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Cytokine-Regulated Phosphorylation and Activation of TET2 by JAK2 in Hematopoiesis.

Jeong JJ, Gu X, Nie J, Sundaravel S, Liu H, Kuo WL, Bhagat TD, Pradhan K, Cao J, Nischal S, McGraw KL, Bhattacharyya S, Bishop MR, Artz A, Thirman MJ, Moliterno A, Ji P, Levine RL, Godley LA, Steidl U, Bieker JJ, List AF, Saunthararajah Y, He C, Verma A, Wickrema A.

Cancer Discov. 2019 Jun;9(6):778-795. doi: 10.1158/2159-8290.CD-18-1138. Epub 2019 Apr 3.


Genetic disarray follows mutant KLF1-E325K expression in a congenital dyserythropoietic anemia patient.

Varricchio L, Planutis A, Manwani D, Jaffray J, Mitchell WB, Migliaccio AR, Bieker JJ.

Haematologica. 2019 Mar 14. pii: haematol.2018.209858. doi: 10.3324/haematol.2018.209858. [Epub ahead of print]


Mutant KLF1 in Adult Anemic Nan Mice Leads to Profound Transcriptome Changes and Disordered Erythropoiesis.

Nébor D, Graber JH, Ciciotte SL, Robledo RF, Papoin J, Hartman E, Gillinder KR, Perkins AC, Bieker JJ, Blanc L, Peters LL.

Sci Rep. 2018 Aug 24;8(1):12793. doi: 10.1038/s41598-018-30839-2.


Survey and evaluation of mutations in the human KLF1 transcription unit.

Gnanapragasam MN, Crispino JD, Ali AM, Weinberg R, Hoffman R, Raza A, Bieker JJ.

Sci Rep. 2018 Apr 26;8(1):6587. doi: 10.1038/s41598-018-24962-3.


Promiscuous DNA-binding of a mutant zinc finger protein corrupts the transcriptome and diminishes cell viability.

Gillinder KR, Ilsley MD, Nébor D, Sachidanandam R, Lajoie M, Magor GW, Tallack MR, Bailey T, Landsberg MJ, Mackay JP, Parker MW, Miles LA, Graber JH, Peters LL, Bieker JJ, Perkins AC.

Nucleic Acids Res. 2017 Feb 17;45(3):1130-1143. doi: 10.1093/nar/gkw1014.


Orchestration of late events in erythropoiesis by KLF1/EKLF.

Gnanapragasam MN, Bieker JJ.

Curr Opin Hematol. 2017 May;24(3):183-190. doi: 10.1097/MOH.0000000000000327. Review.


Neomorphic effects of the neonatal anemia (Nan-Eklf) mutation contribute to deficits throughout development.

Planutis A, Xue L, Trainor CD, Dangeti M, Gillinder K, Siatecka M, Nebor D, Peters LL, Perkins AC, Bieker JJ.

Development. 2017 Feb 1;144(3):430-440. doi: 10.1242/dev.145656.


EKLF/KLF1-regulated cell cycle exit is essential for erythroblast enucleation.

Gnanapragasam MN, McGrath KE, Catherman S, Xue L, Palis J, Bieker JJ.

Blood. 2016 Sep 22;128(12):1631-41. doi: 10.1182/blood-2016-03-706671. Epub 2016 Aug 1.


Krüppeling erythropoiesis: an unexpected broad spectrum of human red blood cell disorders due to KLF1 variants.

Perkins A, Xu X, Higgs DR, Patrinos GP, Arnaud L, Bieker JJ, Philipsen S; KLF1 Consensus Workgroup.

Blood. 2016 Apr 14;127(15):1856-62. doi: 10.1182/blood-2016-01-694331. Epub 2016 Feb 22. Review.


Cis-vaccenic acid induces differentiation and up-regulates gamma globin synthesis in K562, JK1 and transgenic mice erythroid progenitor stem cells.

Aimola IA, Inuwa HM, Nok AJ, Mamman AI, Bieker JJ.

Eur J Pharmacol. 2016 Apr 5;776:9-18. doi: 10.1016/j.ejphar.2016.02.041. Epub 2016 Feb 12.


A Systems Approach Identifies Essential FOXO3 Functions at Key Steps of Terminal Erythropoiesis.

Liang R, Campreciós G, Kou Y, McGrath K, Nowak R, Catherman S, Bigarella CL, Rimmelé P, Zhang X, Gnanapragasam MN, Bieker JJ, Papatsenko D, Ma'ayan A, Bresnick E, Fowler V, Palis J, Ghaffari S.

PLoS Genet. 2015 Oct 9;11(10):e1005526. doi: 10.1371/journal.pgen.1005526. eCollection 2015 Oct.


The DEK Oncoprotein Is a Critical Component of the EKLF/KLF1 Enhancer in Erythroid Cells.

Lohmann F, Dangeti M, Soni S, Chen X, Planutis A, Baron MH, Choi K, Bieker JJ.

Mol Cell Biol. 2015 Nov;35(21):3726-38. doi: 10.1128/MCB.00382-15. Epub 2015 Aug 24.


Transcriptional activity of erythroid Kruppel-like factor (EKLF/KLF1) modulated by PIAS3 (protein inhibitor of activated STAT3).

Siatecka M, Soni S, Planutis A, Bieker JJ.

J Biol Chem. 2015 Apr 10;290(15):9929-40. doi: 10.1074/jbc.M114.610246. Epub 2015 Feb 24.


Alternative splicing of EKLF/KLF1 in murine primary erythroid tissues.

Yien YY, Gnanapragasam MN, Gupta R, Rivella S, Bieker JJ.

Exp Hematol. 2015 Jan;43(1):65-70. doi: 10.1016/j.exphem.2014.08.007. Epub 2014 Oct 2.


Transcription factor EKLF (KLF1) recruitment of the histone chaperone HIRA is essential for β-globin gene expression.

Soni S, Pchelintsev N, Adams PD, Bieker JJ.

Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13337-42. doi: 10.1073/pnas.1405422111. Epub 2014 Sep 2.


KLF1: when less is more.

Manwani D, Bieker JJ.

Blood. 2014 Jul 31;124(5):672-3. doi: 10.1182/blood-2014-05-576967.


Extrinsic and intrinsic control by EKLF (KLF1) within a specialized erythroid niche.

Xue L, Galdass M, Gnanapragasam MN, Manwani D, Bieker JJ.

Development. 2014 Jun;141(11):2245-54. doi: 10.1242/dev.103960.


Identification of NuRSERY, a new functional HDAC complex composed by HDAC5, GATA1, EKLF and pERK present in human erythroid cells.

Varricchio L, Dell'Aversana C, Nebbioso A, Migliaccio G, Altucci L, Mai A, Grazzini G, Bieker JJ, Migliaccio AR.

Int J Biochem Cell Biol. 2014 May;50:112-22. doi: 10.1016/j.biocel.2014.02.019. Epub 2014 Mar 1.


Erythroid transcription factor EKLF/KLF1 mutation causing congenital dyserythropoietic anemia type IV in a patient of Taiwanese origin: review of all reported cases and development of a clinical diagnostic paradigm.

Jaffray JA, Mitchell WB, Gnanapragasam MN, Seshan SV, Guo X, Westhoff CM, Bieker JJ, Manwani D.

Blood Cells Mol Dis. 2013 Aug;51(2):71-5. doi: 10.1016/j.bcmd.2013.02.006. Epub 2013 Mar 20. Review.


EKLF/KLF1, a tissue-restricted integrator of transcriptional control, chromatin remodeling, and lineage determination.

Yien YY, Bieker JJ.

Mol Cell Biol. 2013 Jan;33(1):4-13. doi: 10.1128/MCB.01058-12. Epub 2012 Oct 22. Review.


T-cell acute leukemia 1 (TAL1) regulation of erythropoietin receptor and association with excessive erythrocytosis.

Rogers H, Wang L, Yu X, Alnaeeli M, Cui K, Zhao K, Bieker JJ, Prchal J, Huang S, Weksler B, Noguchi CT.

J Biol Chem. 2012 Oct 26;287(44):36720-31. doi: 10.1074/jbc.M112.378398. Epub 2012 Sep 16.


Functional interactions between erythroid Krüppel-like factor (EKLF/KLF1) and protein phosphatase PPM1B/PP2Cβ.

Yien YY, Bieker JJ.

J Biol Chem. 2012 May 4;287(19):15193-204. doi: 10.1074/jbc.M112.350496. Epub 2012 Mar 5.


GATA2 finds its macrophage niche.

Migliaccio AR, Bieker JJ.

Blood. 2011 Sep 8;118(10):2647-9. doi: 10.1182/blood-2011-06-362772. No abstract available.


Structural and functional characterization of an atypical activation domain in erythroid Kruppel-like factor (EKLF).

Mas C, Lussier-Price M, Soni S, Morse T, Arseneault G, Di Lello P, Lafrance-Vanasse J, Bieker JJ, Omichinski JG.

Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10484-9. doi: 10.1073/pnas.1017029108. Epub 2011 Jun 13.


The multifunctional role of EKLF/KLF1 during erythropoiesis.

Siatecka M, Bieker JJ.

Blood. 2011 Aug 25;118(8):2044-54. doi: 10.1182/blood-2011-03-331371. Epub 2011 May 25. Review.


Design of embedded chimeric peptide nucleic acids that efficiently enter and accurately reactivate gene expression in vivo.

Chen J, Peterson KR, Iancu-Rubin C, Bieker JJ.

Proc Natl Acad Sci U S A. 2010 Sep 28;107(39):16846-51. doi: 10.1073/pnas.0912896107. Epub 2010 Sep 13.


Putting a finger on the switch.

Bieker JJ.

Nat Genet. 2010 Sep;42(9):733-4. doi: 10.1038/ng0910-733.


Severe anemia in the Nan mutant mouse caused by sequence-selective disruption of erythroid Kruppel-like factor.

Siatecka M, Sahr KE, Andersen SG, Mezei M, Bieker JJ, Peters LL.

Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15151-6. doi: 10.1073/pnas.1004996107. Epub 2010 Aug 9.


EKLF directly activates the p21WAF1/CIP1 gene by proximal promoter and novel intronic regulatory regions during erythroid differentiation.

Siatecka M, Lohmann F, Bao S, Bieker JJ.

Mol Cell Biol. 2010 Jun;30(11):2811-22. doi: 10.1128/MCB.01016-09. Epub 2010 Apr 5.


Preferential associations between co-regulated genes reveal a transcriptional interactome in erythroid cells.

Schoenfelder S, Sexton T, Chakalova L, Cope NF, Horton A, Andrews S, Kurukuti S, Mitchell JA, Umlauf D, Dimitrova DS, Eskiw CH, Luo Y, Wei CL, Ruan Y, Bieker JJ, Fraser P.

Nat Genet. 2010 Jan;42(1):53-61. doi: 10.1038/ng.496. Epub 2009 Dec 13.


Distinct modes of gene regulation by a cell-specific transcriptional activator.

Sengupta T, Cohet N, Morlé F, Bieker JJ.

Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4213-8. doi: 10.1073/pnas.0808347106. Epub 2009 Feb 27.


Erythroid Kruppel-like factor (EKLF) is recruited to the gamma-globin gene promoter as a co-activator and is required for gamma-globin gene induction by short-chain fatty acid derivatives.

Perrine SP, Mankidy R, Boosalis MS, Bieker JJ, Faller DV.

Eur J Haematol. 2009 Jun;82(6):466-76. doi: 10.1111/j.1600-0609.2009.01234.x. Epub 2009 Feb 5.


Blood group antigens reveal their maker.

Bieker JJ.

Blood. 2008 Sep 1;112(5):1554-5. doi: 10.1182/blood-2008-06-160580. No abstract available.


Acetylation of EKLF is essential for epigenetic modification and transcriptional activation of the beta-globin locus.

Sengupta T, Chen K, Milot E, Bieker JJ.

Mol Cell Biol. 2008 Oct;28(20):6160-70. doi: 10.1128/MCB.00919-08. Epub 2008 Aug 18.


Activation of Eklf expression during hematopoiesis by Gata2 and Smad5 prior to erythroid commitment.

Lohmann F, Bieker JJ.

Development. 2008 Jun;135(12):2071-82. doi: 10.1242/dev.018200. Epub 2008 Apr 30.


Non-random subcellular distribution of variant EKLF in erythroid cells.

Quadrini KJ, Gruzglin E, Bieker JJ.

Exp Cell Res. 2008 Apr 15;314(7):1595-604. doi: 10.1016/j.yexcr.2008.01.033. Epub 2008 Feb 20.


The erythroblastic island.

Manwani D, Bieker JJ.

Curr Top Dev Biol. 2008;82:23-53. doi: 10.1016/S0070-2153(07)00002-6. Review.


Red cell development. Preface.

Bieker JJ.

Curr Top Dev Biol. 2008;82:XI-XV. doi: 10.1016/S0070-2153(07)00010-5. No abstract available.


Sumoylation of EKLF promotes transcriptional repression and is involved in inhibition of megakaryopoiesis.

Siatecka M, Xue L, Bieker JJ.

Mol Cell Biol. 2007 Dec;27(24):8547-60. Epub 2007 Oct 15.


Novel role for EKLF in megakaryocyte lineage commitment.

Frontelo P, Manwani D, Galdass M, Karsunky H, Lohmann F, Gallagher PG, Bieker JJ.

Blood. 2007 Dec 1;110(12):3871-80. Epub 2007 Aug 22.


Chromatin domain activation via GATA-1 utilization of a small subset of dispersed GATA motifs within a broad chromosomal region.

Im H, Grass JA, Johnson KD, Kim SI, Boyer ME, Imbalzano AN, Bieker JJ, Bresnick EH.

Proc Natl Acad Sci U S A. 2005 Nov 22;102(47):17065-70. Epub 2005 Nov 14.


Probing the onset and regulation of erythroid cell-specific gene expression.

Bieker JJ.

Mt Sinai J Med. 2005 Sep;72(5):333-8. Review.


Stage-specific repression by the EKLF transcriptional activator.

Chen X, Bieker JJ.

Mol Cell Biol. 2004 Dec;24(23):10416-24.


Activation and repression of interleukin-12 p40 transcription by erythroid Kruppel-like factor in macrophages.

Luo Q, Ma X, Wahl SM, Bieker JJ, Crossley M, Montaner LJ.

J Biol Chem. 2004 Apr 30;279(18):18451-6. Epub 2004 Feb 19.


Regulatory elements of the EKLF gene that direct erythroid cell-specific expression during mammalian development.

Xue L, Chen X, Chang Y, Bieker JJ.

Blood. 2004 Jun 1;103(11):4078-83. Epub 2004 Feb 5.


Krüppel-like factors: three fingers in many pies.

Bieker JJ.

J Biol Chem. 2001 Sep 14;276(37):34355-8. Epub 2001 Jul 6. Review. No abstract available.

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