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Items: 1 to 50 of 283

1.

Selective agonist of TRPML2 reveals direct role in chemokine release from innate immune cells.

Plesch E, Chen CC, Butz E, Scotto Rosato A, Krogsaeter EK, Yinan H, Bartel K, Keller M, Robaa D, Teupser D, Holdt LM, Vollmar AM, Sippl W, Puertollano R, Medina D, Biel M, Wahl-Schott C, Bracher F, Grimm C.

Elife. 2018 Nov 27;7. pii: e39720. doi: 10.7554/eLife.39720.

2.

Accessory heterozygous mutations in cone photoreceptor CNGA3 exacerbate CNG channel-associated retinopathy.

Burkard M, Kohl S, Krätzig T, Tanimoto N, Brennenstuhl C, Bausch AE, Junger K, Reuter P, Sothilingam V, Beck SC, Huber G, Ding XQ, Mayer AK, Baumann B, Weisschuh N, Zobor D, Hahn GA, Kellner U, Venturelli S, Becirovic E, Charbel Issa P, Koenekoop RK, Rudolph G, Heckenlively J, Sieving P, Weleber RG, Hamel C, Zong X, Biel M, Lukowski R, Seeliger MW, Michalakis S, Wissinger B, Ruth P.

J Clin Invest. 2018 Dec 3;128(12):5663-5675. doi: 10.1172/JCI96098. Epub 2018 Nov 12.

3.

The protein interaction networks of mucolipins and two-pore channels.

Krogsaeter EK, Biel M, Wahl-Schott C, Grimm C.

Biochim Biophys Acta Mol Cell Res. 2018 Nov 2. pii: S0167-4889(18)30491-9. doi: 10.1016/j.bbamcr.2018.10.020. [Epub ahead of print] Review.

PMID:
30395881
4.

Optimized Subretinal Injection Technique for Gene Therapy Approaches.

Mühlfriedel R, Michalakis S, Garrido MG, Sothilingam V, Schön C, Biel M, Seeliger MW.

Methods Mol Biol. 2019;1834:405-412. doi: 10.1007/978-1-4939-8669-9_26.

PMID:
30324458
5.

In Vitro Evaluation of AAV Vectors for Retinal Gene Therapy.

Wagner JE, Schön C, Becirovic E, Biel M, Michalakis S.

Methods Mol Biol. 2019;1834:383-390. doi: 10.1007/978-1-4939-8669-9_24.

PMID:
30324456
6.

Parental Psychiatric Symptoms and Children's Outcomes: Toward Understanding and Responding to Intergenerational Risk in Child Psychiatry.

Biel MG.

J Am Acad Child Adolesc Psychiatry. 2018 Sep;57(9):632-633. doi: 10.1016/j.jaac.2018.06.010.

PMID:
30196865
7.

Development of Methodology and Study Protocol: Safety and Efficacy of a Single Subretinal Injection of rAAV.hCNGA3 in Patients with CNGA3-Linked Achromatopsia Investigated in an Exploratory Dose-Escalation Trial.

Kahle NA, Peters T, Zobor D, Kuehlewein L, Kohl S, Zhour A, Werner A, Seitz IP, Sothilingam V, Michalakis S, Biel M, Ueffing M, Zrenner E, Bartz-Schmidt KU, Fischer MD, Wilhelm BJC.

Hum Gene Ther Clin Dev. 2018 Sep;29(3):121-131. doi: 10.1089/humc.2018.088.

PMID:
30187779
8.

Optogenetic Control of Neural Circuits in the Mongolian Gerbil.

Keplinger S, Beiderbeck B, Michalakis S, Biel M, Grothe B, Kunz L.

Front Cell Neurosci. 2018 Apr 24;12:111. doi: 10.3389/fncel.2018.00111. eCollection 2018.

9.

Humoral Immune Response After Intravitreal But Not After Subretinal AAV8 in Primates and Patients.

Reichel FF, Peters T, Wilhelm B, Biel M, Ueffing M, Wissinger B, Bartz-Schmidt KU, Klein R, Michalakis S, Fischer MD; RD-CURE Consortium.

Invest Ophthalmol Vis Sci. 2018 Apr 1;59(5):1910-1915. doi: 10.1167/iovs.17-22494.

PMID:
29677353
10.

Hif1a inactivation rescues photoreceptor degeneration induced by a chronic hypoxia-like stress.

Barben M, Ail D, Storti F, Klee K, Schori C, Samardzija M, Michalakis S, Biel M, Meneau I, Blaser F, Barthelmes D, Grimm C.

Cell Death Differ. 2018 Dec;25(12):2071-2085. doi: 10.1038/s41418-018-0094-7. Epub 2018 Apr 17.

11.

Retinal Cyclic Nucleotide-Gated Channels: From Pathophysiology to Therapy.

Michalakis S, Becirovic E, Biel M.

Int J Mol Sci. 2018 Mar 7;19(3). pii: E749. doi: 10.3390/ijms19030749. Review.

12.

A Review of Photodynamic Therapy for Neoplasms of the Head and Neck.

Civantos FJ, Karakullukcu B, Biel M, Silver CE, Rinaldo A, Saba NF, Takes RP, Vander Poorten V, Ferlito A.

Adv Ther. 2018 Mar;35(3):324-340. doi: 10.1007/s12325-018-0659-3. Epub 2018 Feb 7. Review.

PMID:
29417455
13.

Disturbed Processing of Contextual Information in HCN3 Channel Deficient Mice.

Stieglitz MS, Fenske S, Hammelmann V, Becirovic E, Schöttle V, Delorme JE, Schöll-Weidinger M, Mader R, Deussing J, Wolfer DP, Seeliger MW, Albrecht U, Wotjak CT, Biel M, Michalakis S, Wahl-Schott C.

Front Mol Neurosci. 2018 Jan 9;10:436. doi: 10.3389/fnmol.2017.00436. eCollection 2017.

14.

Early Microglia Activation Precedes Photoreceptor Degeneration in a Mouse Model of CNGB1-Linked Retinitis Pigmentosa.

Blank T, Goldmann T, Koch M, Amann L, Schön C, Bonin M, Pang S, Prinz M, Burnet M, Wagner JE, Biel M, Michalakis S.

Front Immunol. 2018 Jan 5;8:1930. doi: 10.3389/fimmu.2017.01930. eCollection 2017.

15.

Endolysosomal Cation Channels and Cancer-A Link with Great Potential.

Grimm C, Bartel K, Vollmar AM, Biel M.

Pharmaceuticals (Basel). 2018 Jan 5;11(1). pii: E4. doi: 10.3390/ph11010004. Review.

16.

Gene therapy successfully delays degeneration in a mouse model of PDE6A-linked retinitis pigmentosa (RP 43).

Schön C, Sothilingam V, Mühlfriedel R, Garcia Garrido M, Beck SC, Tanimoto N, Wissinger B, Paquet-Durand F, Biel M, Michalakis S, Seeliger MW, Consortium RC.

Hum Gene Ther. 2017 Dec 7. doi: 10.1089/hum.2017.156. [Epub ahead of print]

PMID:
29212391
17.

Gene Supplementation Rescues Rod Function and Preserves Photoreceptor and Retinal Morphology in Dogs, Leading the Way Towards Treating Human PDE6A-Retinitis Pigmentosa.

Occelli LM, Schön C, Seeliger MW, Biel M, Michalakis S, Petersen-Jones S, Consortium RC.

Hum Gene Ther. 2017 Dec 6. doi: 10.1089/hum.2017.155. [Epub ahead of print]

PMID:
29212382
18.

Design and Development of AAV-based Gene Supplementation Therapies for Achromatopsia and Retinitis Pigmentosa.

Schön C, Becirovic E, Biel M, Michalakis S.

Methods Mol Biol. 2018;1715:33-46. doi: 10.1007/978-1-4939-7522-8_3.

PMID:
29188504
19.

Superior Retinal Gene Transfer and Biodistribution Profile of Subretinal Versus Intravitreal Delivery of AAV8 in Nonhuman Primates.

Seitz IP, Michalakis S, Wilhelm B, Reichel FF, Ochakovski GA, Zrenner E, Ueffing M, Biel M, Wissinger B, Bartz-Schmidt KU, Peters T, Fischer MD; RD-CURE Consortium.

Invest Ophthalmol Vis Sci. 2017 Nov 1;58(13):5792-5801. doi: 10.1167/iovs.17-22473.

PMID:
29117317
20.

Mental Health Screening Quality Improvement Learning Collaborative in Pediatric Primary Care.

Beers LS, Godoy L, John T, Long M, Biel MG, Anthony B, Mlynarski L, Moon R, Weissman M.

Pediatrics. 2017 Dec;140(6). pii: e20162966. doi: 10.1542/peds.2016-2966. Epub 2017 Nov 7.

21.

Authors' Response to Comment on "Collaborative Training Efforts with Pediatric Providers in Addressing Mental Health Problems in Primary Care".

Biel MG, Beers LS, Godoy L, Mlynarski L, Anthony BJ.

Acad Psychiatry. 2017 Dec;41(6):855-856. doi: 10.1007/s40596-017-0839-5. Epub 2017 Oct 16. No abstract available.

PMID:
29039123
22.

AAV8 Can Induce Innate and Adaptive Immune Response in the Primate Eye.

Reichel FF, Dauletbekov DL, Klein R, Peters T, Ochakovski GA, Seitz IP, Wilhelm B, Ueffing M, Biel M, Wissinger B, Michalakis S, Bartz-Schmidt KU, Fischer MD; RD-CURE Consortium.

Mol Ther. 2017 Dec 6;25(12):2648-2660. doi: 10.1016/j.ymthe.2017.08.018. Epub 2017 Aug 31.

23.

TPC2 polymorphisms associated with a hair pigmentation phenotype in humans result in gain of channel function by independent mechanisms.

Chao YK, Schludi V, Chen CC, Butz E, Nguyen ONP, Müller M, Krüger J, Kammerbauer C, Ben-Johny M, Vollmar AM, Berking C, Biel M, Wahl-Schott CA, Grimm C.

Proc Natl Acad Sci U S A. 2017 Oct 10;114(41):E8595-E8602. doi: 10.1073/pnas.1705739114. Epub 2017 Sep 18.

24.

Using Effective Public Private Collaboration to Advance Integrated Care.

Beers LS, Godoy L, Biel MG.

Child Adolesc Psychiatr Clin N Am. 2017 Oct;26(4):665-675. doi: 10.1016/j.chc.2017.06.003. Epub 2017 Jul 29.

PMID:
28916006
25.

The two-pore channel TPC1 is required for efficient protein processing through early and recycling endosomes.

Castonguay J, Orth JHC, Müller T, Sleman F, Grimm C, Wahl-Schott C, Biel M, Mallmann RT, Bildl W, Schulte U, Klugbauer N.

Sci Rep. 2017 Aug 30;7(1):10038. doi: 10.1038/s41598-017-10607-4.

26.

Subretinal Injection for Gene Therapy Does Not Cause Clinically Significant Outer Nuclear Layer Thinning in Normal Primate Foveae.

Ochakovski GA, Peters T, Michalakis S, Wilhelm B, Wissinger B, Biel M, Bartz-Schmidt KU, Fischer MD; RD-CURE Consortium.

Invest Ophthalmol Vis Sci. 2017 Aug 1;58(10):4155-4160. doi: 10.1167/iovs.17-22402.

PMID:
28829847
27.

Protein kinase A regulates inflammatory pain sensitization by modulating HCN2 channel activity in nociceptive sensory neurons.

Herrmann S, Rajab H, Christ I, Schirdewahn C, Höfler D, Fischer MJM, Bruno A, Fenske S, Gruner C, Kramer F, Wachsmann T, Wahl-Schott C, Stieber J, Biel M, Ludwig A.

Pain. 2017 Oct;158(10):2012-2024. doi: 10.1097/j.pain.0000000000001005.

PMID:
28767511
28.

Small Molecules for Early Endosome-Specific Patch Clamping.

Chen CC, Butz ES, Chao YK, Grishchuk Y, Becker L, Heller S, Slaugenhaupt SA, Biel M, Wahl-Schott C, Grimm C.

Cell Chem Biol. 2017 Jul 20;24(7):907-916.e4. doi: 10.1016/j.chembiol.2017.05.025.

29.

Patch-clamp technique to characterize ion channels in enlarged individual endolysosomes.

Chen CC, Cang C, Fenske S, Butz E, Chao YK, Biel M, Ren D, Wahl-Schott C, Grimm C.

Nat Protoc. 2017 Aug;12(8):1639-1658. doi: 10.1038/nprot.2017.036. Epub 2017 Jul 20.

PMID:
28726848
30.

AAV-Mediated Gene Supplementation Therapy in Achromatopsia Type 2: Preclinical Data on Therapeutic Time Window and Long-Term Effects.

Mühlfriedel R, Tanimoto N, Schön C, Sothilingam V, Garcia Garrido M, Beck SC, Huber G, Biel M, Seeliger MW, Michalakis S.

Front Neurosci. 2017 May 24;11:292. doi: 10.3389/fnins.2017.00292. eCollection 2017.

31.

Photopharmacological control of bipolar cells restores visual function in blind mice.

Laprell L, Tochitsky I, Kaur K, Manookin MB, Stein M, Barber DM, Schön C, Michalakis S, Biel M, Kramer RH, Sumser MP, Trauner D, Van Gelder RN.

J Clin Invest. 2017 Jun 30;127(7):2598-2611. doi: 10.1172/JCI92156. Epub 2017 Jun 5.

32.

Peripherin-2 and Rom-1 have opposing effects on rod outer segment targeting of retinitis pigmentosa-linked peripherin-2 mutants.

Böhm S, Riedmayr LM, Nguyen ONP, Gießl A, Liebscher T, Butz ES, Schön C, Michalakis S, Wahl-Schott C, Biel M, Becirovic E.

Sci Rep. 2017 May 24;7(1):2321. doi: 10.1038/s41598-017-02514-5.

33.

Endoplasmic reticulum (ER) Ca2+-channel activity contributes to ER stress and cone death in cyclic nucleotide-gated channel deficiency.

Butler MR, Ma H, Yang F, Belcher J, Le YZ, Mikoshiba K, Biel M, Michalakis S, Iuso A, Križaj D, Ding XQ.

J Biol Chem. 2017 Jul 7;292(27):11189-11205. doi: 10.1074/jbc.M117.782326. Epub 2017 May 11.

34.

From mucolipidosis type IV to Ebola: TRPML and two-pore channels at the crossroads of endo-lysosomal trafficking and disease.

Grimm C, Butz E, Chen CC, Wahl-Schott C, Biel M.

Cell Calcium. 2017 Nov;67:148-155. doi: 10.1016/j.ceca.2017.04.003. Epub 2017 Apr 23. Review.

PMID:
28457591
35.

Collaborative Training Efforts with Pediatric Providers in Addressing Mental Health Problems in Primary Care.

Biel MG, Anthony BJ, Mlynarski L, Godoy L, Beers LS.

Acad Psychiatry. 2017 Oct;41(5):610-616. doi: 10.1007/s40596-017-0709-1. Epub 2017 Apr 18. No abstract available.

PMID:
28421477
36.

Recombinant tandem of pore-domains in a Weakly Inward rectifying K+ channel 2 (TWIK2) forms active lysosomal channels.

Bobak N, Feliciangeli S, Chen CC, Ben Soussia I, Bittner S, Pagnotta S, Ruck T, Biel M, Wahl-Schott C, Grimm C, Meuth SG, Lesage F.

Sci Rep. 2017 Apr 5;7(1):649. doi: 10.1038/s41598-017-00640-8.

37.

Mosaic synaptopathy and functional defects in Cav1.4 heterozygous mice and human carriers of CSNB2.

Michalakis S, Shaltiel L, Sothilingam V, Koch S, Schludi V, Krause S, Zeitz C, Audo I, Lancelot ME, Hamel C, Meunier I, Preising MN, Friedburg C, Lorenz B, Zabouri N, Haverkamp S, Garrido MG, Tanimoto N, Seeliger MW, Biel M, Wahl-Schott CA.

Hum Mol Genet. 2017 Jan 15;26(2):466. doi: 10.1093/hmg/ddw424. No abstract available.

PMID:
28365780
38.

Two-Pore Channels: Catalyzers of Endolysosomal Transport and Function.

Grimm C, Chen CC, Wahl-Schott C, Biel M.

Front Pharmacol. 2017 Feb 7;8:45. doi: 10.3389/fphar.2017.00045. eCollection 2017. Review.

39.

Cone Genesis Tracing by the Chrnb4-EGFP Mouse Line: Evidences of Cellular Material Fusion after Cone Precursor Transplantation.

Decembrini S, Martin C, Sennlaub F, Chemtob S, Biel M, Samardzija M, Moulin A, Behar-Cohen F, Arsenijevic Y.

Mol Ther. 2017 Mar 1;25(3):634-653. doi: 10.1016/j.ymthe.2016.12.015. Epub 2017 Jan 28.

40.

Two-Pore Channel Function Is Crucial for the Migration of Invasive Cancer Cells.

Nguyen ON, Grimm C, Schneider LS, Chao YK, Atzberger C, Bartel K, Watermann A, Ulrich M, Mayr D, Wahl-Schott C, Biel M, Vollmar AM.

Cancer Res. 2017 Mar 15;77(6):1427-1438. doi: 10.1158/0008-5472.CAN-16-0852. Epub 2017 Jan 20.

41.

Gene therapy for achromatopsia.

Michalakis S, Schön C, Becirovic E, Biel M.

J Gene Med. 2017 Mar;19(3). doi: 10.1002/jgm.2944. Review.

PMID:
28095637
42.

Predictors of Current and Longer-Term Patterns of Abundance of American Pikas (Ochotona princeps) across a Leading-Edge Protected Area.

Moyer-Horner L, Beever EA, Johnson DH, Biel M, Belt J.

PLoS One. 2016 Nov 30;11(11):e0167051. doi: 10.1371/journal.pone.0167051. eCollection 2016.

43.

Quantifying macromolecular interactions in living cells using FRET two-hybrid assays.

Butz ES, Ben-Johny M, Shen M, Yang PS, Sang L, Biel M, Yue DT, Wahl-Schott C.

Nat Protoc. 2016 Dec;11(12):2470-2498. doi: 10.1038/nprot.2016.128. Epub 2016 Nov 10.

PMID:
27831569
44.

AAV Vectors for FRET-Based Analysis of Protein-Protein Interactions in Photoreceptor Outer Segments.

Becirovic E, Böhm S, Nguyen ON, Riedmayr LM, Hammelmann V, Schön C, Butz ES, Wahl-Schott C, Biel M, Michalakis S.

Front Neurosci. 2016 Jul 28;10:356. doi: 10.3389/fnins.2016.00356. eCollection 2016.

45.

Lessons learned: Engaging culturally diverse families in neurodevelopmental disorders intervention research.

Ratto AB, Anthony BJ, Pugliese C, Mendez R, Safer-Lichtenstein J, Dudley KM, Kahn NF, Kenworthy L, Biel M, Martucci JL, Anthony LG.

Autism. 2017 Jul;21(5):622-634. doi: 10.1177/1362361316650394. Epub 2016 Jun 15.

46.

Determination of Rod and Cone Influence to the Early and Late Dynamic of the Pupillary Light Response.

Kostic C, Crippa SV, Martin C, Kardon RH, Biel M, Arsenijevic Y, Kawasaki A.

Invest Ophthalmol Vis Sci. 2016 May 1;57(6):2501-8. doi: 10.1167/iovs.16-19150.

47.

Peripherin-2 differentially interacts with cone opsins in outer segments of cone photoreceptors.

Nguyen ON, Böhm S, Gießl A, Butz ES, Wolfrum U, Brandstätter JH, Wahl-Schott C, Biel M, Becirovic E.

Hum Mol Genet. 2016 Jun 15;25(12):2367-2377. Epub 2016 Mar 30.

PMID:
27033727
48.

HCN1 Channels Enhance Rod System Responsivity in the Retina under Conditions of Light Exposure.

Sothilingam V, Michalakis S, Garcia Garrido M, Biel M, Tanimoto N, Seeliger MW.

PLoS One. 2016 Jan 25;11(1):e0147728. doi: 10.1371/journal.pone.0147728. eCollection 2016.

49.

In Vivo Analysis of Disease-Associated Point Mutations Unveils Profound Differences in mRNA Splicing of Peripherin-2 in Rod and Cone Photoreceptors.

Becirovic E, Böhm S, Nguyen ON, Riedmayr LM, Koch MA, Schulze E, Kohl S, Borsch O, Santos-Ferreira T, Ader M, Michalakis S, Biel M.

PLoS Genet. 2016 Jan 21;12(1):e1005811. doi: 10.1371/journal.pgen.1005811. eCollection 2016 Jan.

50.

Remote and reversible inhibition of neurons and circuits by small molecule induced potassium channel stabilization.

Auffenberg E, Jurik A, Mattusch C, Stoffel R, Genewsky A, Namendorf C, Schmid RM, Rammes G, Biel M, Uhr M, Moosmang S, Michalakis S, Wotjak CT, Thoeringer CK.

Sci Rep. 2016 Jan 13;6:19293. doi: 10.1038/srep19293.

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