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Items: 1 to 50 of 233

1.

A novel series of pyrazole-platinum(II) complexes as potential anti-cancer agents that induce cell cycle arrest and apoptosis in breast cancer cells.

Czarnomysy R, Surażyński A, Muszynska A, Gornowicz A, Bielawska A, Bielawski K.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):1006-1023. doi: 10.1080/14756366.2018.1471687.

PMID:
29862867
2.

[Eating habits of the youth from Ruda Slaska].

Bielawska A, Tomczyk K, Adamek B, Rybus-Kalinowska B, Warakomski J, Łabuz-Roszak B.

Wiad Lek. 2018;71(2 pt 2):358-365. Polish.

PMID:
29786586
3.

Antioxidant and cytotoxic activity of new di- and polyamine caffeine analogues.

Jasiewicz B, Sierakowska A, Jankowski W, Hoffmann M, Piorońska W, Górnicka A, Bielawska A, Bielawski K, Mrówczyńska L.

Free Radic Res. 2018 Jun;52(6):724-736. doi: 10.1080/10715762.2018.1467561.

PMID:
29669446
4.

The molecular mechanism of anticancer action of novel octahydropyrazino[2,1-a:5,4-a']diisoquinoline derivatives in human gastric cancer cells.

Pawłowska N, Gornowicz A, Bielawska A, Surażyński A, Szymanowska A, Czarnomysy R, Bielawski K.

Invest New Drugs. 2018 Mar 17. doi: 10.1007/s10637-018-0584-y. [Epub ahead of print]

PMID:
29549610
5.

Anticancer Effect of a Novel Octahydropyrazino[2,1-a:5,4-a']diisoquinoline Derivative and Its Synergistic Action with Nigella sativa in Human Gastric Cancer Cells.

Czajkowska A, Gornowicz A, Pawłowska N, Czarnomysy R, Nazaruk J, Szymanowski W, Bielawska A, Bielawski K.

Biomed Res Int. 2017;2017:9153403. doi: 10.1155/2017/9153403. Epub 2017 Dec 26.

6.

Mechanism of anticancer action of novel berenil complex of platinum(II) combined with anti-MUC1 in MCF-7 breast cancer cells.

Gornowicz A, Bielawska A, Szymanowski W, Gabryel-Porowska H, Czarnomysy R, Bielawski K.

Oncol Lett. 2018 Feb;15(2):2340-2348. doi: 10.3892/ol.2017.7623. Epub 2017 Dec 14.

7.

Lotus tetragonolobus and Maackia amurensis lectins influence phospho-IκBα, IL-8, Lewis b and H type 1 glycoforms levels in H. pylori infected CRL-1739 gastric cancer cells.

Radziejewska I, Borzym-Kluczyk M, Leszczyńska K, Wosek J, Bielawska A.

Adv Med Sci. 2018 Mar;63(1):205-211. doi: 10.1016/j.advms.2017.06.003. Epub 2017 Dec 1.

PMID:
29197783
8.

Lipotoxic very-long-chain ceramides cause mitochondrial dysfunction, oxidative stress, and cell death in cardiomyocytes.

Law BA, Liao X, Moore KS, Southard A, Roddy P, Ji R, Szulc Z, Bielawska A, Schulze PC, Cowart LA.

FASEB J. 2018 Mar;32(3):1403-1416. doi: 10.1096/fj.201700300R. Epub 2018 Jan 3.

PMID:
29127192
9.

Dual antibacterial and anticancer activity of 4-benzoyl-1-dichlorobenzoylthiosemicarbazide derivatives.

Kapron B, Czarnomysy R, Paneth A, Wujec M, Bielawski K, Bielawska A, Swiatek L, Rajtar B, Polz-Dacewicz M, Plech T.

Anticancer Agents Med Chem. 2017 Oct 23. doi: 10.2174/1871520617666171023142958. [Epub ahead of print]

PMID:
29065843
10.

Blocking Myristoylation of Src Inhibits Its Kinase Activity and Suppresses Prostate Cancer Progression.

Kim S, Alsaidan OA, Goodwin O, Li Q, Sulejmani E, Han Z, Bai A, Albers T, Beharry Z, Zheng YG, Norris JS, Szulc ZM, Bielawska A, Lebedyeva I, Pegan SD, Cai H.

Cancer Res. 2017 Dec 15;77(24):6950-6962. doi: 10.1158/0008-5472.CAN-17-0981. Epub 2017 Oct 16.

PMID:
29038344
11.

Synthesis and antimicrobial activity of chiral quaternary N-spiro ammonium bromides with 3',4'-dihydro-1'H-spiro[isoindoline-2,2'-isoquinoline] skeleton.

Bielawski K, Leszczyńska K, Kałuża Z, Bielawska A, Michalak O, Daniluk T, Staszewska-Krajewska O, Czajkowska A, Pawłowska N, Gornowicz A.

Drug Des Devel Ther. 2017 Jul 5;11:2015-2028. doi: 10.2147/DDDT.S133250. eCollection 2017.

12.

Biological evaluation of octahydropyrazin[2,1-a:5,4-a']diisoquinoline derivatives as potent anticancer agents.

Gornowicz A, Pawłowska N, Czajkowska A, Czarnomysy R, Bielawska A, Bielawski K, Michalak O, Staszewska-Krajewska O, Kałuża Z.

Tumour Biol. 2017 Jun;39(6):1010428317701641. doi: 10.1177/1010428317701641.

PMID:
28618951
13.

Anticancer actions of lysosomally targeted inhibitor, LCL521, of acid ceramidase.

Bai A, Mao C, Jenkins RW, Szulc ZM, Bielawska A, Hannun YA.

PLoS One. 2017 Jun 14;12(6):e0177805. doi: 10.1371/journal.pone.0177805. eCollection 2017.

14.

Inhibiting glucosylceramide synthase exacerbates cisplatin-induced acute kidney injury.

Dupre TV, Doll MA, Shah PP, Sharp CN, Siow D, Megyesi J, Shayman J, Bielawska A, Bielawski J, Beverly LJ, Hernandez-Corbacho M, Clarke CJ, Snider AJ, Schnellmann RG, Obeid LM, Hannun YA, Siskind LJ.

J Lipid Res. 2017 Jul;58(7):1439-1452. doi: 10.1194/jlr.M076745. Epub 2017 May 10.

PMID:
28490444
15.

Novel sphingosine kinase-1 inhibitor, LCL351, reduces immune responses in murine DSS-induced colitis.

Pulkoski-Gross MJ, Uys JD, Orr-Gandy KA, Coant N, Bialkowska AB, Szulc ZM, Bai A, Bielawska A, Townsend DM, Hannun YA, Obeid LM, Snider AJ.

Prostaglandins Other Lipid Mediat. 2017 May;130:47-56. doi: 10.1016/j.prostaglandins.2017.03.006. Epub 2017 Apr 2.

16.

Altered Levels of Serum Ceramide, Sphingosine and Sphingomyelin Are Associated with Colorectal Cancer: A Retrospective Pilot Study.

Separovic D, Shields AF, Philip PA, Bielawski J, Bielawska A, Pierce JS, Tarca AL.

Anticancer Res. 2017 Mar;37(3):1213-1218.

PMID:
28314284
17.

Fumonisin B1 Inhibits Endoplasmic Reticulum Stress Associated-apoptosis After FoscanPDT Combined with C6-Pyridinium Ceramide or Fenretinide.

Boppana NB, Kraveka JM, Rahmaniyan M, Li LI, Bielawska A, Bielawski J, Pierce JS, Delor JS, Zhang K, Korbelik M, Separovic D.

Anticancer Res. 2017 Feb;37(2):455-463.

PMID:
28179290
18.

Synergistic action of cisplatin and echistatin in MDA-MB-231 breast cancer cells.

Czarnomysy R, Surażyński A, Popławska B, Rysiak E, Pawłowska N, Czajkowska A, Bielawski K, Bielawska A.

Mol Cell Biochem. 2017 Mar;427(1-2):13-22. doi: 10.1007/s11010-016-2894-8. Epub 2016 Dec 19.

19.

Ceramide activates lysosomal cathepsin B and cathepsin D to attenuate autophagy and induces ER stress to suppress myeloid-derived suppressor cells.

Liu F, Li X, Lu C, Bai A, Bielawski J, Bielawska A, Marshall B, Schoenlein PV, Lebedyeva IO, Liu K.

Oncotarget. 2016 Dec 20;7(51):83907-83925. doi: 10.18632/oncotarget.13438.

20.

Targeting acid sphingomyelinase with anti-angiogenic chemotherapy.

Jacobi J, García-Barros M, Rao S, Rotolo JA, Thompson C, Mizrachi A, Feldman R, Manova K, Bielawska A, Bielawska J, Fuks Z, Kolesnick R, Haimovitz-Friedman A.

Cell Signal. 2017 Jan;29:52-61. doi: 10.1016/j.cellsig.2016.09.010. Epub 2016 Oct 1.

21.

Cytokine-induced release of ceramide-enriched exosomes as a mediator of cell death signaling in an oligodendroglioma cell line.

Podbielska M, Szulc ZM, Kurowska E, Hogan EL, Bielawski J, Bielawska A, Bhat NR.

J Lipid Res. 2016 Nov;57(11):2028-2039. Epub 2016 Sep 13.

22.

Biological evaluation of dimethylpyridine-platinum complexes with potent antiproliferative activity.

Czarnomysy R, Bielawski K, Muszynska A, Bielawska A, Gornowicz A.

J Enzyme Inhib Med Chem. 2016;31(sup3):150-165. Epub 2016 Aug 4.

PMID:
27488500
23.

Interaction of acid ceramidase inhibitor LCL521 with tumor response to photodynamic therapy and photodynamic therapy-generated vaccine.

Korbelik M, Banáth J, Zhang W, Saw KM, Szulc ZM, Bielawska A, Separovic D.

Int J Cancer. 2016 Sep 15;139(6):1372-8. doi: 10.1002/ijc.30171. Epub 2016 May 18.

24.

Enhanced apoptotic cancer cell killing after Foscan photodynamic therapy combined with fenretinide via de novo sphingolipid biosynthesis pathway.

Boppana NB, DeLor JS, Van Buren E, Bielawska A, Bielawski J, Pierce JS, Korbelik M, Separovic D.

J Photochem Photobiol B. 2016 Jun;159:191-5. doi: 10.1016/j.jphotobiol.2016.02.040. Epub 2016 Mar 16.

PMID:
27085050
25.

Radioactivity of peat mud used in therapy.

Karpińska M, Mnich K, Kapała J, Bielawska A, Kulesza G, Mnich S.

J Environ Radioact. 2016 Feb;152:97-100. doi: 10.1016/j.jenvrad.2015.11.013. Epub 2015 Dec 8.

PMID:
26675542
26.

Ceramide channel: Structural basis for selective membrane targeting.

Perera MN, Ganesan V, Siskind LJ, Szulc ZM, Bielawska A, Bittman R, Colombini M.

Chem Phys Lipids. 2016 Jan;194:110-116. doi: 10.1016/j.chemphyslip.2015.09.007. Epub 2015 Sep 25.

27.

Synthetic approaches for sulfur derivatives containing 1,2,4-triazine moiety: their activity for in vitro screening towards two human cancer cell lines.

Karczmarzyk Z, Wysocki W, Urbańczyk-Lipkowska Z, Kalicki P, Bielawska A, Bielawski K, Ławecka J.

Chem Pharm Bull (Tokyo). 2015;63(7):531-7. doi: 10.1248/cpb.c15-00153.

28.

The combined treatment with novel platinum(II) complex and anti-MUC1 increases apoptotic response in MDA-MB-231 breast cancer cells.

Gornowicz A, Bielawska A, Czarnomysy R, Gabryel-Porowska H, Muszyńska A, Bielawski K.

Mol Cell Biochem. 2015 Oct;408(1-2):103-13. doi: 10.1007/s11010-015-2486-z. Epub 2015 Jun 27.

29.

The redox status of human breast cancer cell lines (MCF-7 and MDA-MB231) treated with novel dinuclear berenil-platinum(II) complexes.

Gęgotek A, Cyuńczyk M, Łuczaj W, Bielawska A, Bielawski K, Skrzydlewska E.

Pharmazie. 2014 Dec;69(12):923-8.

PMID:
25951667
30.

New pyrazolo[4,3-e][1,2,4]triazine sulfonamides as carbonic anhydrase inhibitors.

Mojzych M, Ceruso M, Bielawska A, Bielawski K, Fornal E, Supuran CT.

Bioorg Med Chem. 2015 Jul 1;23(13):3674-80. doi: 10.1016/j.bmc.2015.04.011. Epub 2015 Apr 10.

PMID:
25921266
31.

Expression of Ceramide Synthase 6 Transcriptionally Activates Acid Ceramidase in a c-Jun N-terminal Kinase (JNK)-dependent Manner.

Tirodkar TS, Lu P, Bai A, Scheffel MJ, Gencer S, Garrett-Mayer E, Bielawska A, Ogretmen B, Voelkel-Johnson C.

J Biol Chem. 2015 May 22;290(21):13157-67. doi: 10.1074/jbc.M114.631325. Epub 2015 Apr 3.

32.

Search for human DNA topoisomerase II poisons in the group of 2,5-disubstituted-1,3,4-thiadiazoles.

Plech T, Kaproń B, Paneth A, Wujec M, Czarnomysy R, Bielawska A, Bielawski K, Trotsko N, Kuśmierz E, Paneth P.

J Enzyme Inhib Med Chem. 2015 Dec;30(6):1021-6. doi: 10.3109/14756366.2014.995179. Epub 2015 Sep 4.

PMID:
25792499
33.

Enhanced killing of SCC17B human head and neck squamous cell carcinoma cells after photodynamic therapy plus fenretinide via the de novo sphingolipid biosynthesis pathway and apoptosis.

Boppana NB, Stochaj U, Kodiha M, Bielawska A, Bielawski J, Pierce JS, Korbelik M, Separovic D.

Int J Oncol. 2015 May;46(5):2003-10. doi: 10.3892/ijo.2015.2909. Epub 2015 Feb 26.

34.

Effects of novel alkyl pyridine platinum complexes on apoptosis in Ishikawa endometrial cancer cells.

Czarnomysy R, Bielawska A, Muszyńska A, Bielawski K.

Med Chem. 2015;11(6):540-50.

PMID:
25659127
35.

C6-pyridinium ceramide sensitizes SCC17B human head and neck squamous cell carcinoma cells to photodynamic therapy.

Boppana NB, Stochaj U, Kodiha M, Bielawska A, Bielawski J, Pierce JS, Korbelik M, Separovic D.

J Photochem Photobiol B. 2015 Feb;143:163-8. doi: 10.1016/j.jphotobiol.2015.01.001. Epub 2015 Jan 10.

36.

Time-dependence of ¹³⁷Cs activity concentration in wild game meat in Knyszyn Primeval Forest (Poland).

Kapała J, Mnich K, Mnich S, Karpińska M, Bielawska A.

J Environ Radioact. 2015 Mar;141:76-81. doi: 10.1016/j.jenvrad.2014.11.013. Epub 2015 Jan 2.

PMID:
25559242
37.

Targeting (cellular) lysosomal acid ceramidase by B13: design, synthesis and evaluation of novel DMG-B13 ester prodrugs.

Bai A, Szulc ZM, Bielawski J, Pierce JS, Rembiesa B, Terzieva S, Mao C, Xu R, Wu B, Clarke CJ, Newcomb B, Liu X, Norris J, Hannun YA, Bielawska A.

Bioorg Med Chem. 2014 Dec 15;22(24):6933-44. doi: 10.1016/j.bmc.2014.10.025. Epub 2014 Oct 22.

38.

Apples: content of phenolic compounds vs. variety, part of apple and cultivation model, extraction of phenolic compounds, biological properties.

Kalinowska M, Bielawska A, Lewandowska-Siwkiewicz H, Priebe W, Lewandowski W.

Plant Physiol Biochem. 2014 Nov;84:169-188. doi: 10.1016/j.plaphy.2014.09.006. Epub 2014 Sep 16.

PMID:
25282014
39.

Ceramide synthase inhibitor fumonisin B1 inhibits apoptotic cell death in SCC17B human head and neck squamous carcinoma cells after Pc4 photosensitization.

Boppana NB, Kodiha M, Stochaj U, Lin HS, Haimovitz-Friedman A, Bielawska A, Bielawski J, Divine GW, Boyd JA, Korbelik M, Separovic D.

Photochem Photobiol Sci. 2014 Nov;13(11):1621-7. doi: 10.1039/c4pp00292j.

40.

Dietary glucosylceramides suppress tumor growth in a mouse xenograft model of head and neck squamous cell carcinoma by the inhibition of angiogenesis through an increase in ceramide.

Yazama H, Kitatani K, Fujiwara K, Kato M, Hashimoto-Nishimura M, Kawamoto K, Hasegawa K, Kitano H, Bielawska A, Bielawski J, Okazaki T.

Int J Clin Oncol. 2015 Jun;20(3):438-46. doi: 10.1007/s10147-014-0734-y. Epub 2014 Aug 1.

PMID:
25080062
41.

Cytotoxic activity of octahydropyrazin[2,1-a:5,4-a']diisoquinoline derivatives in human breast cancer cells.

Lepiarczyk M, Kałuża Z, Bielawska A, Czarnomysy R, Gornowicz A, Bielawski K.

Arch Pharm Res. 2015;38(5):628-41. doi: 10.1007/s12272-014-0444-z. Epub 2014 Jul 25.

PMID:
25060945
42.

The assessment of sIgA, histatin-5, and lactoperoxidase levels in saliva of adolescents with dental caries.

Gornowicz A, Tokajuk G, Bielawska A, Maciorkowska E, Jabłoński R, Wójcicka A, Bielawski K.

Med Sci Monit. 2014 Jun 29;20:1095-100. doi: 10.12659/MSM.890468.

43.

Pyrazolo[4,3-e][1,2,4]triazine sulfonamides as carbonic anhydrase inhibitors with antitumor activity.

Mojzych M, Bielawska A, Bielawski K, Ceruso M, Supuran CT.

Bioorg Med Chem. 2014 May 1;22(9):2643-7. doi: 10.1016/j.bmc.2014.03.029. Epub 2014 Mar 27.

PMID:
24713308
44.

Synthesis and kinase inhibitory activity of new sulfonamide derivatives of pyrazolo[4,3-e][1,2,4]triazines.

Mojzych M, Šubertová V, Bielawska A, Bielawski K, Bazgier V, Berka K, Gucký T, Fornal E, Kryštof V.

Eur J Med Chem. 2014 May 6;78:217-24. doi: 10.1016/j.ejmech.2014.03.054. Epub 2014 Mar 18.

PMID:
24681986
45.

Cytotoxic efficacy of a novel dinuclear platinum(II) complex used with anti-MUC1 in human breast cancer cells.

Gornowicz A, Kałuża Z, Bielawska A, Gabryel-Porowska H, Czarnomysy R, Bielawski K.

Mol Cell Biochem. 2014 Jul;392(1-2):161-74. doi: 10.1007/s11010-014-2018-2. Epub 2014 Mar 18.

46.

Mucin levels in saliva of adolescents with dental caries.

Gabryel-Porowska H, Gornowicz A, Bielawska A, Wójcicka A, Maciorkowska E, Grabowska SZ, Bielawski K.

Med Sci Monit. 2014 Jan 18;20:72-7. doi: 10.12659/MSM.889718.

47.

Ceramide targets xIAP and cIAP1 to sensitize metastatic colon and breast cancer cells to apoptosis induction to suppress tumor progression.

Paschall AV, Zimmerman MA, Torres CM, Yang D, Chen MR, Li X, Bieberich E, Bai A, Bielawski J, Bielawska A, Liu K.

BMC Cancer. 2014 Jan 15;14:24. doi: 10.1186/1471-2407-14-24.

48.

Arabidopsis accelerated cell death 11, ACD11, is a ceramide-1-phosphate transfer protein and intermediary regulator of phytoceramide levels.

Simanshu DK, Zhai X, Munch D, Hofius D, Markham JE, Bielawski J, Bielawska A, Malinina L, Molotkovsky JG, Mundy JW, Patel DJ, Brown RE.

Cell Rep. 2014 Jan 30;6(2):388-99. doi: 10.1016/j.celrep.2013.12.023. Epub 2014 Jan 9.

49.

Effects of dinuclear berenil-platinum(II) complexes on fibroblasts redox status.

Gęgotek A, Markowska A, Łuczaj W, Bielawska A, Bielawski K, Ambrożewicz E, Skrzydlewska E.

Adv Med Sci. 2013;58(2):282-91. doi: 10.2478/ams-2013-0029.

PMID:
24127544
50.

Increased killing of SCCVII squamous cell carcinoma cells after the combination of Pc 4 photodynamic therapy and dasatinib is associated with enhanced caspase-3 activity and ceramide synthase 1 upregulation.

Separovic D, Breen P, Boppana NB, Van Buren E, Joseph N, Kraveka JM, Rahmaniyan M, Li L, Gudz TI, Bielawska A, Bai A, Bielawski J, Pierce JS, Korbelik M.

Int J Oncol. 2013 Dec;43(6):2064-72. doi: 10.3892/ijo.2013.2132. Epub 2013 Oct 9.

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