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Periodontal inflammation recruits distant metastatic breast cancer cells by increasing myeloid-derived suppressor cells.

Cheng R, Billet S, Liu C, Haldar S, Choudhury D, Tripathi M, Hav M, Merchant A, Hu T, Huang H, Zhou H, Bhowmick NA.

Oncogene. 2019 Nov 4. doi: 10.1038/s41388-019-1084-z. [Epub ahead of print]


Soluble CD105 is prognostic of disease recurrence in prostate cancer patients.

Placencio-Hickok VR, Madhav A, Kim S, Duong F, Angara B, Liu Z, Bhowmick NA.

Endocr Relat Cancer. 2019 Oct 1. pii: ERC-19-0370.R1. doi: 10.1530/ERC-19-0370. [Epub ahead of print]


Epigenetic changes in fibroblasts drive cancer metabolism and differentiation.

Mishra R, Haldar S, Suchanti S, Bhowmick NA.

Endocr Relat Cancer. 2019 Oct 1. pii: ERC-19-0347.R1. doi: 10.1530/ERC-19-0347. [Epub ahead of print] Review.


Pushing the Heart Over a KLF(15).

Gottlieb RA, Bhowmick NA.

J Am Coll Cardiol. 2019 Oct 8;74(14):1820-1822. doi: 10.1016/j.jacc.2019.08.021. No abstract available.


Visualization of Macropinocytosis in Prostate Fibroblasts.

Mishra R, Bhowmick NA.

Bio Protoc. 2019 May 20;9(10). pii: e3235. doi: 10.21769/BioProtoc.3235.


In Reply.

Brennen WN, Schweizer MT, Wang H, Bivalacqua TJ, Partin AW, Lim SJ, Chapman C, Abdallah R, Levy O, Bhowmick NA, Karp JM, De Marzo A, Isaacs JT, Denmeade SR.

Stem Cells Transl Med. 2019 Jul;8(7):739-740. doi: 10.1002/sctm.19-0068. Epub 2019 Mar 29. No abstract available.


Identification and characterization of small molecule inhibitors of the ubiquitin ligases Siah1/2 in melanoma and prostate cancer cells.

Feng Y, Sessions EH, Zhang F, Ban F, Placencio-Hickok V, Ma CT, Zeng FY, Pass I, Terry DB, Cadwell G, Bankston LA, Liddington RC, Chung TDY, Pinkerton AB, Sergienko E, Gleave M, Bhowmick NA, Jackson MR, Cherkasov A, Ronai ZA.

Cancer Lett. 2019 May 1;449:145-162. doi: 10.1016/j.canlet.2019.02.012. Epub 2019 Feb 14.


A Phase I Study to Assess the Safety and Cancer-Homing Ability of Allogeneic Bone Marrow-Derived Mesenchymal Stem Cells in Men with Localized Prostate Cancer.

Schweizer MT, Wang H, Bivalacqua TJ, Partin AW, Lim SJ, Chapman C, Abdallah R, Levy O, Bhowmick NA, Karp JM, De Marzo A, Isaacs JT, Brennen WN, Denmeade SR.

Stem Cells Transl Med. 2019 May;8(5):441-449. doi: 10.1002/sctm.18-0230. Epub 2019 Feb 8.


Heterogeneous cancer-associated fibroblast population potentiates neuroendocrine differentiation and castrate resistance in a CD105-dependent manner.

Kato M, Placencio-Hickok VR, Madhav A, Haldar S, Tripathi M, Billet S, Mishra R, Smith B, Rohena-Rivera K, Agarwal P, Duong F, Angara B, Hickok D, Liu Z, Bhowmick NA.

Oncogene. 2019 Jan;38(5):716-730. doi: 10.1038/s41388-018-0461-3. Epub 2018 Sep 3.


An Inhibitor of GSK3B and HDACs Kills Pancreatic Cancer Cells and Slows Pancreatic Tumor Growth and Metastasis in Mice.

Edderkaoui M, Chheda C, Soufi B, Zayou F, Hu RW, Ramanujan VK, Pan X, Boros LG, Tajbakhsh J, Madhav A, Bhowmick NA, Wang Q, Lewis M, Tuli R, Habtezion A, Murali R, Pandol SJ.

Gastroenterology. 2018 Dec;155(6):1985-1998.e5. doi: 10.1053/j.gastro.2018.08.028. Epub 2018 Aug 23.


Stromal epigenetic alterations drive metabolic and neuroendocrine prostate cancer reprogramming.

Mishra R, Haldar S, Placencio V, Madhav A, Rohena-Rivera K, Agarwal P, Duong F, Angara B, Tripathi M, Liu Z, Gottlieb RA, Wagner S, Posadas EM, Bhowmick NA.

J Clin Invest. 2018 Oct 1;128(10):4472-4484. doi: 10.1172/JCI99397. Epub 2018 Jul 26.


Notch inhibitor screening reveals an unexpected HES1 heterodimer.

Rohena-Rivera K, Bhowmick NA.

J Biol Chem. 2018 May 25;293(21):8295-8296. doi: 10.1074/jbc.H118.002880.


Antagonizing CD105 enhances radiation sensitivity in prostate cancer.

Madhav A, Andres A, Duong F, Mishra R, Haldar S, Liu Z, Angara B, Gottlieb R, Zumsteg ZS, Bhowmick NA.

Oncogene. 2018 Aug;37(32):4385-4397. doi: 10.1038/s41388-018-0278-0. Epub 2018 May 2.


Regulation of inside-out β1-integrin activation by CDCP1.

Pollan SG, Huang F, Sperger JM, Lang JM, Morrissey C, Cress AE, Chu CY, Bhowmick NA, You S, Freeman MR, Spassov DS, Moasser MM, Carter WG, Satapathy SR, Shah K, Knudsen BS.

Oncogene. 2018 May;37(21):2817-2836. doi: 10.1038/s41388-018-0142-2. Epub 2018 Mar 7.


Reduction of Circulating Cancer Cells and Metastases in Breast-Cancer Models by a Potent EphA2-Agonistic Peptide-Drug Conjugate.

Salem AF, Wang S, Billet S, Chen JF, Udompholkul P, Gambini L, Baggio C, Tseng HR, Posadas EM, Bhowmick NA, Pellecchia M.

J Med Chem. 2018 Mar 8;61(5):2052-2061. doi: 10.1021/acs.jmedchem.7b01837. Epub 2018 Feb 27.


Porphyromonas gingivalis-Derived Lipopolysaccharide Combines Hypoxia to Induce Caspase-1 Activation in Periodontitis.

Cheng R, Liu W, Zhang R, Feng Y, Bhowmick NA, Hu T.

Front Cell Infect Microbiol. 2017 Nov 14;7:474. doi: 10.3389/fcimb.2017.00474. eCollection 2017.


Modulation of cabozantinib efficacy by the prostate tumor microenvironment.

Tripathi M, Nandana S, Billet S, Cavassani KA, Mishra R, Chung LWK, Posadas EM, Bhowmick NA.

Oncotarget. 2017 Sep 23;8(50):87891-87902. doi: 10.18632/oncotarget.21248. eCollection 2017 Oct 20.


S-adenosylmethionine and methylthioadenosine inhibit cancer metastasis by targeting microRNA 34a/b-methionine adenosyltransferase 2A/2B axis.

Tomasi ML, Cossu C, Spissu Y, Floris A, Ryoo M, Iglesias-Ara A, Wang Q, Pandol SJ, Bhowmick NA, Seki E, Posadas EM, Lu SC.

Oncotarget. 2017 Aug 12;8(45):78851-78869. doi: 10.18632/oncotarget.20234. eCollection 2017 Oct 3.


MicroRNA applications for prostate, ovarian and breast cancer in the era of precision medicine.

Smith B, Agarwal P, Bhowmick NA.

Endocr Relat Cancer. 2017 May;24(5):R157-R172. doi: 10.1530/ERC-16-0525. Epub 2017 Mar 13. Review.


MYC Mediates Large Oncosome-Induced Fibroblast Reprogramming in Prostate Cancer.

Minciacchi VR, Spinelli C, Reis-Sobreiro M, Cavallini L, You S, Zandian M, Li X, Mishra R, Chiarugi P, Adam RM, Posadas EM, Viglietto G, Freeman MR, Cocucci E, Bhowmick NA, Di Vizio D.

Cancer Res. 2017 May 1;77(9):2306-2317. doi: 10.1158/0008-5472.CAN-16-2942. Epub 2017 Feb 15. Erratum in: Cancer Res. 2017 Jul 15;77(14 ):3961.


Bone Metastasis of Prostate Cancer Can Be Therapeutically Targeted at the TBX2-WNT Signaling Axis.

Nandana S, Tripathi M, Duan P, Chu CY, Mishra R, Liu C, Jin R, Yamashita H, Zayzafoon M, Bhowmick NA, Zhau HE, Matusik RJ, Chung LW.

Cancer Res. 2017 Mar 15;77(6):1331-1344. doi: 10.1158/0008-5472.CAN-16-0497. Epub 2017 Jan 20.


Histone deacetylase inhibitors mediate DNA damage repair in ameliorating hemorrhagic cystitis.

Haldar S, Dru C, Mishra R, Tripathi M, Duong F, Angara B, Fernandez A, Arditi M, Bhowmick NA.

Sci Rep. 2016 Dec 20;6:39257. doi: 10.1038/srep39257.


Role of EMT in Metastasis and Therapy Resistance.

Smith BN, Bhowmick NA.

J Clin Med. 2016 Jan 27;5(2). pii: E17. doi: 10.3390/jcm5020017. Review.


Cells Comprising the Prostate Cancer Microenvironment Lack Recurrent Clonal Somatic Genomic Aberrations.

Bianchi-Frias D, Basom R, Delrow JJ, Coleman IM, Dakhova O, Qu X, Fang M, Franco OE, Ericson NG, Bielas JH, Hayward SW, True L, Morrissey C, Brown L, Bhowmick NA, Rowley D, Ittmann M, Nelson PS.

Mol Cancer Res. 2016 Apr;14(4):374-84. doi: 10.1158/1541-7786.MCR-15-0330. Epub 2016 Jan 11.


Be resistant to apoptosis: a host factor from gingival fibroblasts.

Cheng R, Hu T, Bhowmick NA.

Cell Death Dis. 2015 Dec 3;6:e2009. doi: 10.1038/cddis.2015.350. No abstract available.


Myeloid-specific TGF-β signaling in bone promotes basic-FGF and breast cancer bone metastasis.

Meng X, Vander Ark A, Lee P, Hostetter G, Bhowmick NA, Matrisian LM, Williams BO, Miranti CK, Li X.

Oncogene. 2016 May 5;35(18):2370-8. doi: 10.1038/onc.2015.297. Epub 2015 Aug 17.


A Review: Phytochemicals Targeting JAK/STAT Signaling and IDO Expression in Cancer.

Arumuggam N, Bhowmick NA, Rupasinghe HP.

Phytother Res. 2015 Jun;29(6):805-17. doi: 10.1002/ptr.5327. Epub 2015 Mar 18. Review.


Inflammation and pyroptosis mediate muscle expansion in an interleukin-1β (IL-1β)-dependent manner.

Haldar S, Dru C, Choudhury D, Mishra R, Fernandez A, Biondi S, Liu Z, Shimada K, Arditi M, Bhowmick NA.

J Biol Chem. 2015 Mar 6;290(10):6574-83. doi: 10.1074/jbc.M114.617886. Epub 2015 Jan 16.


Gingival fibroblasts resist apoptosis in response to oxidative stress in a model of periodontal diseases.

Cheng R, Choudhury D, Liu C, Billet S, Hu T, Bhowmick NA.

Cell Death Discov. 2015 Nov 9;1:15046. doi: 10.1038/cddiscovery.2015.46. eCollection 2015.


Mechanisms of hemorrhagic cystitis.

Haldar S, Dru C, Bhowmick NA.

Am J Clin Exp Urol. 2014 Oct 2;2(3):199-208. eCollection 2014. Review.


A reciprocal role of prostate cancer on stromal DNA damage.

Banerjee J, Mishra R, Li X, Jackson RS 2nd, Sharma A, Bhowmick NA.

Oncogene. 2014 Oct 9;33(41):4924-31. doi: 10.1038/onc.2013.431. Epub 2013 Oct 21.


A comparison of Ku0063794, a dual mTORC1 and mTORC2 inhibitor, and temsirolimus in preclinical renal cell carcinoma models.

Zhang H, Berel D, Wang Y, Li P, Bhowmick NA, Figlin RA, Kim HL.

PLoS One. 2013;8(1):e54918. doi: 10.1371/journal.pone.0054918. Epub 2013 Jan 22.


Targeted delivery of paclitaxel to EphA2-expressing cancer cells.

Wang S, Noberini R, Stebbins JL, Das S, Zhang Z, Wu B, Mitra S, Billet S, Fernandez A, Bhowmick NA, Kitada S, Pasquale EB, Fisher PB, Pellecchia M.

Clin Cancer Res. 2013 Jan 1;19(1):128-37. doi: 10.1158/1078-0432.CCR-12-2654. Epub 2012 Nov 15.


Metastatic ability: adapting to a tissue site unseen.

Bhowmick NA.

Cancer Cell. 2012 Nov 13;22(5):563-4. doi: 10.1016/j.ccr.2012.10.011.


Large oncosomes in human prostate cancer tissues and in the circulation of mice with metastatic disease.

Di Vizio D, Morello M, Dudley AC, Schow PW, Adam RM, Morley S, Mulholland D, Rotinen M, Hager MH, Insabato L, Moses MA, Demichelis F, Lisanti MP, Wu H, Klagsbrun M, Bhowmick NA, Rubin MA, D'Souza-Schorey C, Freeman MR.

Am J Pathol. 2012 Nov;181(5):1573-84. doi: 10.1016/j.ajpath.2012.07.030. Epub 2012 Sep 27.


Sabutoclax, a Mcl-1 antagonist, inhibits tumorigenesis in transgenic mouse and human xenograft models of prostate cancer.

Jackson RS 2nd, Placzek W, Fernandez A, Ziaee S, Chu CY, Wei J, Stebbins J, Kitada S, Fritz G, Reed JC, Chung LW, Pellecchia M, Bhowmick NA.

Neoplasia. 2012 Jul;14(7):656-65.


Understanding the role of stromal fibroblasts in cancer progression.

Tripathi M, Billet S, Bhowmick NA.

Cell Adh Migr. 2012 May-Jun;6(3):231-5. doi: 10.4161/cam.20419. Epub 2012 May 1. Review.


Loss of TGF-β responsiveness in prostate stromal cells alters chemokine levels and facilitates the development of mixed osteoblastic/osteolytic bone lesions.

Li X, Sterling JA, Fan KH, Vessella RL, Shyr Y, Hayward SW, Matrisian LM, Bhowmick NA.

Mol Cancer Res. 2012 Apr;10(4):494-503. doi: 10.1158/1541-7786.MCR-11-0506. Epub 2012 Jan 30.


Yes-associated protein expression in head and neck squamous cell carcinoma nodal metastasis.

Ge L, Smail M, Meng W, Shyr Y, Ye F, Fan KH, Li X, Zhou HM, Bhowmick NA.

PLoS One. 2011;6(11):e27529. doi: 10.1371/journal.pone.0027529. Epub 2011 Nov 9.


Loss of epithelial oestrogen receptor α inhibits oestrogen-stimulated prostate proliferation and squamous metaplasia via in vivo tissue selective knockout models.

Chen M, Yeh CR, Chang HC, Vitkus S, Wen XQ, Bhowmick NA, Wolfe A, Yeh S.

J Pathol. 2012 Jan;226(1):17-27. doi: 10.1002/path.2949. Epub 2011 Nov 9.


Serum methionine metabolites are risk factors for metastatic prostate cancer progression.

Stabler S, Koyama T, Zhao Z, Martinez-Ferrer M, Allen RH, Luka Z, Loukachevitch LV, Clark PE, Wagner C, Bhowmick NA.

PLoS One. 2011;6(8):e22486. doi: 10.1371/journal.pone.0022486. Epub 2011 Aug 10.


Role for stromal heterogeneity in prostate tumorigenesis.

Kiskowski MA, Jackson RS 2nd, Banerjee J, Li X, Kang M, Iturregui JM, Franco OE, Hayward SW, Bhowmick NA.

Cancer Res. 2011 May 15;71(10):3459-70. doi: 10.1158/0008-5472.CAN-10-2999. Epub 2011 Mar 28.


Altered TGF-β signaling in a subpopulation of human stromal cells promotes prostatic carcinogenesis.

Franco OE, Jiang M, Strand DW, Peacock J, Fernandez S, Jackson RS 2nd, Revelo MP, Bhowmick NA, Hayward SW.

Cancer Res. 2011 Feb 15;71(4):1272-81. doi: 10.1158/0008-5472.CAN-10-3142. Epub 2011 Feb 8.


Mesenchymal stem cell recruitment and improved bladder function after bladder outlet obstruction: preliminary data.

Woo LL, Tanaka ST, Anumanthan G, Pope JC 4th, Thomas JC, Adams MC, Brock JW 3rd, Bhowmick NA.

J Urol. 2011 Mar;185(3):1132-8. doi: 10.1016/j.juro.2010.10.033. Epub 2011 Jan 21.


Bone marrow derived mesenchymal stem cells incorporate into the prostate during regrowth.

Placencio VR, Li X, Sherrill TP, Fritz G, Bhowmick NA.

PLoS One. 2010 Sep 23;5(9):e12920. doi: 10.1371/journal.pone.0012920.


Epithelial Hic-5/ARA55 expression contributes to prostate tumorigenesis and castrate responsiveness.

Li X, Martinez-Ferrer M, Botta V, Uwamariya C, Banerjee J, Bhowmick NA.

Oncogene. 2011 Jan 13;30(2):167-77. doi: 10.1038/onc.2010.400. Epub 2010 Sep 6.


Dermal transforming growth factor-beta responsiveness mediates wound contraction and epithelial closure.

Martinez-Ferrer M, Afshar-Sherif AR, Uwamariya C, de Crombrugghe B, Davidson JM, Bhowmick NA.

Am J Pathol. 2010 Jan;176(1):98-107. doi: 10.2353/ajpath.2010.090283. Epub 2009 Dec 3.


Recruitment of bone marrow derived cells to the bladder after bladder outlet obstruction.

Tanaka ST, Martinez-Ferrer M, Makari JH, Wills ML, Thomas JC, Adams MC, Brock JW 3rd, Pope JC 4th, Bhowmick NA.

J Urol. 2009 Oct;182(4 Suppl):1769-74. doi: 10.1016/j.juro.2009.02.081. Epub 2009 Aug 18.


Bladder stromal loss of transforming growth factor receptor II decreases fibrosis after bladder obstruction.

Anumanthan G, Tanaka ST, Adams CM, Thomas JC, Wills ML, Adams MC, Hayward SW, Matusik RJ, Bhowmick NA, Brock JW 3rd, Pope JC 4th.

J Urol. 2009 Oct;182(4 Suppl):1775-80. doi: 10.1016/j.juro.2009.05.126. Epub 2009 Aug 18.


Autoimmune pancreatitis results from loss of TGFbeta signalling in S100A4-positive dendritic cells.

Boomershine CS, Chamberlain A, Kendall P, Afshar-Sharif AR, Huang H, Washington MK, Lawson WE, Thomas JW, Blackwell TS, Bhowmick NA.

Gut. 2009 Sep;58(9):1267-74. doi: 10.1136/gut.2008.170779. Epub 2009 Jul 21.

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