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Targeting nonsense-mediated mRNA decay in colorectal cancers with microsatellite instability.

Bokhari A, Jonchere V, Lagrange A, Bertrand R, Svrcek M, Marisa L, Buhard O, Greene M, Demidova A, Jia J, Adriaenssens E, Chassat T, Biard DS, Flejou JF, Lejeune F, Duval A, Collura A.

Oncogenesis. 2018 Sep 19;7(9):70. doi: 10.1038/s41389-018-0079-x.


Breast cancer stem cell-like cells generated during TGFβ-induced EMT are radioresistant.

Konge J, Leteurtre F, Goislard M, Biard D, Morel-Altmeyer S, Vaurijoux A, Gruel G, Chevillard S, Lebeau J.

Oncotarget. 2018 May 4;9(34):23519-23531. doi: 10.18632/oncotarget.25240. eCollection 2018 May 4.


Superoxide dismutase 2 (SOD2) contributes to genetic stability of native and T315I-mutated BCR-ABL expressing leukemic cells.

Girerd S, Tosca L, Herault O, Vignon C, Biard D, Aggoune D, Dkhissi F, Bonnet ML, Sorel N, Desterke C, Bennaceur-Griscelli A, Tachdjian G, Guilhot F, Guilhot J, Chomel JC, Turhan AG.

Biochem Biophys Res Commun. 2018 Apr 15;498(4):715-722. doi: 10.1016/j.bbrc.2018.03.023. Epub 2018 Mar 17.


Characterization of DNA ADP-ribosyltransferase activities of PARP2 and PARP3: new insights into DNA ADP-ribosylation.

Zarkovic G, Belousova EA, Talhaoui I, Saint-Pierre C, Kutuzov MM, Matkarimov BT, Biard D, Gasparutto D, Lavrik OI, Ishchenko AA.

Nucleic Acids Res. 2018 Mar 16;46(5):2417-2431. doi: 10.1093/nar/gkx1318.


Reactive oxygen species levels control NF-κB activation by low dose deferasirox in erythroid progenitors of low risk myelodysplastic syndromes.

Meunier M, Ancelet S, Lefebvre C, Arnaud J, Garrel C, Pezet M, Wang Y, Faure P, Szymanski G, Duployez N, Preudhomme C, Biard D, Polack B, Cahn JY, Moulis JM, Park S.

Oncotarget. 2017 Nov 6;8(62):105510-105524. doi: 10.18632/oncotarget.22299. eCollection 2017 Dec 1.


Mammary adipocytes stimulate breast cancer invasion through metabolic remodeling of tumor cells.

Wang YY, Attané C, Milhas D, Dirat B, Dauvillier S, Guerard A, Gilhodes J, Lazar I, Alet N, Laurent V, Le Gonidec S, Biard D, Hervé C, Bost F, Ren GS, Bono F, Escourrou G, Prentki M, Nieto L, Valet P, Muller C.

JCI Insight. 2017 Feb 23;2(4):e87489. doi: 10.1172/jci.insight.87489.


HSP110 promotes colorectal cancer growth through STAT3 activation.

Berthenet K, Bokhari A, Lagrange A, Marcion G, Boudesco C, Causse S, De Thonel A, Svrcek M, Goloudina AR, Dumont S, Hammann A, Biard DS, Demidov ON, Seigneuric R, Duval A, Collura A, Jego G, Garrido C.

Oncogene. 2017 Apr 20;36(16):2328-2336. doi: 10.1038/onc.2016.403. Epub 2016 Nov 7.


A balanced pyrimidine pool is required for optimal Chk1 activation to prevent ultrafine anaphase bridge formation.

Gemble S, Buhagiar-Labarchède G, Onclercq-Delic R, Biard D, Lambert S, Amor-Guéret M.

J Cell Sci. 2016 Aug 15;129(16):3167-77. doi: 10.1242/jcs.187781. Epub 2016 Jul 6.


Translesion synthesis mechanisms depend on the nature of DNA damage in UV-irradiated human cells.

Quinet A, Martins DJ, Vessoni AT, Biard D, Sarasin A, Stary A, Menck CF.

Nucleic Acids Res. 2016 Jul 8;44(12):5717-31. doi: 10.1093/nar/gkw280. Epub 2016 Apr 19.


Disruption of phactr-1 pathway triggers pro-inflammatory and pro-atherogenic factors: New insights in atherosclerosis development.

Jarray R, Pavoni S, Borriello L, Allain B, Lopez N, Bianco S, Liu WQ, Biard D, Demange L, Hermine O, Garbay C, Raynaud F, Lepelletier Y.

Biochimie. 2015 Nov;118:151-61. doi: 10.1016/j.biochi.2015.09.008. Epub 2015 Sep 9.


A new phosphorylated form of Ku70 identified in resistant leukemic cells confers fast but unfaithful DNA repair in cancer cell lines.

Bouley J, Saad L, Grall R, Schellenbauer A, Biard D, Paget V, Morel-Altmeyer S, Guipaud O, Chambon C, Salles B, Maloum K, Merle-Béral H, Chevillard S, Delic J.

Oncotarget. 2015 Sep 29;6(29):27980-8000. doi: 10.18632/oncotarget.4735.


Cdk5 promotes DNA replication stress checkpoint activation through RPA-32 phosphorylation, and impacts on metastasis free survival in breast cancer patients.

Chiker S, Pennaneach V, Loew D, Dingli F, Biard D, Cordelières FP, Gemble S, Vacher S, Bieche I, Hall J, Fernet M.

Cell Cycle. 2015;14(19):3066-78. doi: 10.1080/15384101.2015.1078020.


Pyrimidine Pool Disequilibrium Induced by a Cytidine Deaminase Deficiency Inhibits PARP-1 Activity, Leading to the Under Replication of DNA.

Gemble S, Ahuja A, Buhagiar-Labarchède G, Onclercq-Delic R, Dairou J, Biard DS, Lambert S, Lopes M, Amor-Guéret M.

PLoS Genet. 2015 Jul 16;11(7):e1005384. doi: 10.1371/journal.pgen.1005384. eCollection 2015 Jul.


Reversal of mitochondrial defects with CSB-dependent serine protease inhibitors in patient cells of the progeroid Cockayne syndrome.

Chatre L, Biard DS, Sarasin A, Ricchetti M.

Proc Natl Acad Sci U S A. 2015 Jun 2;112(22):E2910-9. doi: 10.1073/pnas.1422264112. Epub 2015 May 18.


Interaction with OGG1 is required for efficient recruitment of XRCC1 to base excision repair and maintenance of genetic stability after exposure to oxidative stress.

Campalans A, Moritz E, Kortulewski T, Biard D, Epe B, Radicella JP.

Mol Cell Biol. 2015 May;35(9):1648-58. doi: 10.1128/MCB.00134-15. Epub 2015 Mar 2.


Forced extinction of CD24 stem-like breast cancer marker alone promotes radiation resistance through the control of oxidative stress.

Bensimon J, Biard D, Paget V, Goislard M, Morel-Altmeyer S, Konge J, Chevillard S, Lebeau J.

Mol Carcinog. 2016 Mar;55(3):245-54. doi: 10.1002/mc.22273. Epub 2015 Jan 16.


PARP-2 depletion results in lower radiation cell survival but cell line-specific differences in poly(ADP-ribose) levels.

Boudra MT, Bolin C, Chiker S, Fouquin A, Zaremba T, Vaslin L, Biard D, Cordelières FP, Mégnin-Chanet F, Favaudon V, Fernet M, Pennaneach V, Hall J.

Cell Mol Life Sci. 2015 Apr;72(8):1585-97. doi: 10.1007/s00018-014-1765-2. Epub 2014 Oct 22.


Involvement of the Artemis protein in the relative biological efficiency observed with the 76-MeV proton beam used at the Institut Curie Proton Therapy Center in Orsay.

Calugaru V, Nauraye C, Cordelières FP, Biard D, De Marzi L, Hall J, Favaudon V, Mégnin-Chanet F.

Int J Radiat Oncol Biol Phys. 2014 Sep 1;90(1):36-43. doi: 10.1016/j.ijrobp.2014.05.018. Erratum in: Int J Radiat Oncol Biol Phys. 2015 Feb 1;91(2):457.


RAD50 phosphorylation promotes ATR downstream signaling and DNA restart following replication stress.

Gatei M, Kijas AW, Biard D, Dörk T, Lavin MF.

Hum Mol Genet. 2014 Aug 15;23(16):4232-48. doi: 10.1093/hmg/ddu141. Epub 2014 Apr 2.


Patients with colorectal tumors with microsatellite instability and large deletions in HSP110 T17 have improved response to 5-fluorouracil–based chemotherapy.

Collura A, Lagrange A, Svrcek M, Marisa L, Buhard O, Guilloux A, Wanherdrick K, Dorard C, Taieb A, Saget A, Loh M, Soong R, Zeps N, Platell C, Mews A, Iacopetta B, De Thonel A, Seigneuric R, Marcion G, Chapusot C, Lepage C, Bouvier AM, Gaub MP, Milano G, Selves J, Senet P, Delarue P, Arzouk H, Lacoste C, Coquelle A, Bengrine-Lefèvre L, Tournigand C, Lefèvre JH, Parc Y, Biard DS, Fléjou JF, Garrido C, Duval A.

Gastroenterology. 2014 Feb;146(2):401-11.e1.


PARP1-TDP1 coupling for the repair of topoisomerase I-induced DNA damage.

Das BB, Huang SY, Murai J, Rehman I, Amé JC, Sengupta S, Das SK, Majumdar P, Zhang H, Biard D, Majumder HK, Schreiber V, Pommier Y.

Nucleic Acids Res. 2014 Apr;42(7):4435-49. doi: 10.1093/nar/gku088. Epub 2014 Feb 3.


Gap-filling and bypass at the replication fork are both active mechanisms for tolerance of low-dose ultraviolet-induced DNA damage in the human genome.

Quinet A, Vessoni AT, Rocha CR, Gottifredi V, Biard D, Sarasin A, Menck CF, Stary A.

DNA Repair (Amst). 2014 Feb;14:27-38. doi: 10.1016/j.dnarep.2013.12.005. Epub 2013 Dec 28.


Poly (ADP-ribose) glycohydrolase regulates retinoic acid receptor-mediated gene expression.

Le May N, Iltis I, Amé JC, Zhovmer A, Biard D, Egly JM, Schreiber V, Coin F.

Mol Cell. 2012 Dec 14;48(5):785-98. doi: 10.1016/j.molcel.2012.09.021. Epub 2012 Oct 25.


The cross talk between pathways in the repair of 8-oxo-7,8-dihydroguanine in mouse and human cells.

Parlanti E, D'Errico M, Degan P, Calcagnile A, Zijno A, van der Pluijm I, van der Horst GT, Biard DS, Dogliotti E.

Free Radic Biol Med. 2012 Dec 1;53(11):2171-7. doi: 10.1016/j.freeradbiomed.2012.08.593. Epub 2012 Sep 7.


Partial complementation of a DNA ligase I deficiency by DNA ligase III and its impact on cell survival and telomere stability in mammalian cells.

Le Chalony C, Hoffschir F, Gauthier LR, Gross J, Biard DS, Boussin FD, Pennaneach V.

Cell Mol Life Sci. 2012 Sep;69(17):2933-49. doi: 10.1007/s00018-012-0975-8. Epub 2012 Mar 30.


The impact of cyclin-dependent kinase 5 depletion on poly(ADP-ribose) polymerase activity and responses to radiation.

Bolin C, Boudra MT, Fernet M, Vaslin L, Pennaneach V, Zaremba T, Biard D, Cordelières FP, Favaudon V, Mégnin-Chanet F, Hall J.

Cell Mol Life Sci. 2012 Mar;69(6):951-62. doi: 10.1007/s00018-011-0811-6. Epub 2011 Sep 16.


Depletion of the novel protein PHACTR-1 from human endothelial cells abolishes tube formation and induces cell death receptor apoptosis.

Jarray R, Allain B, Borriello L, Biard D, Loukaci A, Larghero J, Hadj-Slimane R, Garbay C, Lepelletier Y, Raynaud F.

Biochimie. 2011 Oct;93(10):1668-75. doi: 10.1016/j.biochi.2011.07.010. Epub 2011 Jul 26.


Rad51 and DNA-PKcs are involved in the generation of specific telomere aberrations induced by the quadruplex ligand 360A that impair mitotic cell progression and lead to cell death.

Gauthier LR, Granotier C, Hoffschir F, Etienne O, Ayouaz A, Desmaze C, Mailliet P, Biard DS, Boussin FD.

Cell Mol Life Sci. 2012 Feb;69(4):629-40. doi: 10.1007/s00018-011-0767-6. Epub 2011 Jul 20.


Differential contribution of XPC, RAD23A, RAD23B and CENTRIN 2 to the UV-response in human cells.

Renaud E, Miccoli L, Zacal N, Biard DS, Craescu CT, Rainbow AJ, Angulo JF.

DNA Repair (Amst). 2011 Aug 15;10(8):835-47. doi: 10.1016/j.dnarep.2011.05.003. Epub 2011 Jun 14.


A DNA-dependent stress response involving DNA-PK occurs in hypoxic cells and contributes to cellular adaptation to hypoxia.

Bouquet F, Ousset M, Biard D, Fallone F, Dauvillier S, Frit P, Salles B, Muller C.

J Cell Sci. 2011 Jun 1;124(Pt 11):1943-51. doi: 10.1242/jcs.078030.


Poly(ADP-ribose) polymerase 3 (PARP3), a newcomer in cellular response to DNA damage and mitotic progression.

Boehler C, Gauthier LR, Mortusewicz O, Biard DS, Saliou JM, Bresson A, Sanglier-Cianferani S, Smith S, Schreiber V, Boussin F, Dantzer F.

Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2783-8. doi: 10.1073/pnas.1016574108. Epub 2011 Jan 26.


Proteomic analysis of BRCA1-depleted cell line reveals a putative role for replication protein A2 up-regulation in BRCA1 breast tumor development.

Bouley J, Pionneau C, Varinot J, Biard D, Genestie C, Antoine M, Coulet F, Stern MH, Stoppa-Lyonnet D, Soubrier F.

Proteomics Clin Appl. 2010 May;4(5):489-98. doi: 10.1002/prca.200900107. Epub 2010 Jan 4.


Loss of ATM positively regulates the expression of hypoxia inducible factor 1 (HIF-1) through oxidative stress: Role in the physiopathology of the disease.

Ousset M, Bouquet F, Fallone F, Biard D, Dray C, Valet P, Salles B, Muller C.

Cell Cycle. 2010 Jul 15;9(14):2814-22. Epub 2010 Jul 3.


Role of the ubiquitin-binding domain of Polη in Rad18-independent translesion DNA synthesis in human cell extracts.

Schmutz V, Janel-Bintz R, Wagner J, Biard D, Shiomi N, Fuchs RP, Cordonnier AM.

Nucleic Acids Res. 2010 Oct;38(19):6456-65. doi: 10.1093/nar/gkq403. Epub 2010 Jun 6.


NER factors are recruited to active promoters and facilitate chromatin modification for transcription in the absence of exogenous genotoxic attack.

Le May N, Mota-Fernandes D, Vélez-Cruz R, Iltis I, Biard D, Egly JM.

Mol Cell. 2010 Apr 9;38(1):54-66. doi: 10.1016/j.molcel.2010.03.004.


NADPH oxidase 1 modulates WNT and NOTCH1 signaling to control the fate of proliferative progenitor cells in the colon.

Coant N, Ben Mkaddem S, Pedruzzi E, Guichard C, Tréton X, Ducroc R, Freund JN, Cazals-Hatem D, Bouhnik Y, Woerther PL, Skurnik D, Grodet A, Fay M, Biard D, Lesuffleur T, Deffert C, Moreau R, Groyer A, Krause KH, Daniel F, Ogier-Denis E.

Mol Cell Biol. 2010 Jun;30(11):2636-50. doi: 10.1128/MCB.01194-09. Epub 2010 Mar 29.


ATR contributes to telomere maintenance in human cells.

Pennarun G, Hoffschir F, Revaud D, Granotier C, Gauthier LR, Mailliet P, Biard DS, Boussin FD.

Nucleic Acids Res. 2010 May;38(9):2955-63. doi: 10.1093/nar/gkp1248. Epub 2010 Feb 10.


Activation of NRF2 by nitrosative agents and H2O2 involves KEAP1 disulfide formation.

Fourquet S, Guerois R, Biard D, Toledano MB.

J Biol Chem. 2010 Mar 12;285(11):8463-71. doi: 10.1074/jbc.M109.051714. Epub 2010 Jan 8.


ARTEMIS nuclease facilitates apoptotic chromatin cleavage.

Britton S, Frit P, Biard D, Salles B, Calsou P.

Cancer Res. 2009 Oct 15;69(20):8120-6. doi: 10.1158/0008-5472.CAN-08-4400. Epub 2009 Oct 6.


Radiation-induced mitotic catastrophe in PARG-deficient cells.

Amé JC, Fouquerel E, Gauthier LR, Biard D, Boussin FD, Dantzer F, de Murcia G, Schreiber V.

J Cell Sci. 2009 Jun 15;122(Pt 12):1990-2002. doi: 10.1242/jcs.039115. Epub 2009 May 19.


Human DNA polymerase eta is required for common fragile site stability during unperturbed DNA replication.

Rey L, Sidorova JM, Puget N, Boudsocq F, Biard DS, Monnat RJ Jr, Cazaux C, Hoffmann JS.

Mol Cell Biol. 2009 Jun;29(12):3344-54. doi: 10.1128/MCB.00115-09. Epub 2009 Apr 20.


Novel anti-metastatic action of cidofovir mediated by inhibition of E6/E7, CXCR4 and Rho/ROCK signaling in HPV tumor cells.

Amine A, Rivera S, Opolon P, Dekkal M, Biard DS, Bouamar H, Louache F, McKay MJ, Bourhis J, Deutsch E, Vozenin-Brotons MC.

PLoS One. 2009;4(3):e5018. doi: 10.1371/journal.pone.0005018. Epub 2009 Mar 26.


Role of TLS DNA polymerases eta and kappa in processing naturally occurring structured DNA in human cells.

Bétous R, Rey L, Wang G, Pillaire MJ, Puget N, Selves J, Biard DS, Shin-ya K, Vasquez KM, Cazaux C, Hoffmann JS.

Mol Carcinog. 2009 Apr;48(4):369-78. doi: 10.1002/mc.20509.


Expression of the TrkA or TrkB receptor tyrosine kinase alters the double-strand break (DSB) repair capacity of SY5Y neuroblastoma cells.

Schulte JH, Kuhfittig-Kulle S, Klein-Hitpass L, Schramm A, Biard DS, Pfeiffer P, Eggert A.

DNA Repair (Amst). 2008 Oct 1;7(10):1757-64. doi: 10.1016/j.dnarep.2008.07.004. Epub 2008 Aug 20.


Moderate variations in CDC25B protein levels modulate the response to DNA damaging agents.

Aressy B, Bugler B, Valette A, Biard D, Ducommun B.

Cell Cycle. 2008 Jul 15;7(14):2234-40. Epub 2008 May 14.


PARP inhibition versus PARP-1 silencing: different outcomes in terms of single-strand break repair and radiation susceptibility.

Godon C, Cordelières FP, Biard D, Giocanti N, Mégnin-Chanet F, Hall J, Favaudon V.

Nucleic Acids Res. 2008 Aug;36(13):4454-64. doi: 10.1093/nar/gkn403. Epub 2008 Jul 4.


Role of ATM in the telomere response to the G-quadruplex ligand 360A.

Pennarun G, Granotier C, Hoffschir F, Mandine E, Biard D, Gauthier LR, Boussin FD.

Nucleic Acids Res. 2008 Mar;36(5):1741-54. doi: 10.1093/nar/gkn026. Epub 2008 Feb 7.


Interplay between Cernunnos-XLF and nonhomologous end-joining proteins at DNA ends in the cell.

Wu PY, Frit P, Malivert L, Revy P, Biard D, Salles B, Calsou P.

J Biol Chem. 2007 Nov 2;282(44):31937-43. Epub 2007 Aug 24.


Long-term XPC silencing reduces DNA double-strand break repair.

Despras E, Pfeiffer P, Salles B, Calsou P, Kuhfittig-Kulle S, Angulo JF, Biard DS.

Cancer Res. 2007 Mar 15;67(6):2526-34.

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