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Loss of Endogenous HMGB2 Promotes Cardiac Dysfunction and Pressure Overload-Induced Heart Failure in Mice.

Sato M, Miyata K, Tian Z, Kadomatsu T, Ujihara Y, Morinaga J, Horiguchi H, Endo M, Zhao J, Zhu S, Sugizaki T, Igata K, Muramatsu M, Minami T, Ito T, Bianchi ME, Mohri S, Araki K, Node K, Oike Y.

Circ J. 2019 Jan 25;83(2):368-378. doi: 10.1253/circj.CJ-18-0925. Epub 2018 Nov 27.


The Janus face of HMGB1 in heart disease: a necessary update.

Raucci A, Di Maggio S, Scavello F, D'Ambrosio A, Bianchi ME, Capogrossi MC.

Cell Mol Life Sci. 2019 Jan;76(2):211-229. doi: 10.1007/s00018-018-2930-9. Epub 2018 Oct 10. Review.


Redox-Mediated Mechanisms Fuel Monocyte Responses to CXCL12/HMGB1 in Active Rheumatoid Arthritis.

Cecchinato V, D'Agostino G, Raeli L, Nerviani A, Schiraldi M, Danelon G, Manzo A, Thelen M, Ciurea A, Bianchi ME, Rubartelli A, Pitzalis C, Uguccioni M.

Front Immunol. 2018 Sep 19;9:2118. doi: 10.3389/fimmu.2018.02118. eCollection 2018.


Correction to: Exploring the biological functional mechanism of the HMGB1/TLR4/MD-2 complex by surface plasmon resonance.

He M, Bianchi ME, Coleman TR, Tracey KJ, Al-Abed Y.

Mol Med. 2018 Jun 13;24(1):31. doi: 10.1186/s10020-018-0030-9.


Exploring the biological functional mechanism of the HMGB1/TLR4/MD-2 complex by surface plasmon resonance.

He M, Bianchi ME, Coleman TR, Tracey KJ, Al-Abed Y.

Mol Med. 2018 May 10;24(1):21. doi: 10.1186/s10020-018-0023-8. Erratum in: Mol Med. 2018 Jun 13;24(1):31.


Platelet microparticles sustain autophagy-associated activation of neutrophils in systemic sclerosis.

Maugeri N, Capobianco A, Rovere-Querini P, Ramirez GA, Tombetti E, Valle PD, Monno A, D'Alberti V, Gasparri AM, Franchini S, D'Angelo A, Bianchi ME, Manfredi AA.

Sci Transl Med. 2018 Jul 25;10(451). pii: eaao3089. doi: 10.1126/scitranslmed.aao3089.


miR-34a Promotes Vascular Smooth Muscle Cell Calcification by Downregulating SIRT1 (Sirtuin 1) and Axl (AXL Receptor Tyrosine Kinase).

Badi I, Mancinelli L, Polizzotto A, Ferri D, Zeni F, Burba I, Milano G, Brambilla F, Saccu C, Bianchi ME, Pompilio G, Capogrossi MC, Raucci A.

Arterioscler Thromb Vasc Biol. 2018 Sep;38(9):2079-2090. doi: 10.1161/ATVBAHA.118.311298.


LPS-Challenged Macrophages Release Microvesicles Coated With Histones.

Nair RR, Mazza D, Brambilla F, Gorzanelli A, Agresti A, Bianchi ME.

Front Immunol. 2018 Jun 27;9:1463. doi: 10.3389/fimmu.2018.01463. eCollection 2018.


[Prevalence of obesity and arterial hypertension and their relationship with age and gender in the city of Resistencia, Argentina, in the years 2008-2014].

Bianchi MEV, Cusumano AM, Torres C, Rojas NG, Velasco GA.

Hipertens Riesgo Vasc. 2019 Jan - Mar;36(1):14-20. doi: 10.1016/j.hipert.2018.04.003. Epub 2018 May 17. Spanish.


Brain-released alarmins and stress response synergize in accelerating atherosclerosis progression after stroke.

Roth S, Singh V, Tiedt S, Schindler L, Huber G, Geerlof A, Antoine DJ, Anfray A, Orset C, Gauberti M, Fournier A, Holdt LM, Harris HE, Engelhardt B, Bianchi ME, Vivien D, Haffner C, Bernhagen J, Dichgans M, Liesz A.

Sci Transl Med. 2018 Mar 14;10(432). pii: eaao1313. doi: 10.1126/scitranslmed.aao1313.


From Human Megakaryocytes to Platelets: Effects of Aspirin on High-Mobility Group Box 1/Receptor for Advanced Glycation End Products Axis.

Mardente S, Mari E, Massimi I, Tafani M, Guerriero R, Morsilli O, Pulcinelli FM, Bianchi ME, Zicari A.

Front Immunol. 2018 Jan 12;8:1946. doi: 10.3389/fimmu.2017.01946. eCollection 2017.


High mobility group box 1 orchestrates tissue regeneration via CXCR4.

Tirone M, Tran NL, Ceriotti C, Gorzanelli A, Canepari M, Bottinelli R, Raucci A, Di Maggio S, Santiago C, Mellado M, Saclier M, François S, Careccia G, He M, De Marchis F, Conti V, Ben Larbi S, Cuvellier S, Casalgrandi M, Preti A, Chazaud B, Al-Abed Y, Messina G, Sitia G, Brunelli S, Bianchi ME, Vénéreau E.

J Exp Med. 2018 Jan 2;215(1):303-318. doi: 10.1084/jem.20160217. Epub 2017 Dec 4.


High-mobility group box 1 protein orchestrates responses to tissue damage via inflammation, innate and adaptive immunity, and tissue repair.

Bianchi ME, Crippa MP, Manfredi AA, Mezzapelle R, Rovere Querini P, Venereau E.

Immunol Rev. 2017 Nov;280(1):74-82. doi: 10.1111/imr.12601. Review.


Live-cell p53 single-molecule binding is modulated by C-terminal acetylation and correlates with transcriptional activity.

Loffreda A, Jacchetti E, Antunes S, Rainone P, Daniele T, Morisaki T, Bianchi ME, Tacchetti C, Mazza D.

Nat Commun. 2017 Aug 22;8(1):313. doi: 10.1038/s41467-017-00398-7.


HMGB1 is upregulated in the airways in asthma and potentiates airway smooth muscle contraction via TLR4.

Di Candia L, Gomez E, Venereau E, Chachi L, Kaur D, Bianchi ME, Challiss RAJ, Brightling CE, Saunders RM.

J Allergy Clin Immunol. 2017 Aug;140(2):584-587.e8. doi: 10.1016/j.jaci.2016.11.049. Epub 2017 Mar 1. No abstract available.


HMGB1 targeting by ethyl pyruvate suppresses malignant phenotype of human mesothelioma.

Pellegrini L, Xue J, Larson D, Pastorino S, Jube S, Forest KH, Saad-Jube ZS, Napolitano A, Pagano I, Negi VS, Bianchi ME, Morris P, Pass HI, Gaudino G, Carbone M, Yang H.

Oncotarget. 2017 Apr 4;8(14):22649-22661. doi: 10.18632/oncotarget.15152.


The shedding-derived soluble receptor for advanced glycation endproducts sustains inflammation during acute Pseudomonas aeruginosa lung infection.

Antonelli A, Di Maggio S, Rejman J, Sanvito F, Rossi A, Catucci A, Gorzanelli A, Bragonzi A, Bianchi ME, Raucci A.

Biochim Biophys Acta Gen Subj. 2017 Feb;1861(2):354-364. doi: 10.1016/j.bbagen.2016.11.040. Epub 2016 Nov 30.


The Mouse-Specific Splice Variant mRAGE_v4 Encodes a Membrane-Bound RAGE That Is Resistant to Shedding and Does Not Contribute to the Production of Soluble RAGE.

Di Maggio S, Gatti E, Liu J, Bertolotti M, Fritz G, Bianchi ME, Raucci A.

PLoS One. 2016 Sep 21;11(9):e0153832. doi: 10.1371/journal.pone.0153832. eCollection 2016.


Oxidative stress controls the choice of alternative last exons via a Brahma-BRCA1-CstF pathway.

Fontana GA, Rigamonti A, Lenzken SC, Filosa G, Alvarez R, Calogero R, Bianchi ME, Barabino SM.

Nucleic Acids Res. 2017 Jan 25;45(2):902-914. doi: 10.1093/nar/gkw780. Epub 2016 Sep 2.


Single-cell analyses reveal an attenuated NF-κB response in the Salmonella-infected fibroblast.

Ramos-Marquès E, Zambrano S, Tiérrez A, Bianchi ME, Agresti A, García-Del Portillo F.

Virulence. 2017 Aug 18;8(6):719-740. doi: 10.1080/21505594.2016.1229727. Epub 2016 Aug 30.


Disulfide HMGB1 derived from platelets coordinates venous thrombosis in mice.

Stark K, Philippi V, Stockhausen S, Busse J, Antonelli A, Miller M, Schubert I, Hoseinpour P, Chandraratne S, von Brühl ML, Gaertner F, Lorenz M, Agresti A, Coletti R, Antoine DJ, Heermann R, Jung K, Reese S, Laitinen I, Schwaiger M, Walch A, Sperandio M, Nawroth PP, Reinhardt C, Jäckel S, Bianchi ME, Massberg S.

Blood. 2016 Nov 17;128(20):2435-2449. Epub 2016 Aug 29.


Leukocytes recruited by tumor-derived HMGB1 sustain peritoneal carcinomatosis.

Cottone L, Capobianco A, Gualteroni C, Monno A, Raccagni I, Valtorta S, Canu T, Di Tomaso T, Lombardo A, Esposito A, Moresco RM, Maschio AD, Naldini L, Rovere-Querini P, Bianchi ME, Manfredi AA.

Oncoimmunology. 2016 Jan 8;5(5):e1122860. doi: 10.1080/2162402X.2015.1122860. eCollection 2016 May.


HMGB1 as biomarker and drug target.

Venereau E, De Leo F, Mezzapelle R, Careccia G, Musco G, Bianchi ME.

Pharmacol Res. 2016 Sep;111:534-544. doi: 10.1016/j.phrs.2016.06.031. Epub 2016 Jul 1. Review.


Epithelial calcineurin controls microbiota-dependent intestinal tumor development.

Peuker K, Muff S, Wang J, Künzel S, Bosse E, Zeissig Y, Luzzi G, Basic M, Strigli A, Ulbricht A, Kaser A, Arlt A, Chavakis T, van den Brink GR, Schafmayer C, Egberts JH, Becker T, Bianchi ME, Bleich A, Röcken C, Hampe J, Schreiber S, Baines JF, Blumberg RS, Zeissig S.

Nat Med. 2016 May;22(5):506-15. doi: 10.1038/nm.4072. Epub 2016 Apr 4.


Human malignant mesothelioma is recapitulated in immunocompetent BALB/c mice injected with murine AB cells.

Mezzapelle R, Rrapaj E, Gatti E, Ceriotti C, Marchis FD, Preti A, Spinelli AE, Perani L, Venturini M, Valtorta S, Moresco RM, Pecciarini L, Doglioni C, Frenquelli M, Crippa L, Recordati C, Scanziani E, de Vries H, Berns A, Frapolli R, Boldorini R, D'Incalci M, Bianchi ME, Crippa MP.

Sci Rep. 2016 Mar 10;6:22850. doi: 10.1038/srep22850.


NF-κB oscillations translate into functionally related patterns of gene expression.

Zambrano S, De Toma I, Piffer A, Bianchi ME, Agresti A.

Elife. 2016 Jan 14;5:e09100. doi: 10.7554/eLife.09100.


Interplay between stochasticity and negative feedback leads to pulsed dynamics and distinct gene activity patterns.

Zambrano S, Bianchi ME, Agresti A, Molina N.

Phys Rev E Stat Nonlin Soft Matter Phys. 2015 Aug;92(2):022711. Epub 2015 Aug 14.


DAMPs from Cell Death to New Life.

Vénéreau E, Ceriotti C, Bianchi ME.

Front Immunol. 2015 Aug 18;6:422. doi: 10.3389/fimmu.2015.00422. eCollection 2015. Review.


Aspirin's Active Metabolite Salicylic Acid Targets High Mobility Group Box 1 to Modulate Inflammatory Responses.

Choi HW, Tian M, Song F, Venereau E, Preti A, Park SW, Hamilton K, Swapna GV, Manohar M, Moreau M, Agresti A, Gorzanelli A, De Marchis F, Wang H, Antonyak M, Micikas RJ, Gentile DR, Cerione RA, Schroeder FC, Montelione GT, Bianchi ME, Klessig DF.

Mol Med. 2015 Jun 18;21:526-35. doi: 10.2119/molmed.2015.00148.


Aspirin delays mesothelioma growth by inhibiting HMGB1-mediated tumor progression.

Yang H, Pellegrini L, Napolitano A, Giorgi C, Jube S, Preti A, Jennings CJ, De Marchis F, Flores EG, Larson D, Pagano I, Tanji M, Powers A, Kanodia S, Gaudino G, Pastorino S, Pass HI, Pinton P, Bianchi ME, Carbone M.

Cell Death Dis. 2015 Jun 11;6:e1786. doi: 10.1038/cddis.2015.153.


Cancer cell-autonomous contribution of type I interferon signaling to the efficacy of chemotherapy.

Sistigu A, Yamazaki T, Vacchelli E, Chaba K, Enot DP, Adam J, Vitale I, Goubar A, Baracco EE, Remédios C, Fend L, Hannani D, Aymeric L, Ma Y, Niso-Santano M, Kepp O, Schultze JL, Tüting T, Belardelli F, Bracci L, La Sorsa V, Ziccheddu G, Sestili P, Urbani F, Delorenzi M, Lacroix-Triki M, Quidville V, Conforti R, Spano JP, Pusztai L, Poirier-Colame V, Delaloge S, Penault-Llorca F, Ladoire S, Arnould L, Cyrta J, Dessoliers MC, Eggermont A, Bianchi ME, Pittet M, Engblom C, Pfirschke C, Préville X, Uzè G, Schreiber RD, Chow MT, Smyth MJ, Proietti E, André F, Kroemer G, Zitvogel L.

Nat Med. 2014 Nov;20(11):1301-9. doi: 10.1038/nm.3708. Epub 2014 Oct 26.


Histone content increases in differentiating embryonic stem cells.

Karnavas T, Pintonello L, Agresti A, Bianchi ME.

Front Physiol. 2014 Aug 28;5:330. doi: 10.3389/fphys.2014.00330. eCollection 2014.


Activated platelets present high mobility group box 1 to neutrophils, inducing autophagy and promoting the extrusion of neutrophil extracellular traps.

Maugeri N, Campana L, Gavina M, Covino C, De Metrio M, Panciroli C, Maiuri L, Maseri A, D'Angelo A, Bianchi ME, Rovere-Querini P, Manfredi AA.

J Thromb Haemost. 2014 Dec;12(12):2074-88. doi: 10.1111/jth.12710. Epub 2014 Nov 14.


5-Fluorouracil causes leukocytes attraction in the peritoneal cavity by activating autophagy and HMGB1 release in colon carcinoma cells.

Cottone L, Capobianco A, Gualteroni C, Perrotta C, Bianchi ME, Rovere-Querini P, Manfredi AA.

Int J Cancer. 2015 Mar 15;136(6):1381-9. doi: 10.1002/ijc.29125. Epub 2014 Aug 18.


Nucleosome loss facilitates the chemotactic response of macrophages.

De Toma I, Rossetti G, Zambrano S, Bianchi ME, Agresti A.

J Intern Med. 2014 Nov;276(5):454-69. doi: 10.1111/joim.12286. Epub 2014 Aug 5. Review.


Leukocyte HMGB1 is required for vessel remodeling in regenerating muscles.

Campana L, Santarella F, Esposito A, Maugeri N, Rigamonti E, Monno A, Canu T, Del Maschio A, Bianchi ME, Manfredi AA, Rovere-Querini P.

J Immunol. 2014 Jun 1;192(11):5257-64. doi: 10.4049/jimmunol.1300938. Epub 2014 Apr 21.


High-throughput analysis of NF-κB dynamics in single cells reveals basal nuclear localization of NF-κB and spontaneous activation of oscillations.

Zambrano S, Bianchi ME, Agresti A.

PLoS One. 2014 Mar 4;9(3):e90104. doi: 10.1371/journal.pone.0090104. eCollection 2014.


Ultraviolet-radiation-induced inflammation promotes angiotropism and metastasis in melanoma.

Bald T, Quast T, Landsberg J, Rogava M, Glodde N, Lopez-Ramos D, Kohlmeyer J, Riesenberg S, van den Boorn-Konijnenberg D, Hömig-Hölzel C, Reuten R, Schadow B, Weighardt H, Wenzel D, Helfrich I, Schadendorf D, Bloch W, Bianchi ME, Lugassy C, Barnhill RL, Koch M, Fleischmann BK, Förster I, Kastenmüller W, Kolanus W, Hölzel M, Gaffal E, Tüting T.

Nature. 2014 Mar 6;507(7490):109-13. doi: 10.1038/nature13111. Epub 2014 Feb 26.


How macrophages ring the inflammation alarm.

Bianchi ME, Manfredi AA.

Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):2866-7. doi: 10.1073/pnas.1324285111. Epub 2014 Feb 14. No abstract available.


A systematic nomenclature for the redox states of high mobility group box (HMGB) proteins.

Antoine DJ, Harris HE, Andersson U, Tracey KJ, Bianchi ME.

Mol Med. 2014 Mar 24;20:135-7. doi: 10.2119/molmed.2014.00022.


The receptor for advanced glycation end-products (RAGE) is only present in mammals, and belongs to a family of cell adhesion molecules (CAMs).

Sessa L, Gatti E, Zeni F, Antonelli A, Catucci A, Koch M, Pompilio G, Fritz G, Raucci A, Bianchi ME.

PLoS One. 2014 Jan 27;9(1):e86903. doi: 10.1371/journal.pone.0086903. eCollection 2014.


A simple model of NF-κB dynamics reproduces experimental observations.

Zambrano S, Bianchi ME, Agresti A.

J Theor Biol. 2014 Apr 21;347:44-53. doi: 10.1016/j.jtbi.2014.01.015. Epub 2014 Jan 18.


Killing cancer cells, twice with one shot.

Bianchi ME.

Cell Death Differ. 2014 Jan;21(1):1-2. doi: 10.1038/cdd.2013.147. No abstract available.


Music provided through a portable media player (iPod) blunts pain during physical therapy.

Bellieni CV, Cioncoloni D, Mazzanti S, Bianchi ME, Morrone I, Becattelli R, Perrone S, Buonocore G.

Pain Manag Nurs. 2013 Dec;14(4):e151-e155. doi: 10.1016/j.pmn.2011.09.003. Epub 2011 Nov 16.


Disulfide-containing high mobility group box-1 promotes N-methyl-D-aspartate receptor function and excitotoxicity by activating Toll-like receptor 4-dependent signaling in hippocampal neurons.

Balosso S, Liu J, Bianchi ME, Vezzani A.

Antioxid Redox Signal. 2014 Oct 20;21(12):1726-40. doi: 10.1089/ars.2013.5349. Epub 2014 Jan 3.


Oxidative stress elicits platelet/leukocyte inflammatory interactions via HMGB1: a candidate for microvessel injury in sytemic sclerosis.

Maugeri N, Rovere-Querini P, Baldini M, Baldissera E, Sabbadini MG, Bianchi ME, Manfredi AA.

Antioxid Redox Signal. 2014 Mar 1;20(7):1060-74. doi: 10.1089/ars.2013.5298. Epub 2014 Jan 17.


HuR and miR-1192 regulate myogenesis by modulating the translation of HMGB1 mRNA.

Dormoy-Raclet V, Cammas A, Celona B, Lian XJ, van der Giessen K, Zivojnovic M, Brunelli S, Riuzzi F, Sorci G, Wilhelm BT, Di Marco S, Donato R, Bianchi ME, Gallouzi IE.

Nat Commun. 2013;4:2388. doi: 10.1038/ncomms3388.


Receptor for Advanced Glycation Endproducts is upregulated in temporal lobe epilepsy and contributes to experimental seizures.

Iori V, Maroso M, Rizzi M, Iyer AM, Vertemara R, Carli M, Agresti A, Antonelli A, Bianchi ME, Aronica E, Ravizza T, Vezzani A.

Neurobiol Dis. 2013 Oct;58:102-14. doi: 10.1016/j.nbd.2013.03.006. Epub 2013 Mar 21.


HMGB1 and leukocyte migration during trauma and sterile inflammation.

Venereau E, Schiraldi M, Uguccioni M, Bianchi ME.

Mol Immunol. 2013 Aug;55(1):76-82. doi: 10.1016/j.molimm.2012.10.037. Epub 2012 Dec 1. Review.


Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release.

Venereau E, Casalgrandi M, Schiraldi M, Antoine DJ, Cattaneo A, De Marchis F, Liu J, Antonelli A, Preti A, Raeli L, Shams SS, Yang H, Varani L, Andersson U, Tracey KJ, Bachi A, Uguccioni M, Bianchi ME.

J Exp Med. 2012 Aug 27;209(9):1519-28. doi: 10.1084/jem.20120189. Epub 2012 Aug 6.

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