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Items: 38

1.

Assessment of sigma-1 receptor occupancy in mice with non-radiolabelled FTC-146 as a tracer.

Bhyrapuneni G, Thentu JB, Mohammed AR, Aleti RR, Padala NP, Ajjala DR, Nirogi R.

J Recept Signal Transduct Res. 2018 Jun 18:1-9. doi: 10.1080/10799893.2018.1478855. [Epub ahead of print]

PMID:
29912606
2.

SUVN-502, a novel, potent, pure, and orally active 5-HT6 receptor antagonist: pharmacological, behavioral, and neurochemical characterization.

Nirogi R, Abraham R, Benade V, Medapati RB, Jayarajan P, Bhyrapuneni G, Muddana N, Mekala VR, Subramanian R, Shinde A, Kambhampati R, Jasti V.

Behav Pharmacol. 2018 May 29. doi: 10.1097/FBP.0000000000000414. [Epub ahead of print]

PMID:
29847336
3.

Safety, Tolerability and Pharmacokinetics of the Serotonin 5-HT6 Receptor Antagonist, SUVN-502, in Healthy Young Adults and Elderly Subjects.

Nirogi R, Mudigonda K, Bhyrapuneni G, Muddana NR, Goyal VK, Pandey SK, Palacharla RC.

Clin Drug Investig. 2018 May;38(5):401-415. doi: 10.1007/s40261-018-0618-4.

PMID:
29380267
4.

Simultaneous monitoring of electroencephalographic characteristics in animals subjected to behavioral tests: a preclinical investigation.

Nirogi R, Daripelli S, Benade V, Tirumalasetty C, Bhyrapuneni G, Jayarajan P.

Behav Pharmacol. 2017 Dec;28(8):661-669. doi: 10.1097/FBP.0000000000000364.

PMID:
29099402
5.

Mechanistic evaluation of tapentadol in reducing the pain perception using in-vivo brain and spinal cord microdialysis in rats.

Benade V, Nirogi R, Bhyrapuneni G, Daripelli S, Ayyanki G, Irappanavar S, Ponnamaneni R, Manoharan A.

Eur J Pharmacol. 2017 Aug 15;809:224-230. doi: 10.1016/j.ejphar.2017.04.013. Epub 2017 Apr 12.

PMID:
28412373
6.

Discovery and Development of 1-[(2-Bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1H-indole Dimesylate Monohydrate (SUVN-502): A Novel, Potent, Selective and Orally Active Serotonin 6 (5-HT6) Receptor Antagonist for Potential Treatment of Alzheimer's Disease.

Nirogi R, Shinde A, Kambhampati RS, Mohammed AR, Saraf SK, Badange RK, Bandyala TR, Bhatta V, Bojja K, Reballi V, Subramanian R, Benade V, Palacharla RC, Bhyrapuneni G, Jayarajan P, Goyal V, Jasti V.

J Med Chem. 2017 Mar 9;60(5):1843-1859. doi: 10.1021/acs.jmedchem.6b01662. Epub 2017 Feb 17.

PMID:
28212021
7.

Inhibition of cytochrome P450 enzymes by saturated and unsaturated fatty acids in human liver microsomes, characterization of enzyme kinetics in the presence of bovine serum albumin (0.1 and 1.0% w/v) and in vitro - in vivo extrapolation of hepatic clearance.

Palacharla RC, Uthukam V, Manoharan A, Ponnamaneni RK, Padala NP, Boggavarapu RK, Bhyrapuneni G, Ajjala DR, Nirogi R.

Eur J Pharm Sci. 2017 Apr 1;101:80-89. doi: 10.1016/j.ejps.2017.01.027. Epub 2017 Feb 4.

PMID:
28179134
8.

Simultaneous in-vivo receptor occupancy assays for serotonin 1A, 2A, and dopamine 2 receptors with the use of non-radiolabelled tracers: Proposed method in screening antipsychotics.

Thentu JB, Nirogi R, Bhyrapuneni G, Ajjala DR, Aleti RR, Palacharla RC.

J Pharmacol Toxicol Methods. 2017 May - Jun;85:22-28. doi: 10.1016/j.vascn.2017.01.001. Epub 2017 Jan 4.

PMID:
28063918
9.

Skin sample preparation by collagenase digestion for diclofenac quantification using LC-MS/MS after topical application.

Nirogi R, Padala NS, Boggavarapu RK, Kalaikadhiban I, Ajjala DR, Bhyrapuneni G, Muddana NR.

Bioanalysis. 2016 Jun;8(12):1251-63. doi: 10.4155/bio-2016-0031. Epub 2016 May 26.

PMID:
27226048
10.

Benzamide derivatives and their constrained analogs as histamine H3 receptor antagonists.

Nirogi R, Shinde A, Tiriveedhi V, Kota L, Saraf SK, Badange RK, Mohammed AR, Subramanian R, Muddana N, Bhyrapuneni G, Abraham R.

Eur J Med Chem. 2016 Jan 27;108:655-662. doi: 10.1016/j.ejmech.2015.12.005. Epub 2015 Dec 10.

PMID:
26731168
11.

5-HT6 receptor antagonist attenuates the memory deficits associated with neuropathic pain and improves the efficacy of gabapentinoids.

Jayarajan P, Nirogi R, Shinde A, Goura V, Babu VA, Yathavakilla S, Bhyrapuneni G.

Pharmacol Rep. 2015 Oct;67(5):934-42. doi: 10.1016/j.pharep.2015.03.013. Epub 2015 Apr 8.

PMID:
26398388
12.

Synthesis and SAR of Imidazo[1,5-a]pyridine derivatives as 5-HT4 receptor partial agonists for the treatment of cognitive disorders associated with Alzheimer's disease.

Nirogi R, Mohammed AR, Shinde AK, Bogaraju N, Gagginapalli SR, Ravella SR, Kota L, Bhyrapuneni G, Muddana NR, Benade V, Palacharla RC, Jayarajan P, Subramanian R, Goyal VK.

Eur J Med Chem. 2015 Oct 20;103:289-301. doi: 10.1016/j.ejmech.2015.08.051. Epub 2015 Sep 1.

PMID:
26363507
13.

Evaluation of metabolism dependent inhibition of CYP2B6 mediated bupropion hydroxylation in human liver microsomes by monoamine oxidase inhibitors and prediction of potential as perpetrators of drug interaction.

Nirogi R, Palacharla RC, Mohammed AR, Manoharan A, Ponnamaneni RK, Bhyrapuneni G.

Chem Biol Interact. 2015 Mar 25;230:9-20. doi: 10.1016/j.cbi.2015.01.028. Epub 2015 Feb 3.

PMID:
25656918
14.

Chemical inhibitors of CYP450 enzymes in liver microsomes: combining selectivity and unbound fractions to guide selection of appropriate concentration in phenotyping assays.

Nirogi R, Palacharla RC, Uthukam V, Manoharan A, Srikakolapu SR, Kalaikadhiban I, Boggavarapu RK, Ponnamaneni RK, Ajjala DR, Bhyrapuneni G.

Xenobiotica. 2015 Feb;45(2):95-106. doi: 10.3109/00498254.2014.945196. Epub 2014 Jul 29.

PMID:
25070627
15.

Identification of a suitable and selective inhibitor towards aldehyde oxidase catalyzed reactions.

Nirogi R, Kandikere V, Palacharla RC, Bhyrapuneni G, Kanamarlapudi VB, Ponnamaneni RK, Manoharan AK.

Xenobiotica. 2014 Mar;44(3):197-204. doi: 10.3109/00498254.2013.819594. Epub 2013 Oct 24.

PMID:
24156774
16.

LC-MS/MS method for the determination of pitolisant: application to rat pharmacokinetic and brain penetration studies.

Nirogi R, Ajjala DR, Kandikere V, Pantangi HR, Jonnala MR, Bhyrapuneni G, Muddana NR, Vurimindi H.

Biomed Chromatogr. 2013 Nov;27(11):1431-7. doi: 10.1002/bmc.2939. Epub 2013 Jun 13.

PMID:
23760876
17.

LC-MS/MS method for the quantification of almotriptan in dialysates: application to rat brain and blood microdialysis study.

Nirogi R, Ajjala DR, Kandikere V, Aleti R, Pantangi HR, Srikakolapu SR, Benade V, Bhyrapuneni G, Vurimindi H.

J Pharm Biomed Anal. 2013 Jul-Aug;81-82:160-7. doi: 10.1016/j.jpba.2013.04.008. Epub 2013 Apr 16.

PMID:
23666253
18.

In-vivo rat striatal 5-HT4 receptor occupancy using non-radiolabelled SB207145.

Nirogi R, Kandikere V, Bhyrapuneni G, Saralaya R, Ajjala DR, Aleti RR, Rasheed MA.

J Pharm Pharmacol. 2013 May;65(5):704-12. doi: 10.1111/jphp.12030. Epub 2013 Jan 25.

PMID:
23600388
19.

Aripiprazole in an animal model of chronic alcohol consumption and dopamine D₂ receptor occupancy in rats.

Nirogi R, Kandikere V, Jayarajan P, Bhyrapuneni G, Saralaya R, Muddana N, Abraham R.

Am J Drug Alcohol Abuse. 2013 Mar;39(2):72-9. doi: 10.3109/00952990.2012.730590.

PMID:
23421566
20.

A sensitive and selective quantification of catecholamine neurotransmitters in rat microdialysates by pre-column dansyl chloride derivatization using liquid chromatography-tandem mass spectrometry.

Nirogi R, Komarneni P, Kandikere V, Boggavarapu R, Bhyrapuneni G, Benade V, Gorentla S.

J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Jan 15;913-914:41-7. doi: 10.1016/j.jchromb.2012.09.034. Epub 2012 Sep 27.

PMID:
23270937
21.

LC-MS/MS method for the quantification of aldose reductase inhibitor-epalrestat and application to pharmacokinetic study.

Nirogi R, Kandikere V, Ajjala DR, Bhyrapuneni G, Muddana NR.

J Pharm Biomed Anal. 2013 Feb 23;74:227-34. doi: 10.1016/j.jpba.2012.10.020. Epub 2012 Oct 23.

PMID:
23245255
22.

Design, synthesis, and pharmacological evaluation of piperidin-4-yl amino aryl sulfonamides: novel, potent, selective, orally active, and brain penetrant 5-HT₆ receptor antagonists.

Nirogi R, Shinde A, Daulatabad A, Kambhampati R, Gudla P, Shaik M, Gampa M, Balasubramaniam S, Gangadasari P, Reballi V, Badange R, Bojja K, Subramanian R, Bhyrapuneni G, Muddana N, Jayarajan P.

J Med Chem. 2012 Nov 8;55(21):9255-69. doi: 10.1021/jm300955x. Epub 2012 Sep 28.

PMID:
23006002
23.

Approach to reduce the non-specific binding in microdialysis.

Nirogi R, Kandikere V, Bhyrapuneni G, Benade V, Saralaya R, Irappanavar S, Muddana N, Ajjala DR.

J Neurosci Methods. 2012 Aug 15;209(2):379-87. doi: 10.1016/j.jneumeth.2012.06.010. Epub 2012 Jun 23.

PMID:
22732212
24.

Pharmacokinetic profiling of efavirenz-emtricitabine-tenofovir fixed dose combination in pregnant and non-pregnant rats.

Nirogi R, Bhyrapuneni G, Kandikere V, Muddana N, Saralaya R, Komarneni P, Mudigonda K, Mukkanti K.

Biopharm Drug Dispos. 2012 Jul;33(5):265-77. doi: 10.1002/bdd.1794. Epub 2012 Jun 20.

PMID:
22610784
25.

Methyllycaconitine: a non-radiolabeled ligand for mapping α7 neuronal nicotinic acetylcholine receptors - in vivo target localization and biodistribution in rat brain.

Nirogi R, Kandikere V, Bhyrapuneni G, Saralaya R, Muddana N, Komarneni P.

J Pharmacol Toxicol Methods. 2012 Jul;66(1):22-8. doi: 10.1016/j.vascn.2012.05.003. Epub 2012 May 16.

PMID:
22609758
26.

Rat thalamic α₄β₂ neuronal nicotinic acetylcholine receptor occupancy assay using LC-MS/MS.

Nirogi R, Kandikere V, Bhyrapuneni G, Saralaya R, Muddana N, Ajjala DR.

J Pharmacol Toxicol Methods. 2012 May-Jun;65(3):136-41. doi: 10.1016/j.vascn.2012.04.007. Epub 2012 Apr 21.

PMID:
22546347
27.

In vivo receptor occupancy assay of histamine H₃ receptor antagonist in rats using non-radiolabeled tracer.

Nirogi R, Kandikere V, Bhyrapuneni G, Muddana N, Saralaya R, Ponnamaneni RK, Manoharan AK.

J Pharmacol Toxicol Methods. 2012 May-Jun;65(3):115-21. doi: 10.1016/j.vascn.2012.03.003. Epub 2012 Apr 1.

PMID:
22487318
28.

Difference in the norepinephrine levels of experimental and non-experimental rats with age in the object recognition task.

Nirogi R, Abraham R, Jayarajan P, Medapati RB, Shanmuganathan D, Kandikere V, Irappanavar S, Saralaya R, Benade V, Bhyrapuneni G, Muddana N.

Brain Res. 2012 May 9;1453:40-5. doi: 10.1016/j.brainres.2012.03.013. Epub 2012 Mar 13.

PMID:
22464882
29.

Exploring dried blood spot sampling technique for simultaneous quantification of antiretrovirals: lamivudine, stavudine and nevirapine in a rodent pharmacokinetic study.

Nirogi R, Kandikere V, Komarneni P, Aleti R, Padala N, Kalaikadhiban I, Bhyrapuneni G, Muddana N.

Biomed Chromatogr. 2012 Dec;26(12):1472-81. doi: 10.1002/bmc.2718. Epub 2012 Feb 16.

PMID:
22344535
30.

Concurrent administration of atypical antipsychotics and donepezil: drug interaction study in rats.

Nirogi R, Bhyrapuneni G, Kandikere V, Benade V, Muddana N, Saralaya R, Irappanavar S, Ponnamaneni R, Mukkanti K.

Eur J Drug Metab Pharmacokinet. 2012 Feb 3. [Epub ahead of print]

PMID:
22302541
31.

Effect of dimethyl sulfoxide on in vitro cytochrome P4501A2 mediated phenacetin O-deethylation in human liver microsomes.

Nirogi R, Kandikere V, Bhyrapuneni G, Ponnamaneni RK, Palacharla Rc, Manoharan A.

Drug Metab Dispos. 2011 Nov;39(11):2162-4. doi: 10.1124/dmd.111.041160. Epub 2011 Aug 8.

32.

Rigidized 1-aryl sulfonyl tryptamines: synthesis and pharmacological evaluation as 5-HT6 receptor ligands.

Nirogi R, Dwarampudi A, Kambhampati R, Bhatta V, Kota L, Shinde A, Badange R, Jayarajan P, Bhyrapuneni G, Dubey PK.

Bioorg Med Chem Lett. 2011 Aug 1;21(15):4577-80. doi: 10.1016/j.bmcl.2011.05.106. Epub 2011 Jun 6.

PMID:
21724392
33.

Quantification of methyllycaconitine, selective α7 nicotinic receptor antagonist, in rodent plasma and brain tissue by liquid chromatography tandem mass spectrometry--application to neuropharmacokinetics of methyllycaconitine in rats.

Nirogi R, Kandikere V, Komarneni P, Aleti R, Boggavarapu R, Bhyrapuneni G, Muddana N, Mukkanti K.

Biomed Chromatogr. 2011 Nov;25(11):1273-82. doi: 10.1002/bmc.1603. Epub 2011 Feb 18.

PMID:
21337354
34.

A simple and rapid method to collect the cerebrospinal fluid of rats and its application for the assessment of drug penetration into the central nervous system.

Nirogi R, Kandikere V, Mudigonda K, Bhyrapuneni G, Muddana N, Saralaya R, Benade V.

J Neurosci Methods. 2009 Mar 30;178(1):116-9. doi: 10.1016/j.jneumeth.2008.12.001. Epub 2008 Dec 6.

PMID:
19109998
36.

Sensitive liquid chromatography tandem mass spectrometry method for the quantification of Quetiapine in plasma.

Nirogi R, Bhyrapuneni G, Kandikere V, Mudigonda K, Ajjala D, Mukkanti K.

Biomed Chromatogr. 2008 Oct;22(10):1043-55. doi: 10.1002/bmc.1012.

PMID:
18781706
37.

Liquid chromatography tandem mass spectrometry method for the quantification of amisulpride with LLOQ of 100 pg/mL using 100 microL of plasma.

Nirogi R, Bhyrapuneni G, Kandikere V, Mudigonda K, Ajjala D, Suraneni R, Mukkanti K.

Biomed Chromatogr. 2008 Dec;22(12):1424-33. doi: 10.1002/bmc.1076.

PMID:
18655221
38.

Quantification of tenatoprazole in rat plasma by HPLC: validation and its application to pharmacokinetic studies.

Nirogi R, Kandikere V, Mudigonda K, Bhyrapuneni G.

Biomed Chromatogr. 2007 Dec;21(12):1240-4.

PMID:
17590865

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