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Items: 1 to 50 of 249

1.

Urinary liver-type fatty acid binding protein is an independent predictor of stroke and mortality in individuals with type 1 diabetes.

Panduru NM, Forsblom C, Saraheimo M, Thorn LM, Gordin D, Elonen N, Harjusalo V, Bierhaus A, Humpert PM, Groop PH; FinnDiane Study Group.

Diabetologia. 2017 Sep;60(9):1782-1790. doi: 10.1007/s00125-017-4328-x. Epub 2017 Jun 10.

PMID:
28601908
2.

Receptor for Advanced Glycation End Products (RAGE) Serves a Protective Role during Klebsiella pneumoniae - Induced Pneumonia.

Achouiti A, de Vos AF, van 't Veer C, Florquin S, Tanck MW, Nawroth PP, Bierhaus A, van der Poll T, van Zoelen MA.

PLoS One. 2016 Jan 29;11(1):e0141000. doi: 10.1371/journal.pone.0141000. eCollection 2016.

3.

Kidney injury molecule-1 and the loss of kidney function in diabetic nephropathy: a likely causal link in patients with type 1 diabetes.

Panduru NM, Sandholm N, Forsblom C, Saraheimo M, Dahlström EH, Thorn LM, Gordin D, Tolonen N, Wadén J, Harjutsalo V, Bierhaus A, Humpert PM, Groop PH; FinnDiane Study Group.

Diabetes Care. 2015 Jun;38(6):1130-7. doi: 10.2337/dc14-2330. Epub 2015 Mar 17.

PMID:
25784666
4.

Urinary adiponectin is an independent predictor of progression to end-stage renal disease in patients with type 1 diabetes and diabetic nephropathy.

Panduru NM, Saraheimo M, Forsblom C, Thorn LM, Gordin D, Wadén J, Tolonen N, Bierhaus A, Humpert PM, Groop PH; FinnDiane Study Group.

Diabetes Care. 2015 May;38(5):883-90. doi: 10.2337/dc14-2276. Epub 2015 Feb 26.

PMID:
25720601
5.

Role of the receptor for advanced glycation endproducts (RAGE) in retinal vasodegenerative pathology during diabetes in mice.

McVicar CM, Ward M, Colhoun LM, Guduric-Fuchs J, Bierhaus A, Fleming T, Schlotterer A, Kolibabka M, Hammes HP, Chen M, Stitt AW.

Diabetologia. 2015 May;58(5):1129-37. doi: 10.1007/s00125-015-3523-x. Epub 2015 Feb 17.

6.

Methylglyoxal as a new biomarker in patients with septic shock: an observational clinical study.

Brenner T, Fleming T, Uhle F, Silaff S, Schmitt F, Salgado E, Ulrich A, Zimmermann S, Bruckner T, Martin E, Bierhaus A, Nawroth PP, Weigand MA, Hofer S.

Crit Care. 2014 Dec 12;18(6):683. doi: 10.1186/s13054-014-0683-x.

7.

daf-16/FOXO and glod-4/glyoxalase-1 are required for the life-prolonging effect of human insulin under high glucose conditions in Caenorhabditis elegans.

Mendler M, Schlotterer A, Ibrahim Y, Kukudov G, Fleming T, Bierhaus A, Riedinger C, Schwenger V, Herzig S, Hecker M, Tyedmers J, Nawroth PP, Morcos M.

Diabetologia. 2015 Feb;58(2):393-401. doi: 10.1007/s00125-014-3415-5. Epub 2014 Oct 17.

PMID:
25322843
8.

Quinapril treatment abolishes diabetes-associated atherosclerosis in RAGE/apolipoprotein E double knockout mice.

Watson AM, Li J, Samijono D, Bierhaus A, Thomas MC, Jandeleit-Dahm KA, Cooper ME.

Atherosclerosis. 2014 Aug;235(2):444-8. doi: 10.1016/j.atherosclerosis.2014.05.945. Epub 2014 Jun 4.

PMID:
24945577
9.

Effects of stress reduction on cardiovascular risk factors in type 2 diabetes patients with early kidney disease - results of a randomized controlled trial (HEIDIS).

Kopf S, Oikonomou D, Hartmann M, Feier F, Faude-Lang V, Morcos M, Häring HU, Herzog W, Bierhaus A, Humpert PM, Nawroth PP.

Exp Clin Endocrinol Diabetes. 2014 Jun;122(6):341-9. doi: 10.1055/s-0034-1372583. Epub 2014 May 5.

PMID:
24798861
10.

Nε-(carboxymethyl)lysine-receptor for advanced glycation end product axis is a key modulator of obesity-induced dysregulation of adipokine expression and insulin resistance.

Gaens KH, Goossens GH, Niessen PM, van Greevenbroek MM, van der Kallen CJ, Niessen HW, Rensen SS, Buurman WA, Greve JW, Blaak EE, van Zandvoort MA, Bierhaus A, Stehouwer CD, Schalkwijk CG.

Arterioscler Thromb Vasc Biol. 2014 Jun;34(6):1199-208. doi: 10.1161/ATVBAHA.113.302281. Epub 2014 Apr 10.

11.

RAGE regulates immune cell infiltration and angiogenesis in choroidal neovascularization.

Chen M, Glenn JV, Dasari S, McVicar C, Ward M, Colhoun L, Quinn M, Bierhaus A, Xu H, Stitt AW.

PLoS One. 2014 Feb 26;9(2):e89548. doi: 10.1371/journal.pone.0089548. eCollection 2014.

12.

Sp1-dependent regulation of PPARα in bone metabolism.

Duttenhoefer F, Biswas SK, Igwe JC, Sauerbier S, Bierhaus A.

Int J Oral Maxillofac Implants. 2014 Jan-Feb;29(1):e107-16. doi: 10.11607/jomi.te49.

PMID:
24451878
13.

Urinary excretion of high molecular weight adiponectin is an independent predictor of decline of renal function in type 2 diabetes.

Kopf S, Oikonomou D, von Eynatten M, Kieser M, Zdunek D, Hess G, Morcos M, Forsblom C, Bierhaus A, Groop PH, Nawroth PP, Humpert PM.

Acta Diabetol. 2014;51(3):479-89. doi: 10.1007/s00592-013-0542-2. Epub 2013 Dec 24.

PMID:
24366425
14.

Methylglyoxal evokes pain by stimulating TRPA1.

Andersson DA, Gentry C, Light E, Vastani N, Vallortigara J, Bierhaus A, Fleming T, Bevan S.

PLoS One. 2013 Oct 22;8(10):e77986. doi: 10.1371/journal.pone.0077986. eCollection 2013. Erratum in: PLoS One. 2013;8(12). doi:10.1371/annotation/e707d50a-13b3-4cc3-b507-7d8360d8f048.

15.

Urinary n-acetyl-beta-d-glucosaminidase excretion: an indicator of neuropathy in type 2 diabetes.

Kopf S, Oikonomou D, Zdunek D, von Eynatten M, Hess G, Nawroth PP, Bierhaus A, Humpert PM.

Exp Clin Endocrinol Diabetes. 2013 Nov;121(10):601-6. doi: 10.1055/s-0033-1355384. Epub 2013 Sep 20.

PMID:
24057510
16.

Aging-dependent reduction in glyoxalase 1 delays wound healing.

Fleming TH, Theilen TM, Masania J, Wunderle M, Karimi J, Vittas S, Bernauer R, Bierhaus A, Rabbani N, Thornalley PJ, Kroll J, Tyedmers J, Nawrotzki R, Herzig S, Brownlee M, Nawroth PP.

Gerontology. 2013;59(5):427-37. doi: 10.1159/000351628. Epub 2013 Jun 22.

PMID:
23797271
17.

C332C genotype of glyoxalase 1 and its association with late diabetic complications.

Groener JB, Reismann P, Fleming T, Kalscheuer H, Lehnhoff D, Hamann A, Roser P, Bierhaus A, Nawroth PP, Rudofsky G.

Exp Clin Endocrinol Diabetes. 2013 Jul;121(7):436-9. doi: 10.1055/s-0033-1345124. Epub 2013 Jun 17.

PMID:
23775136
18.

CD166/ALCAM mediates proinflammatory effects of S100B in delayed type hypersensitivity.

von Bauer R, Oikonomou D, Sulaj A, Mohammed S, Hotz-Wagenblatt A, Gröne HJ, Arnold B, Falk C, Luethje D, Erhardt A, Stern DM, Bierhaus A, Nawroth PP.

J Immunol. 2013 Jul 1;191(1):369-77. doi: 10.4049/jimmunol.1201864. Epub 2013 May 31.

19.

The receptor for advanced glycation end products is dispensable in a mouse model of oral and esophageal carcinogenesis.

Mark R, Bermejo JL, Bierhaus A, Plinkert PK, Angel P, Hess J.

Histol Histopathol. 2013 Dec;28(12):1585-94. doi: 10.14670/HH-28.1585. Epub 2013 May 28.

PMID:
23712426
20.

RAGE-mediated interstitial fibrosis in neonatal obstructive nephropathy is independent of NF-κB activation.

Gasparitsch M, Arndt AK, Pawlitschek F, Oberle S, Keller U, Kasper M, Bierhaus A, Schaefer F, Weber LT, Lange-Sperandio B.

Kidney Int. 2013 Nov;84(5):911-9. doi: 10.1038/ki.2013.171. Epub 2013 May 15.

21.

Serum soluble receptor for advanced glycation end products (sRAGE) is independently associated with cigarette smoking in non-diabetic healthy subjects.

Biswas SK, Mudi SR, Mollah FH, Bierhaus A, Arslan MI.

Diab Vasc Dis Res. 2013 Jul;10(4):380-2. doi: 10.1177/1479164113479618. Epub 2013 Mar 21.

PMID:
23520177
22.

High mobility group box 1 prolongs inflammation and worsens disease in pneumococcal meningitis.

Höhne C, Wenzel M, Angele B, Hammerschmidt S, Häcker H, Klein M, Bierhaus A, Sperandio M, Pfister HW, Koedel U.

Brain. 2013 Jun;136(Pt 6):1746-59. doi: 10.1093/brain/awt064. Epub 2013 Mar 21.

PMID:
23518713
23.

Receptor for advanced glycation endproducts (RAGE) is a key regulator of oval cell activation and inflammation-associated liver carcinogenesis in mice.

Pusterla T, Nèmeth J, Stein I, Wiechert L, Knigin D, Marhenke S, Longerich T, Kumar V, Arnold B, Vogel A, Bierhaus A, Pikarsky E, Hess J, Angel P.

Hepatology. 2013 Jul;58(1):363-73. doi: 10.1002/hep.26395.

PMID:
23504974
24.

Urinary liver-type fatty acid-binding protein and progression of diabetic nephropathy in type 1 diabetes.

Panduru NM, Forsblom C, Saraheimo M, Thorn L, Bierhaus A, Humpert PM, Groop PH; FinnDiane Study Group.

Diabetes Care. 2013 Jul;36(7):2077-83. doi: 10.2337/dc12-1868. Epub 2013 Feb 1.

25.

Association of reduced glyoxalase 1 activity and painful peripheral diabetic neuropathy in type 1 and 2 diabetes mellitus patients.

Skapare E, Konrade I, Liepinsh E, Strele I, Makrecka M, Bierhaus A, Lejnieks A, Pirags V, Dambrova M.

J Diabetes Complications. 2013 May-Jun;27(3):262-7. doi: 10.1016/j.jdiacomp.2012.12.002. Epub 2013 Jan 23.

PMID:
23351995
26.

HMGB1 is associated with atherosclerotic plaque composition and burden in patients with stable coronary artery disease.

Andrassy M, Volz HC, Maack B, Schuessler A, Gitsioudis G, Hofmann N, Laohachewin D, Wienbrandt AR, Kaya Z, Bierhaus A, Giannitsis E, Katus HA, Korosoglou G.

PLoS One. 2012;7(12):e52081. doi: 10.1371/journal.pone.0052081. Epub 2012 Dec 17. Erratum in: PLoS One. 2014;9(5):e99246. Maack, Bjoern [added].

27.

Targeting activation of specific NF-κB subunits prevents stress-dependent atherothrombotic gene expression.

Djuric Z, Kashif M, Fleming T, Muhammad S, Piel D, von Bauer R, Bea F, Herzig S, Zeier M, Pizzi M, Isermann B, Hecker M, Schwaninger M, Bierhaus A, Nawroth PP.

Mol Med. 2012 Dec 20;18:1375-86. doi: 10.2119/molmed.2012.00282.

28.

Endothelial progenitor cells in regeneration after acute lung injury: do they play a role?

Rafat N, Tönshoff B, Bierhaus A, Beck GC.

Am J Respir Cell Mol Biol. 2013 Apr;48(4):399-405. doi: 10.1165/rcmb.2011-0132TR. Review.

PMID:
23103996
29.

The lectin-like domain of thrombomodulin ameliorates diabetic glomerulopathy via complement inhibition.

Wang H, Vinnikov I, Shahzad K, Bock F, Ranjan S, Wolter J, Kashif M, Oh J, Bierhaus A, Nawroth P, Kirschfink M, Conway EM, Madhusudhan T, Isermann B.

Thromb Haemost. 2012 Dec;108(6):1141-53. doi: 10.1160/TH12-07-0460. Epub 2012 Sep 26.

PMID:
23014597
30.

Cellular infiltrates and NFκB subunit c-Rel signaling in kidney allografts of patients with clinical operational tolerance.

Becker LE, de Oliveira Biazotto F, Conrad H, Schaier M, Kihm LP, Gross-Weissmann ML, Waldherr R, Bierhaus A, Nawroth PP, Zeier M, Morath C.

Transplantation. 2012 Oct 15;94(7):729-37. doi: 10.1097/TP.0b013e31826032be.

PMID:
22955189
31.

RAGE-dependent activation of gene expression of superoxide dismutase and vanins by AGE-rich extracts in mice cardiac tissue and murine cardiac fibroblasts.

Leuner B, Ruhs S, Brömme HJ, Bierhaus A, Sel S, Silber RE, Somoza V, Simm A, Nass N.

Food Funct. 2012 Oct;3(10):1091-8. Epub 2012 Jul 9.

PMID:
22772773
32.

Methylglyoxal activates nociceptors through transient receptor potential channel A1 (TRPA1): a possible mechanism of metabolic neuropathies.

Eberhardt MJ, Filipovic MR, Leffler A, de la Roche J, Kistner K, Fischer MJ, Fleming T, Zimmermann K, Ivanovic-Burmazovic I, Nawroth PP, Bierhaus A, Reeh PW, Sauer SK.

J Biol Chem. 2012 Aug 17;287(34):28291-306. doi: 10.1074/jbc.M111.328674. Epub 2012 Jun 27.

33.

Alagebrium reduces glomerular fibrogenesis and inflammation beyond preventing RAGE activation in diabetic apolipoprotein E knockout mice.

Watson AM, Gray SP, Jiaze L, Soro-Paavonen A, Wong B, Cooper ME, Bierhaus A, Pickering R, Tikellis C, Tsorotes D, Thomas MC, Jandeleit-Dahm KA.

Diabetes. 2012 Aug;61(8):2105-13. doi: 10.2337/db11-1546. Epub 2012 Jun 14.

34.

Receptor for advanced glycation end products is protective during murine tuberculosis.

van Zoelen MA, Wieland CW, van der Windt GJ, Florquin S, Nawroth PP, Bierhaus A, van der Poll T.

Mol Immunol. 2012 Oct;52(3-4):183-9. doi: 10.1016/j.molimm.2012.05.014. Epub 2012 Jun 13.

PMID:
22698798
35.

Identical LDL-cholesterol lowering but non-identical effects on NF-κB activity: High dose simvastatin vs combination therapy with ezetimibe.

Rudofsky G, Reismann P, Groener JB, Djuric Z, Fleming T, Metzner C, Grafe IA, Bierhaus A, Nawroth PP.

Atherosclerosis. 2012 Jul;223(1):190-6. doi: 10.1016/j.atherosclerosis.2012.04.003. Epub 2012 May 7.

PMID:
22633472
36.

L-arginine and asymmetric dimethylarginine are early predictors for survival in septic patients with acute liver failure.

Brenner T, Fleming TH, Rosenhagen C, Krauser U, Mieth M, Bruckner T, Martin E, Nawroth PP, Weigand MA, Bierhaus A, Hofer S.

Mediators Inflamm. 2012;2012:210454. doi: 10.1155/2012/210454. Epub 2012 May 6.

37.

Methylglyoxal modification of Nav1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy.

Bierhaus A, Fleming T, Stoyanov S, Leffler A, Babes A, Neacsu C, Sauer SK, Eberhardt M, Schnölzer M, Lasitschka F, Neuhuber WL, Kichko TI, Konrade I, Elvert R, Mier W, Pirags V, Lukic IK, Morcos M, Dehmer T, Rabbani N, Thornalley PJ, Edelstein D, Nau C, Forbes J, Humpert PM, Schwaninger M, Ziegler D, Stern DM, Cooper ME, Haberkorn U, Brownlee M, Reeh PW, Nawroth PP.

Nat Med. 2012 Jun;18(6):926-33. doi: 10.1038/nm.2750. Erratum in: Nat Med. 2012 Sep;18(9):1445. Lasischka, Felix [corrected to Lasitschka, Felix].

PMID:
22581285
38.

Depletion of the receptor for advanced glycation end products (RAGE) sensitizes towards apoptosis via p53 and p73 posttranslational regulation.

Brune M, Müller M, Melino G, Bierhaus A, Schilling T, Nawroth PP.

Oncogene. 2013 Mar 14;32(11):1460-8. doi: 10.1038/onc.2012.150. Epub 2012 Apr 30.

PMID:
22543586
39.

The Complexity of Sporadic Alzheimer's Disease Pathogenesis: The Role of RAGE as Therapeutic Target to Promote Neuroprotection by Inhibiting Neurovascular Dysfunction.

Perrone L, Sbai O, Nawroth PP, Bierhaus A.

Int J Alzheimers Dis. 2012;2012:734956. doi: 10.1155/2012/734956. Epub 2012 Mar 11.

40.

Rage signalling promotes intestinal tumourigenesis.

Heijmans J, Büller NV, Hoff E, Dihal AA, van der Poll T, van Zoelen MA, Bierhaus A, Biemond I, Hardwick JC, Hommes DW, Muncan V, van den Brink GR.

Oncogene. 2013 Feb 28;32(9):1202-6. doi: 10.1038/onc.2012.119. Epub 2012 Apr 2.

PMID:
22469986
41.

Critical evaluation of mouse models used to study pain and loss of pain perception in diabetic neuropathy.

Bierhaus A, Nawroth PP.

Exp Clin Endocrinol Diabetes. 2012 Apr;120(4):188-90. doi: 10.1055/s-0032-1304567. Epub 2012 Mar 8. Review.

PMID:
22402946
42.

RAGE influences obesity in mice. Effects of the presence of RAGE on weight gain, AGE accumulation, and insulin levels in mice on a high fat diet.

Leuner B, Max M, Thamm K, Kausler C, Yakobus Y, Bierhaus A, Sel S, Hofmann B, Silber RE, Simm A, Nass N.

Z Gerontol Geriatr. 2012 Feb;45(2):102-8. doi: 10.1007/s00391-011-0279-x.

PMID:
22350391
43.

Sustained effects of a mindfulness-based stress-reduction intervention in type 2 diabetic patients: design and first results of a randomized controlled trial (the Heidelberger Diabetes and Stress-study).

Hartmann M, Kopf S, Kircher C, Faude-Lang V, Djuric Z, Augstein F, Friederich HC, Kieser M, Bierhaus A, Humpert PM, Herzog W, Nawroth PP.

Diabetes Care. 2012 May;35(5):945-7. doi: 10.2337/dc11-1343. Epub 2012 Feb 14.

44.

S100A8/A9 aggravates post-ischemic heart failure through activation of RAGE-dependent NF-κB signaling.

Volz HC, Laohachewin D, Seidel C, Lasitschka F, Keilbach K, Wienbrandt AR, Andrassy J, Bierhaus A, Kaya Z, Katus HA, Andrassy M.

Basic Res Cardiol. 2012 Mar;107(2):250. doi: 10.1007/s00395-012-0250-z. Epub 2012 Feb 10.

PMID:
22318783
45.

Is diabetes an acquired disorder of reactive glucose metabolites and their intermediates?

Fleming T, Cuny J, Nawroth G, Djuric Z, Humpert PM, Zeier M, Bierhaus A, Nawroth PP.

Diabetologia. 2012 Apr;55(4):1151-5. doi: 10.1007/s00125-012-2452-1. Epub 2012 Jan 22.

PMID:
22270223
46.

Receptor for advanced glycation endproducts (RAGE) deficiency protects against MPTP toxicity.

Teismann P, Sathe K, Bierhaus A, Leng L, Martin HL, Bucala R, Weigle B, Nawroth PP, Schulz JB.

Neurobiol Aging. 2012 Oct;33(10):2478-90. doi: 10.1016/j.neurobiolaging.2011.12.006. Epub 2012 Jan 9.

47.

Nuclear factor erythroid-derived 2 (Nfe2) regulates JunD DNA-binding activity via acetylation: a novel mechanism regulating trophoblast differentiation.

Kashif M, Hellwig A, Hashemolhosseini S, Kumar V, Bock F, Wang H, Shahzad K, Ranjan S, Wolter J, Madhusudhan T, Bierhaus A, Nawroth P, Isermann B.

J Biol Chem. 2012 Feb 17;287(8):5400-11. doi: 10.1074/jbc.M111.289801. Epub 2011 Dec 15.

48.

Left ventricular diastolic function in type 2 diabetes mellitus is associated with myocardial triglyceride content but not with impaired myocardial perfusion reserve.

Korosoglou G, Humpert PM, Ahrens J, Oikonomou D, Osman NF, Gitsioudis G, Buss SJ, Steen H, Schnackenburg B, Bierhaus A, Nawroth PP, Katus HA.

J Magn Reson Imaging. 2012 Apr;35(4):804-11. doi: 10.1002/jmri.22879. Epub 2011 Nov 8.

PMID:
22068959
49.

RAGE does not contribute to renal injury and damage upon ischemia/reperfusion-induced injury.

Dessing MC, Pulskens WP, Teske GJ, Butter LM, van der Poll T, Yang H, Tracey KJ, Nawroth PP, Bierhaus A, Florquin S, Leemans JC.

J Innate Immun. 2012;4(1):80-5. doi: 10.1159/000334251. Epub 2011 Nov 4.

50.

RAGE and ICAM-1 differentially control leukocyte recruitment during acute inflammation in a stimulus-dependent manner.

Frommhold D, Kamphues A, Dannenberg S, Buschmann K, Zablotskaya V, Tschada R, Lange-Sperandio B, Nawroth PP, Poeschl J, Bierhaus A, Sperandio M.

BMC Immunol. 2011 Oct 4;12:56. doi: 10.1186/1471-2172-12-56.

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