman P, Shen MM, Taketo MM, Wills M, Matusik RJ.

Prostate. 2009 Feb 15;69(3):249-62. doi: 10.1002/pros.20877.


Transforming growth factor-beta regulates mammary carcinoma cell survival and interaction with the adjacent microenvironment.

Bierie B, Stover DG, Abel TW, Chytil A, Gorska AE, Aakre M, Forrester E, Yang L, Wagner KU, Moses HL.

Cancer Res. 2008 Mar 15;68(6):1809-19. doi: 10.1158/0008-5472.CAN-07-5597.


A delicate balance: TGF-beta and the tumor microenvironment.

Stover DG, Bierie B, Moses HL.

J Cell Biochem. 2007 Jul 1;101(4):851-61. Review.


Tumour microenvironment: TGFbeta: the molecular Jekyll and Hyde of cancer.

Bierie B, Moses HL.

Nat Rev Cancer. 2006 Jul;6(7):506-20. Review.


Under pressure: stromal fibroblasts change their ways.

Bierie B, Moses HL.

Cell. 2005 Dec 16;123(6):985-7.


Genomic and proteomic analysis of mammary tumors arising in transgenic mice.

Xie L, Xu BJ, Gorska AE, Shyr Y, Schwartz SA, Cheng N, Levy S, Bierie B, Caprioli RM, Moses HL.

J Proteome Res. 2005 Nov-Dec;4(6):2088-98.


TGF-beta and cancer.

Bierie B, Moses HL.

Cytokine Growth Factor Rev. 2006 Feb-Apr;17(1-2):29-40. Epub 2005 Nov 10. Review.


SOCS3 promotes apoptosis of mammary differentiated cells.

Le Provost F, Miyoshi K, Vilotte JL, Bierie B, Robinson GW, Hennighausen L.

Biochem Biophys Res Commun. 2005 Dec 30;338(4):1696-701. Epub 2005 Nov 2.


C/EBPdelta is a crucial regulator of pro-apoptotic gene expression during mammary gland involution.

Thangaraju M, Rudelius M, Bierie B, Raffeld M, Sharan S, Hennighausen L, Huang AM, Sterneck E.

Development. 2005 Nov;132(21):4675-85. Epub 2005 Sep 28.


Mammary gland remodeling depends on gp130 signaling through Stat3 and MAPK.

Zhao L, Hart S, Cheng J, Melenhorst JJ, Bierie B, Ernst M, Stewart C, Schaper F, Heinrich PC, Ullrich A, Robinson GW, Hennighausen L.

J Biol Chem. 2004 Oct 15;279(42):44093-100. Epub 2004 Jul 30.


Biogenesis and function of mouse mammary epithelium depends on the presence of functional alpha-catenin.

Nemade RV, Bierie B, Nozawa M, Bry C, Smith GH, Vasioukhin V, Fuchs E, Hennighausen L.

Mech Dev. 2004 Jan;121(1):91-9.


Identification of genes differentially expressed in mouse mammary epithelium transformed by an activated beta-catenin.

Renou JP, Bierie B, Miyoshi K, Cui Y, Djiane J, Reichenstein M, Shani M, Hennighausen L.

Oncogene. 2003 Jul 17;22(29):4594-610.


Activation of beta-catenin in prostate epithelium induces hyperplasias and squamous transdifferentiation.

Bierie B, Nozawa M, Renou JP, Shillingford JM, Morgan F, Oka T, Taketo MM, Cardiff RD, Miyoshi K, Wagner KU, Robinson GW, Hennighausen L.

Oncogene. 2003 Jun 19;22(25):3875-87.


Proteotyping of mammary tissue from transgenic and gene knockout mice with immunohistochemical markers: a tool to define developmental lesions.

Shillingford JM, Miyoshi K, Robinson GW, Bierie B, Cao Y, Karin M, Hennighausen L.

J Histochem Cytochem. 2003 May;51(5):555-65.


Deletion of Stat3 blocks mammary gland involution and extends functional competence of the secretory epithelium in the absence of lactogenic stimuli.

Humphreys RC, Bierie B, Zhao L, Raz R, Levy D, Hennighausen L.

Endocrinology. 2002 Sep;143(9):3641-50.


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