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Correction: Seeking snow and breathing hard - Behavioral tactics in high elevation mammals to combat warming temperatures.

Sarmento W, Biel M, Berger J.

PLoS One. 2020 Jan 30;15(1):e0228820. doi: 10.1371/journal.pone.0228820. eCollection 2020.


Advancing Gene Therapy for PDE6A Retinitis Pigmentosa.

Petersen-Jones SM, Occelli LM, Biel M, Michalakis S.

Adv Exp Med Biol. 2019;1185:103-107. doi: 10.1007/978-3-030-27378-1_17.


Seeking snow and breathing hard - Behavioral tactics in high elevation mammals to combat warming temperatures.

Sarmento W, Biel M, Berger J.

PLoS One. 2019 Dec 11;14(12):e0225456. doi: 10.1371/journal.pone.0225456. eCollection 2019. Erratum in: PLoS One. 2020 Jan 30;15(1):e0228820.


Enigmatic rhodopsin mutation creates an exceptionally strong splice acceptor site.

Riedmayr LM, Böhm S, Biel M, Becirovic E.

Hum Mol Genet. 2020 Jan 15;29(2):295-304. doi: 10.1093/hmg/ddz291.


Intrinsic Differential Scanning Fluorimetry for Fast and Easy Identification of Adeno-Associated Virus Serotypes.

Rieser R, Penaud-Budloo M, Bouzelha M, Rossi A, Menzen T, Biel M, Büning H, Ayuso E, Winter G, Michalakis S.

J Pharm Sci. 2020 Jan;109(1):854-862. doi: 10.1016/j.xphs.2019.10.031. Epub 2019 Oct 19.


HCN3 ion channels: roles in sensory neuronal excitability and pain.

Lainez S, Tsantoulas C, Biel M, McNaughton PA.

J Physiol. 2019 Sep;597(17):4661-4675. doi: 10.1113/JP278211. Epub 2019 Jul 27.


Is There a Selfie Epidemic?

Reilly MJ, Parsa KM, Biel M.

JAMA Facial Plast Surg. 2019 Sep 1;21(5):367-368. doi: 10.1001/jamafacial.2019.0419. No abstract available.


Abolishing cAMP sensitivity in HCN2 pacemaker channels induces generalized seizures.

Hammelmann V, Stieglitz MS, Hülle H, Le Meur K, Kass J, Brümmer M, Gruner C, Rötzer RD, Fenske S, Hartmann J, Zott B, Lüthi A, Spahn S, Moser M, Isbrandt D, Ludwig A, Konnerth A, Wahl-Schott C, Biel M.

JCI Insight. 2019 May 2;4(9). pii: 126418. doi: 10.1172/jci.insight.126418. eCollection 2019 May 2.


The Science of Well-Being: Integration into Clinical Child Psychiatry.

Rettew DC, Biel MG, Bostic JQ.

Child Adolesc Psychiatr Clin N Am. 2019 Apr;28(2):xiii-xiv. doi: 10.1016/j.chc.2019.01.001. Epub 2019 Feb 6. No abstract available.


Where Do We Go from Here? Additional Opportunities to Address Well-Being in Child Psychiatry Clinical Practice and Advocacy for Children and Families.

Aron E, Biel MG.

Child Adolesc Psychiatr Clin N Am. 2019 Apr;28(2):281-288. doi: 10.1016/j.chc.2018.11.012. Epub 2019 Jan 3. Review.


Applying Mindfulness-Based Practices in Child Psychiatry.

Mathis ET, Dente E, Biel MG.

Child Adolesc Psychiatr Clin N Am. 2019 Apr;28(2):209-220. doi: 10.1016/j.chc.2018.11.004. Epub 2018 Dec 24. Review.


Selective agonist of TRPML2 reveals direct role in chemokine release from innate immune cells.

Plesch E, Chen CC, Butz E, Scotto Rosato A, Krogsaeter EK, Yinan H, Bartel K, Keller M, Robaa D, Teupser D, Holdt LM, Vollmar AM, Sippl W, Puertollano R, Medina D, Biel M, Wahl-Schott C, Bracher F, Grimm C.

Elife. 2018 Nov 27;7. pii: e39720. doi: 10.7554/eLife.39720.


Accessory heterozygous mutations in cone photoreceptor CNGA3 exacerbate CNG channel-associated retinopathy.

Burkard M, Kohl S, Krätzig T, Tanimoto N, Brennenstuhl C, Bausch AE, Junger K, Reuter P, Sothilingam V, Beck SC, Huber G, Ding XQ, Mayer AK, Baumann B, Weisschuh N, Zobor D, Hahn GA, Kellner U, Venturelli S, Becirovic E, Charbel Issa P, Koenekoop RK, Rudolph G, Heckenlively J, Sieving P, Weleber RG, Hamel C, Zong X, Biel M, Lukowski R, Seeliger MW, Michalakis S, Wissinger B, Ruth P.

J Clin Invest. 2018 Dec 3;128(12):5663-5675. doi: 10.1172/JCI96098. Epub 2018 Nov 12.


The protein interaction networks of mucolipins and two-pore channels.

Krogsaeter EK, Biel M, Wahl-Schott C, Grimm C.

Biochim Biophys Acta Mol Cell Res. 2019 Jul;1866(7):1111-1123. doi: 10.1016/j.bbamcr.2018.10.020. Epub 2018 Nov 2.


Optimized Subretinal Injection Technique for Gene Therapy Approaches.

Mühlfriedel R, Michalakis S, Garrido MG, Sothilingam V, Schön C, Biel M, Seeliger MW.

Methods Mol Biol. 2019;1834:405-412. doi: 10.1007/978-1-4939-8669-9_26.


In Vitro Evaluation of AAV Vectors for Retinal Gene Therapy.

Wagner JE, Schön C, Becirovic E, Biel M, Michalakis S.

Methods Mol Biol. 2019;1834:383-390. doi: 10.1007/978-1-4939-8669-9_24.


Parental Psychiatric Symptoms and Children's Outcomes: Toward Understanding and Responding to Intergenerational Risk in Child Psychiatry.

Biel MG.

J Am Acad Child Adolesc Psychiatry. 2018 Sep;57(9):632-633. doi: 10.1016/j.jaac.2018.06.010.


Development of Methodology and Study Protocol: Safety and Efficacy of a Single Subretinal Injection of rAAV.hCNGA3 in Patients with CNGA3-Linked Achromatopsia Investigated in an Exploratory Dose-Escalation Trial.

Kahle NA, Peters T, Zobor D, Kuehlewein L, Kohl S, Zhour A, Werner A, Seitz IP, Sothilingam V, Michalakis S, Biel M, Ueffing M, Zrenner E, Bartz-Schmidt KU, Fischer MD, Wilhelm BJC.

Hum Gene Ther Clin Dev. 2018 Sep;29(3):121-131. doi: 10.1089/humc.2018.088.


Optogenetic Control of Neural Circuits in the Mongolian Gerbil.

Keplinger S, Beiderbeck B, Michalakis S, Biel M, Grothe B, Kunz L.

Front Cell Neurosci. 2018 Apr 24;12:111. doi: 10.3389/fncel.2018.00111. eCollection 2018.


Humoral Immune Response After Intravitreal But Not After Subretinal AAV8 in Primates and Patients.

Reichel FF, Peters T, Wilhelm B, Biel M, Ueffing M, Wissinger B, Bartz-Schmidt KU, Klein R, Michalakis S, Fischer MD; RD-CURE Consortium.

Invest Ophthalmol Vis Sci. 2018 Apr 1;59(5):1910-1915. doi: 10.1167/iovs.17-22494.


Hif1a inactivation rescues photoreceptor degeneration induced by a chronic hypoxia-like stress.

Barben M, Ail D, Storti F, Klee K, Schori C, Samardzija M, Michalakis S, Biel M, Meneau I, Blaser F, Barthelmes D, Grimm C.

Cell Death Differ. 2018 Dec;25(12):2071-2085. doi: 10.1038/s41418-018-0094-7. Epub 2018 Apr 17.


Retinal Cyclic Nucleotide-Gated Channels: From Pathophysiology to Therapy.

Michalakis S, Becirovic E, Biel M.

Int J Mol Sci. 2018 Mar 7;19(3). pii: E749. doi: 10.3390/ijms19030749. Review.


A Review of Photodynamic Therapy for Neoplasms of the Head and Neck.

Civantos FJ, Karakullukcu B, Biel M, Silver CE, Rinaldo A, Saba NF, Takes RP, Vander Poorten V, Ferlito A.

Adv Ther. 2018 Mar;35(3):324-340. doi: 10.1007/s12325-018-0659-3. Epub 2018 Feb 7. Review.


Disturbed Processing of Contextual Information in HCN3 Channel Deficient Mice.

Stieglitz MS, Fenske S, Hammelmann V, Becirovic E, Schöttle V, Delorme JE, Schöll-Weidinger M, Mader R, Deussing J, Wolfer DP, Seeliger MW, Albrecht U, Wotjak CT, Biel M, Michalakis S, Wahl-Schott C.

Front Mol Neurosci. 2018 Jan 9;10:436. doi: 10.3389/fnmol.2017.00436. eCollection 2017.


Early Microglia Activation Precedes Photoreceptor Degeneration in a Mouse Model of CNGB1-Linked Retinitis Pigmentosa.

Blank T, Goldmann T, Koch M, Amann L, Schön C, Bonin M, Pang S, Prinz M, Burnet M, Wagner JE, Biel M, Michalakis S.

Front Immunol. 2018 Jan 5;8:1930. doi: 10.3389/fimmu.2017.01930. eCollection 2017.


Endolysosomal Cation Channels and Cancer-A Link with Great Potential.

Grimm C, Bartel K, Vollmar AM, Biel M.

Pharmaceuticals (Basel). 2018 Jan 5;11(1). pii: E4. doi: 10.3390/ph11010004. Review.


Gene therapy successfully delays degeneration in a mouse model of PDE6A-linked retinitis pigmentosa (RP 43).

Schön C, Sothilingam V, Mühlfriedel R, Garcia Garrido M, Beck SC, Tanimoto N, Wissinger B, Paquet-Durand F, Biel M, Michalakis S, Seeliger MW, Consortium RC.

Hum Gene Ther. 2017 Dec 7. doi: 10.1089/hum.2017.156. [Epub ahead of print]


Gene Supplementation Rescues Rod Function and Preserves Photoreceptor and Retinal Morphology in Dogs, Leading the Way Towards Treating Human PDE6A-Retinitis Pigmentosa.

Occelli LM, Schön C, Seeliger MW, Biel M, Michalakis S, Petersen-Jones S, Consortium RC.

Hum Gene Ther. 2017 Dec 6. doi: 10.1089/hum.2017.155. [Epub ahead of print]


Design and Development of AAV-based Gene Supplementation Therapies for Achromatopsia and Retinitis Pigmentosa.

Schön C, Becirovic E, Biel M, Michalakis S.

Methods Mol Biol. 2018;1715:33-46. doi: 10.1007/978-1-4939-7522-8_3.


Superior Retinal Gene Transfer and Biodistribution Profile of Subretinal Versus Intravitreal Delivery of AAV8 in Nonhuman Primates.

Seitz IP, Michalakis S, Wilhelm B, Reichel FF, Ochakovski GA, Zrenner E, Ueffing M, Biel M, Wissinger B, Bartz-Schmidt KU, Peters T, Fischer MD; RD-CURE Consortium.

Invest Ophthalmol Vis Sci. 2017 Nov 1;58(13):5792-5801. doi: 10.1167/iovs.17-22473.


Mental Health Screening Quality Improvement Learning Collaborative in Pediatric Primary Care.

Beers LS, Godoy L, John T, Long M, Biel MG, Anthony B, Mlynarski L, Moon R, Weissman M.

Pediatrics. 2017 Dec;140(6). pii: e20162966. doi: 10.1542/peds.2016-2966. Epub 2017 Nov 7.


Authors' Response to Comment on "Collaborative Training Efforts with Pediatric Providers in Addressing Mental Health Problems in Primary Care".

Biel MG, Beers LS, Godoy L, Mlynarski L, Anthony BJ.

Acad Psychiatry. 2017 Dec;41(6):855-856. doi: 10.1007/s40596-017-0839-5. Epub 2017 Oct 16. No abstract available.


AAV8 Can Induce Innate and Adaptive Immune Response in the Primate Eye.

Reichel FF, Dauletbekov DL, Klein R, Peters T, Ochakovski GA, Seitz IP, Wilhelm B, Ueffing M, Biel M, Wissinger B, Michalakis S, Bartz-Schmidt KU, Fischer MD; RD-CURE Consortium.

Mol Ther. 2017 Dec 6;25(12):2648-2660. doi: 10.1016/j.ymthe.2017.08.018. Epub 2017 Aug 31.


TPC2 polymorphisms associated with a hair pigmentation phenotype in humans result in gain of channel function by independent mechanisms.

Chao YK, Schludi V, Chen CC, Butz E, Nguyen ONP, Müller M, Krüger J, Kammerbauer C, Ben-Johny M, Vollmar AM, Berking C, Biel M, Wahl-Schott CA, Grimm C.

Proc Natl Acad Sci U S A. 2017 Oct 10;114(41):E8595-E8602. doi: 10.1073/pnas.1705739114. Epub 2017 Sep 18.


Using Effective Public Private Collaboration to Advance Integrated Care.

Beers LS, Godoy L, Biel MG.

Child Adolesc Psychiatr Clin N Am. 2017 Oct;26(4):665-675. doi: 10.1016/j.chc.2017.06.003. Epub 2017 Jul 29.


The two-pore channel TPC1 is required for efficient protein processing through early and recycling endosomes.

Castonguay J, Orth JHC, Müller T, Sleman F, Grimm C, Wahl-Schott C, Biel M, Mallmann RT, Bildl W, Schulte U, Klugbauer N.

Sci Rep. 2017 Aug 30;7(1):10038. doi: 10.1038/s41598-017-10607-4.


Subretinal Injection for Gene Therapy Does Not Cause Clinically Significant Outer Nuclear Layer Thinning in Normal Primate Foveae.

Ochakovski GA, Peters T, Michalakis S, Wilhelm B, Wissinger B, Biel M, Bartz-Schmidt KU, Fischer MD; RD-CURE Consortium.

Invest Ophthalmol Vis Sci. 2017 Aug 1;58(10):4155-4160. doi: 10.1167/iovs.17-22402.


Protein kinase A regulates inflammatory pain sensitization by modulating HCN2 channel activity in nociceptive sensory neurons.

Herrmann S, Rajab H, Christ I, Schirdewahn C, Höfler D, Fischer MJM, Bruno A, Fenske S, Gruner C, Kramer F, Wachsmann T, Wahl-Schott C, Stieber J, Biel M, Ludwig A.

Pain. 2017 Oct;158(10):2012-2024. doi: 10.1097/j.pain.0000000000001005.


Small Molecules for Early Endosome-Specific Patch Clamping.

Chen CC, Butz ES, Chao YK, Grishchuk Y, Becker L, Heller S, Slaugenhaupt SA, Biel M, Wahl-Schott C, Grimm C.

Cell Chem Biol. 2017 Jul 20;24(7):907-916.e4. doi: 10.1016/j.chembiol.2017.05.025.


Patch-clamp technique to characterize ion channels in enlarged individual endolysosomes.

Chen CC, Cang C, Fenske S, Butz E, Chao YK, Biel M, Ren D, Wahl-Schott C, Grimm C.

Nat Protoc. 2017 Aug;12(8):1639-1658. doi: 10.1038/nprot.2017.036. Epub 2017 Jul 20.


AAV-Mediated Gene Supplementation Therapy in Achromatopsia Type 2: Preclinical Data on Therapeutic Time Window and Long-Term Effects.

Mühlfriedel R, Tanimoto N, Schön C, Sothilingam V, Garcia Garrido M, Beck SC, Huber G, Biel M, Seeliger MW, Michalakis S.

Front Neurosci. 2017 May 24;11:292. doi: 10.3389/fnins.2017.00292. eCollection 2017.


Photopharmacological control of bipolar cells restores visual function in blind mice.

Laprell L, Tochitsky I, Kaur K, Manookin MB, Stein M, Barber DM, Schön C, Michalakis S, Biel M, Kramer RH, Sumser MP, Trauner D, Van Gelder RN.

J Clin Invest. 2017 Jun 30;127(7):2598-2611. doi: 10.1172/JCI92156. Epub 2017 Jun 5.


Peripherin-2 and Rom-1 have opposing effects on rod outer segment targeting of retinitis pigmentosa-linked peripherin-2 mutants.

Böhm S, Riedmayr LM, Nguyen ONP, Gießl A, Liebscher T, Butz ES, Schön C, Michalakis S, Wahl-Schott C, Biel M, Becirovic E.

Sci Rep. 2017 May 24;7(1):2321. doi: 10.1038/s41598-017-02514-5.


Endoplasmic reticulum (ER) Ca2+-channel activity contributes to ER stress and cone death in cyclic nucleotide-gated channel deficiency.

Butler MR, Ma H, Yang F, Belcher J, Le YZ, Mikoshiba K, Biel M, Michalakis S, Iuso A, Križaj D, Ding XQ.

J Biol Chem. 2017 Jul 7;292(27):11189-11205. doi: 10.1074/jbc.M117.782326. Epub 2017 May 11.


From mucolipidosis type IV to Ebola: TRPML and two-pore channels at the crossroads of endo-lysosomal trafficking and disease.

Grimm C, Butz E, Chen CC, Wahl-Schott C, Biel M.

Cell Calcium. 2017 Nov;67:148-155. doi: 10.1016/j.ceca.2017.04.003. Epub 2017 Apr 23. Review.


Collaborative Training Efforts with Pediatric Providers in Addressing Mental Health Problems in Primary Care.

Biel MG, Anthony BJ, Mlynarski L, Godoy L, Beers LS.

Acad Psychiatry. 2017 Oct;41(5):610-616. doi: 10.1007/s40596-017-0709-1. Epub 2017 Apr 18. No abstract available.


Recombinant tandem of pore-domains in a Weakly Inward rectifying K+ channel 2 (TWIK2) forms active lysosomal channels.

Bobak N, Feliciangeli S, Chen CC, Ben Soussia I, Bittner S, Pagnotta S, Ruck T, Biel M, Wahl-Schott C, Grimm C, Meuth SG, Lesage F.

Sci Rep. 2017 Apr 5;7(1):649. doi: 10.1038/s41598-017-00640-8.


Mosaic synaptopathy and functional defects in Cav1.4 heterozygous mice and human carriers of CSNB2.

Michalakis S, Shaltiel L, Sothilingam V, Koch S, Schludi V, Krause S, Zeitz C, Audo I, Lancelot ME, Hamel C, Meunier I, Preising MN, Friedburg C, Lorenz B, Zabouri N, Haverkamp S, Garrido MG, Tanimoto N, Seeliger MW, Biel M, Wahl-Schott CA.

Hum Mol Genet. 2017 Jan 15;26(2):466. doi: 10.1093/hmg/ddw424. No abstract available.


Two-Pore Channels: Catalyzers of Endolysosomal Transport and Function.

Grimm C, Chen CC, Wahl-Schott C, Biel M.

Front Pharmacol. 2017 Feb 7;8:45. doi: 10.3389/fphar.2017.00045. eCollection 2017. Review.


Cone Genesis Tracing by the Chrnb4-EGFP Mouse Line: Evidences of Cellular Material Fusion after Cone Precursor Transplantation.

Decembrini S, Martin C, Sennlaub F, Chemtob S, Biel M, Samardzija M, Moulin A, Behar-Cohen F, Arsenijevic Y.

Mol Ther. 2017 Mar 1;25(3):634-653. doi: 10.1016/j.ymthe.2016.12.015. Epub 2017 Jan 28.

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