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Attack of the clones: whole genome-based characterization of two closely related enterohemorrhagic Escherichia coli O26 epidemic lineages.

Karnisova L, Marejkova M, Hrbackova H, Mellmann A, Karch H, Fruth A, Drevinek P, Blahova K, Bielaszewska M, Nunvar J.

BMC Genomics. 2018 Aug 31;19(1):647. doi: 10.1186/s12864-018-5045-7.


Enterohemorrhagic Escherichia coli O157 outer membrane vesicles induce interleukin 8 production in human intestinal epithelial cells by signaling via Toll-like receptors TLR4 and TLR5 and activation of the nuclear factor NF-κB.

Bielaszewska M, Marejková M, Bauwens A, Kunsmann-Prokscha L, Mellmann A, Karch H.

Int J Med Microbiol. 2018 Oct;308(7):882-889. doi: 10.1016/j.ijmm.2018.06.004. Epub 2018 Jun 19.


Endothelial progenitor cells accelerate endothelial regeneration in an in vitro model of Shigatoxin-2a-induced injury via soluble growth factors.

Patry C, Betzen C, Fathalizadeh F, Fichtner A, Westhoff JH, Fleming T, Eckstein V, Bruckner T, Bielaszewska M, Karch H, Hoffmann GF, Tönshoff B, Rafat N.

Am J Physiol Renal Physiol. 2018 Oct 1;315(4):F861-F869. doi: 10.1152/ajprenal.00633.2017. Epub 2018 Mar 7.


Sorbitol-Fermenting Enterohemorrhagic Escherichia coli O157:H- Isolates from Czech Patients with Novel Plasmid Composition Not Previously Seen in German Isolates.

Bauwens A, Marejková M, Middendorf-Bauchart B, Prager R, Kossow A, Zhang W, Karch H, Mellmann A, Bielaszewska M.

Appl Environ Microbiol. 2017 Nov 16;83(23). pii: e01454-17. doi: 10.1128/AEM.01454-17. Print 2017 Dec 1.


Intrahost milieu modulates production of outer membrane vesicles, vesicle-associated Shiga toxin 2a and cytotoxicity in Escherichia coli O157:H7 and O104:H4.

Bauwens A, Kunsmann L, Marejková M, Zhang W, Karch H, Bielaszewska M, Mellmann A.

Environ Microbiol Rep. 2017 Oct;9(5):626-634. doi: 10.1111/1758-2229.12562. Epub 2017 Jul 21.


Antibiotic-Mediated Modulations of Outer Membrane Vesicles in Enterohemorrhagic Escherichia coli O104:H4 and O157:H7.

Bauwens A, Kunsmann L, Karch H, Mellmann A, Bielaszewska M.

Antimicrob Agents Chemother. 2017 Aug 24;61(9). pii: e00937-17. doi: 10.1128/AAC.00937-17. Print 2017 Sep.


Host cell interactions of outer membrane vesicle-associated virulence factors of enterohemorrhagic Escherichia coli O157: Intracellular delivery, trafficking and mechanisms of cell injury.

Bielaszewska M, Rüter C, Bauwens A, Greune L, Jarosch KA, Steil D, Zhang W, He X, Lloubes R, Fruth A, Kim KS, Schmidt MA, Dobrindt U, Mellmann A, Karch H.

PLoS Pathog. 2017 Feb 3;13(2):e1006159. doi: 10.1371/journal.ppat.1006159. eCollection 2017 Feb.


Experimental Infection of Calves with Escherichia coli O104:H4 outbreak strain.

Hamm K, Barth SA, Stalb S, Geue L, Liebler-Tenorio E, Teifke JP, Lange E, Tauscher K, Kotterba G, Bielaszewska M, Karch H, Menge C.

Sci Rep. 2016 Sep 7;6:32812. doi: 10.1038/srep32812.


Shiga toxin of enterohaemorrhagic Escherichia coli directly injures developing human erythrocytes.

Betz J, Dorn I, Kouzel IU, Bauwens A, Meisen I, Kemper B, Bielaszewska M, Mormann M, Weymann L, Sibrowski W, Karch H, Schlenke P, Müthing J.

Cell Microbiol. 2016 Oct;18(10):1339-48. doi: 10.1111/cmi.12592. Epub 2016 Apr 29.


Molecular Characterization of Human Atypical Sorbitol-Fermenting Enteropathogenic Escherichia coli O157 Reveals High Diversity.

Kossow A, Zhang W, Bielaszewska M, Rhode S, Hansen K, Fruth A, Rüter C, Karch H, Mellmann A.

J Clin Microbiol. 2016 May;54(5):1357-63. doi: 10.1128/JCM.02897-15. Epub 2016 Mar 16.


Shiga Toxin 2a-Induced Endothelial Injury in Hemolytic Uremic Syndrome: A Metabolomic Analysis.

Betzen C, Plotnicki K, Fathalizadeh F, Pappan K, Fleming T, Bielaszewska M, Karch H, Tönshoff B, Rafat N.

J Infect Dis. 2016 Mar 15;213(6):1031-40. doi: 10.1093/infdis/jiv540. Epub 2015 Nov 17.


Virulence from vesicles: Novel mechanisms of host cell injury by Escherichia coli O104:H4 outbreak strain.

Kunsmann L, Rüter C, Bauwens A, Greune L, Glüder M, Kemper B, Fruth A, Wai SN, He X, Lloubes R, Schmidt MA, Dobrindt U, Mellmann A, Karch H, Bielaszewska M.

Sci Rep. 2015 Aug 18;5:13252. doi: 10.1038/srep13252.


Characterization of urinary tract infection-associated Shiga toxin-producing Escherichia coli.

Toval F, Schiller R, Meisen I, Putze J, Kouzel IU, Zhang W, Karch H, Bielaszewska M, Mormann M, Müthing J, Dobrindt U.

Infect Immun. 2014 Nov;82(11):4631-42. doi: 10.1128/IAI.01701-14. Epub 2014 Aug 25.


Hemolysin of enterohemorrhagic Escherichia coli: structure, transport, biological activity and putative role in virulence.

Bielaszewska M, Aldick T, Bauwens A, Karch H.

Int J Med Microbiol. 2014 Jul;304(5-6):521-9. doi: 10.1016/j.ijmm.2014.05.005. Epub 2014 May 15. Review.


Characterization of Escherichia coli isolates from hospital inpatients or outpatients with urinary tract infection.

Toval F, Köhler CD, Vogel U, Wagenlehner F, Mellmann A, Fruth A, Schmidt MA, Karch H, Bielaszewska M, Dobrindt U.

J Clin Microbiol. 2014 Feb;52(2):407-18. doi: 10.1128/JCM.02069-13. Epub 2013 Nov 13.


Heteropathogenic virulence and phylogeny reveal phased pathogenic metamorphosis in Escherichia coli O2:H6.

Bielaszewska M, Schiller R, Lammers L, Bauwens A, Fruth A, Middendorf B, Schmidt MA, Tarr PI, Dobrindt U, Karch H, Mellmann A.

EMBO Mol Med. 2014 Mar;6(3):347-57. doi: 10.1002/emmm.201303133. Epub 2014 Jan 10.


Enterohemorrhagic Escherichia coli hemolysin employs outer membrane vesicles to target mitochondria and cause endothelial and epithelial apoptosis.

Bielaszewska M, Rüter C, Kunsmann L, Greune L, Bauwens A, Zhang W, Kuczius T, Kim KS, Mellmann A, Schmidt MA, Karch H.

PLoS Pathog. 2013;9(12):e1003797. doi: 10.1371/journal.ppat.1003797. Epub 2013 Dec 12.


Interaction of Shiga toxin 2 with complement regulators of the factor H protein family.

Poolpol K, Orth-Höller D, Speth C, Zipfel PF, Skerka C, de Córdoba SR, Brockmeyer J, Bielaszewska M, Würzner R.

Mol Immunol. 2014 Mar;58(1):77-84. doi: 10.1016/j.molimm.2013.11.009. Epub 2013 Dec 5.


Evolution of enterohemorrhagic escherichia coli O26 based on single-nucleotide polymorphisms.

Bletz S, Bielaszewska M, Leopold SR, Köck R, Witten A, Schuldes J, Zhang W, Karch H, Mellmann A.

Genome Biol Evol. 2013;5(10):1807-16. doi: 10.1093/gbe/evt136.


Phylogeny and phenotypes of clinical and environmental Shiga toxin-producing Escherichia coli O174.

Zhang W, Nadirk J, Kossow A, Bielaszewska M, Leopold SR, Witten A, Fruth A, Karch H, Ammon A, Mellmann A.

Environ Microbiol. 2014 Apr;16(4):963-76. doi: 10.1111/1462-2920.12234. Epub 2013 Aug 27.


Lability of the pAA Virulence Plasmid in Escherichia coli O104:H4: Implications for Virulence in Humans.

Zhang W, Bielaszewska M, Kunsmann L, Mellmann A, Bauwens A, Köck R, Kossow A, Anders A, Gatermann S, Karch H.

PLoS One. 2013 Jun 21;8(6):e66717. doi: 10.1371/journal.pone.0066717. Print 2013.


Thalamic involvement in patients with neurologic impairment due to Shiga toxin 2.

Meuth SG, Göbel K, Kanyshkova T, Ehling P, Ritter MA, Schwindt W, Bielaszewska M, Lebiedz P, Coulon P, Herrmann AM, Storck W, Kohmann D, Müthing J, Pavenstädt H, Kuhlmann T, Karch H, Peters G, Budde T, Wiendl H, Pape HC.

Ann Neurol. 2013 Mar;73(3):419-29. doi: 10.1002/ana.23814. Epub 2013 Feb 19.


Enterohemorrhagic Escherichia coli O26:H11/H-: a new virulent clone emerges in Europe.

Bielaszewska M, Mellmann A, Bletz S, Zhang W, Köck R, Kossow A, Prager R, Fruth A, Orth-Höller D, Marejková M, Morabito S, Caprioli A, Piérard D, Smith G, Jenkins C, Curová K, Karch H.

Clin Infect Dis. 2013 May;56(10):1373-81. doi: 10.1093/cid/cit055. Epub 2013 Feb 1.


Association of Shiga toxin glycosphingolipid receptors with membrane microdomains of toxin-sensitive lymphoid and myeloid cells.

Kouzel IU, Pohlentz G, Storck W, Radamm L, Hoffmann P, Bielaszewska M, Bauwens A, Cichon C, Schmidt MA, Mormann M, Karch H, Müthing J.

J Lipid Res. 2013 Mar;54(3):692-710. doi: 10.1194/jlr.M031781. Epub 2012 Dec 17.


Shiga toxin glycosphingolipid receptor expression and toxin susceptibility of human pancreatic ductal adenocarcinomas of differing origin and differentiation.

Storck W, Meisen I, Gianmoena K, Pläger I, Kouzel IU, Bielaszewska M, Haier J, Mormann M, Humpf HU, Karch H, Müthing J.

Biol Chem. 2012 Aug;393(8):785-99. doi: 10.1515/hsz-2012-0165.


Uncommon membrane distribution of Shiga toxin glycosphingolipid receptors in toxin-sensitive human glomerular microvascular endothelial cells.

Betz J, Bauwens A, Kunsmann L, Bielaszewska M, Mormann M, Humpf HU, Karch H, Friedrich AW, Müthing J.

Biol Chem. 2012 Mar;393(3):133-47. doi: 10.1515/hsz-2011-0288.


Alignment-free design of highly discriminatory diagnostic primer sets for Escherichia coli O104:H4 outbreak strains.

Pritchard L, Holden NJ, Bielaszewska M, Karch H, Toth IK.

PLoS One. 2012;7(4):e34498. doi: 10.1371/journal.pone.0034498. Epub 2012 Apr 5.


Effects of antibiotics on Shiga toxin 2 production and bacteriophage induction by epidemic Escherichia coli O104:H4 strain.

Bielaszewska M, Idelevich EA, Zhang W, Bauwens A, Schaumburg F, Mellmann A, Peters G, Karch H.

Antimicrob Agents Chemother. 2012 Jun;56(6):3277-82. doi: 10.1128/AAC.06315-11. Epub 2012 Mar 5.


Phylogeny of Shiga toxin-producing Escherichia coli O157 isolated from cattle and clinically ill humans.

Bono JL, Smith TP, Keen JE, Harhay GP, McDaneld TG, Mandrell RE, Jung WK, Besser TE, Gerner-Smidt P, Bielaszewska M, Karch H, Clawson ML.

Mol Biol Evol. 2012 Aug;29(8):2047-62. doi: 10.1093/molbev/mss072. Epub 2012 Feb 21.


Real-time multiplex PCR for detecting Shiga toxin 2-producing Escherichia coli O104:H4 in human stools.

Zhang W, Bielaszewska M, Bauwens A, Fruth A, Mellmann A, Karch H.

J Clin Microbiol. 2012 May;50(5):1752-4. doi: 10.1128/JCM.06817-11. Epub 2012 Feb 15.


Promiscuous Shiga toxin 2e and its intimate relationship to Forssman.

Müthing J, Meisen I, Zhang W, Bielaszewska M, Mormann M, Bauerfeind R, Schmidt MA, Friedrich AW, Karch H.

Glycobiology. 2012 Jun;22(6):849-62. doi: 10.1093/glycob/cws009. Epub 2012 Jan 25.


Prospective genomic characterization of the German enterohemorrhagic Escherichia coli O104:H4 outbreak by rapid next generation sequencing technology.

Mellmann A, Harmsen D, Cummings CA, Zentz EB, Leopold SR, Rico A, Prior K, Szczepanowski R, Ji Y, Zhang W, McLaughlin SF, Henkhaus JK, Leopold B, Bielaszewska M, Prager R, Brzoska PM, Moore RL, Guenther S, Rothberg JM, Karch H.

PLoS One. 2011;6(7):e22751. doi: 10.1371/journal.pone.0022751. Epub 2011 Jul 20.


Characterisation of the Escherichia coli strain associated with an outbreak of haemolytic uraemic syndrome in Germany, 2011: a microbiological study.

Bielaszewska M, Mellmann A, Zhang W, Köck R, Fruth A, Bauwens A, Peters G, Karch H.

Lancet Infect Dis. 2011 Sep;11(9):671-6. doi: 10.1016/S1473-3099(11)70165-7. Epub 2011 Jun 22.


Enterohaemorrhagic Escherichia coli haemolysin is cleaved and inactivated by serine protease EspPα.

Brockmeyer J, Aldick T, Soltwisch J, Zhang W, Tarr PI, Weiss A, Dreisewerd K, Müthing J, Bielaszewska M, Karch H.

Environ Microbiol. 2011 May;13(5):1327-41. doi: 10.1111/j.1462-2920.2011.02431.x. Epub 2011 Feb 23.


Chromosomal instability in enterohaemorrhagic Escherichia coli O157:H7: impact on adherence, tellurite resistance and colony phenotype.

Bielaszewska M, Middendorf B, Tarr PI, Zhang W, Prager R, Aldick T, Dobrindt U, Karch H, Mellmann A.

Mol Microbiol. 2011 Feb;79(4):1024-44. doi: 10.1111/j.1365-2958.2010.07499.x. Epub 2011 Jan 4.


Watch out for the even eviler cousin-sorbitol-fermenting E coli O157.

Werber D, Bielaszewska M, Frank C, Stark K, Karch H.

Lancet. 2011 Jan 22;377(9762):298-9. doi: 10.1016/S0140-6736(11)60090-1. No abstract available.


Shiga toxin glycosphingolipid receptors in microvascular and macrovascular endothelial cells: differential association with membrane lipid raft microdomains.

Betz J, Bielaszewska M, Thies A, Humpf HU, Dreisewerd K, Karch H, Kim KS, Friedrich AW, Müthing J.

J Lipid Res. 2011 Apr;52(4):618-34. doi: 10.1194/jlr.M010819. Epub 2011 Jan 20.


Differential cytotoxic actions of Shiga toxin 1 and Shiga toxin 2 on microvascular and macrovascular endothelial cells.

Bauwens A, Bielaszewska M, Kemper B, Langehanenberg P, von Bally G, Reichelt R, Mulac D, Humpf HU, Friedrich AW, Kim KS, Karch H, Müthing J.

Thromb Haemost. 2011 Mar;105(3):515-28. doi: 10.1160/TH10-02-0140. Epub 2010 Dec 6.


Enterohemorrhagic Escherichia coli O26:H11-Associated Hemolytic Uremic Syndrome: Bacteriology and Clinical Presentation.

Zimmerhackl LB, Rosales A, Hofer J, Riedl M, Jungraithmayr T, Mellmann A, Bielaszewska M, Karch H.

Semin Thromb Hemost. 2010 Sep;36(6):586-93. doi: 10.1055/s-0030-1262880. Epub 2010 Sep 23.


Distribution and phylogeny of immunoglobulin-binding protein G in Shiga toxin-producing Escherichia coli and its association with adherence phenotypes.

Merkel V, Ohder B, Bielaszewska M, Zhang W, Fruth A, Menge C, Borrmann E, Middendorf B, Müthing J, Karch H, Mellmann A.

Infect Immun. 2010 Aug;78(8):3625-36. doi: 10.1128/IAI.00006-10. Epub 2010 Jun 14.


Phylogenetic analysis of enterohemorrhagic Escherichia coli O157, Germany, 1987-2008.

Jenke C, Harmsen D, Weniger T, Rothganger J, Hyytia-Trees E, Bielaszewska M, Karch H, Mellmann A.

Emerg Infect Dis. 2010 Apr;16(4):610-6. doi: 10.3201/eid1604.091361.


Epidemiology and pathogenesis of enterohaemorrhagic Escherichia coil.

Karch H, Mellmann A, Bielaszewska M.

Berl Munch Tierarztl Wochenschr. 2009 Nov-Dec;122(11-12):417-24. Review.


Vacuolisation of human microvascular endothelial cells by enterohaemorrhagic Escherichia coli.

Bielaszewska M, Bauwens A, Greune L, Kemper B, Dobrindt U, Geelen JM, Kim KS, Schmidt MA, Karch H.

Thromb Haemost. 2009 Dec;102(6):1080-92. doi: 10.1160/TH09-07-0499.


Phylogeny and disease association of Shiga toxin-producing Escherichia coli O91.

Mellmann A, Fruth A, Friedrich AW, Wieler LH, Harmsen D, Werber D, Middendorf B, Bielaszewska M, Karch H.

Emerg Infect Dis. 2009 Sep;15(9):1474-7. doi: 10.3201/eid1509.090161.


Structure and function relationship of the autotransport and proteolytic activity of EspP from Shiga toxin-producing Escherichia coli.

Brockmeyer J, Spelten S, Kuczius T, Bielaszewska M, Karch H.

PLoS One. 2009 Jul 1;4(7):e6100. doi: 10.1371/journal.pone.0006100.


Intrahost genome alterations in enterohemorrhagic Escherichia coli.

Mellmann A, Bielaszewska M, Karch H.

Gastroenterology. 2009 May;136(6):1925-38. Review.


Shiga toxin, cytolethal distending toxin, and hemolysin repertoires in clinical Escherichia coli O91 isolates.

Bielaszewska M, Stoewe F, Fruth A, Zhang W, Prager R, Brockmeyer J, Mellmann A, Karch H, Friedrich AW.

J Clin Microbiol. 2009 Jul;47(7):2061-6. doi: 10.1128/JCM.00201-09. Epub 2009 Apr 29.


Phenotypic and genotypic traits of Shiga toxin-negative E. coli O157:H7/H(-) bovine and porcine strains.

Stephan R, Zhang W, Bielaszewska M, Mellmann A, Karch H.

Foodborne Pathog Dis. 2009 Mar;6(2):235-43. doi: 10.1089/fpd.2008.0205.


Vesicular stabilization and activity augmentation of enterohaemorrhagic Escherichia coli haemolysin.

Aldick T, Bielaszewska M, Uhlin BE, Humpf HU, Wai SN, Karch H.

Mol Microbiol. 2009 Mar;71(6):1496-508. doi: 10.1111/j.1365-2958.2009.06618.x. Epub 2009 Feb 2.


Sorbitol-fermenting enterohaemorrhagic Escherichia coli O157:H- causes another outbreak of haemolytic uraemic syndrome in children.

Alpers K, Werber D, Frank C, Koch J, Friedrich AW, Karch H, An DER Heiden M, Prager R, Fruth A, Bielaszewska M, Morlock G, Heissenhuber A, Diedler A, Gerber A, Ammon A.

Epidemiol Infect. 2009 Mar;137(3):389-95. doi: 10.1017/S0950268808001465. Epub 2009 Feb 9.


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