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Items: 24


Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation.

Liao F, Li A, Xiong M, Bien-Ly N, Jiang H, Zhang Y, Finn MB, Hoyle R, Keyser J, Lefton KB, Robinson GO, Serrano JR, Silverman AP, Guo JL, Getz J, Henne K, Leyns CE, Gallardo G, Ulrich JD, Sullivan PM, Lerner EP, Hudry E, Sweeney ZK, Dennis MS, Hyman BT, Watts RJ, Holtzman DM.

J Clin Invest. 2018 May 1;128(5):2144-2155. doi: 10.1172/JCI96429. Epub 2018 Mar 30.


Preclinical Safety Profile of a Depleting Antibody against CRTh2 for Asthma: Well Tolerated Despite Unexpected CRTh2 Expression on Vascular Pericytes in the Central Nervous System and Gastric Mucosa.

Rajapaksa KS, Huang T, Sharma N, Liu S, Solon M, Reyes A, Paul S, Yee A, Tao J, Chalasani S, Bien-Ly N, Barck K, Carano RA, Wang J, Rangell L, Bremer M, Danilenko DM, Katavolos P, Hotzel I, Reif K, Austin CD.

Toxicol Sci. 2016 Jul;152(1):72-84. doi: 10.1093/toxsci/kfw067. Epub 2016 Apr 21.


Discovery of Novel Blood-Brain Barrier Targets to Enhance Brain Uptake of Therapeutic Antibodies.

Zuchero YJ, Chen X, Bien-Ly N, Bumbaca D, Tong RK, Gao X, Zhang S, Hoyte K, Luk W, Huntley MA, Phu L, Tan C, Kallop D, Weimer RM, Lu Y, Kirkpatrick DS, Ernst JA, Chih B, Dennis MS, Watts RJ.

Neuron. 2016 Jan 6;89(1):70-82. doi: 10.1016/j.neuron.2015.11.024. Epub 2015 Dec 10.


Lack of Widespread BBB Disruption in Alzheimer's Disease Models: Focus on Therapeutic Antibodies.

Bien-Ly N, Boswell CA, Jeet S, Beach TG, Hoyte K, Luk W, Shihadeh V, Ulufatu S, Foreman O, Lu Y, DeVoss J, van der Brug M, Watts RJ.

Neuron. 2015 Oct 21;88(2):289-97. doi: 10.1016/j.neuron.2015.09.036.


Dissecting gene expression at the blood-brain barrier.

Huntley MA, Bien-Ly N, Daneman R, Watts RJ.

Front Neurosci. 2014 Nov 6;8:355. doi: 10.3389/fnins.2014.00355. eCollection 2014. Review.


The blood-brain barrier's gut check.

Bien-Ly N, Watts RJ.

Sci Transl Med. 2014 Nov 19;6(263):263fs46. doi: 10.1126/scitranslmed.aaa2543. No abstract available.


Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates.

Yu YJ, Atwal JK, Zhang Y, Tong RK, Wildsmith KR, Tan C, Bien-Ly N, Hersom M, Maloney JA, Meilandt WJ, Bumbaca D, Gadkar K, Hoyte K, Luk W, Lu Y, Ernst JA, Scearce-Levie K, Couch JA, Dennis MS, Watts RJ.

Sci Transl Med. 2014 Nov 5;6(261):261ra154. doi: 10.1126/scitranslmed.3009835.


Apolipoprotein E4 produced in GABAergic interneurons causes learning and memory deficits in mice.

Knoferle J, Yoon SY, Walker D, Leung L, Gillespie AK, Tong LM, Bien-Ly N, Huang Y.

J Neurosci. 2014 Oct 15;34(42):14069-78. doi: 10.1523/JNEUROSCI.2281-14.2014.


Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants.

Bien-Ly N, Yu YJ, Bumbaca D, Elstrott J, Boswell CA, Zhang Y, Luk W, Lu Y, Dennis MS, Weimer RM, Chung I, Watts RJ.

J Exp Med. 2014 Feb 10;211(2):233-44. doi: 10.1084/jem.20131660. Epub 2014 Jan 27.


Hilar GABAergic interneuron activity controls spatial learning and memory retrieval.

Andrews-Zwilling Y, Gillespie AK, Kravitz AV, Nelson AB, Devidze N, Lo I, Yoon SY, Bien-Ly N, Ring K, Zwilling D, Potter GB, Rubenstein JL, Kreitzer AC, Huang Y.

PLoS One. 2012;7(7):e40555. doi: 10.1371/journal.pone.0040555. Epub 2012 Jul 5.


ApoE and TDP-43 neuropathology in two siblings with familial FTLD-motor neuron disease.

Vossel KA, Bien-Ly N, Bernardo A, Rascovsky K, Karydas A, Rabinovici GD, Sidhu M, Huang EJ, Miller BL, Huang Y, Seeley WW.

Neurocase. 2013;19(3):295-301. doi: 10.1080/13554794.2012.667124. Epub 2012 Apr 18.


Reducing human apolipoprotein E levels attenuates age-dependent Aβ accumulation in mutant human amyloid precursor protein transgenic mice.

Bien-Ly N, Gillespie AK, Walker D, Yoon SY, Huang Y.

J Neurosci. 2012 Apr 4;32(14):4803-11. doi: 10.1523/JNEUROSCI.0033-12.2012.


C-terminal-truncated apolipoprotein (apo) E4 inefficiently clears amyloid-beta (Abeta) and acts in concert with Abeta to elicit neuronal and behavioral deficits in mice.

Bien-Ly N, Andrews-Zwilling Y, Xu Q, Bernardo A, Wang C, Huang Y.

Proc Natl Acad Sci U S A. 2011 Mar 8;108(10):4236-41. doi: 10.1073/pnas.1018381108. Epub 2011 Feb 22.


Apolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice.

Andrews-Zwilling Y, Bien-Ly N, Xu Q, Li G, Bernardo A, Yoon SY, Zwilling D, Yan TX, Chen L, Huang Y.

J Neurosci. 2010 Oct 13;30(41):13707-17. doi: 10.1523/JNEUROSCI.4040-10.2010.


GABAergic interneuron dysfunction impairs hippocampal neurogenesis in adult apolipoprotein E4 knockin mice.

Li G, Bien-Ly N, Andrews-Zwilling Y, Xu Q, Bernardo A, Ring K, Halabisky B, Deng C, Mahley RW, Huang Y.

Cell Stem Cell. 2009 Dec 4;5(6):634-45. doi: 10.1016/j.stem.2009.10.015.


Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease.

Palop JJ, Chin J, Roberson ED, Wang J, Thwin MT, Bien-Ly N, Yoo J, Ho KO, Yu GQ, Kreitzer A, Finkbeiner S, Noebels JL, Mucke L.

Neuron. 2007 Sep 6;55(5):697-711.


Accelerating amyloid-beta fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models.

Cheng IH, Scearce-Levie K, Legleiter J, Palop JJ, Gerstein H, Bien-Ly N, Puoliväli J, Lesné S, Ashe KH, Muchowski PJ, Mucke L.

J Biol Chem. 2007 Aug 17;282(33):23818-28. Epub 2007 Jun 4.


Reelin depletion in the entorhinal cortex of human amyloid precursor protein transgenic mice and humans with Alzheimer's disease.

Chin J, Massaro CM, Palop JJ, Thwin MT, Yu GQ, Bien-Ly N, Bender A, Mucke L.

J Neurosci. 2007 Mar 14;27(11):2727-33.


Reduction in mitochondrial superoxide dismutase modulates Alzheimer's disease-like pathology and accelerates the onset of behavioral changes in human amyloid precursor protein transgenic mice.

Esposito L, Raber J, Kekonius L, Yan F, Yu GQ, Bien-Ly N, Puoliväli J, Scearce-Levie K, Masliah E, Mucke L.

J Neurosci. 2006 May 10;26(19):5167-79.


Fyn kinase induces synaptic and cognitive impairments in a transgenic mouse model of Alzheimer's disease.

Chin J, Palop JJ, Puoliväli J, Massaro C, Bien-Ly N, Gerstein H, Scearce-Levie K, Masliah E, Mucke L.

J Neurosci. 2005 Oct 19;25(42):9694-703.


Vulnerability of dentate granule cells to disruption of arc expression in human amyloid precursor protein transgenic mice.

Palop JJ, Chin J, Bien-Ly N, Massaro C, Yeung BZ, Yu GQ, Mucke L.

J Neurosci. 2005 Oct 19;25(42):9686-93.


Synergistic induction of tissue factor by coagulation factor Xa and TNF: evidence for involvement of negative regulatory signaling cascades.

Hezi-Yamit A, Wong PW, Bien-Ly N, Komuves LG, Prasad KS, Phillips DR, Sinha U.

Proc Natl Acad Sci U S A. 2005 Aug 23;102(34):12077-82. Epub 2005 Aug 16.


Aggressive amyloidosis in mice expressing human amyloid peptides with the Arctic mutation.

Cheng IH, Palop JJ, Esposito LA, Bien-Ly N, Yan F, Mucke L.

Nat Med. 2004 Nov;10(11):1190-2. Epub 2004 Oct 24.


Identification of an orphan guanylate cyclase receptor selectively expressed in mouse testis.

Kuhn M, Ng CK, Su YH, Kilić A, Mitko D, Bien-Ly N, Kömüves LG, Yang RB.

Biochem J. 2004 Apr 15;379(Pt 2):385-93.

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