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Translating preclinical MRI methods to clinical oncology.

Hormuth DA 2nd, Sorace AG, Virostko J, Abramson RG, Bhujwalla ZM, Enriquez-Navas P, Gillies R, Hazle JD, Mason RP, Quarles CC, Weis JA, Whisenant JG, Xu J, Yankeelov TE.

J Magn Reson Imaging. 2019 Mar 29. doi: 10.1002/jmri.26731. [Epub ahead of print] Review.


Molecular and functional imaging insights into the role of hypoxia in cancer aggression.

Kakkad S, Krishnamachary B, Jacob D, Pacheco-Torres J, Goggins E, Bharti SK, Penet MF, Bhujwalla ZM.

Cancer Metastasis Rev. 2019 Jun;38(1-2):51-64. doi: 10.1007/s10555-019-09788-3. Review.


Human Cancer Cell Membrane-Coated Biomimetic Nanoparticles Reduce Fibroblast-Mediated Invasion and Metastasis and Induce T-Cells.

Jin J, Krishnamachary B, Barnett JD, Chatterjee S, Chang D, Mironchik Y, Wildes F, Jaffee EM, Nimmagadda S, Bhujwalla ZM.

ACS Appl Mater Interfaces. 2019 Feb 27;11(8):7850-7861. doi: 10.1021/acsami.8b22309. Epub 2019 Feb 14.


MRI and MRS of intact perfused cancer cell metabolism, invasion, and stromal cell interactions.

Penet MF, Shah T, Wildes F, Krishnamachary B, Bharti SK, Pacheco-Torres J, Artemov D, Bhujwalla ZM.

NMR Biomed. 2019 Jan 28:e4053. doi: 10.1002/nbm.4053. [Epub ahead of print]


Hypoxia Patterns in Primary and Metastatic Prostate Cancer Environments.

Bharti SK, Kakkad S, Danhier P, Wildes F, Penet MF, Krishnamachary B, Bhujwalla ZM.

Neoplasia. 2019 Feb;21(2):239-246. doi: 10.1016/j.neo.2018.12.004. Epub 2019 Jan 10.


Ascites Volumes and the Ovarian Cancer Microenvironment.

Penet MF, Krishnamachary B, Wildes FB, Mironchik Y, Hung CF, Wu TC, Bhujwalla ZM.

Front Oncol. 2018 Dec 17;8:595. doi: 10.3389/fonc.2018.00595. eCollection 2018.


Choline Kinase Alpha Inhibition by EB-3D Triggers Cellular Senescence, Reduces Tumor Growth and Metastatic Dissemination in Breast Cancer.

Mariotto E, Viola G, Ronca R, Persano L, Aveic S, Bhujwalla ZM, Mori N, Accordi B, Serafin V, López-Cara LC, Bortolozzi R.

Cancers (Basel). 2018 Oct 22;10(10). pii: E391. doi: 10.3390/cancers10100391.


Optimized acriflavine-loaded lipid nanocapsules as a safe and effective delivery system to treat breast cancer.

Montigaud Y, Ucakar B, Krishnamachary B, Bhujwalla ZM, Feron O, Préat V, Danhier F, Gallez B, Danhier P.

Int J Pharm. 2018 Nov 15;551(1-2):322-328. doi: 10.1016/j.ijpharm.2018.09.034. Epub 2018 Sep 17.


Molecular causes of elevated phosphoethanolamine in breast and pancreatic cancer cells.

Shah T, Krishnamachary B, Wildes F, Wijnen JP, Glunde K, Bhujwalla ZM.

NMR Biomed. 2018 Aug;31(8):e3936. doi: 10.1002/nbm.3936. Epub 2018 Jun 21.


Hypoxia-Induced Reporter Genes with Different Half-Lives.

Krishnamachary B, Danhier P, Kakkad S, Bharti SK, Bhujwalla ZM.

Methods Mol Biol. 2018;1790:113-125. doi: 10.1007/978-1-4939-7860-1_9.


Theranostics and metabolotheranostics for precision medicine in oncology.

Bhujwalla ZM, Kakkad S, Chen Z, Jin J, Hapuarachchige S, Artemov D, Penet MF.

J Magn Reson. 2018 Jun;291:141-151. doi: 10.1016/j.jmr.2018.03.004. Epub 2018 Apr 26.


Metabolic consequences of HIF silencing in a triple negative human breast cancer xenograft.

Bharti SK, Mironchik Y, Wildes F, Penet MF, Goggins E, Krishnamachary B, Bhujwalla ZM.

Oncotarget. 2018 Feb 24;9(20):15326-15339. doi: 10.18632/oncotarget.24569. eCollection 2018 Mar 16.


Metabolomic characterization of experimental ovarian cancer ascitic fluid.

Bharti SK, Wildes F, Hung CF, Wu TC, Bhujwalla ZM, Penet MF.

Metabolomics. 2017 Oct;13. pii: 113. doi: 10.1007/s11306-017-1254-3. Epub 2017 Aug 24.


Acid-degradable Dextran as an Image Guided siRNA Carrier for COX-2 Downregulation.

Chen Z, Krishnamachary B, Penet MF, Bhujwalla ZM.

Theranostics. 2018 Jan 1;8(1):1-12. doi: 10.7150/thno.21052. eCollection 2018.


Hypoxia Inducible Factors Modify Collagen I Fibers in MDA-MB-231 Triple Negative Breast Cancer Xenografts.

Goggins E, Kakkad S, Mironchik Y, Jacob D, Wildes F, Krishnamachary B, Bhujwalla ZM.

Neoplasia. 2018 Feb;20(2):131-139. doi: 10.1016/j.neo.2017.11.010. Epub 2017 Dec 13.


Combined PET/MRI: Global Warming-Summary Report of the 6th International Workshop on PET/MRI, March 27-29, 2017, Tübingen, Germany.

Bailey DL, Pichler BJ, Gückel B, Antoch G, Barthel H, Bhujwalla ZM, Biskup S, Biswal S, Bitzer M, Boellaard R, Braren RF, Brendle C, Brindle K, Chiti A, la Fougère C, Gillies R, Goh V, Goyen M, Hacker M, Heukamp L, Knudsen GM, Krackhardt AM, Law I, Morris JC, Nikolaou K, Nuyts J, Ordonez AA, Pantel K, Quick HH, Riklund K, Sabri O, Sattler B, Troost EGC, Zaiss M, Zender L, Beyer T.

Mol Imaging Biol. 2018 Feb;20(1):4-20. doi: 10.1007/s11307-017-1123-5.


Molecular Effects of Doxorubicin on Choline Metabolism in Breast Cancer.

Cheng M, Rizwan A, Jiang L, Bhujwalla ZM, Glunde K.

Neoplasia. 2017 Aug;19(8):617-627. doi: 10.1016/j.neo.2017.05.004. Epub 2017 Jun 24.


Editorial: Exploring Cancer Metabolic Reprogramming through Molecular Imaging.

Podo F, Bhujwalla ZM, Iorio E.

Front Oncol. 2017 Apr 26;7:79. doi: 10.3389/fonc.2017.00079. eCollection 2017. No abstract available.


Delayed Progression of Lung Metastases Following Delivery of a Prodrug-activating Enzyme.

Dore-Savard L, Chen Z, Winnard PT Jr, Krishnamachary B, Raman V, Black ME, Bhujwalla ZM.

Anticancer Res. 2017 May;37(5):2195-2200.


Degradable Dextran Nanopolymer as a Carrier for Choline Kinase (ChoK) siRNA Cancer Therapy.

Chen Z, Krishnamachary B, Bhujwalla ZM.

Nanomaterials (Basel). 2016 Feb 22;6(2). pii: E34. doi: 10.3390/nano6020034.


Breast cancer cell cyclooxygenase-2 expression alters extracellular matrix structure and function and numbers of cancer associated fibroblasts.

Krishnamachary B, Stasinopoulos I, Kakkad S, Penet MF, Jacob D, Wildes F, Mironchik Y, Pathak AP, Solaiyappan M, Bhujwalla ZM.

Oncotarget. 2017 Mar 14;8(11):17981-17994. doi: 10.18632/oncotarget.14912.


Targeting Phospholipid Metabolism in Cancer.

Cheng M, Bhujwalla ZM, Glunde K.

Front Oncol. 2016 Dec 27;6:266. doi: 10.3389/fonc.2016.00266. eCollection 2016. Review.


The Tumor Microenvironment Modulates Choline and Lipid Metabolism.

Mori N, Wildes F, Takagi T, Glunde K, Bhujwalla ZM.

Front Oncol. 2016 Dec 22;6:262. doi: 10.3389/fonc.2016.00262. eCollection 2016.


A PSMA-targeted theranostic agent for photodynamic therapy.

Chen Y, Chatterjee S, Lisok A, Minn I, Pullambhatla M, Wharram B, Wang Y, Jin J, Bhujwalla ZM, Nimmagadda S, Mease RC, Pomper MG.

J Photochem Photobiol B. 2017 Feb;167:111-116. doi: 10.1016/j.jphotobiol.2016.12.018. Epub 2016 Dec 18.


The Angiogenic Secretome in VEGF overexpressing Breast Cancer Xenografts.

Dore-Savard L, Lee E, Kakkad S, Popel AS, Bhujwalla ZM.

Sci Rep. 2016 Dec 20;6:39460. doi: 10.1038/srep39460.


Effect of Pantethine on Ovarian Tumor Progression and Choline Metabolism.

Penet MF, Krishnamachary B, Wildes F, Mironchik Y, Mezzanzanica D, Podo F, de Reggi M, Gharib B, Bhujwalla ZM.

Front Oncol. 2016 Nov 16;6:244. eCollection 2016.


Structure and Function of a Prostate Cancer Dissemination-Permissive Extracellular Matrix.

Penet MF, Kakkad S, Pathak AP, Krishnamachary B, Mironchik Y, Raman V, Solaiyappan M, Bhujwalla ZM.

Clin Cancer Res. 2017 May 1;23(9):2245-2254. doi: 10.1158/1078-0432.CCR-16-1516. Epub 2016 Oct 31.


Magnetic Resonance Imaging and Spectroscopy in Cancer Theranostic Imaging.

Penet MF, Jin J, Chen Z, Bhujwalla ZM.

Top Magn Reson Imaging. 2016 Oct;25(5):215-221. Review.


Collagen fibers mediate MRI-detected water diffusion and anisotropy in breast cancers.

Kakkad S, Zhang J, Akhbardeh A, Jacob D, Krishnamachary B, Solaiyappan M, Jacobs MA, Raman V, Leibfritz D, Glunde K, Bhujwalla ZM.

Neoplasia. 2016 Oct;18(10):585-593. doi: 10.1016/j.neo.2016.08.004. Epub 2016 Sep 19.


Choline Metabolism Alteration: A Focus on Ovarian Cancer.

Bagnoli M, Granata A, Nicoletti R, Krishnamachary B, Bhujwalla ZM, Canese R, Podo F, Canevari S, Iorio E, Mezzanzanica D.

Front Oncol. 2016 Jun 22;6:153. doi: 10.3389/fonc.2016.00153. eCollection 2016. Review.


Targeting choline phospholipid metabolism: GDPD5 and GDPD6 silencing decrease breast cancer cell proliferation, migration, and invasion.

Cao MD, Cheng M, Rizwan A, Jiang L, Krishnamachary B, Bhujwalla ZM, Bathen TF, Glunde K.

NMR Biomed. 2016 Aug;29(8):1098-107. doi: 10.1002/nbm.3573. Epub 2016 Jun 30.


Phototheranostics of CD44-positive cell populations in triple negative breast cancer.

Jin J, Krishnamachary B, Mironchik Y, Kobayashi H, Bhujwalla ZM.

Sci Rep. 2016 Jun 15;6:27871. doi: 10.1038/srep27871.


Lymphatic endothelial cells actively regulate prostate cancer cell invasion.

Shah T, Wildes F, Kakkad S, Artemov D, Bhujwalla ZM.

NMR Biomed. 2016 Jul;29(7):904-11. doi: 10.1002/nbm.3543. Epub 2016 May 5.


Developing imidazoles as CEST MRI pH sensors.

Yang X, Song X, Ray Banerjee S, Li Y, Byun Y, Liu G, Bhujwalla ZM, Pomper MG, McMahon MT.

Contrast Media Mol Imaging. 2016 Jul;11(4):304-12. doi: 10.1002/cmmi.1693. Epub 2016 Apr 13.


A fully human CXCR4 antibody demonstrates diagnostic utility and therapeutic efficacy in solid tumor xenografts.

Azad BB, Chatterjee S, Lesniak WG, Lisok A, Pullambhatla M, Bhujwalla ZM, Pomper MG, Nimmagadda S.

Oncotarget. 2016 Mar 15;7(11):12344-58. doi: 10.18632/oncotarget.7111.


Detection of Pancreatic Cancer-Induced Cachexia Using a Fluorescent Myoblast Reporter System and Analysis of Metabolite Abundance.

Winnard PT Jr, Bharti SK, Penet MF, Marik R, Mironchik Y, Wildes F, Maitra A, Bhujwalla ZM.

Cancer Res. 2016 Mar 15;76(6):1441-50. doi: 10.1158/0008-5472.CAN-15-1740. Epub 2015 Dec 30.


PSMA-specific theranostic nanoplex for combination of TRAIL gene and 5-FC prodrug therapy of prostate cancer.

Chen Z, Penet MF, Krishnamachary B, Banerjee SR, Pomper MG, Bhujwalla ZM.

Biomaterials. 2016 Feb;80:57-67. doi: 10.1016/j.biomaterials.2015.11.048. Epub 2015 Dec 2.


Combining Optical Reporter Proteins with Different Half-lives to Detect Temporal Evolution of Hypoxia and Reoxygenation in Tumors.

Danhier P, Krishnamachary B, Bharti S, Kakkad S, Mironchik Y, Bhujwalla ZM.

Neoplasia. 2015 Dec;17(12):871-881. doi: 10.1016/j.neo.2015.11.007.


Effect of alginate microencapsulation on the catalytic efficiency and in vitro enzyme-prodrug therapeutic efficacy of cytosine deaminase and of recombinant E. coli expressing cytosine deaminase.

Funaro MG, Nemani KV, Chen Z, Bhujwalla ZM, Griswold KE, Gimi B.

J Microencapsul. 2016 Feb;33(1):64-70. doi: 10.3109/02652048.2015.1115902. Epub 2015 Dec 7.


Magnetic Resonance Spectroscopy of siRNA-Based Cancer Therapy.

Penet MF, Chen Z, Mori N, Krishnamachary B, Bhujwalla ZM.

Methods Mol Biol. 2016;1372:37-47. doi: 10.1007/978-1-4939-3148-4_3.


Choline kinase-α protein and phosphatidylcholine but not phosphocholine are required for breast cancer cell survival.

Mori N, Wildes F, Kakkad S, Jacob D, Solaiyappan M, Glunde K, Bhujwalla ZM.

NMR Biomed. 2015 Dec;28(12):1697-706. doi: 10.1002/nbm.3429. Epub 2015 Oct 27.


Breast cancer cell adhesome and degradome interact to drive metastasis.

Rizwan A, Cheng M, Bhujwalla ZM, Krishnamachary B, Jiang L, Glunde K.

NPJ Breast Cancer. 2015 Oct 28;1:15017. doi: 10.1038/npjbcancer.2015.17. eCollection 2015.


HIF isoforms have divergent effects on invasion, metastasis, metabolism and formation of lipid droplets.

Shah T, Krishnamachary B, Wildes F, Mironchik Y, Kakkad SM, Jacob D, Artemov D, Bhujwalla ZM.

Oncotarget. 2015 Sep 29;6(29):28104-19. doi: 10.18632/oncotarget.4612.


Synthesis and Evaluation of Gd(III) -Based Magnetic Resonance Contrast Agents for Molecular Imaging of Prostate-Specific Membrane Antigen.

Banerjee SR, Ngen EJ, Rotz MW, Kakkad S, Lisok A, Pracitto R, Pullambhatla M, Chen Z, Shah T, Artemov D, Meade TJ, Bhujwalla ZM, Pomper MG.

Angew Chem Int Ed Engl. 2015 Sep 7;54(37):10778-82. doi: 10.1002/anie.201503417. Epub 2015 Jul 23.


MALDI-Mass Spectrometric Imaging Revealing Hypoxia-Driven Lipids and Proteins in a Breast Tumor Model.

Jiang L, Chughtai K, Purvine SO, Bhujwalla ZM, Raman V, Paša-Tolić L, Heeren RMA, Glunde K.

Anal Chem. 2015 Jun 16;87(12):5947-5956. doi: 10.1021/ac504503x. Epub 2015 Jun 4.


Metastatic breast cancer cells in lymph nodes increase nodal collagen density.

Rizwan A, Bulte C, Kalaichelvan A, Cheng M, Krishnamachary B, Bhujwalla ZM, Jiang L, Glunde K.

Sci Rep. 2015 May 7;5:10002. doi: 10.1038/srep10002.


Choline metabolism-based molecular diagnosis of cancer: an update.

Glunde K, Penet MF, Jiang L, Jacobs MA, Bhujwalla ZM.

Expert Rev Mol Diagn. 2015 Jun;15(6):735-47. doi: 10.1586/14737159.2015.1039515. Epub 2015 Apr 28. Review.


Cancer cachexia, recent advances, and future directions.

Penet MF, Bhujwalla ZM.

Cancer J. 2015 Mar-Apr;21(2):117-22. doi: 10.1097/PPO.0000000000000100. Review.


Targeting Glutamine Metabolism in Breast Cancer with Aminooxyacetate.

Korangath P, Teo WW, Sadik H, Han L, Mori N, Huijts CM, Wildes F, Bharti S, Zhang Z, Santa-Maria CA, Tsai H, Dang CV, Stearns V, Bhujwalla ZM, Sukumar S.

Clin Cancer Res. 2015 Jul 15;21(14):3263-73. doi: 10.1158/1078-0432.CCR-14-1200. Epub 2015 Mar 26.


Global metabolic profile identifies choline kinase alpha as a key regulator of glutathione-dependent antioxidant cell defense in ovarian carcinoma.

Granata A, Nicoletti R, Perego P, Iorio E, Krishnamachary B, Benigni F, Ricci A, Podo F, Bhujwalla ZM, Canevari S, Bagnoli M, Mezzanzanica D.

Oncotarget. 2015 May 10;6(13):11216-30.

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