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Rotational symmetry of the structured Chip/LDB-SSDP core module of the Wnt enhanceosome.

Renko M, Fiedler M, Rutherford TJ, Schaefer JV, Plückthun A, Bienz M.

Proc Natl Acad Sci U S A. 2019 Oct 15;116(42):20977-20983. doi: 10.1073/pnas.1912705116. Epub 2019 Sep 30.


Bone Marrow Immunohistochemistry and Flow Cytometry in the Diagnosis of Malignant Hematologic Diseases With Emphasis on Lymphomas: A Comparative Retrospective Study.

Landry M, Bienz MN, Sawan B, Temmar R, Beauregard P, Chaunt F, Lavigne J, Knecht H.

Appl Immunohistochem Mol Morphol. 2019 Jul 8. doi: 10.1097/PAI.0000000000000787. [Epub ahead of print]


Heparin-induced thrombocytopaenia presenting as acute aortic mural thrombosis.

Bienz MJ, Obrocki P, Russell J, Jena R, Mendichovszky IA.

BJR Case Rep. 2018 Oct 5;5(1):20180025. doi: 10.1259/bjrcr.20180025. eCollection 2019 Feb.


Bcl9 and Pygo synergise downstream of Apc to effect intestinal neoplasia in FAP mouse models.

Mieszczanek J, van Tienen LM, Ibrahim AEK, Winton DJ, Bienz M.

Nat Commun. 2019 Feb 13;10(1):724. doi: 10.1038/s41467-018-08164-z.


Low endoscopy bleeding risk in patients with congenital bleeding disorders.

Tomaszewski M, Bienz M, Kherad O, Restellini S, Laflèche T, Barkun A, Warner M, Bessissow T.

Haemophilia. 2019 Mar;25(2):289-295. doi: 10.1111/hae.13691. Epub 2019 Feb 12.


Severe pet-transmitted zoonosis in a patient with a compromised immune system.

Bienz M, Tomaszewski M, McDonald EG.

CMAJ. 2018 Nov 12;190(45):E1332-E1336. doi: 10.1503/cmaj.180720. No abstract available.


Multiprotein complexes governing Wnt signal transduction.

Gammons M, Bienz M.

Curr Opin Cell Biol. 2018 Apr;51:42-49. doi: 10.1016/ Epub 2017 Nov 15. Review.


Wnt-Dependent Inactivation of the Groucho/TLE Co-repressor by the HECT E3 Ubiquitin Ligase Hyd/UBR5.

Flack JE, Mieszczanek J, Novcic N, Bienz M.

Mol Cell. 2017 Jul 20;67(2):181-193.e5. doi: 10.1016/j.molcel.2017.06.009. Epub 2017 Jul 6.


Histone modifications for chromatin dynamics and cellular plasticity.

Kutateladze TG, Gozani O, Bienz M, Ostankovitch M.

J Mol Biol. 2017 Jun 30;429(13):1921-1923. doi: 10.1016/j.jmb.2017.06.001. No abstract available.


Correction: Constitutive scaffolding of multiple Wnt enhanceosome components by Legless/BCL9.

van Tienen LM, Mieszczanek J, Fiedler M, Rutherford T, Bienz M.

Elife. 2017 Mar 30;6. pii: e27150. doi: 10.7554/eLife.27150. No abstract available.


Constitutive scaffolding of multiple Wnt enhanceosome components by Legless/BCL9.

van Tienen LM, Mieszczanek J, Fiedler M, Rutherford TJ, Bienz M.

Elife. 2017 Mar 15;6. pii: e20882. doi: 10.7554/eLife.20882. Erratum in: Elife. 2017 Mar 30;6:.


Essential role of the Dishevelled DEP domain in a Wnt-dependent human-cell-based complementation assay.

Gammons MV, Rutherford TJ, Steinhart Z, Angers S, Bienz M.

J Cell Sci. 2016 Oct 15;129(20):3892-3902.


Erectile function recovery after robotic-assisted radical prostatectomy (RARP): long term exhaustive analysis across all preoperative potency categories.

Alenizi AM, Zorn KC, Bienz M, Rajih E, Hueber PA, Al-Hathal N, Benayoun S, Lebeau T, El-Hakim A.

Can J Urol. 2016 Oct;23(5):8451-8456.


Wnt Signalosome Assembly by DEP Domain Swapping of Dishevelled.

Gammons MV, Renko M, Johnson CM, Rutherford TJ, Bienz M.

Mol Cell. 2016 Oct 6;64(1):92-104. doi: 10.1016/j.molcel.2016.08.026. Epub 2016 Sep 29.


IκB-Kinase-epsilon (IKKε) over-expression promotes the growth of prostate cancer through the C/EBP-β dependent activation of IL-6 gene expression.

Péant B, Gilbert S, Le Page C, Poisson A, L'Ecuyer E, Boudhraa Z, Bienz MN, Delvoye N, Saad F, Mes-Masson AM.

Oncotarget. 2017 Feb 28;8(9):14487-14501. doi: 10.18632/oncotarget.11629.


Disinhibition of the HECT E3 ubiquitin ligase WWP2 by polymerized Dishevelled.

Mund T, Graeb M, Mieszczanek J, Gammons M, Pelham HR, Bienz M.

Open Biol. 2015 Dec;5(12):150185. doi: 10.1098/rsob.150185.


Traitement de l'adénome par vaporisation au laser Greenlight XPS-180W : analyse multicentrique des taux de complications et des résultats fonctionnels à 2ans selon le volume prostatique.

Hueber P, Bienz M, Liberman D, Misrai V, Rutman M, Te A, Chughtai B, Barber N, Emara A, Gonzalez R, Munver R, Zorn K.

Prog Urol. 2014 Nov;24(13):878. doi: 10.1016/j.purol.2014.08.206. Epub 2014 Oct 30. French. No abstract available.


Pregnancy, Primary Aldosteronism, and Adrenal CTNNB1 Mutations.

Teo AE, Garg S, Shaikh LH, Zhou J, Karet Frankl FE, Gurnell M, Happerfield L, Marker A, Bienz M, Azizan EA, Brown MJ.

N Engl J Med. 2015 Oct 8;373(15):1429-36. doi: 10.1056/NEJMoa1504869. Epub 2015 Sep 23.


An ancient Pygo-dependent Wnt enhanceosome integrated by Chip/LDB-SSDP.

Fiedler M, Graeb M, Mieszczanek J, Rutherford TJ, Johnson CM, Bienz M.

Elife. 2015 Aug 27;4. doi: 10.7554/eLife.09073.


Prevalence and risk factors of contralateral extraprostatic extension in men undergoing radical prostatectomy for unilateral disease at biopsy: A global multi-institutional experience.

Bienz M, Hueber PA, Trudeau V, Alenizi AM, Valdivieso R, Alom M, Balbay MD, Canda AE, Mouraviev V, Albala DM, El-Hakim A, Trinh QD, Latour M, Saad F, Zorn KC.

Can Urol Assoc J. 2015 Jul-Aug;9(7-8):E434-8. doi: 10.5489/cuaj.2786.


Factors predicting prolonged operative time for individual surgical steps of robot-assisted radical prostatectomy (RARP): A single surgeon's experience.

Alenizi AM, Valdivieso R, Rajih E, Meskawi M, Toarta C, Bienz M, Azizi M, Hueber PA, Lavigueur-Blouin H, Trudeau V, Trinh QD, El-Hakim A, Zorn KC.

Can Urol Assoc J. 2015 Jul-Aug;9(7-8):E417-22. doi: 10.5489/cuaj.2805.


Management of bone metastases in prostate cancer: a review.

Bienz M, Saad F.

Curr Opin Support Palliat Care. 2015 Sep;9(3):261-7. doi: 10.1097/SPC.0000000000000157. Review.


Uroflow Stop Test and Potency Recovery: A Surrogate for Pelvic Floor Integrity Post Robotic-Assisted Radical Prostatectomy?

Alenizi AM, Bienz M, Rajih E, Alesawi A, Al-Hathal N, Benayoun S, Lebeau T, Zorn KC, El-Hakim A.

Urology. 2015 Oct;86(4):766-71. doi: 10.1016/j.urology.2015.05.041. Epub 2015 Aug 4.


Androgen-deprivation therapy and bone loss in prostate cancer patients: a clinical review.

Bienz M, Saad F.

Bonekey Rep. 2015 Jun 24;4:716. doi: 10.1038/bonekey.2015.85. eCollection 2015. Review.


Microcirculatory response during on-pump versus off-pump coronary artery bypass graft surgery.

Bienz M, Drullinsky D, Stevens LM, Bracco D, Noiseux N.

Perfusion. 2016 Apr;31(3):207-15. doi: 10.1177/0267659115590481. Epub 2015 Jun 19.


Ubiquitination of the Dishevelled DIX domain blocks its head-to-tail polymerization.

Madrzak J, Fiedler M, Johnson CM, Ewan R, Knebel A, Bienz M, Chin JW.

Nat Commun. 2015 Apr 24;6:6718. doi: 10.1038/ncomms7718.


Photoselective Vaporization of the Prostate for Benign Prostatic Hyperplasia Using the 180 Watt System: Multicenter Study of the Impact of Prostate Size on Safety and Outcomes.

Hueber PA, Bienz MN, Valdivieso R, Lavigueur-Blouin H, Misrai V, Rutman M, Te AE, Chughtai B, Barber NJ, Emara AM, Munver R, Trinh QD, Zorn KC.

J Urol. 2015 Aug;194(2):462-9. doi: 10.1016/j.juro.2015.03.113. Epub 2015 Apr 4.


Predictors of early continence following robot-assisted radical prostatectomy.

Lavigueur-Blouin H, Noriega AC, Valdivieso R, Hueber PA, Bienz M, Alhathal N, Latour M, Trinh QD, El-Hakim A, Zorn KC.

Can Urol Assoc J. 2015 Jan-Feb;9(1-2):e93-7. doi: 10.5489/cuaj.2086.


Boosting Wnt activity during colorectal cancer progression through selective hypermethylation of Wnt signaling antagonists.

Silva AL, Dawson SN, Arends MJ, Guttula K, Hall N, Cameron EA, Huang TH, Brenton JD, Tavaré S, Bienz M, Ibrahim AE.

BMC Cancer. 2014 Nov 29;14:891. doi: 10.1186/1471-2407-14-891.


Competitive binding of a benzimidazole to the histone-binding pocket of the Pygo PHD finger.

Miller TC, Rutherford TJ, Birchall K, Chugh J, Fiedler M, Bienz M.

ACS Chem Biol. 2014 Dec 19;9(12):2864-74. doi: 10.1021/cb500585s. Epub 2014 Oct 24.


Signalosome assembly by domains undergoing dynamic head-to-tail polymerization.

Bienz M.

Trends Biochem Sci. 2014 Oct;39(10):487-95. doi: 10.1016/j.tibs.2014.08.006. Epub 2014 Sep 16. Review.


Oncological and functional outcomes of 722 robot-assisted radical prostatectomy (RARP) cases: The largest Canadian 5-year experience.

Tholomier C, Bienz M, Hueber PA, Trinh QD, Hakim AE, Alhathal N, Lebeau T, Benayoun S, Valdivieso R, Liberman D, Saad F, Lattouf JB, Widmer H, Begin L, Latour M, Zorn KC.

Can Urol Assoc J. 2014 May;8(5-6):195-201. doi: 10.5489/cuaj.2016. Erratum in: Can Urol Assoc J. 2015 Sep-Oct;9(9-10):E760.


Accuracy of transrectal ultrasonography to evaluate pathologic prostate weight: correlation with various prostate size groups.

Bienz M, Hueber PA, Al-Hathal N, McCormack M, Bhojani N, Trinh QD, Zorn KC.

Urology. 2014 Jul;84(1):169-74. doi: 10.1016/j.urology.2014.02.022.


Comparison of fracture risk assessment tool score to bone mineral density for estimating fracture risk in patients with advanced prostate cancer on androgen deprivation therapy.

James H 3rd, Aleksic I, Bienz MN, Pieczonka C, Iannotta P, Albala D, Mariados N, Mouraviev V, Saad F.

Urology. 2014 Jul;84(1):164-8. doi: 10.1016/j.urology.2013.12.071.


Urological resident exposure to transurethral surgical options for BPH management in 2012-2013: A pan-Canadian survey.

Ben-Zvi T, Hueber PA, Valdivieso R, Azizi M, Tholomier C, Bienz M, Bhojani N, Trinh QD, Zorn KC.

Can Urol Assoc J. 2014 Jan-Feb;8(1-2):54-60. doi: 10.5489/cuaj.1647. No abstract available. Erratum in: Can Urol Assoc J. 2015 Mar-Apr;9(3-4):E236. Azzizi, Mounsif [corrected to Azizi, Mounsif].


LEF1 and B9L shield β-catenin from inactivation by Axin, desensitizing colorectal cancer cells to tankyrase inhibitors.

de la Roche M, Ibrahim AE, Mieszczanek J, Bienz M.

Cancer Res. 2014 Mar 1;74(5):1495-505. doi: 10.1158/0008-5472.CAN-13-2682. Epub 2014 Jan 13.


Evolutionary adaptation of the fly Pygo PHD finger toward recognizing histone H3 tail methylated at arginine 2.

Miller TC, Mieszczanek J, Sánchez-Barrena MJ, Rutherford TJ, Fiedler M, Bienz M.

Structure. 2013 Dec 3;21(12):2208-20. doi: 10.1016/j.str.2013.09.013. Epub 2013 Oct 31.


Biochemistry. A lipid linchpin for Wnt-Fz docking.

Bienz M, He X.

Science. 2012 Jul 6;337(6090):44-5. doi: 10.1126/science.1224468. Epub 2012 May 31. No abstract available.


An intrinsically labile α-helix abutting the BCL9-binding site of β-catenin is required for its inhibition by carnosic acid.

de la Roche M, Rutherford TJ, Gupta D, Veprintsev DB, Saxty B, Freund SM, Bienz M.

Nat Commun. 2012 Feb 21;3:680. doi: 10.1038/ncomms1680.


An ankyrin-repeat ubiquitin-binding domain determines TRABID's specificity for atypical ubiquitin chains.

Licchesi JD, Mieszczanek J, Mevissen TE, Rutherford TJ, Akutsu M, Virdee S, El Oualid F, Chin JW, Ovaa H, Bienz M, Komander D.

Nat Struct Mol Biol. 2011 Dec 11;19(1):62-71. doi: 10.1038/nsmb.2169.


Inhibition of GSK3 by Wnt signalling--two contrasting models.

Metcalfe C, Bienz M.

J Cell Sci. 2011 Nov 1;124(Pt 21):3537-44. doi: 10.1242/jcs.091991.


Dishevelled interacts with the DIX domain polymerization interface of Axin to interfere with its function in down-regulating β-catenin.

Fiedler M, Mendoza-Topaz C, Rutherford TJ, Mieszczanek J, Bienz M.

Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):1937-42. doi: 10.1073/pnas.1017063108. Epub 2011 Jan 18.


Dvl2 promotes intestinal length and neoplasia in the ApcMin mouse model for colorectal cancer.

Metcalfe C, Ibrahim AE, Graeb M, de la Roche M, Schwarz-Romond T, Fiedler M, Winton DJ, Corfield A, Bienz M.

Cancer Res. 2010 Aug 15;70(16):6629-38. doi: 10.1158/0008-5472.CAN-10-1616. Epub 2010 Jul 27.


Allosteric remodelling of the histone H3 binding pocket in the Pygo2 PHD finger triggered by its binding to the B9L/BCL9 co-factor.

Miller TC, Rutherford TJ, Johnson CM, Fiedler M, Bienz M.

J Mol Biol. 2010 Sep 3;401(5):969-84. doi: 10.1016/j.jmb.2010.07.007. Epub 2010 Jul 14.


Stability elements in the LRP6 cytoplasmic tail confer efficient signalling upon DIX-dependent polymerization.

Metcalfe C, Mendoza-Topaz C, Mieszczanek J, Bienz M.

J Cell Sci. 2010 May 1;123(Pt 9):1588-99. doi: 10.1242/jcs.067546. Epub 2010 Apr 13.


A role of Pygopus as an anti-repressor in facilitating Wnt-dependent transcription.

Mieszczanek J, de la Roche M, Bienz M.

Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19324-9. doi: 10.1073/pnas.0806098105. Epub 2008 Nov 26.


The function of BCL9 in Wnt/beta-catenin signaling and colorectal cancer cells.

de la Roche M, Worm J, Bienz M.

BMC Cancer. 2008 Jul 15;8:199. doi: 10.1186/1471-2407-8-199.


Decoding of methylated histone H3 tail by the Pygo-BCL9 Wnt signaling complex.

Fiedler M, Sánchez-Barrena MJ, Nekrasov M, Mieszczanek J, Rybin V, Müller J, Evans P, Bienz M.

Mol Cell. 2008 May 23;30(4):507-18. doi: 10.1016/j.molcel.2008.03.011.

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