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Higher Caloric Exposure in Critically Ill Patients Transiently Accelerates Thyroid Hormone Activation.

McKeever L, Peterson SJ, Lateef O, Freels S, Fonseca TL, Bocco BMLC, Fernandes GW, Roehl K, Nowak K, Mozer M, Bianco AC, Braunschweig CA.

J Clin Endocrinol Metab. 2020 Feb 1;105(2). pii: dgz077. doi: 10.1210/clinem/dgz077.


Patient Context and Thyrotropin Levels Are Important When Considering Treatment of Subclinical Hypothyroidism.

Sawka AM, Cappola AR, Peeters RP, Kopp PA, Bianco AC, Jonklaas J.

Thyroid. 2019 Oct;29(10):1359-1363. doi: 10.1089/thy.2019.0494. Epub 2019 Oct 3. No abstract available.


Sustained Release T3 Therapy: Animal Models and Translational Applications.

Idrees T, Price JD, Piccariello T, Bianco AC.

Front Endocrinol (Lausanne). 2019 Aug 13;10:544. doi: 10.3389/fendo.2019.00544. eCollection 2019. Review.


The Swinging Pendulum in Treatment for Hypothyroidism: From (and Toward?) Combination Therapy.

McAninch EA, Bianco AC.

Front Endocrinol (Lausanne). 2019 Jul 9;10:446. doi: 10.3389/fendo.2019.00446. eCollection 2019. Review.


Urgent need for further research in subclinical hypothyroidism.

Taylor P, Bianco AC.

Nat Rev Endocrinol. 2019 Sep;15(9):503-504. doi: 10.1038/s41574-019-0239-x. No abstract available.


Paradigms of Dynamic Control of Thyroid Hormone Signaling.

Bianco AC, Dumitrescu A, Gereben B, Ribeiro MO, Fonseca TL, Fernandes GW, Bocco BMLC.

Endocr Rev. 2019 Aug 1;40(4):1000-1047. doi: 10.1210/er.2018-00275. Review.


Hepatic Inactivation of the Type 2 Deiodinase Confers Resistance to Alcoholic Liver Steatosis.

Fonseca TL, Fernandes GW, Bocco BMLC, Keshavarzian A, Jakate S, Donohue TM Jr, Gereben B, Bianco AC.

Alcohol Clin Exp Res. 2019 Jul;43(7):1376-1383. doi: 10.1111/acer.14027. Epub 2019 Apr 26.


Type 2 deiodinase polymorphism causes ER stress and hypothyroidism in the brain.

Jo S, Fonseca TL, Bocco BMLC, Fernandes GW, McAninch EA, Bolin AP, Da Conceição RR, Werneck-de-Castro JP, Ignacio DL, Egri P, Németh D, Fekete C, Bernardi MM, Leitch VD, Mannan NS, Curry KF, Butterfield NC, Bassett JHD, Williams GR, Gereben B, Ribeiro MO, Bianco AC.

J Clin Invest. 2019 Jan 2;129(1):230-245. doi: 10.1172/JCI123176. Epub 2018 Dec 3.


Amiodarone and thyroid physiology, pathophysiology, diagnosis and management.

Trohman RG, Sharma PS, McAninch EA, Bianco AC.

Trends Cardiovasc Med. 2019 Jul;29(5):285-295. doi: 10.1016/j.tcm.2018.09.005. Epub 2018 Sep 20.


Metal Coordinated Poly-Zinc-Liothyronine Provides Stable Circulating Triiodothyronine Levels in Hypothyroid Rats.

Da Conceição RR, Fernandes GW, Fonseca TL, Bocco BMLC, Bianco AC.

Thyroid. 2018 Nov;28(11):1425-1433. doi: 10.1089/thy.2018.0205.


Systemic Thyroid Hormone Status During Levothyroxine Therapy In Hypothyroidism: A Systematic Review and Meta-Analysis.

McAninch EA, Rajan KB, Miller CH, Bianco AC.

J Clin Endocrinol Metab. 2018 Aug 15. doi: 10.1210/jc.2018-01361. [Epub ahead of print]


Does Sex Bias Play a Role for Dissatisfied Patients With Hypothyroidism?

McAninch EA, Glueck JS, Bianco AC.

J Endocr Soc. 2018 Jul 9;2(8):970-973. doi: 10.1210/js.2018-00169. eCollection 2018 Aug 1. Review.


Pathophysiological relevance of deiodinase polymorphism.

Bianco AC, Kim BS.

Curr Opin Endocrinol Diabetes Obes. 2018 Oct;25(5):341-346. doi: 10.1097/MED.0000000000000428. Review.


Induction of Type 2 Iodothyronine Deiodinase After Status Epilepticus Modifies Hippocampal Gene Expression in Male Mice.

Nascimento BPP, Bocco BMLC, Fernandes GW, Fonseca TL, McAninch EA, Cardoso CV, Bondan EF, Nassif RJ, Cysneiros RM, Bianco AC, Ribeiro MO.

Endocrinology. 2018 Aug 1;159(8):3090-3104. doi: 10.1210/en.2018-00146.


The Deiodinase Trio and Thyroid Hormone Signaling.

Bianco AC, da Conceição RR.

Methods Mol Biol. 2018;1801:67-83. doi: 10.1007/978-1-4939-7902-8_8. Review.


An Online Survey of Hypothyroid Patients Demonstrates Prominent Dissatisfaction.

Peterson SJ, Cappola AR, Castro MR, Dayan CM, Farwell AP, Hennessey JV, Kopp PA, Ross DS, Samuels MH, Sawka AM, Taylor PN, Jonklaas J, Bianco AC.

Thyroid. 2018 Jun;28(6):707-721. doi: 10.1089/thy.2017.0681. Epub 2018 Apr 5.


A Common DIO2 Polymorphism and Alzheimer Disease Dementia in African and European Americans.

McAninch EA, Rajan KB, Evans DA, Jo S, Chaker L, Peeters RP, Bennett DA, Mash DC, Bianco AC.

J Clin Endocrinol Metab. 2018 May 1;103(5):1818-1826. doi: 10.1210/jc.2017-01196.


Hypothyroidism and hypertension: fact or myth? - Authors' reply.

Chaker L, Bianco AC, Jonklaas J, Peeters RP.

Lancet. 2018 Jan 6;391(10115):30. doi: 10.1016/S0140-6736(17)33321-4. No abstract available.


The Foxo1-Inducible Transcriptional Repressor Zfp125 Causes Hepatic Steatosis and Hypercholesterolemia.

Fernandes GW, Bocco BMLC, Fonseca TL, McAninch EA, Jo S, Lartey LJ, O-Sullivan I, Unterman TG, Preite NZ, Voigt RM, Forsyth CB, Keshavarzian A, Sinkó R, Goldfine AB, Patti ME, Ribeiro MO, Gereben B, Bianco AC.

Cell Rep. 2018 Jan 9;22(2):523-534. doi: 10.1016/j.celrep.2017.12.053.


A Transgenic Mouse Model for Detection of Tissue-Specific Thyroid Hormone Action.

Mohácsik P, Erdélyi F, Baranyi M, Botz B, Szabó G, Tóth M, Haltrich I, Helyes Z, Sperlágh B, Tóth Z, Sinkó R, Lechan RM, Bianco AC, Fekete C, Gereben B.

Endocrinology. 2018 Feb 1;159(2):1159-1171. doi: 10.1210/en.2017-00582.


Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial function.

Yu G, Tzouvelekis A, Wang R, Herazo-Maya JD, Ibarra GH, Srivastava A, de Castro JPW, DeIuliis G, Ahangari F, Woolard T, Aurelien N, Arrojo E Drigo R, Gan Y, Graham M, Liu X, Homer RJ, Scanlan TS, Mannam P, Lee PJ, Herzog EL, Bianco AC, Kaminski N.

Nat Med. 2018 Jan;24(1):39-49. doi: 10.1038/nm.4447. Epub 2017 Dec 4.



Chaker L, Bianco AC, Jonklaas J, Peeters RP.

Lancet. 2017 Sep 23;390(10101):1550-1562. doi: 10.1016/S0140-6736(17)30703-1. Epub 2017 Mar 20. Review.


Myocardial Inactivation of Thyroid Hormones in Patients with Aortic Stenosis.

Paolino BS, Pomerantzeff PM, Dallan LAO, Gaiotto FA, Preite NZ, Latrônico AC, Nicolau JC, Bianco AC, Giraldez RRCV.

Thyroid. 2017 May;27(5):738-745. doi: 10.1089/thy.2016.0514. Epub 2017 Apr 12.


Early Developmental Disruption of Type 2 Deiodinase Pathway in Mouse Skeletal Muscle Does Not Impair Muscle Function.

Ignacio DL, Silvestre DH, Anne-Palmer E, Bocco BM, Fonseca TL, Ribeiro MO, Gereben B, Bianco AC, Werneck-de-Castro JP.

Thyroid. 2017 Apr;27(4):577-586. doi: 10.1089/thy.2016.0392. Epub 2017 Feb 10.


Disruption of beta3 adrenergic receptor increases susceptibility to DIO in mouse.

Preite NZ, Nascimento BP, Muller CR, Américo AL, Higa TS, Evangelista FS, Lancellotti CL, Henriques FS, Batista ML Jr, Bianco AC, Ribeiro MO.

J Endocrinol. 2016 Dec;231(3):259-269. Epub 2016 Sep 26.


Cognitive decline following incident and preexisting diabetes mellitus in a population sample.

Rajan KB, Arvanitakis Z, Lynch EB, McAninch EA, Wilson RS, Weuve J, Barnes LL, Bianco AC, Evans DA.

Neurology. 2016 Oct 18;87(16):1681-1687. Epub 2016 Sep 21.


Is a Normal TSH Synonymous With "Euthyroidism" in Levothyroxine Monotherapy?

Peterson SJ, McAninch EA, Bianco AC.

J Clin Endocrinol Metab. 2016 Dec;101(12):4964-4973. Epub 2016 Oct 4. Erratum in: J Clin Endocrinol Metab. 2017 Apr 1;102(4):1406.


The Relationship Between Work Relative Value Unit Awareness and Work Relative Value Unit Accumulation Among Physicians.

Lowe K, Bianco AC, Canar J, Kasdorf K, Mantei B, Smith BT.

J Med Pract Manage. 2016 Sep;32(2):86-91.


Type 2 Deiodinase Disruption in Astrocytes Results in Anxiety-Depressive-Like Behavior in Male Mice.

Bocco BM, Werneck-de-Castro JP, Oliveira KC, Fernandes GW, Fonseca TL, Nascimento BP, McAninch EA, Ricci E, Kvárta-Papp Z, Fekete C, Bernardi MM, Gereben B, Bianco AC, Ribeiro MO.

Endocrinology. 2016 Sep;157(9):3682-95. doi: 10.1210/en.2016-1272. Epub 2016 Aug 8.


Carbapenem-resistant Enterobacteriaceae on a cardiac surgery intensive care unit: successful measures for infection control.

Abboud CS, de Souza EE, Zandonadi EC, Borges LS, Miglioli L, Monaco FC, Barbosa VL, Cortez D, Bianco AC, Braz A, Monteiro J.

J Hosp Infect. 2016 Sep;94(1):60-4. doi: 10.1016/j.jhin.2016.06.010. Epub 2016 Jun 18.


Thyroid hormone activation by type 2 deiodinase mediates exercise-induced peroxisome proliferator-activated receptor-γ coactivator-1α expression in skeletal muscle.

Bocco BM, Louzada RA, Silvestre DH, Santos MC, Anne-Palmer E, Rangel IF, Abdalla S, Ferreira AC, Ribeiro MO, Gereben B, Carvalho DP, Bianco AC, Werneck-de-Castro JP.

J Physiol. 2016 Sep 15;594(18):5255-69. doi: 10.1113/JP272440. Epub 2016 Aug 18.


Combined treatment with caffeic and ferulic acid from Baccharis uncinella C. DC. (Asteraceae) protects against metabolic syndrome in mice.

Bocco BM, Fernandes GW, Lorena FB, Cysneiros RM, Christoffolete MA, Grecco SS, Lancellotti CL, Romoff P, Lago JH, Bianco AC, Ribeiro MO.

Braz J Med Biol Res. 2016 Mar;49(3). pii: S0100-879X2016000300604. doi: 10.1590/1414-431X20155003. Epub 2016 Feb 2.


The History and Future of Treatment of Hypothyroidism.

McAninch EA, Bianco AC.

Ann Intern Med. 2016 Jan 5;164(1):50-6. doi: 10.7326/M15-1799. Erratum in: Ann Intern Med. 2016 Mar 1;164(5):376.


Of rats and men: thyroid homeostasis in rodents and human beings - Authors' reply.

McAninch EA, Bianco AC.

Lancet Diabetes Endocrinol. 2015 Dec;3(12):933. doi: 10.1016/S2213-8587(15)00428-3. No abstract available.


Perinatal deiodinase 2 expression in hepatocytes defines epigenetic susceptibility to liver steatosis and obesity.

Fonseca TL, Fernandes GW, McAninch EA, Bocco BM, Abdalla SM, Ribeiro MO, Mohácsik P, Fekete C, Li D, Xing X, Wang T, Gereben B, Bianco AC.

Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):14018-23. doi: 10.1073/pnas.1508943112. Epub 2015 Oct 27.


Coupling between Nutrient Availability and Thyroid Hormone Activation.

Lartey LJ, Werneck-de-Castro JP, O-Sullivan I, Unterman TG, Bianco AC.

J Biol Chem. 2015 Dec 18;290(51):30551-61. doi: 10.1074/jbc.M115.665505. Epub 2015 Oct 23.


Scope and limitations of iodothyronine deiodinases in hypothyroidism.

Gereben B, McAninch EA, Ribeiro MO, Bianco AC.

Nat Rev Endocrinol. 2015 Nov;11(11):642-652. doi: 10.1038/nrendo.2015.155. Epub 2015 Sep 29. Review.


New insights into the variable effectiveness of levothyroxine monotherapy for hypothyroidism.

McAninch EA, Bianco AC.

Lancet Diabetes Endocrinol. 2015 Oct;3(10):756-8. doi: 10.1016/S2213-8587(15)00325-3. Epub 2015 Sep 8. No abstract available.


Thyroid Hormone Signaling in Male Mouse Skeletal Muscle Is Largely Independent of D2 in Myocytes.

Werneck-de-Castro JP, Fonseca TL, Ignacio DL, Fernandes GW, Andrade-Feraud CM, Lartey LJ, Ribeiro MB, Ribeiro MO, Gereben B, Bianco AC.

Endocrinology. 2015 Oct;156(10):3842-52. doi: 10.1210/en.2015-1246. Epub 2015 Jul 27.


Thyroid function in critically ill patients.

Fliers E, Bianco AC, Langouche L, Boelen A.

Lancet Diabetes Endocrinol. 2015 Oct;3(10):816-25. doi: 10.1016/S2213-8587(15)00225-9. Epub 2015 Jun 10. Review.


Disruption of type 2 iodothyronine deiodinase activity in cultured human glial cells by polybrominated diphenyl ethers.

Roberts SC, Bianco AC, Stapleton HM.

Chem Res Toxicol. 2015 Jun 15;28(6):1265-74. doi: 10.1021/acs.chemrestox.5b00072. Epub 2015 Jun 2.


Epicardial adipose tissue has a unique transcriptome modified in severe coronary artery disease.

McAninch EA, Fonseca TL, Poggioli R, Panos AL, Salerno TA, Deng Y, Li Y, Bianco AC, Iacobellis G.

Obesity (Silver Spring). 2015 Jun;23(6):1267-78. doi: 10.1002/oby.21059. Epub 2015 May 9.


S-nitrosoglutathione reductase-dependent PPARγ denitrosylation participates in MSC-derived adipogenesis and osteogenesis.

Cao Y, Gomes SA, Rangel EB, Paulino EC, Fonseca TL, Li J, Teixeira MB, Gouveia CH, Bianco AC, Kapiloff MS, Balkan W, Hare JM.

J Clin Invest. 2015 Apr;125(4):1679-91. doi: 10.1172/JCI73780. Epub 2015 Mar 23.


Prevalent polymorphism in thyroid hormone-activating enzyme leaves a genetic fingerprint that underlies associated clinical syndromes.

McAninch EA, Jo S, Preite NZ, Farkas E, Mohácsik P, Fekete C, Egri P, Gereben B, Li Y, Deng Y, Patti ME, Zevenbergen C, Peeters RP, Mash DC, Bianco AC.

J Clin Endocrinol Metab. 2015 Mar;100(3):920-33. doi: 10.1210/jc.2014-4092. Epub 2015 Jan 8.


Differences in hypothalamic type 2 deiodinase ubiquitination explain localized sensitivity to thyroxine.

Werneck de Castro JP, Fonseca TL, Ueta CB, McAninch EA, Abdalla S, Wittmann G, Lechan RM, Gereben B, Bianco AC.

J Clin Invest. 2015 Feb;125(2):769-81. doi: 10.1172/JCI77588. Epub 2015 Jan 2.


Guidelines for the treatment of hypothyroidism: prepared by the american thyroid association task force on thyroid hormone replacement.

Jonklaas J, Bianco AC, Bauer AJ, Burman KD, Cappola AR, Celi FS, Cooper DS, Kim BW, Peeters RP, Rosenthal MS, Sawka AM; American Thyroid Association Task Force on Thyroid Hormone Replacement.

Thyroid. 2014 Dec;24(12):1670-751. doi: 10.1089/thy.2014.0028.


Defending plasma T3 is a biological priority.

Abdalla SM, Bianco AC.

Clin Endocrinol (Oxf). 2014 Nov;81(5):633-41. doi: 10.1111/cen.12538. Epub 2014 Aug 7. Review.


Maternal inheritance of an inactive type III deiodinase gene allele affects mouse pancreatic β-cells and disrupts glucose homeostasis.

Medina MC, Fonesca TL, Molina J, Fachado A, Castillo M, Dong L, Soares R, Hernández A, Caicedo A, Bianco AC.

Endocrinology. 2014 Aug;155(8):3160-71. doi: 10.1210/en.2013-1208. Epub 2014 Jun 2.


Inactivation of the adrenergic receptor β2 disrupts glucose homeostasis in mice.

Fernandes GW, Ueta CB, Fonseca TL, Gouveia CH, Lancellotti CL, Brum PC, Christoffolete MA, Bianco AC, Ribeiro MO.

J Endocrinol. 2014 Jun;221(3):381-90. doi: 10.1530/JOE-13-0526.


Thyroid hormone signaling in energy homeostasis and energy metabolism.

McAninch EA, Bianco AC.

Ann N Y Acad Sci. 2014 Apr;1311:77-87. doi: 10.1111/nyas.12374. Epub 2014 Feb 20. Review.

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