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Items: 47

1.

High information content assays for genetic toxicology testing: A report of the International Workshops on Genotoxicity Testing (IWGT).

Dertinger SD, Totsuka Y, Bielas JH, Doherty AT, Kleinjans J, Honma M, Marchetti F, Schuler MJ, Thybaud V, White P, Yauk CL.

Mutat Res. 2019 Nov;847:403022. doi: 10.1016/j.mrgentox.2019.02.003. Epub 2019 Feb 21.

PMID:
31699343
2.

Lower mitochondrial DNA content but not increased mutagenesis associates with decreased base excision repair activity in brains of AD subjects.

Soltys DT, Pereira CPM, Rowies FT, Farfel JM, Grinberg LT, Suemoto CK, Leite REP, Rodriguez RD, Ericson NG, Bielas JH, Souza-Pinto NC.

Neurobiol Aging. 2019 Jan;73:161-170. doi: 10.1016/j.neurobiolaging.2018.09.015. Epub 2018 Sep 22.

PMID:
30359878
3.

Acquired cancer resistance to combination immunotherapy from transcriptional loss of class I HLA.

Paulson KG, Voillet V, McAfee MS, Hunter DS, Wagener FD, Perdicchio M, Valente WJ, Koelle SJ, Church CD, Vandeven N, Thomas H, Colunga AG, Iyer JG, Yee C, Kulikauskas R, Koelle DM, Pierce RH, Bielas JH, Greenberg PD, Bhatia S, Gottardo R, Nghiem P, Chapuis AG.

Nat Commun. 2018 Sep 24;9(1):3868. doi: 10.1038/s41467-018-06300-3.

4.

Multiple Molecular Mechanisms Rescue mtDNA Disease in C. elegans.

Haroon S, Li A, Weinert JL, Fritsch C, Ericson NG, Alexander-Floyd J, Braeckman BP, Haynes CM, Bielas JH, Gidalevitz T, Vermulst M.

Cell Rep. 2018 Mar 20;22(12):3115-3125. doi: 10.1016/j.celrep.2018.02.099.

5.

Rapidly inducible Cas9 and DSB-ddPCR to probe editing kinetics.

Rose JC, Stephany JJ, Valente WJ, Trevillian BM, Dang HV, Bielas JH, Maly DJ, Fowler DM.

Nat Methods. 2017 Sep;14(9):891-896. doi: 10.1038/nmeth.4368. Epub 2017 Jul 24.

6.

Cyclophosphamide leads to persistent deficits in physical performance and in vivo mitochondria function in a mouse model of chemotherapy late effects.

Crouch ML, Knowels G, Stuppard R, Ericson NG, Bielas JH, Marcinek DJ, Syrjala KL.

PLoS One. 2017 Jul 10;12(7):e0181086. doi: 10.1371/journal.pone.0181086. eCollection 2017.

7.

Age-related accumulation of phosphorylated mitofusin 2 protein in retinal ganglion cells correlates with glaucoma progression.

Nivison MP, Ericson NG, Green VM, Bielas JH, Campbell JS, Horner PJ.

Exp Neurol. 2017 Oct;296:49-61. doi: 10.1016/j.expneurol.2017.07.001. Epub 2017 Jul 3.

8.

Towards precision prevention: Technologies for identifying healthy individuals with high risk of disease.

Nagel ZD, Engelward BP, Brenner DJ, Begley TJ, Sobol RW, Bielas JH, Stambrook PJ, Wei Q, Hu JJ, Terry MB, Dilworth C, McAllister KA, Reinlib L, Worth L, Shaughnessy DT.

Mutat Res. 2017 Aug;800-802:14-28. doi: 10.1016/j.mrfmmm.2017.03.007. Epub 2017 Apr 6. Review.

9.

Massively parallel digital transcriptional profiling of single cells.

Zheng GX, Terry JM, Belgrader P, Ryvkin P, Bent ZW, Wilson R, Ziraldo SB, Wheeler TD, McDermott GP, Zhu J, Gregory MT, Shuga J, Montesclaros L, Underwood JG, Masquelier DA, Nishimura SY, Schnall-Levin M, Wyatt PW, Hindson CM, Bharadwaj R, Wong A, Ness KD, Beppu LW, Deeg HJ, McFarland C, Loeb KR, Valente WJ, Ericson NG, Stevens EA, Radich JP, Mikkelsen TS, Hindson BJ, Bielas JH.

Nat Commun. 2017 Jan 16;8:14049. doi: 10.1038/ncomms14049.

10.

Editorial overview: Molecular and genetic bases of disease.

Suzuki CK, Bielas JH.

Curr Opin Genet Dev. 2016 Jun;38:iv-vi. doi: 10.1016/j.gde.2016.09.001. Epub 2016 Sep 24. No abstract available.

PMID:
27680305
11.

Mitochondrial DNA exhibits resistance to induced point and deletion mutations.

Valente WJ, Ericson NG, Long AS, White PA, Marchetti F, Bielas JH.

Nucleic Acids Res. 2016 Oct 14;44(18):8513-8524. Epub 2016 Aug 22.

12.

Cells Comprising the Prostate Cancer Microenvironment Lack Recurrent Clonal Somatic Genomic Aberrations.

Bianchi-Frias D, Basom R, Delrow JJ, Coleman IM, Dakhova O, Qu X, Fang M, Franco OE, Ericson NG, Bielas JH, Hayward SW, True L, Morrissey C, Brown L, Bhowmick NA, Rowley D, Ittmann M, Nelson PS.

Mol Cancer Res. 2016 Apr;14(4):374-84. doi: 10.1158/1541-7786.MCR-15-0330. Epub 2016 Jan 11.

13.

Epithelial mesenchymal-like transition occurs in a subset of cells in castration resistant prostate cancer bone metastases.

Haider M, Zhang X, Coleman I, Ericson N, True LD, Lam HM, Brown LG, Ketchanji M, Nghiem B, Lakely B, Coleman R, Montgomery B, Lange PH, Roudier M, Higano CS, Bielas JH, Nelson PS, Vessella RL, Morrissey C.

Clin Exp Metastasis. 2016 Mar;33(3):239-48. doi: 10.1007/s10585-015-9773-7. Epub 2015 Dec 14.

14.

The metabolome regulates the epigenetic landscape during naive-to-primed human embryonic stem cell transition.

Sperber H, Mathieu J, Wang Y, Ferreccio A, Hesson J, Xu Z, Fischer KA, Devi A, Detraux D, Gu H, Battle SL, Showalter M, Valensisi C, Bielas JH, Ericson NG, Margaretha L, Robitaille AM, Margineantu D, Fiehn O, Hockenbery D, Blau CA, Raftery D, Margolin AA, Hawkins RD, Moon RT, Ware CB, Ruohola-Baker H.

Nat Cell Biol. 2015 Dec;17(12):1523-35. doi: 10.1038/ncb3264. Epub 2015 Nov 16.

15.

Targeted single molecule mutation detection with massively parallel sequencing.

Gregory MT, Bertout JA, Ericson NG, Taylor SD, Mukherjee R, Robins HS, Drescher CW, Bielas JH.

Nucleic Acids Res. 2016 Feb 18;44(3):e22. doi: 10.1093/nar/gkv915. Epub 2015 Sep 17.

16.

Subacute calorie restriction and rapamycin discordantly alter mouse liver proteome homeostasis and reverse aging effects.

Karunadharma PP, Basisty N, Dai DF, Chiao YA, Quarles EK, Hsieh EJ, Crispin D, Bielas JH, Ericson NG, Beyer RP, MacKay VL, MacCoss MJ, Rabinovitch PS.

Aging Cell. 2015 Aug;14(4):547-57. doi: 10.1111/acel.12317. Epub 2015 Mar 23.

17.

Skeletal muscle mitochondrial DNA deletions are not increased in CuZn-superoxide dismutase deficient mice.

Wanagat J, Ahmadieh N, Bielas JH, Ericson NG, Van Remmen H.

Exp Gerontol. 2015 Jan;61:15-9. doi: 10.1016/j.exger.2014.11.012. Epub 2014 Nov 20.

18.

Response to: 'when man got his mtDNA deletions?'.

Taylor SD, Salk JJ, Bielas JH.

Aging Cell. 2014 Aug;13(4):583. doi: 10.1111/acel.12230. Epub 2014 Jun 4. No abstract available.

19.

Digital genomic quantification of tumor-infiltrating lymphocytes.

Robins HS, Ericson NG, Guenthoer J, O'Briant KC, Tewari M, Drescher CW, Bielas JH.

Sci Transl Med. 2013 Dec 4;5(214):214ra169. doi: 10.1126/scitranslmed.3007247.

20.

High-throughput sequencing of T-cell receptors reveals a homogeneous repertoire of tumour-infiltrating lymphocytes in ovarian cancer.

Emerson RO, Sherwood AM, Rieder MJ, Guenthoer J, Williamson DW, Carlson CS, Drescher CW, Tewari M, Bielas JH, Robins HS.

J Pathol. 2013 Dec;231(4):433-440. doi: 10.1002/path.4260.

21.

Simultaneous digital quantification and fluorescence-based size characterization of massively parallel sequencing libraries.

Laurie MT, Bertout JA, Taylor SD, Burton JN, Shendure JA, Bielas JH.

Biotechniques. 2013 Aug;55(2):61-7. doi: 10.2144/000114063.

22.

Targeted enrichment and high-resolution digital profiling of mitochondrial DNA deletions in human brain.

Taylor SD, Ericson NG, Burton JN, Prolla TA, Silber JR, Shendure J, Bielas JH.

Aging Cell. 2014 Feb;13(1):29-38. doi: 10.1111/acel.12146. Epub 2013 Sep 11.

23.

Heterogeneity of tumor-induced gene expression changes in the human metabolic network.

Hu J, Locasale JW, Bielas JH, O'Sullivan J, Sheahan K, Cantley LC, Vander Heiden MG, Vitkup D.

Nat Biotechnol. 2013 Jun;31(6):522-9. doi: 10.1038/nbt.2530. Epub 2013 Apr 21.

24.

Decreased mitochondrial DNA mutagenesis in human colorectal cancer.

Ericson NG, Kulawiec M, Vermulst M, Sheahan K, O'Sullivan J, Salk JJ, Bielas JH.

PLoS Genet. 2012;8(6):e1002689. doi: 10.1371/journal.pgen.1002689. Epub 2012 Jun 7.

25.

Aging neural progenitor cells have decreased mitochondrial content and lower oxidative metabolism.

Stoll EA, Cheung W, Mikheev AM, Sweet IR, Bielas JH, Zhang J, Rostomily RC, Horner PJ.

J Biol Chem. 2011 Nov 4;286(44):38592-601. doi: 10.1074/jbc.M111.252171. Epub 2011 Sep 7.

26.

Roles of DNA polymerase I in leading and lagging-strand replication defined by a high-resolution mutation footprint of ColE1 plasmid replication.

Allen JM, Simcha DM, Ericson NG, Alexander DL, Marquette JT, Van Biber BP, Troll CJ, Karchin R, Bielas JH, Loeb LA, Camps M.

Nucleic Acids Res. 2011 Sep 1;39(16):7020-33. doi: 10.1093/nar/gkr157. Epub 2011 May 26.

27.

A random mutation capture assay to detect genomic point mutations in mouse tissue.

Wright JH, Modjeski KL, Bielas JH, Preston BD, Fausto N, Loeb LA, Campbell JS.

Nucleic Acids Res. 2011 Jun;39(11):e73. doi: 10.1093/nar/gkr142. Epub 2011 Apr 1.

28.

Generation, function, and prognostic utility of somatic mitochondrial DNA mutations in cancer.

Kulawiec M, Salk JJ, Ericson NG, Wanagat J, Bielas JH.

Environ Mol Mutagen. 2010 Jun;51(5):427-39. doi: 10.1002/em.20582. Review.

PMID:
20544883
29.

Molecularly evolved thymidylate synthase inhibits 5-fluorodeoxyuridine toxicity in human hematopoietic cells.

Bielas JH, Schmitt MW, Icreverzi A, Ericson NG, Loeb LA.

Hum Gene Ther. 2009 Dec;20(12):1703-7. doi: 10.1089/hum.2009.053.

30.

Quantification of random mutations in the mitochondrial genome.

Vermulst M, Bielas JH, Loeb LA.

Methods. 2008 Dec;46(4):263-8. doi: 10.1016/j.ymeth.2008.10.008. Epub 2008 Oct 21.

31.

Genetic instability is not a requirement for tumor development.

Bodmer W, Bielas JH, Beckman RA.

Cancer Res. 2008 May 15;68(10):3558-60; discussion 3560-1. doi: 10.1158/0008-5472.CAN-07-6544. Review. No abstract available. Erratum in: Cancer Res. 2008 Jun 15;68(12):4958. Bielas, Jason H [added]; Beckman, Robert A [added].

32.

Cancers exhibit a mutator phenotype: clinical implications.

Loeb LA, Bielas JH, Beckman RA.

Cancer Res. 2008 May 15;68(10):3551-7; discussion 3557. doi: 10.1158/0008-5472.CAN-07-5835. Review.

33.

DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice.

Vermulst M, Wanagat J, Kujoth GC, Bielas JH, Rabinovitch PS, Prolla TA, Loeb LA.

Nat Genet. 2008 Apr;40(4):392-4. doi: 10.1038/ng.95. Epub 2008 Mar 2.

PMID:
18311139
34.

Mitochondrial point mutations do not limit the natural lifespan of mice.

Vermulst M, Bielas JH, Kujoth GC, Ladiges WC, Rabinovitch PS, Prolla TA, Loeb LA.

Nat Genet. 2007 Apr;39(4):540-3. Epub 2007 Mar 4.

PMID:
17334366
35.

LOH-proficient embryonic stem cells: a model of cancer progenitor cells?

Bielas JH, Venkatesan RN, Loeb LA.

Trends Genet. 2007 Apr;23(4):154-7. Epub 2007 Feb 27. Review.

PMID:
17328987
36.

Limits to the Human Cancer Genome Project?

Loeb LA, Bielas JH.

Science. 2007 Feb 9;315(5813):762; author reply 764-5. No abstract available.

PMID:
17297724
37.

Human cancers express a mutator phenotype.

Bielas JH, Loeb KR, Rubin BP, True LD, Loeb LA.

Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18238-42. Epub 2006 Nov 15. Erratum in: Proc Natl Acad Sci U S A. 2006 Dec 19;103(51):19605.

38.

Non-transcribed strand repair revealed in quiescent cells.

Bielas JH.

Mutagenesis. 2006 Jan;21(1):49-53. Epub 2006 Jan 4.

PMID:
16394029
39.

Generation of mutator mutants during carcinogenesis.

Venkatesan RN, Bielas JH, Loeb LA.

DNA Repair (Amst). 2006 Mar 7;5(3):294-302. Epub 2005 Dec 15. Review.

PMID:
16359931
40.

Quantification of random genomic mutations.

Bielas JH, Loeb LA.

Nat Methods. 2005 Apr;2(4):285-90. Epub 2005 Mar 23.

PMID:
15782221
41.

Unifying concept of DNA repair: the polymerase scanning hypothesis.

Heddle JA, Bielas JH.

Environ Mol Mutagen. 2005 Mar-Apr;45(2-3):143-9. Review.

PMID:
15672383
42.

Mutator phenotype in cancer: timing and perspectives.

Bielas JH, Loeb LA.

Environ Mol Mutagen. 2005 Mar-Apr;45(2-3):206-13. Review.

PMID:
15672382
43.

Quiescent murine cells lack global genomic repair but are proficient in transcription-coupled repair.

Bielas JH, Heddle JA.

DNA Repair (Amst). 2004 Jul 2;3(7):711-7.

PMID:
15177180
44.
45.
46.

Proliferation is necessary for both repair and mutation in transgenic mouse cells.

Bielas JH, Heddle JA.

Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11391-6.

47.

The cII locus in the MutaMouse system.

Swiger RR, Cosentino L, Shima N, Bielas JH, Cruz-Munoz W, Heddle JA.

Environ Mol Mutagen. 1999;34(2-3):201-7.

PMID:
10529745

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