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Long noncoding RNA MALAT1 in exosomes drives regenerative function and modulates inflammation-linked networks following traumatic brain injury.

Patel NA, Moss LD, Lee JY, Tajiri N, Acosta S, Hudson C, Parag S, Cooper DR, Borlongan CV, Bickford PC.

J Neuroinflammation. 2018 Jul 12;15(1):204. doi: 10.1186/s12974-018-1240-3.


Astaxanthin is neuroprotective in an aged mouse model of Parkinson's disease.

Grimmig B, Daly L, Subbarayan M, Hudson C, Williamson R, Nash K, Bickford PC.

Oncotarget. 2017 Dec 28;9(12):10388-10401. doi: 10.18632/oncotarget.23737. eCollection 2018 Feb 13.


HIV Non-Nucleoside Reverse Transcriptase Inhibitor Efavirenz Reduces Neural Stem Cell Proliferation in Vitro and in Vivo.

Jin J, Grimmig B, Izzo J, Brown LAM, Hudson C, Smith AJ, Tan J, Bickford PC, Giunta B.

Cell Transplant. 2016 Nov;25(11):1967-1977. doi: 10.3727/096368916X691457.


Proteomic anaysis of aged microglia: shifts in transcription, bioenergetics, and nutrient response.

Flowers A, Bell-Temin H, Jalloh A, Stevens SM Jr, Bickford PC.

J Neuroinflammation. 2017 May 3;14(1):96. doi: 10.1186/s12974-017-0840-7.


Neuroprotective mechanisms of astaxanthin: a potential therapeutic role in preserving cognitive function in age and neurodegeneration.

Grimmig B, Kim SH, Nash K, Bickford PC, Douglas Shytle R.

Geroscience. 2017 Feb;39(1):19-32. doi: 10.1007/s11357-017-9958-x. Epub 2017 Feb 13. Review.


Aging leads to altered microglial function that reduces brain resiliency increasing vulnerability to neurodegenerative diseases.

Bickford PC, Flowers A, Grimmig B.

Exp Gerontol. 2017 Aug;94:4-8. doi: 10.1016/j.exger.2017.01.027. Epub 2017 Feb 2. Review.


MALAT1 in Human Adipose Stem Cells Modulates Survival and Alternative Splicing of PKCδII in HT22 Cells.

El Bassit G, Patel RS, Carter G, Shibu V, Patel AA, Song S, Murr M, Cooper DR, Bickford PC, Patel NA.

Endocrinology. 2017 Jan 1;158(1):183-195. doi: 10.1210/en.2016-1819.


Immunomodulators as Therapeutic Agents in Mitigating the Progression of Parkinson's Disease.

Grimmig B, Morganti J, Nash K, Bickford PC.

Brain Sci. 2016 Sep 23;6(4). pii: E41. doi: 10.3390/brainsci6040041. Review.


Erratum to: NT-020 treatment reduces inflammation and augments Nrf-2 and Wnt signaling in aged rats.

Flowers A, Lee JY, Grimmig B, Acosta S, Hudson C, Small B, Sanberg CD, Bickford PC.

J Neuroinflammation. 2016 Sep 5;13(1):229. No abstract available.


Novel Molecular Insights into Classical and Alternative Activation States of Microglia as Revealed by Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC)-based Proteomics.

Bell-Temin H, Culver-Cochran AE, Chaput D, Carlson CM, Kuehl M, Burkhardt BR, Bickford PC, Liu B, Stevens SM Jr.

Mol Cell Proteomics. 2015 Dec;14(12):3173-84. doi: 10.1074/mcp.M115.053926. Epub 2015 Sep 30.


Nutraceutical intervention reverses the negative effects of blood from aged rats on stem cells.

Bickford PC, Kaneko Y, Grimmig B, Pappas C, Small B, Sanberg CD, Sanberg PR, Tan J, Douglas Shytle R.

Age (Dordr). 2015 Oct;37(5):103. doi: 10.1007/s11357-015-9840-7. Epub 2015 Sep 26.


NT-020 treatment reduces inflammation and augments Nrf-2 and Wnt signaling in aged rats.

Flowers A, Lee JY, Acosta S, Hudson C, Small B, Sanberg CD, Bickford PC.

J Neuroinflammation. 2015 Sep 17;12:174. doi: 10.1186/s12974-015-0395-4. Erratum in: J Neuroinflammation. 2016;13(1):229.


Anti-human α-synuclein N-terminal peptide antibody protects against dopaminergic cell death and ameliorates behavioral deficits in an AAV-α-synuclein rat model of Parkinson's disease.

Shahaduzzaman M, Nash K, Hudson C, Sharif M, Grimmig B, Lin X, Bai G, Liu H, Ugen KE, Cao C, Bickford PC.

PLoS One. 2015 Feb 6;10(2):e0116841. doi: 10.1371/journal.pone.0116841. eCollection 2015.


Fractalkine over expression suppresses α-synuclein-mediated neurodegeneration.

Nash KR, Moran P, Finneran DJ, Hudson C, Robinson J, Morgan D, Bickford PC.

Mol Ther. 2015 Jan;23(1):17-23. doi: 10.1038/mt.2014.175. Epub 2014 Sep 8.


Intravenous transplants of human adipose-derived stem cell protect the brain from traumatic brain injury-induced neurodegeneration and motor and cognitive impairments: cell graft biodistribution and soluble factors in young and aged rats.

Tajiri N, Acosta SA, Shahaduzzaman M, Ishikawa H, Shinozuka K, Pabon M, Hernandez-Ontiveros D, Kim DW, Metcalf C, Staples M, Dailey T, Vasconcellos J, Franyuti G, Gould L, Patel N, Cooper D, Kaneko Y, Borlongan CV, Bickford PC.

J Neurosci. 2014 Jan 1;34(1):313-26. doi: 10.1523/JNEUROSCI.2425-13.2014.


Nutraceutical intervention improves older adults' cognitive functioning.

Small BJ, Rawson KS, Martin C, Eisel SL, Sanberg CD, McEvoy CL, Sanberg PR, Shytle RD, Tan J, Bickford PC.

Rejuvenation Res. 2014 Feb;17(1):27-32. doi: 10.1089/rej.2013.1477.


α-Synuclein is a pathological link and therapeutic target for Parkinson's disease and traumatic brain injury.

Shahaduzzaman M, Acosta S, Bickford PC, Borlongan CV.

Med Hypotheses. 2013 Oct;81(4):675-80. doi: 10.1016/j.mehy.2013.07.025. Epub 2013 Aug 6.


Neuronal nicotinic receptor agonists improve gait and balance in olivocerebellar ataxia.

Wecker L, Engberg ME, Philpot RM, Lambert CS, Kang CW, Antilla JC, Bickford PC, Hudson CE, Zesiewicz TA, Rowell PP.

Neuropharmacology. 2013 Oct;73:75-86. doi: 10.1016/j.neuropharm.2013.05.016. Epub 2013 May 24.


Fractalkine overexpression suppresses tau pathology in a mouse model of tauopathy.

Nash KR, Lee DC, Hunt JB Jr, Morganti JM, Selenica ML, Moran P, Reid P, Brownlow M, Guang-Yu Yang C, Savalia M, Gemma C, Bickford PC, Gordon MN, Morgan D.

Neurobiol Aging. 2013 Jun;34(6):1540-8. doi: 10.1016/j.neurobiolaging.2012.12.011. Epub 2013 Jan 16.


Long-term upregulation of inflammation and suppression of cell proliferation in the brain of adult rats exposed to traumatic brain injury using the controlled cortical impact model.

Acosta SA, Tajiri N, Shinozuka K, Ishikawa H, Grimmig B, Diamond DM, Sanberg PR, Bickford PC, Kaneko Y, Borlongan CV.

PLoS One. 2013;8(1):e53376. doi: 10.1371/journal.pone.0053376. Epub 2013 Jan 3. Erratum in: PLoS One. 2013;8(8). doi:10.1371/annotation/a04a7468-d105-42f3-ba47-263ea2864681. Diamond, David [corrected to Diamond, David M].


A single administration of human umbilical cord blood T cells produces long-lasting effects in the aging hippocampus.

Shahaduzzaman M, Golden JE, Green S, Gronda AE, Adrien E, Ahmed A, Sanberg PR, Bickford PC, Gemma C, Willing AE.

Age (Dordr). 2013 Dec;35(6):2071-87. doi: 10.1007/s11357-012-9496-5. Epub 2012 Dec 22.


The soluble isoform of CX3CL1 is necessary for neuroprotection in a mouse model of Parkinson's disease.

Morganti JM, Nash KR, Grimmig BA, Ranjit S, Small B, Bickford PC, Gemma C.

J Neurosci. 2012 Oct 17;32(42):14592-601. doi: 10.1523/JNEUROSCI.0539-12.2012.


A spirulina-enhanced diet provides neuroprotection in an α-synuclein model of Parkinson's disease.

Pabon MM, Jernberg JN, Morganti J, Contreras J, Hudson CE, Klein RL, Bickford PC.

PLoS One. 2012;7(9):e45256. doi: 10.1371/journal.pone.0045256. Epub 2012 Sep 18.


Intravenous grafts of amniotic fluid-derived stem cells induce endogenous cell proliferation and attenuate behavioral deficits in ischemic stroke rats.

Tajiri N, Acosta S, Glover LE, Bickford PC, Jacotte Simancas A, Yasuhara T, Date I, Solomita MA, Antonucci I, Stuppia L, Kaneko Y, Borlongan CV.

PLoS One. 2012;7(8):e43779. doi: 10.1371/journal.pone.0043779. Epub 2012 Aug 17.


Dietary supplementations as neuroprotective therapies: focus on NT-020 diet benefits in a rat model of stroke.

Kaneko Y, Cortes L, Sanberg C, Acosta S, Bickford PC, Borlongan CV.

Int J Mol Sci. 2012;13(6):7424-44. doi: 10.3390/ijms13067424. Epub 2012 Jun 15. Review.


CX3CR1 deficiency leads to impairment of hippocampal cognitive function and synaptic plasticity.

Rogers JT, Morganti JM, Bachstetter AD, Hudson CE, Peters MM, Grimmig BA, Weeber EJ, Bickford PC, Gemma C.

J Neurosci. 2011 Nov 9;31(45):16241-50. doi: 10.1523/JNEUROSCI.3667-11.2011.


Neuron-Microglia Dialogue and Hippocampal Neurogenesis in the Aged Brain.

Gemma C, Bachstetter AD, Bickford PC.

Aging Dis. 2010 Dec 1;1(3):232-244.


Optimized turmeric extract reduces β-Amyloid and phosphorylated Tau protein burden in Alzheimer's transgenic mice.

Shytle RD, Tan J, Bickford PC, Rezai-Zadeh K, Hou L, Zeng J, Sanberg PR, Sanberg CD, Alberte RS, Fink RC, Roschek B Jr.

Curr Alzheimer Res. 2012 May;9(4):500-6.


Role of TNFα Induced Inflammation in Delay Eyeblink Conditioning in Young and Aged Rats.

Paredes D, Acosta S, Gemma C, Bickford PC.

Aging Dis. 2010 Dec 1;1(3):191-198.


A high-fat/high-cholesterol diet inhibits growth of fetal hippocampal transplants via increased inflammation.

Freeman LR, Small BJ, Bickford PC, Umphlet C, Granholm AC.

Cell Transplant. 2011;20(10):1499-514. doi: 10.3727/096368910X557281. Epub 2011 Mar 7.


CX3CL1 reduces neurotoxicity and microglial activation in a rat model of Parkinson's disease.

Pabon MM, Bachstetter AD, Hudson CE, Gemma C, Bickford PC.

J Neuroinflammation. 2011 Jan 25;8:9. doi: 10.1186/1742-2094-8-9.


Oxidative Stress and the Aging Brain: From Theory to Prevention.

Gemma C, Vila J, Bachstetter A, Bickford PC.

In: Riddle DR, editor. Brain Aging: Models, Methods, and Mechanisms. Boca Raton (FL): CRC Press/Taylor & Francis; 2007. Chapter 15.


NT-020, a natural therapeutic approach to optimize spatial memory performance and increase neural progenitor cell proliferation and decrease inflammation in the aged rat.

Acosta S, Jernberg J, Sanberg CD, Sanberg PR, Small BJ, Gemma C, Bickford PC.

Rejuvenation Res. 2010 Oct;13(5):581-8. doi: 10.1089/rej.2009.1011. Epub 2010 Jun 29.


Spirulina promotes stem cell genesis and protects against LPS induced declines in neural stem cell proliferation.

Bachstetter AD, Jernberg J, Schlunk A, Vila JL, Hudson C, Cole MJ, Shytle RD, Tan J, Sanberg PR, Sanberg CD, Borlongan C, Kaneko Y, Tajiri N, Gemma C, Bickford PC.

PLoS One. 2010 May 5;5(5):e10496. doi: 10.1371/journal.pone.0010496.


Nanolipidic particles improve the bioavailability and alpha-secretase inducing ability of epigallocatechin-3-gallate (EGCG) for the treatment of Alzheimer's disease.

Smith A, Giunta B, Bickford PC, Fountain M, Tan J, Shytle RD.

Int J Pharm. 2010 Apr 15;389(1-2):207-12. doi: 10.1016/j.ijpharm.2010.01.012. Epub 2010 Jan 18.


Acute Treatment With Herbal Extracts Provides Neuroprotective Benefits in In Vitro and In Vivo Stroke Models, Characterized by Reduced Ischemic Cell Death and Maintenance of Motor and Neurological Functions.

Kaneko Y, Eve DJ, Yu S, Shojo H, Bae EC, Park DH, Roschek B Jr, Alberte RS, Sanberg PR, Sanberg CD, Bickford PC, Borlongan CV.

Cell Med. 2010 Jan 1;1(3):137-142.


Effects of blue-green algae extracts on the proliferation of human adult stem cells in vitro: a preliminary study.

Shytle DR, Tan J, Ehrhart J, Smith AJ, Sanberg CD, Sanberg PR, Anderson J, Bickford PC.

Med Sci Monit. 2010 Jan;16(1):BR1-5.


Fractalkine and CX 3 CR1 regulate hippocampal neurogenesis in adult and aged rats.

Bachstetter AD, Morganti JM, Jernberg J, Schlunk A, Mitchell SH, Brewster KW, Hudson CE, Cole MJ, Harrison JK, Bickford PC, Gemma C.

Neurobiol Aging. 2011 Nov;32(11):2030-44. doi: 10.1016/j.neurobiolaging.2009.11.022. Epub 2009 Dec 16.


Blueberry supplementation attenuates microglial activation in hippocampal intraocular grafts to aged hosts.

Willis LM, Freeman L, Bickford PC, Quintero EM, Umphlet CD, Moore AB, Goetzl L, Granholm AC.

Glia. 2010 Apr 15;58(6):679-90. doi: 10.1002/glia.20954.


Optimized turmeric extracts have potent anti-amyloidogenic effects.

Shytle RD, Bickford PC, Rezai-zadeh K, Hou L, Zeng J, Tan J, Sanberg PR, Sanberg CD, Roschek B Jr, Fink RC, Alberte RS.

Curr Alzheimer Res. 2009 Dec;6(6):564-71.


Blueberry-enriched diet ameliorates age-related declines in NMDA receptor-dependent LTP.

Coultrap SJ, Bickford PC, Browning MD.

Age (Dordr). 2008 Dec;30(4):263-72. doi: 10.1007/s11357-008-9067-y. Epub 2008 Aug 10.


Beneficial effects of antioxidant-enriched diet for tyrosine hydroxylase-positive neurons in ventral mesencephalic tissue in oculo grafts.

Berglöf E, Small BJ, Bickford PC, Strömberg I.

J Comp Neurol. 2009 Jul 1;515(1):72-82. doi: 10.1002/cne.22002.


Neurotransmitter release during delay eyeblink classical conditioning: role of norepinephrine in consolidation and effect of age.

Paredes DA, Cartford MC, Catlow BJ, Samec A, Avilas M, George A, Schlunck A, Small B, Bickford PC.

Neurobiol Learn Mem. 2009 Oct;92(3):267-82. doi: 10.1016/j.nlm.2008.08.008. Epub 2008 Oct 21.


Blueberry opposes beta-amyloid peptide-induced microglial activation via inhibition of p44/42 mitogen-activation protein kinase.

Zhu Y, Bickford PC, Sanberg P, Giunta B, Tan J.

Rejuvenation Res. 2008 Oct;11(5):891-901. doi: 10.1089/rej.2008.0757.


Human umbilical cord blood treatment in a mouse model of ALS: optimization of cell dose.

Garbuzova-Davis S, Sanberg CD, Kuzmin-Nichols N, Willing AE, Gemma C, Bickford PC, Miller C, Rossi R, Sanberg PR.

PLoS One. 2008 Jun 25;3(6):e2494. doi: 10.1371/journal.pone.0002494.


Dietary blueberry supplementation affects growth but not vascularization of neural transplants.

Willis LM, Small BJ, Bickford PC, Umphlet CD, Moore AB, Granholm AC.

J Cereb Blood Flow Metab. 2008 Jun;28(6):1150-64. doi: 10.1038/jcbfm.2008.3. Epub 2008 Feb 20.


Peripheral injection of human umbilical cord blood stimulates neurogenesis in the aged rat brain.

Bachstetter AD, Pabon MM, Cole MJ, Hudson CE, Sanberg PR, Willing AE, Bickford PC, Gemma C.

BMC Neurosci. 2008 Feb 14;9:22. doi: 10.1186/1471-2202-9-22.


Dietary supplementation exerts neuroprotective effects in ischemic stroke model.

Yasuhara T, Hara K, Maki M, Masuda T, Sanberg CD, Sanberg PR, Bickford PC, Borlongan CV.

Rejuvenation Res. 2008 Feb;11(1):201-14. doi: 10.1089/rej.2007.0608.


Navigating cellular repair for the central nervous system.

Sanberg PR, Willing AE, Garbuzova-Davis S, Bickford PC, Van Loveren H, Klasko SK, Sanberg CD, Borlongan CV, Eve DJ.

Clin Neurosurg. 2008;55:133-7. Review. No abstract available.


Blockade of caspase-1 increases neurogenesis in the aged hippocampus.

Gemma C, Bachstetter AD, Cole MJ, Fister M, Hudson C, Bickford PC.

Eur J Neurosci. 2007 Nov;26(10):2795-803.


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