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Items: 40


Increased Genetic Instability and Accelerated Progression of Colitis-Associated Colorectal Cancer through Intestinal Epithelium-specific Deletion of Klf4.

Yang VW, Liu Y, Kim J, Shroyer KR, Bialkowska AB.

Mol Cancer Res. 2019 Jan;17(1):165-176. doi: 10.1158/1541-7786.MCR-18-0399. Epub 2018 Aug 14.


Krüppel-like factor 4 is a negative regulator of STAT3-induced glomerular epithelial cell proliferation.

Estrada CC, Paladugu P, Guo Y, Pace J, Revelo MP, Salant DJ, Shankland SJ, D'Agati VD, Mehrotra A, Cardona S, Bialkowska AB, Yang VW, He JC, Mallipattu SK.

JCI Insight. 2018 Jun 21;3(12). pii: 98214. doi: 10.1172/jci.insight.98214. eCollection 2018 Jun 21.


Krüppel-like Factor 5, Increased in Pancreatic Ductal Adenocarcinoma, Promotes Proliferation, Acinar-to-Ductal Metaplasia, Pancreatic Intraepithelial Neoplasia, and Tumor Growth in Mice.

He P, Yang JW, Yang VW, Bialkowska AB.

Gastroenterology. 2018 Apr;154(5):1494-1508.e13. doi: 10.1053/j.gastro.2017.12.005. Epub 2017 Dec 15.


Krüppel-like factor 5 is essential for maintenance of barrier function in mouse colon.

Liu Y, Chidgey M, Yang VW, Bialkowska AB.

Am J Physiol Gastrointest Liver Physiol. 2017 Nov 1;313(5):G478-G491. doi: 10.1152/ajpgi.00172.2017. Epub 2017 Sep 1.


The loss of Krüppel-like factor 15 in Foxd1+ stromal cells exacerbates kidney fibrosis.

Gu X, Mallipattu SK, Guo Y, Revelo MP, Pace J, Miller T, Gao X, Jain MK, Bialkowska AB, Yang VW, He JC, Mei C.

Kidney Int. 2017 Nov;92(5):1178-1193. doi: 10.1016/j.kint.2017.03.037. Epub 2017 Jun 24.


Novel sphingosine kinase-1 inhibitor, LCL351, reduces immune responses in murine DSS-induced colitis.

Pulkoski-Gross MJ, Uys JD, Orr-Gandy KA, Coant N, Bialkowska AB, Szulc ZM, Bai A, Bielawska A, Townsend DM, Hannun YA, Obeid LM, Snider AJ.

Prostaglandins Other Lipid Mediat. 2017 May;130:47-56. doi: 10.1016/j.prostaglandins.2017.03.006. Epub 2017 Apr 2.


SP and KLF Transcription Factors in Digestive Physiology and Diseases.

Kim CK, He P, Bialkowska AB, Yang VW.

Gastroenterology. 2017 Jun;152(8):1845-1875. doi: 10.1053/j.gastro.2017.03.035. Epub 2017 Mar 30. Review.


Krüppel-like factors in mammalian stem cells and development.

Bialkowska AB, Yang VW, Mallipattu SK.

Development. 2017 Mar 1;144(5):737-754. doi: 10.1242/dev.145441. Review.


The Role of Intestinal Stem Cells in Epithelial Regeneration Following Radiation-Induced Gut Injury.

Kim CK, Yang VW, Bialkowska AB.

Curr Stem Cell Rep. 2017;3(4):320-332. doi: 10.1007/s40778-017-0103-7. Epub 2017 Oct 5. Review.


Epithelial derived-matrix metalloproteinase (MMP9) exhibits a novel defensive role of tumor suppressor in colitis associated cancer by activating MMP9-Notch1-ARF-p53 axis.

Walter L, Pujada A, Bhatnagar N, Bialkowska AB, Yang VW, Laroui H, Garg P.

Oncotarget. 2017 Jan 3;8(1):364-378. doi: 10.18632/oncotarget.13406.


Intestinal stem cell resurgence by enterocyte precursors.

Kim CK, Bialkowska AB, Yang VW.

Stem Cell Investig. 2016 Sep 23;3:49. eCollection 2016. No abstract available.


Role of neutral ceramidase in colon cancer.

García-Barros M, Coant N, Kawamori T, Wada M, Snider AJ, Truman JP, Wu BX, Furuya H, Clarke CJ, Bialkowska AB, Ghaleb A, Yang VW, Obeid LM, Hannun YA.

FASEB J. 2016 Dec;30(12):4159-4171. Epub 2016 Sep 8.


Improved Swiss-rolling Technique for Intestinal Tissue Preparation for Immunohistochemical and Immunofluorescent Analyses.

Bialkowska AB, Ghaleb AM, Nandan MO, Yang VW.

J Vis Exp. 2016 Jul 13;(113). doi: 10.3791/54161.


Krüppel-Like Factor 15 Mediates Glucocorticoid-Induced Restoration of Podocyte Differentiation Markers.

Mallipattu SK, Guo Y, Revelo MP, Roa-Peña L, Miller T, Ling J, Shankland SJ, Bialkowska AB, Ly V, Estrada C, Jain MK, Lu Y, Ma'ayan A, Mehrotra A, Yacoub R, Nord EP, Woroniecki RP, Yang VW, He JC.

J Am Soc Nephrol. 2017 Jan;28(1):166-184. doi: 10.1681/ASN.2015060672. Epub 2016 Jun 10.


Krüppel-like Factor 4 Modulates Development of BMI1(+) Intestinal Stem Cell-Derived Lineage Following γ-Radiation-Induced Gut Injury in Mice.

Kuruvilla JG, Kim CK, Ghaleb AM, Bialkowska AB, Kuo CJ, Yang VW.

Stem Cell Reports. 2016 Jun 14;6(6):815-824. doi: 10.1016/j.stemcr.2016.04.014. Epub 2016 May 26.


Murine Model for Colitis-Associated Cancer of the Colon.

Snider AJ, Bialkowska AB, Ghaleb AM, Yang VW, Obeid LM, Hannun YA.

Methods Mol Biol. 2016;1438:245-54. doi: 10.1007/978-1-4939-3661-8_14. Review.


Alkaline ceramidase 3 deficiency aggravates colitis and colitis-associated tumorigenesis in mice by hyperactivating the innate immune system.

Wang K, Xu R, Snider AJ, Schrandt J, Li Y, Bialkowska AB, Li M, Zhou J, Hannun YA, Obeid LM, Yang VW, Mao C.

Cell Death Dis. 2016 Mar 3;7:e2124. doi: 10.1038/cddis.2016.36.


KLF4 Suppresses Tumor Formation in Genetic and Pharmacological Mouse Models of Colonic Tumorigenesis.

Ghaleb AM, Elkarim EA, Bialkowska AB, Yang VW.

Mol Cancer Res. 2016 Apr;14(4):385-96. doi: 10.1158/1541-7786.MCR-15-0410. Epub 2016 Feb 2.


ML264, A Novel Small-Molecule Compound That Potently Inhibits Growth of Colorectal Cancer.

Ruiz de Sabando A, Wang C, He Y, García-Barros M, Kim J, Shroyer KR, Bannister TD, Yang VW, Bialkowska AB.

Mol Cancer Ther. 2016 Jan;15(1):72-83. doi: 10.1158/1535-7163.MCT-15-0600. Epub 2015 Nov 30.


Role of Krüppel-like factor 5 in the maintenance of the stem cell niche in the intestinal crypt.

Kuruvilla JG, Ghaleb AM, Bialkowska AB, Nandan MO, Yang VW.

Stem Cell Transl Investig. 2015;2(2). pii: e839.


IQ Motif-Containing GTPase-Activating Protein 2 (IQGAP2) Is a Novel Regulator of Colonic Inflammation in Mice.

Ghaleb AM, Bialkowska AB, Snider AJ, Gnatenko DV, Hannun YA, Yang VW, Schmidt VA.

PLoS One. 2015 Jun 5;10(6):e0129314. doi: 10.1371/journal.pone.0129314. eCollection 2015.


Krüppel-like factor 6 regulates mitochondrial function in the kidney.

Mallipattu SK, Horne SJ, D'Agati V, Narla G, Liu R, Frohman MA, Dickman K, Chen EY, Ma'ayan A, Bialkowska AB, Ghaleb AM, Nandan MO, Jain MK, Daehn I, Chuang PY, Yang VW, He JC.

J Clin Invest. 2015 Mar 2;125(3):1347-61. doi: 10.1172/JCI77084. Epub 2015 Feb 17.


Krüppel-like factor 5 is essential for proliferation and survival of mouse intestinal epithelial stem cells.

Nandan MO, Ghaleb AM, Bialkowska AB, Yang VW.

Stem Cell Res. 2015 Jan;14(1):10-9. doi: 10.1016/j.scr.2014.10.008. Epub 2014 Nov 6.


Krüppel-like factor 4 is a radioprotective factor for the intestine following γ-radiation-induced gut injury in mice.

Talmasov D, Xinjun Z, Yu B, Nandan MO, Bialkowska AB, Elkarim E, Kuruvilla J, Yang VW, Ghaleb AM.

Am J Physiol Gastrointest Liver Physiol. 2015 Jan 15;308(2):G121-38. doi: 10.1152/ajpgi.00080.2014. Epub 2014 Nov 20.


Establishment of highly tumorigenic human colorectal cancer cell line (CR4) with properties of putative cancer stem cells.

Rowehl RA, Burke S, Bialkowska AB, Pettet DW 3rd, Rowehl L, Li E, Antoniou E, Zhang Y, Bergamaschi R, Shroyer KR, Ojima I, Botchkina GI.

PLoS One. 2014 Jun 12;9(6):e99091. doi: 10.1371/journal.pone.0099091. eCollection 2014.


Inducible intestine-specific deletion of Krüppel-like factor 5 is characterized by a regenerative response in adult mouse colon.

Nandan MO, Ghaleb AM, Liu Y, Bialkowska AB, McConnell BB, Shroyer KR, Robine S, Yang VW.

Dev Biol. 2014 Mar 15;387(2):191-202. doi: 10.1016/j.ydbio.2014.01.002. Epub 2014 Jan 15.


Prostate cancer stem cell-targeted efficacy of a new-generation taxoid, SBT-1214 and novel polyenolic zinc-binding curcuminoid, CMC2.24.

Botchkina GI, Zuniga ES, Rowehl RH, Park R, Bhalla R, Bialkowska AB, Johnson F, Golub LM, Zhang Y, Ojima I, Shroyer KR.

PLoS One. 2013 Sep 24;8(9):e69884. doi: 10.1371/journal.pone.0069884. eCollection 2013.


High-throughput screening strategies for targeted identification of therapeutic compounds in colorectal cancer.

Bialkowska AB, Yang VW.

Future Oncol. 2012 Mar;8(3):259-72. doi: 10.2217/fon.12.19. Review.


Chemoprevention of familial adenomatous polyposis by bromo-noscapine (EM011) in the Apc(Min/+) mouse model.

Li S, Ghaleb AM, He J, Bughani U, Bialkowska AB, Yang VW, Joshi HC.

Int J Cancer. 2012 Sep 15;131(6):1435-44. doi: 10.1002/ijc.27344. Epub 2012 Feb 9.


The E3 ubiquitin ligase SMAD ubiquitination regulatory factor 2 negatively regulates Krüppel-like factor 5 protein.

Du JX, Hagos EG, Nandan MO, Bialkowska AB, Yu B, Yang VW.

J Biol Chem. 2011 Nov 18;286(46):40354-64. doi: 10.1074/jbc.M111.258707. Epub 2011 Sep 27.


Identification of small-molecule inhibitors of the colorectal cancer oncogene Krüppel-like factor 5 expression by ultrahigh-throughput screening.

Bialkowska AB, Crisp M, Bannister T, He Y, Chowdhury S, Schürer S, Chase P, Spicer T, Madoux F, Tian C, Hodder P, Zaharevitz D, Yang VW.

Mol Cancer Ther. 2011 Nov;10(11):2043-51. doi: 10.1158/1535-7163.MCT-11-0550. Epub 2011 Sep 1.


Krüppel-like factor 5 protects against dextran sulfate sodium-induced colonic injury in mice by promoting epithelial repair.

McConnell BB, Kim SS, Bialkowska AB, Yu K, Sitaraman SV, Yang VW.

Gastroenterology. 2011 Feb;140(2):540-549.e2. doi: 10.1053/j.gastro.2010.10.061. Epub 2010 Nov 12.


Haploinsufficiency of Krüppel-like factor 5 rescues the tumor-initiating effect of the Apc(Min) mutation in the intestine.

McConnell BB, Bialkowska AB, Nandan MO, Ghaleb AM, Gordon FJ, Yang VW.

Cancer Res. 2009 May 15;69(10):4125-33. doi: 10.1158/0008-5472.CAN-08-4402. Epub 2009 May 12.


Identification of novel small-molecule compounds that inhibit the proproliferative Kruppel-like factor 5 in colorectal cancer cells by high-throughput screening.

Bialkowska AB, Du Y, Fu H, Yang VW.

Mol Cancer Ther. 2009 Mar;8(3):563-70. doi: 10.1158/1535-7163.MCT-08-0767. Epub 2009 Feb 24.


Mouse embryonic fibroblasts null for the Krüppel-like factor 4 gene are genetically unstable.

Hagos EG, Ghaleb AM, Dalton WB, Bialkowska AB, Yang VW.

Oncogene. 2009 Mar 5;28(9):1197-205. doi: 10.1038/onc.2008.465. Epub 2009 Jan 12.


Notch inhibits expression of the Krüppel-like factor 4 tumor suppressor in the intestinal epithelium.

Ghaleb AM, Aggarwal G, Bialkowska AB, Nandan MO, Yang VW.

Mol Cancer Res. 2008 Dec;6(12):1920-7. doi: 10.1158/1541-7786.MCR-08-0224.


SUMOylation regulates nuclear localization of Krüppel-like factor 5.

Du JX, Bialkowska AB, McConnell BB, Yang VW.

J Biol Chem. 2008 Nov 14;283(46):31991-2002. doi: 10.1074/jbc.M803612200. Epub 2008 Sep 9.


Krüppel-like factor 5 mediates cellular transformation during oncogenic KRAS-induced intestinal tumorigenesis.

Nandan MO, McConnell BB, Ghaleb AM, Bialkowska AB, Sheng H, Shao J, Babbin BA, Robine S, Yang VW.

Gastroenterology. 2008 Jan;134(1):120-30. Epub 2007 Oct 17.

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