Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 176


DNA Methylation Directs Polycomb-Dependent 3D Genome Re-organization in Naive Pluripotency.

McLaughlin K, Flyamer IM, Thomson JP, Mjoseng HK, Shukla R, Williamson I, Grimes GR, Illingworth RS, Adams IR, Pennings S, Meehan RR, Bickmore WA.

Cell Rep. 2019 Nov 12;29(7):1974-1985.e6. doi: 10.1016/j.celrep.2019.10.031.


EvoChromo: towards a synthesis of chromatin biology and evolution.

Drinnenberg IA, Berger F, Elsässer SJ, Andersen PR, Ausió J, Bickmore WA, Blackwell AR, Erwin DH, Gahan JM, Gaut BS, Harvey ZH, Henikoff S, Kao JY, Kurdistani SK, Lemos B, Levine MT, Luger K, Malik HS, Martín-Durán JM, Peichel CL, Renfree MB, Rutowicz K, Sarkies P, Schmitz RJ, Technau U, Thornton JW, Warnecke T, Wolfe KH.

Development. 2019 Sep 26;146(19). pii: dev178962. doi: 10.1242/dev.178962.


Chromatin topology, condensates and gene regulation: shifting paradigms or just a phase?

Mir M, Bickmore W, Furlong EEM, Narlikar G.

Development. 2019 Sep 25;146(19). pii: dev182766. doi: 10.1242/dev.182766.


Editorial overview: Genome architecture and expression.

Bickmore W, Pombo A.

Curr Opin Genet Dev. 2019 Apr;55:iii-iv. doi: 10.1016/j.gde.2019.09.001. No abstract available.


Developmentally regulated Shh expression is robust to TAD perturbations.

Williamson I, Kane L, Devenney PS, Flyamer IM, Anderson E, Kilanowski F, Hill RE, Bickmore WA, Lettice LA.

Development. 2019 Sep 30;146(19). pii: dev179523. doi: 10.1242/dev.179523.


Decreased Enhancer-Promoter Proximity Accompanying Enhancer Activation.

Benabdallah NS, Williamson I, Illingworth RS, Kane L, Boyle S, Sengupta D, Grimes GR, Therizols P, Bickmore WA.

Mol Cell. 2019 Nov 7;76(3):473-484.e7. doi: 10.1016/j.molcel.2019.07.038. Epub 2019 Sep 4.


Patterns in the genome.

Bickmore WA.

Heredity (Edinb). 2019 Jul;123(1):50-57. doi: 10.1038/s41437-019-0220-4. Epub 2019 Jun 12. Review.


Publisher Correction: BRD4 interacts with NIPBL and BRD4 is mutated in a Cornelia de Lange-like syndrome.

Olley G, Ansari M, Bengani H, Grimes GR, Rhodes J, von Kriegsheim A, Blatnik A, Stewart FJ, Wakeling E, Carroll N, Ross A, Park SM; Deciphering Developmental Disorders Study, Bickmore WA, Pradeepa MM, FitzPatrick DR.

Nat Genet. 2019 Jul;51(7):1192. doi: 10.1038/s41588-019-0448-1.


Nuclear pore density controls heterochromatin reorganization during senescence.

Boumendil C, Hari P, Olsen KCF, Acosta JC, Bickmore WA.

Genes Dev. 2019 Feb 1;33(3-4):144-149. doi: 10.1101/gad.321117.118. Epub 2019 Jan 28.


Funding mechanisms risk promoting conscious bias.

Bickmore W, Cunningham-Burley S, Frame M.

Nature. 2018 Oct;562(7726):192. doi: 10.1038/d41586-018-06979-w. No abstract available.


Challenges and guidelines toward 4D nucleome data and model standards.

Marti-Renom MA, Almouzni G, Bickmore WA, Bystricky K, Cavalli G, Fraser P, Gasser SM, Giorgetti L, Heard E, Nicodemi M, Nollmann M, Orozco M, Pombo A, Torres-Padilla ME.

Nat Genet. 2018 Oct;50(10):1352-1358. doi: 10.1038/s41588-018-0236-3. Epub 2018 Sep 27. Review.


PRC1 Fine-tunes Gene Repression and Activation to Safeguard Skin Development and Stem Cell Specification.

Cohen I, Zhao D, Bar C, Valdes VJ, Dauber-Decker KL, Nguyen MB, Nakayama M, Rendl M, Bickmore WA, Koseki H, Zheng D, Ezhkova E.

Cell Stem Cell. 2018 May 3;22(5):726-739.e7. doi: 10.1016/j.stem.2018.04.005.


Publisher Correction: BRD4 interacts with NIPBL and BRD4 is mutated in a Cornelia de Lange-like syndrome.

Olley G, Ansari M, Bengani H, Grimes GR, Rhodes J, von Kriegsheim A, Blatnik A, Stewart FJ, Wakeling E, Carroll N, Ross A, Park SM, Bickmore WA, Pradeepa MM, FitzPatrick DR; Deciphering Developmental Disorders Study.

Nat Genet. 2018 May;50(5):767. doi: 10.1038/s41588-018-0069-0.


BRD4 interacts with NIPBL and BRD4 is mutated in a Cornelia de Lange-like syndrome.

Olley G, Ansari M, Bengani H, Grimes GR, Rhodes J, von Kriegsheim A, Blatnik A, Stewart FJ, Wakeling E, Carroll N, Ross A, Park SM; Deciphering Developmental Disorders Study, Bickmore WA, Pradeepa MM, FitzPatrick DR.

Nat Genet. 2018 Mar;50(3):329-332. doi: 10.1038/s41588-018-0042-y. Epub 2018 Jan 29. Erratum in: Nat Genet. 2018 Feb 12;:. Nat Genet. 2019 Jul;51(7):1192.


Bidirectional transcription initiation marks accessible chromatin and is not specific to enhancers.

Young RS, Kumar Y, Bickmore WA, Taylor MS.

Genome Biol. 2017 Dec 28;18(1):242. doi: 10.1186/s13059-017-1379-8.


Glucocorticoid Receptor Binding Induces Rapid and Prolonged Large-Scale Chromatin Decompaction at Multiple Target Loci.

Jubb AW, Boyle S, Hume DA, Bickmore WA.

Cell Rep. 2017 Dec 12;21(11):3022-3031. doi: 10.1016/j.celrep.2017.11.053.


A mechanism of cohesin-dependent loop extrusion organizes zygotic genome architecture.

Gassler J, Brandão HB, Imakaev M, Flyamer IM, Ladstätter S, Bickmore WA, Peters JM, Mirny LA, Tachibana K.

EMBO J. 2017 Dec 15;36(24):3600-3618. doi: 10.15252/embj.201798083. Epub 2017 Dec 7.


Expression of progerin does not result in an increased mutation rate.

Deniaud E, Lemaître C, Boyle S, Bickmore WA.

Chromosome Res. 2017 Oct;25(3-4):227-239. doi: 10.1007/s10577-017-9556-x. Epub 2017 May 6.


Psip1/p52 regulates posterior Hoxa genes through activation of lncRNA Hottip.

Pradeepa MM, McKenna F, Taylor GC, Bengani H, Grimes GR, Wood AJ, Bhatia S, Bickmore WA.

PLoS Genet. 2017 Apr 6;13(4):e1006677. doi: 10.1371/journal.pgen.1006677. eCollection 2017 Apr.


Repo-Man/PP1 regulates heterochromatin formation in interphase.

de Castro IJ, Budzak J, Di Giacinto ML, Ligammari L, Gokhan E, Spanos C, Moralli D, Richardson C, de Las Heras JI, Salatino S, Schirmer EC, Ullman KS, Bickmore WA, Green C, Rappsilber J, Lamble S, Goldberg MW, Vinciotti V, Vagnarelli P.

Nat Commun. 2017 Jan 16;8:14048. doi: 10.1038/ncomms14048.


A Hox-Embedded Long Noncoding RNA: Is It All Hot Air?

Selleri L, Bartolomei MS, Bickmore WA, He L, Stubbs L, Reik W, Barsh GS.

PLoS Genet. 2016 Dec 15;12(12):e1006485. doi: 10.1371/journal.pgen.1006485. eCollection 2016 Dec. No abstract available.


SBE6: a novel long-range enhancer involved in driving sonic hedgehog expression in neural progenitor cells.

Benabdallah NS, Gautier P, Hekimoglu-Balkan B, Lettice LA, Bhatia S, Bickmore WA.

Open Biol. 2016 Nov;6(11). pii: 160197.


Condensin II mutation causes T-cell lymphoma through tissue-specific genome instability.

Woodward J, Taylor GC, Soares DC, Boyle S, Sie D, Read D, Chathoth K, Vukovic M, Tarrats N, Jamieson D, Campbell KJ, Blyth K, Acosta JC, Ylstra B, Arends MJ, Kranc KR, Jackson AP, Bickmore WA, Wood AJ.

Genes Dev. 2016 Oct 1;30(19):2173-2186. Epub 2016 Oct 13.


Polycomb enables primitive endoderm lineage priming in embryonic stem cells.

Illingworth RS, Hölzenspies JJ, Roske FV, Bickmore WA, Brickman JM.

Elife. 2016 Oct 10;5. pii: e14926. doi: 10.7554/eLife.14926.


Shh and ZRS enhancer colocalisation is specific to the zone of polarising activity.

Williamson I, Lettice LA, Hill RE, Bickmore WA.

Development. 2016 Aug 15;143(16):2994-3001. doi: 10.1242/dev.139188. Epub 2016 Jul 11.


Histone H3 globular domain acetylation identifies a new class of enhancers.

Pradeepa MM, Grimes GR, Kumar Y, Olley G, Taylor GC, Schneider R, Bickmore WA.

Nat Genet. 2016 Jun;48(6):681-6. doi: 10.1038/ng.3550. Epub 2016 Apr 18.


Polycomb-mediated chromatin compaction weathers the STORM.

Williamson I, Bickmore WA, Illingworth RS.

Genome Biol. 2016 Feb 25;17:35. doi: 10.1186/s13059-016-0899-y.


Enhancer Turnover Is Associated with a Divergent Transcriptional Response to Glucocorticoid in Mouse and Human Macrophages.

Jubb AW, Young RS, Hume DA, Bickmore WA.

J Immunol. 2016 Jan 15;196(2):813-822. doi: 10.4049/jimmunol.1502009. Epub 2015 Dec 9.


The Hierarchy of Transcriptional Activation: From Enhancer to Promoter.

Vernimmen D, Bickmore WA.

Trends Genet. 2015 Dec;31(12):696-708. doi: 10.1016/j.tig.2015.10.004. Review.


Regulatory Domains and Their Mechanisms.

Benabdallah NS, Bickmore WA.

Cold Spring Harb Symp Quant Biol. 2015;80:45-51. doi: 10.1101/sqb.2015.80.027268. Epub 2015 Nov 20. Review.


The E3 ubiquitin ligase activity of RING1B is not essential for early mouse development.

Illingworth RS, Moffat M, Mann AR, Read D, Hunter CJ, Pradeepa MM, Adams IR, Bickmore WA.

Genes Dev. 2015 Sep 15;29(18):1897-902. doi: 10.1101/gad.268151.115.


Divergent transcriptional activation by glucocorticoids in mouse and human macrophages.

Jubb A, Young R, Bickmore W, Hume D.

Lancet. 2015 Feb 26;385 Suppl 1:S54. doi: 10.1016/S0140-6736(15)60369-5.


Estrogen-induced chromatin decondensation and nuclear re-organization linked to regional epigenetic regulation in breast cancer.

Rafique S, Thomas JS, Sproul D, Bickmore WA.

Genome Biol. 2015 Aug 3;16:145. doi: 10.1186/s13059-015-0719-9.


The frequent evolutionary birth and death of functional promoters in mouse and human.

Young RS, Hayashizaki Y, Andersson R, Sandelin A, Kawaji H, Itoh M, Lassmann T, Carninci P; FANTOM Consortium, Bickmore WA, Forrest AR, Taylor MS.

Genome Res. 2015 Oct;25(10):1546-57. doi: 10.1101/gr.190546.115. Epub 2015 Jul 30.


An Overview of Genome Organization and How We Got There: from FISH to Hi-C.

Fraser J, Williamson I, Bickmore WA, Dostie J.

Microbiol Mol Biol Rev. 2015 Sep;79(3):347-72. doi: 10.1128/MMBR.00006-15. Review.


Chromatin at the nuclear periphery and the regulation of genome functions.

Lemaître C, Bickmore WA.

Histochem Cell Biol. 2015 Aug;144(2):111-22. doi: 10.1007/s00418-015-1346-y. Epub 2015 Jul 14. Review.


A TAD Closer to Understanding Dosage Compensation.

Wood AJ, Bickmore WA.

Dev Cell. 2015 Jun 8;33(5):498-9. doi: 10.1016/j.devcel.2015.05.021.


Reed-Sternberg cells form by abscission failure in the presence of functional Aurora B kinase.

Xavier de Carvalho A, Maiato H, Maia AF, Ribeiro SA, Pontes P, Bickmore W, Earnshaw WC, Sambade C.

PLoS One. 2015 May 1;10(5):e0124629. doi: 10.1371/journal.pone.0124629. eCollection 2015.


Spatial genome organization: contrasting views from chromosome conformation capture and fluorescence in situ hybridization.

Williamson I, Berlivet S, Eskeland R, Boyle S, Illingworth RS, Paquette D, Dostie J, Bickmore WA.

Genes Dev. 2014 Dec 15;28(24):2778-91. doi: 10.1101/gad.251694.114.


Chromatin decondensation is sufficient to alter nuclear organization in embryonic stem cells.

Therizols P, Illingworth RS, Courilleau C, Boyle S, Wood AJ, Bickmore WA.

Science. 2014 Dec 5;346(6214):1238-42. doi: 10.1126/science.1259587.


Psip1/Ledgf p75 restrains Hox gene expression by recruiting both trithorax and polycomb group proteins.

Pradeepa MM, Grimes GR, Taylor GC, Sutherland HG, Bickmore WA.

Nucleic Acids Res. 2014 Aug;42(14):9021-32. doi: 10.1093/nar/gku647. Epub 2014 Jul 23.


PRC2-independent chromatin compaction and transcriptional repression in cancer.

Vallot C, Hérault A, Boyle S, Bickmore WA, Radvanyi F.

Oncogene. 2015 Feb 5;34(6):741-51. doi: 10.1038/onc.2013.604. Epub 2014 Jan 27.


H4K16 acetylation marks active genes and enhancers of embryonic stem cells, but does not alter chromatin compaction.

Taylor GC, Eskeland R, Hekimoglu-Balkan B, Pradeepa MM, Bickmore WA.

Genome Res. 2013 Dec;23(12):2053-65. doi: 10.1101/gr.155028.113. Epub 2013 Aug 29.


Correction: FGF Signalling Regulates Chromatin Organisation during Neural Differentiation via Mechanisms that Can Be Uncoupled from Transcription.

Patel NS, Rhinn M, Semprich CI, Halley PA, Dollé P, Bickmore WA, Storey KG.

PLoS Genet. 2013 Aug 12;9(8). doi: 10.1371/annotation/c066bb84-13ea-4b36-a481-f149df8ce929. eCollection 2013 Aug.


Transcription. Flashing a light on the spatial organization of transcription.

Rickman C, Bickmore WA.

Science. 2013 Aug 9;341(6146):621-2. doi: 10.1126/science.1242889. No abstract available.


The spatial organization of the human genome.

Bickmore WA.

Annu Rev Genomics Hum Genet. 2013;14:67-84. doi: 10.1146/annurev-genom-091212-153515. Epub 2013 Jul 15. Review.


FGF signalling regulates chromatin organisation during neural differentiation via mechanisms that can be uncoupled from transcription.

Patel NS, Rhinn M, Semprich CI, Halley PA, Dollé P, Bickmore WA, Storey KG.

PLoS Genet. 2013;9(7):e1003614. doi: 10.1371/journal.pgen.1003614. Epub 2013 Jul 18. Erratum in: PLoS Genet. 2013 Aug 12;9(8):.


Regional chromatin decompaction in Cornelia de Lange syndrome associated with NIPBL disruption can be uncoupled from cohesin and CTCF.

Nolen LD, Boyle S, Ansari M, Pritchard E, Bickmore WA.

Hum Mol Genet. 2013 Oct 15;22(20):4180-93. doi: 10.1093/hmg/ddt265. Epub 2013 Jun 10.


Regulation from a distance: long-range control of gene expression in development and disease.

van Heyningen V, Bickmore W.

Philos Trans R Soc Lond B Biol Sci. 2013 May 6;368(1620):20120372. doi: 10.1098/rstb.2012.0372. Print 2013. No abstract available.


Divergence of mammalian higher order chromatin structure is associated with developmental loci.

Chambers EV, Bickmore WA, Semple CA.

PLoS Comput Biol. 2013 Apr;9(4):e1003017. doi: 10.1371/journal.pcbi.1003017. Epub 2013 Apr 4.

Supplemental Content

Loading ...
Support Center