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Items: 1 to 50 of 66

1.

Brain Uptake of [13C] and [14C]Sucrose Quantified by Microdialysis and Whole Tissue Analysis in Mice.

Alqahtani F, Chowdhury EA, Bhattacharya R, Noorani B, Mehvar R, Bickel U.

Drug Metab Dispos. 2018 Nov;46(11):1514-1518. doi: 10.1124/dmd.118.082909. Epub 2018 Aug 16.

PMID:
30115645
2.

Simultaneous UPLC-MS/MS analysis of two stable isotope labeled versions of sucrose in mouse plasma and brain samples as markers of blood-brain barrier permeability and brain vascular space.

Chowdhury EA, Alqahtani F, Bhattacharya R, Mehvar R, Bickel U.

J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Jan 15;1073:19-26. doi: 10.1016/j.jchromb.2017.12.007. Epub 2017 Dec 6.

PMID:
29232607
3.

Effects of hepatic ischemia-reperfusion injury on the blood-brain barrier permeability to [14C] and [13C]sucrose.

Miah MK, Bickel U, Mehvar R.

Metab Brain Dis. 2017 Dec;32(6):1903-1912. doi: 10.1007/s11011-017-0069-2. Epub 2017 Aug 4.

4.

Evaluation of [14C] and [13C]Sucrose as Blood-Brain Barrier Permeability Markers.

Miah MK, Chowdhury EA, Bickel U, Mehvar R.

J Pharm Sci. 2017 Jun;106(6):1659-1669. doi: 10.1016/j.xphs.2017.02.011. Epub 2017 Feb 24.

5.

Preparation and preliminary characterization of recombinant neurolysin for in vivo studies.

Wangler NJ, Jayaraman S, Zhu R, Mechref Y, Abbruscato TJ, Bickel U, Karamyan VT.

J Biotechnol. 2016 Sep 20;234:105-115. doi: 10.1016/j.jbiotec.2016.07.007. Epub 2016 Aug 2.

PMID:
27496565
6.

Development and validation of a sensitive UPLC-MS/MS method for the quantitation of [(13)C]sucrose in rat plasma, blood, and brain: Its application to the measurement of blood-brain barrier permeability.

Miah MK, Bickel U, Mehvar R.

J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Mar 15;1015-1016:105-110. doi: 10.1016/j.jchromb.2016.02.017. Epub 2016 Feb 16.

7.

Effects of Pringle maneuver and partial hepatectomy on the pharmacokinetics and blood-brain barrier permeability of sodium fluorescein in rats.

Miah MK, Shaik IH, Bickel U, Mehvar R.

Brain Res. 2015 Aug 27;1618:249-60. doi: 10.1016/j.brainres.2015.05.038. Epub 2015 Jun 5.

8.

Transferrin receptor mediated brain uptake during ischemia and reperfusion.

Hao J, Bickel U.

J Pharm Pharm Sci. 2013;16(4):541-50.

9.
10.

Effects of short-term portacaval anastomosis on the peripheral and brain disposition of the blood-brain barrier permeability marker sodium fluorescein in rats.

Shaik IH, Miah MK, Bickel U, Mehvar R.

Brain Res. 2013 Sep 19;1531:84-93. doi: 10.1016/j.brainres.2013.07.040. Epub 2013 Jul 31.

11.

Liposome-encapsulated polyethylenimine/oligonucleotide polyplexes prepared by reverse-phase evaporation technique.

Ko YT, Bickel U.

AAPS PharmSciTech. 2012 Jun;13(2):373-8. doi: 10.1208/s12249-012-9757-8. Epub 2012 Feb 11.

12.

Polyethylenimine/oligonucleotide polyplexes investigated by fluorescence resonance energy transfer and fluorescence anisotropy.

Ko YT, Bickel U, Huang J.

Oligonucleotides. 2011 Mar-Apr;21(2):109-14. doi: 10.1089/oli.2010.0271. Epub 2011 Mar 21.

13.

Unifying the mathematical modeling of in vivo and in vitro microdialysis.

Bungay PM, Sumbria RK, Bickel U.

J Pharm Biomed Anal. 2011 Apr 28;55(1):54-63. doi: 10.1016/j.jpba.2011.01.005. Epub 2011 Jan 19.

14.

TCR mimic monoclonal antibodies induce apoptosis of tumor cells via immune effector-independent mechanisms.

Verma B, Jain R, Caseltine S, Rennels A, Bhattacharya R, Markiewski MM, Rawat A, Neethling F, Bickel U, Weidanz JA.

J Immunol. 2011 Mar 1;186(5):3265-76. doi: 10.4049/jimmunol.1002376. Epub 2011 Jan 31.

15.

Acute depression of energy metabolism after microdialysis probe implantation is distinct from ischemia-induced changes in mouse brain.

Sumbria RK, Klein J, Bickel U.

Neurochem Res. 2011 Jan;36(1):109-16. doi: 10.1007/s11064-010-0276-2. Epub 2010 Sep 28.

PMID:
20878232
16.

A novel vascular targeting strategy for brain-derived endothelial cells using a TCR mimic antibody.

Bhattacharya R, Xu Y, Rahman MA, Couraud PO, Romero IA, Weksler BB, Weidanz JA, Bickel U.

J Cell Physiol. 2010 Nov;225(3):664-72. doi: 10.1002/jcp.22256.

17.

Delivery of NADPH-cytochrome P450 reductase antisense oligos using avidin-biotin approach.

Pillai VC, Yesudas R, Shaik IH, Thekkumkara TJ, Bickel U, Srivenugopal KS, Mehvar R.

Bioconjug Chem. 2010 Feb 17;21(2):203-7. doi: 10.1021/bc900449b.

PMID:
20063878
18.

Metabolic and transmitter changes in core and penumbra after middle cerebral artery occlusion in mice.

Kiewert C, Mdzinarishvili A, Hartmann J, Bickel U, Klein J.

Brain Res. 2010 Feb 2;1312:101-7. doi: 10.1016/j.brainres.2009.11.068. Epub 2009 Dec 2.

19.

Nicotine exacerbates brain edema during in vitro and in vivo focal ischemic conditions.

Paulson JR, Yang T, Selvaraj PK, Mdzinarishvili A, Van der Schyf CJ, Klein J, Bickel U, Abbruscato TJ.

J Pharmacol Exp Ther. 2010 Feb;332(2):371-9. doi: 10.1124/jpet.109.157776. Epub 2009 Nov 4.

20.

Liposome encapsulated polyethylenimine/ODN polyplexes for brain targeting.

Ko YT, Bhattacharya R, Bickel U.

J Control Release. 2009 Feb 10;133(3):230-7. doi: 10.1016/j.jconrel.2008.10.013. Epub 2008 Oct 26.

PMID:
19013203
21.

Neuroprotection in mice by NGP1-01 after transient focal brain ischemia.

Hao J, Mdzinarishvili A, Abbruscato TJ, Klein J, Geldenhuys WJ, Van der Schyf CJ, Bickel U.

Brain Res. 2008 Feb 27;1196:113-20. doi: 10.1016/j.brainres.2007.11.075. Epub 2008 Jan 29.

PMID:
18234166
22.

Bap29varP, a variant of Bap29, influences the cell surface expression of the human P-glycoprotein.

Rao PS, Bickel U, Srivenugopal KS, Rao US.

Int J Oncol. 2008 Jan;32(1):135-44.

PMID:
18097552
23.

Targeted delivery of complexes of biotin-PEG-polyethylenimine and NF-kappaB decoys to brain-derived endothelial cells in vitro.

Bhattacharya R, Osburg B, Fischer D, Bickel U.

Pharm Res. 2008 Mar;25(3):605-15. Epub 2007 Oct 20.

PMID:
17952570
24.

NMDA receptor-antagonistic properties of hyperforin, a constituent of St. John's Wort.

Kumar V, Mdzinarishvili A, Kiewert C, Abbruscato T, Bickel U, van der Schyf CJ, Klein J.

J Pharmacol Sci. 2006 Sep;102(1):47-54. Epub 2006 Aug 26.

25.

NGP1-01, a lipophilic polycyclic cage amine, is neuroprotective in focal ischemia.

Mdzinarishvili A, Geldenhuys WJ, Abbruscato TJ, Bickel U, Klein J, Van der Schyf CJ.

Neurosci Lett. 2005 Jul 22-29;383(1-2):49-53. Epub 2005 Apr 13.

PMID:
15936510
26.

Inhibition of monocyte adhesion on brain-derived endothelial cells by NF-kappaB decoy/polyethylenimine complexes.

Fischer D, Bhattacharya R, Osburg B, Bickel U.

J Gene Med. 2005 Aug;7(8):1063-76.

PMID:
15772940
27.

How to measure drug transport across the blood-brain barrier.

Bickel U.

NeuroRx. 2005 Jan;2(1):15-26. Review.

28.
29.
30.

Effect of endotoxin on expression of TNF receptors and transport of TNF-alpha at the blood-brain barrier of the rat.

Osburg B, Peiser C, Dömling D, Schomburg L, Ko YT, Voigt K, Bickel U.

Am J Physiol Endocrinol Metab. 2002 Nov;283(5):E899-908.

31.

The structure of PEG-modified poly(ethylene imines) influences biodistribution and pharmacokinetics of their complexes with NF-kappaB decoy in mice.

Kunath K, von Harpe A, Petersen H, Fischer D, Voigt K, Kissel T, Bickel U.

Pharm Res. 2002 Jun;19(6):810-7.

PMID:
12134951
32.

Sniffing neuropeptides: a transnasal approach to the human brain.

Born J, Lange T, Kern W, McGregor GP, Bickel U, Fehm HL.

Nat Neurosci. 2002 Jun;5(6):514-6. No abstract available.

PMID:
11992114
33.

In vivo pharmacokinetics of calreticulin S-domain, an inhibitor of the classical complement pathway.

Lynch NJ, Schneider H, Sim RB, Bickel U, Schwaeble WJ.

Int Immunopharmacol. 2002 Mar;2(4):415-22.

PMID:
11962721
35.

Delivery of peptides and proteins through the blood-brain barrier.

Bickel U, Yoshikawa T, Pardridge WM.

Adv Drug Deliv Rev. 2001 Mar 1;46(1-3):247-79. Review.

PMID:
11259843
36.

The melanocortin melanocyte-stimulating hormone/adrenocorticotropin(4-10) decreases body fat in humans.

Fehm HL, Smolnik R, Kern W, McGregor GP, Bickel U, Born J.

J Clin Endocrinol Metab. 2001 Mar;86(3):1144-8.

PMID:
11238499
37.

Targeting rat anti-mouse transferrin receptor monoclonal antibodies through blood-brain barrier in mouse.

Lee HJ, Engelhardt B, Lesley J, Bickel U, Pardridge WM.

J Pharmacol Exp Ther. 2000 Mar;292(3):1048-52.

PMID:
10688622
38.

The O-demethylation of the antidementia drug galanthamine is catalysed by cytochrome P450 2D6.

Bachus R, Bickel U, Thomsen T, Roots I, Kewitz H.

Pharmacogenetics. 1999 Dec;9(6):661-8.

PMID:
10634129
39.

Does short-term treatment with modafinil affect blood pressure in patients with obstructive sleep apnea?

Heitmann J, Cassel W, Grote L, Bickel U, Hartlaub U, Penzel T, Peter JH.

Clin Pharmacol Ther. 1999 Mar;65(3):328-35.

PMID:
10096265
40.

No increase in blood-brain barrier permeability after intraperitoneal injection of endotoxin in the rat.

Bickel U, Grave B, Kang YS, del Rey A, Voigt K.

J Neuroimmunol. 1998 May 15;85(2):131-6.

PMID:
9630161
41.

Blood-brain barrier permeability to morphine-6-glucuronide is markedly reduced compared with morphine.

Wu D, Kang YS, Bickel U, Pardridge WM.

Drug Metab Dispos. 1997 Jun;25(6):768-71.

PMID:
9193881
42.

Brain microvascular and astrocyte localization of P-glycoprotein.

Pardridge WM, Golden PL, Kang YS, Bickel U.

J Neurochem. 1997 Mar;68(3):1278-85.

43.

Poor permeability of morphine 3-glucuronide and morphine 6-glucuronide through the blood-brain barrier in the rat.

Bickel U, Schumacher OP, Kang YS, Voigt K.

J Pharmacol Exp Ther. 1996 Jul;278(1):107-13.

PMID:
8764341
44.

In vivo cleavability of a disulfide-based chimeric opioid peptide in rat brain.

Bickel U, Kang YS, Pardridge WM.

Bioconjug Chem. 1995 Mar-Apr;6(2):211-8.

PMID:
7599264
45.

Vector-mediated delivery of opioid peptides to the brain.

Bickel U, Pardridge WM.

NIDA Res Monogr. 1995;154:28-46. Review. No abstract available.

PMID:
8606748
46.
47.
48.

Blood-brain barrier transport of neuropeptides: analysis with a metabolically stable dermorphin analogue.

Samii A, Bickel U, Stroth U, Pardridge WM.

Am J Physiol. 1994 Jul;267(1 Pt 1):E124-31.

PMID:
8048500
49.
50.

Synthesis and bioactivity of monobiotinylated DALDA: a mu-specific opioid peptide designed for targeted brain delivery.

Bickel U, Yamada S, Pardridge WM.

J Pharmacol Exp Ther. 1994 Feb;268(2):791-6.

PMID:
8113991

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