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Items: 19

1.

Photoactivable Glycolipid Antigens Generate Stable Conjugates with CD1d for Invariant Natural Killer T Cell Activation.

Veerapen N, Kharkwal SS, Jervis P, Bhowruth V, Besra AK, North SJ, Haslam SM, Dell A, Hobrath J, Quaid PJ, Moynihan PJ, Cox LR, Kharkwal H, Zauderer M, Besra GS, Porcelli SA.

Bioconjug Chem. 2018 Sep 19;29(9):3161-3173. doi: 10.1021/acs.bioconjchem.8b00484. Epub 2018 Aug 23.

PMID:
30085659
2.

Identification of a Potent Microbial Lipid Antigen for Diverse NKT Cells.

Wolf BJ, Tatituri RV, Almeida CF, Le Nours J, Bhowruth V, Johnson D, Uldrich AP, Hsu FF, Brigl M, Besra GS, Rossjohn J, Godfrey DI, Brenner MB.

J Immunol. 2015 Sep 15;195(6):2540-51. doi: 10.4049/jimmunol.1501019. Epub 2015 Aug 7.

3.

Recognition of microbial and mammalian phospholipid antigens by NKT cells with diverse TCRs.

Tatituri RV, Watts GF, Bhowruth V, Barton N, Rothchild A, Hsu FF, Almeida CF, Cox LR, Eggeling L, Cardell S, Rossjohn J, Godfrey DI, Behar SM, Besra GS, Brenner MB, Brigl M.

Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1827-32. doi: 10.1073/pnas.1220601110. Epub 2013 Jan 10.

4.

Structural basis of inhibition of Mycobacterium tuberculosis DprE1 by benzothiazinone inhibitors.

Batt SM, Jabeen T, Bhowruth V, Quill L, Lund PA, Eggeling L, Alderwick LJ, Fütterer K, Besra GS.

Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11354-9. doi: 10.1073/pnas.1205735109. Epub 2012 Jun 25.

5.

Saposins utilize two strategies for lipid transfer and CD1 antigen presentation.

León L, Tatituri RV, Grenha R, Sun Y, Barral DC, Minnaard AJ, Bhowruth V, Veerapen N, Besra GS, Kasmar A, Peng W, Moody DB, Grabowski GA, Brenner MB.

Proc Natl Acad Sci U S A. 2012 Mar 20;109(12):4357-64. doi: 10.1073/pnas.1200764109. Epub 2012 Feb 13.

6.

Innate and cytokine-driven signals, rather than microbial antigens, dominate in natural killer T cell activation during microbial infection.

Brigl M, Tatituri RV, Watts GF, Bhowruth V, Leadbetter EA, Barton N, Cohen NR, Hsu FF, Besra GS, Brenner MB.

J Exp Med. 2011 Jun 6;208(6):1163-77. doi: 10.1084/jem.20102555. Epub 2011 May 9.

7.

Identification of arylamine N-acetyltransferase inhibitors as an approach towards novel anti-tuberculars.

Westwood IM, Bhakta S, Russell AJ, Fullam E, Anderton MC, Kawamura A, Mulvaney AW, Vickers RJ, Bhowruth V, Besra GS, Lalvani A, Davies SG, Sim E.

Protein Cell. 2010 Jan;1(1):82-95. doi: 10.1007/s13238-010-0006-1. Epub 2010 Mar 18.

8.

Crystal structure of bovine CD1b3 with endogenously bound ligands.

Girardi E, Wang J, Mac TT, Versluis C, Bhowruth V, Besra G, Heck AJ, Van Rhijn I, Zajonc DM.

J Immunol. 2010 Jul 1;185(1):376-86. doi: 10.4049/jimmunol.1000042. Epub 2010 Jun 2.

9.

Novel generation mycobacterial adjuvant based on liposome-encapsulated monomycoloyl glycerol from Mycobacterium bovis bacillus Calmette-Guérin.

Andersen CA, Rosenkrands I, Olsen AW, Nordly P, Christensen D, Lang R, Kirschning C, Gomes JM, Bhowruth V, Minnikin DE, Besra GS, Follmann F, Andersen P, Agger EM.

J Immunol. 2009 Aug 15;183(4):2294-302. doi: 10.4049/jimmunol.0804091. Epub 2009 Jul 20.

10.

Adjuvant properties of a simplified C32 monomycolyl glycerol analogue.

Bhowruth V, Minnikin DE, Agger EM, Andersen P, Bramwell VW, Perrie Y, Besra GS.

Bioorg Med Chem Lett. 2009 Apr 1;19(7):2029-32. doi: 10.1016/j.bmcl.2009.02.027. Epub 2009 Feb 11.

PMID:
19251417
11.

A simple mycobacterial monomycolated glycerol lipid has potent immunostimulatory activity.

Andersen CS, Agger EM, Rosenkrands I, Gomes JM, Bhowruth V, Gibson KJ, Petersen RV, Minnikin DE, Besra GS, Andersen P.

J Immunol. 2009 Jan 1;182(1):424-32.

12.

Tuberculosis: a balanced diet of lipids and carbohydrates.

Bhowruth V, Alderwick LJ, Brown AK, Bhatt A, Besra GS.

Biochem Soc Trans. 2008 Aug;36(Pt 4):555-65. doi: 10.1042/BST0360555. Review.

PMID:
18631118
13.

Synthesis and biological evaluation of NAS-21 and NAS-91 analogues as potential inhibitors of the mycobacterial FAS-II dehydratase enzyme Rv0636.

Bhowruth V, Brown AK, Besra GS.

Microbiology. 2008 Jul;154(Pt 7):1866-75. doi: 10.1099/mic.0.2008/017434-0.

14.

New drugs and vaccines for drug-resistant Mycobacterium tuberculosis infections.

Dover LG, Bhatt A, Bhowruth V, Willcox BE, Besra GS.

Expert Rev Vaccines. 2008 May;7(4):481-97. doi: 10.1586/14760584.7.4.481. Review.

PMID:
18444894
15.

Flavonoid inhibitors as novel antimycobacterial agents targeting Rv0636, a putative dehydratase enzyme involved in Mycobacterium tuberculosis fatty acid synthase II.

Brown AK, Papaemmanouil A, Bhowruth V, Bhatt A, Dover LG, Besra GS.

Microbiology. 2007 Oct;153(Pt 10):3314-22.

PMID:
17906131
16.

Synthesis and biological evaluation of a C5-biphenyl thiolactomycin library.

Bhowruth V, Brown AK, Senior SJ, Snaith JS, Besra GS.

Bioorg Med Chem Lett. 2007 Oct 15;17(20):5643-6. Epub 2007 Aug 22.

PMID:
17766110
17.

Tuberculosis chemotherapy: recent developments and future perspectives.

Bhowruth V, Dover LG, Besra GS.

Prog Med Chem. 2007;45:169-203. Review. No abstract available.

PMID:
17280904
18.

EthA, a common activator of thiocarbamide-containing drugs acting on different mycobacterial targets.

Dover LG, Alahari A, Gratraud P, Gomes JM, Bhowruth V, Reynolds RC, Besra GS, Kremer L.

Antimicrob Agents Chemother. 2007 Mar;51(3):1055-63. Epub 2007 Jan 12.

19.

Symmetrical and unsymmetrical analogues of isoxyl; active agents against Mycobacterium tuberculosis.

Bhowruth V, Brown AK, Reynolds RC, Coxon GD, Mackay SP, Minnikin DE, Besra GS.

Bioorg Med Chem Lett. 2006 Sep 15;16(18):4743-7. Epub 2006 Jul 27.

PMID:
16875817

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