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Items: 50

1.

The anti-parasitic agent suramin and several of its analogues are inhibitors of the DNA binding protein Mcm10.

Paulson CN, John K, Baxley RM, Kurniawan F, Orellana K, Francis R, Sobeck A, Eichman BF, Chazin WJ, Aihara H, Georg GI, Hawkinson JE, Bielinsky AK.

Open Biol. 2019 Aug 30;9(8):190117. doi: 10.1098/rsob.190117. Epub 2019 Aug 14.

2.

Correction: Rapid DNA replication origin licensing protects stem cell pluripotency.

Matson JP, Dumitru R, Coryell P, Baxley RM, Chen W, Twaroski K, Webber BR, Tolar J, Bielinsky AK, Purvis JE, Cook JG.

Elife. 2019 Jun 5;8. pii: e49040. doi: 10.7554/eLife.49040.

3.

Mechanisms of DNA Damage Tolerance: Post-Translational Regulation of PCNA.

Leung W, Baxley RM, Moldovan GL, Bielinsky AK.

Genes (Basel). 2018 Dec 24;10(1). pii: E10. doi: 10.3390/genes10010010. Review.

4.

Crystal Structure of Entamoeba histolytica Cdc45 Suggests a Conformational Switch that May Regulate DNA Replication.

Kurniawan F, Shi K, Kurahashi K, Bielinsky AK, Aihara H.

iScience. 2018 May 25;3:102-109. doi: 10.1016/j.isci.2018.04.011.

5.

Flap endonuclease overexpression drives genome instability and DNA damage hypersensitivity in a PCNA-dependent manner.

Becker JR, Gallo D, Leung W, Croissant T, Thu YM, Nguyen HD, Starr TK, Brown GW, Bielinsky AK.

Nucleic Acids Res. 2018 Jun 20;46(11):5634-5650. doi: 10.1093/nar/gky313.

6.

Rapid DNA replication origin licensing protects stem cell pluripotency.

Matson JP, Dumitru R, Coryell P, Baxley RM, Chen W, Twaroski K, Webber BR, Tolar J, Bielinsky AK, Purvis JE, Cook JG.

Elife. 2017 Nov 17;6. pii: e30473. doi: 10.7554/eLife.30473. Erratum in: Elife. 2019 Jun 05;8:.

7.

Mapping ubiquitination sites of S. cerevisiae Mcm10.

Zhang T, Fultz BL, Das-Bradoo S, Bielinsky AK.

Biochem Biophys Rep. 2016 Dec;8:212-218. doi: 10.1016/j.bbrep.2016.09.003. Epub 2016 Sep 19.

8.

Mcm10: A Dynamic Scaffold at Eukaryotic Replication Forks.

Baxley RM, Bielinsky AK.

Genes (Basel). 2017 Feb 17;8(2). pii: E73. doi: 10.3390/genes8020073. Review.

9.

Not just for coding: a new role for histone tails in replication enzyme activation.

Bielinsky AK, Leung W.

FEBS J. 2016 Dec;283(23):4244-4246. doi: 10.1111/febs.13958.

10.

Mcm10: The glue at replication forks.

Bielinsky AK.

Cell Cycle. 2016 Nov 16;15(22):3024-3025. Epub 2016 Aug 2. No abstract available.

11.

Slx5/Slx8 Promotes Replication Stress Tolerance by Facilitating Mitotic Progression.

Thu YM, Van Riper SK, Higgins L, Zhang T, Becker JR, Markowski TW, Nguyen HD, Griffin TJ, Bielinsky AK.

Cell Rep. 2016 May 10;15(6):1254-65. doi: 10.1016/j.celrep.2016.04.017. Epub 2016 Apr 28.

12.

Penetrating enemy territory: Soluble PCNA-peptides stress out MYCN-overexpressing neuroblastomas.

Bielinsky AK.

EBioMedicine. 2015 Dec 17;2(12):1844-5. doi: 10.1016/j.ebiom.2015.12.012. eCollection 2015 Dec. No abstract available.

13.

Genetic Interactions Implicating Postreplicative Repair in Okazaki Fragment Processing.

Becker JR, Pons C, Nguyen HD, Costanzo M, Boone C, Myers CL, Bielinsky AK.

PLoS Genet. 2015 Nov 6;11(11):e1005659. doi: 10.1371/journal.pgen.1005659. eCollection 2015 Nov.

14.

eIF4E threshold levels differ in governing normal and neoplastic expansion of mammary stem and luminal progenitor cells.

Avdulov S, Herrera J, Smith K, Peterson M, Gomez-Garcia JR, Beadnell TC, Schwertfeger KL, Benyumov AO, Manivel JC, Li S, Bielinsky AK, Yee D, Bitterman PB, Polunovsky VA.

Cancer Res. 2015 Feb 15;75(4):687-97. doi: 10.1158/0008-5472.CAN-14-2571. Epub 2014 Dec 18.

15.

The N-terminus of Mcm10 is important for interaction with the 9-1-1 clamp and in resistance to DNA damage.

Alver RC, Zhang T, Josephrajan A, Fultz BL, Hendrix CJ, Das-Bradoo S, Bielinsky AK.

Nucleic Acids Res. 2014 Jul;42(13):8389-404. doi: 10.1093/nar/gku479. Epub 2014 Jun 27.

16.

Mcm10 deficiency causes defective-replisome-induced mutagenesis and a dependency on error-free postreplicative repair.

Becker JR, Nguyen HD, Wang X, Bielinsky AK.

Cell Cycle. 2014;13(11):1737-48. doi: 10.4161/cc.28652. Epub 2014 Mar 27.

17.

MCM10: one tool for all-Integrity, maintenance and damage control.

Thu YM, Bielinsky AK.

Semin Cell Dev Biol. 2014 Jun;30:121-30. doi: 10.1016/j.semcdb.2014.03.017. Epub 2014 Mar 21. Review.

18.

RNF4 and PLK1 are required for replication fork collapse in ATR-deficient cells.

Ragland RL, Patel S, Rivard RS, Smith K, Peters AA, Bielinsky AK, Brown EJ.

Genes Dev. 2013 Oct 15;27(20):2259-73. doi: 10.1101/gad.223180.113.

19.

Mcm10 self-association is mediated by an N-terminal coiled-coil domain.

Du W, Josephrajan A, Adhikary S, Bowles T, Bielinsky AK, Eichman BF.

PLoS One. 2013 Jul 23;8(7):e70518. doi: 10.1371/journal.pone.0070518. Print 2013.

20.

Unligated Okazaki Fragments Induce PCNA Ubiquitination and a Requirement for Rad59-Dependent Replication Fork Progression.

Nguyen HD, Becker J, Thu YM, Costanzo M, Koch EN, Smith S, Myung K, Myers CL, Boone C, Bielinsky AK.

PLoS One. 2013 Jun 18;8(6):e66379. doi: 10.1371/journal.pone.0066379. Print 2013.

21.

Enigmatic roles of Mcm10 in DNA replication.

Thu YM, Bielinsky AK.

Trends Biochem Sci. 2013 Apr;38(4):184-94. doi: 10.1016/j.tibs.2012.12.003. Epub 2013 Jan 17. Review.

22.

Damage-specific modification of PCNA.

Das-Bradoo S, Nguyen HD, Bielinsky AK.

Cell Cycle. 2010 Sep 15;9(18):3674-9. doi: 10.4161/cc.9.18.13121. Epub 2010 Sep 21.

23.

Termination at sTop2.

Alver RC, Bielinsky AK.

Mol Cell. 2010 Aug 27;39(4):487-9. doi: 10.1016/j.molcel.2010.08.006.

24.

HDM2 ERKs PCNA.

Nguyen HD, Bielinsky AK.

J Cell Biol. 2010 Aug 23;190(4):487-9. doi: 10.1083/jcb.201007096.

25.

Ubc4 and Not4 regulate steady-state levels of DNA polymerase-α to promote efficient and accurate DNA replication.

Haworth J, Alver RC, Anderson M, Bielinsky AK.

Mol Biol Cell. 2010 Sep 15;21(18):3205-19. doi: 10.1091/mbc.E09-06-0452. Epub 2010 Jul 21.

26.

Defects in DNA ligase I trigger PCNA ubiquitylation at Lys 107.

Das-Bradoo S, Nguyen HD, Wood JL, Ricke RM, Haworth JC, Bielinsky AK.

Nat Cell Biol. 2010 Jan;12(1):74-9; sup pp 1-20. doi: 10.1038/ncb2007. Epub 2009 Dec 13.

27.

Developmental origins of cancer.

Johnson KJ, Springer NM, Bielinsky AK, Largaespada DA, Ross JA.

Cancer Res. 2009 Aug 15;69(16):6375-7. doi: 10.1158/0008-5472.CAN-09-1391. Epub 2009 Aug 4. No abstract available.

28.

Analyzing origin activation patterns by copy number change experiments.

Raveendranathan M, Bielinsky AK.

Methods Mol Biol. 2009;521:279-94. doi: 10.1007/978-1-60327-815-7_15.

PMID:
19563112
29.

Replication initiation point mapping: approach and implications.

Das-Bradoo S, Bielinsky AK.

Methods Mol Biol. 2009;521:105-20. doi: 10.1007/978-1-60327-815-7_6.

PMID:
19563103
30.

Structural basis for DNA binding by replication initiator Mcm10.

Warren EM, Vaithiyalingam S, Haworth J, Greer B, Bielinsky AK, Chazin WJ, Eichman BF.

Structure. 2008 Dec 10;16(12):1892-901. doi: 10.1016/j.str.2008.10.005.

31.

Human Mcm10 regulates the catalytic subunit of DNA polymerase-alpha and prevents DNA damage during replication.

Chattopadhyay S, Bielinsky AK.

Mol Biol Cell. 2007 Oct;18(10):4085-95. Epub 2007 Aug 15.

32.

Scarce but scary.

Bielinsky AK.

Nat Genet. 2007 Jun;39(6):707-8. No abstract available.

PMID:
17534363
33.
34.

Genome-wide replication profiles of S-phase checkpoint mutants reveal fragile sites in yeast.

Raveendranathan M, Chattopadhyay S, Bolon YT, Haworth J, Clarke DJ, Bielinsky AK.

EMBO J. 2006 Aug 9;25(15):3627-39. Epub 2006 Aug 3.

35.

Interaction between PCNA and diubiquitinated Mcm10 is essential for cell growth in budding yeast.

Das-Bradoo S, Ricke RM, Bielinsky AK.

Mol Cell Biol. 2006 Jul;26(13):4806-17.

36.
37.

Encircled: large-scale purification of replication origins from Mammalian chromosomes.

Bielinsky AK, Raveendranathan M.

Mol Cell. 2006 Mar 17;21(6):735-6. Review.

38.

Easy detection of chromatin binding proteins by the Histone Association Assay.

Ricke RM, Bielinsky AK.

Biol Proced Online. 2005;7:60-9. Epub 2005 May 9.

39.

Mcm10 regulates the stability and chromatin association of DNA polymerase-alpha.

Ricke RM, Bielinsky AK.

Mol Cell. 2004 Oct 22;16(2):173-85.

40.

Replication origins: why do we need so many?

Bielinsky AK.

Cell Cycle. 2003 Jul-Aug;2(4):307-9. Review.

PMID:
12851480
41.

DNA replication and chromatin.

Gerbi SA, Bielinsky AK.

Curr Opin Genet Dev. 2002 Apr;12(2):243-8. Review.

PMID:
11893499
42.

Origin recognition complex binding to a metazoan replication origin.

Bielinsky AK, Blitzblau H, Beall EL, Ezrokhi M, Smith HS, Botchan MR, Gerbi SA.

Curr Biol. 2001 Sep 18;11(18):1427-31.

43.

Where it all starts: eukaryotic origins of DNA replication.

Bielinsky AK, Gerbi SA.

J Cell Sci. 2001 Feb;114(Pt 4):643-51. Review.

44.

Antigen presentation function of brain-derived dendriform cells depends on astrocyte help.

Fischer HG, Bielinsky AK.

Int Immunol. 1999 Aug;11(8):1265-74.

PMID:
10421784
45.

Chromosomal ARS1 has a single leading strand start site.

Bielinsky AK, Gerbi SA.

Mol Cell. 1999 Apr;3(4):477-86.

46.

Replication initiation point mapping.

Gerbi SA, Bielinsky AK.

Methods. 1997 Nov;13(3):271-80. Review.

PMID:
9441853
47.

Discrete start sites for DNA synthesis in the yeast ARS1 origin.

Bielinsky AK, Gerbi SA.

Science. 1998 Jan 2;279(5347):95-8.

48.

Divalent cations (Mg2+, Ca2+) differentially influence the beta 1 integrin-mediated migration of human fibroblasts and keratinocytes to different extracellular matrix proteins.

Lange TS, Kirchberg J, Bielinsky AK, Leuker A, Bank I, Ruzicka T, Scharffetter-Kochanek K.

Exp Dermatol. 1995 Jun;4(3):130-7.

PMID:
7551560
49.

Mg2+ and Ca2+ differentially regulate beta 1 integrin-mediated adhesion of dermal fibroblasts and keratinocytes to various extracellular matrix proteins.

Lange TS, Bielinsky AK, Kirchberg K, Bank I, Herrmann K, Krieg T, Scharffetter-Kochanek K.

Exp Cell Res. 1994 Sep;214(1):381-8.

PMID:
7521847

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