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Mechanism of internalization of MDA-7/IL-24 protein and its cognate receptors following ligand-receptor docking.

Pradhan AK, Bhoopathi P, Talukdar S, Das SK, Emdad L, Sarkar D, Ivanov AI, Fisher PB.

Oncotarget. 2019 Aug 20;10(49):5103-5117. doi: 10.18632/oncotarget.27150. eCollection 2019 Aug 20.


Regulation of neuroblastoma migration, invasion, and in vivo metastasis by genetic and pharmacological manipulation of MDA-9/Syntenin.

Bhoopathi P, Pradhan AK, Bacolod MD, Emdad L, Sarkar D, Das SK, Fisher PB.

Oncogene. 2019 Oct;38(41):6781-6793. doi: 10.1038/s41388-019-0920-5. Epub 2019 Aug 12.


Recent insights into apoptosis and toxic autophagy: The roles of MDA-7/IL-24, a multidimensional anti-cancer therapeutic.

Emdad L, Bhoopathi P, Talukdar S, Pradhan AK, Sarkar D, Wang XY, Das SK, Fisher PB.

Semin Cancer Biol. 2019 Jul 26. pii: S1044-579X(19)30023-9. doi: 10.1016/j.semcancer.2019.07.013. [Epub ahead of print] Review.


Suppression of Prostate Cancer Pathogenesis Using an MDA-9/Syntenin (SDCBP) PDZ1 Small-Molecule Inhibitor.

Das SK, Kegelman TP, Pradhan AK, Shen XN, Bhoopathi P, Talukdar S, Maji S, Sarkar D, Emdad L, Fisher PB.

Mol Cancer Ther. 2019 Nov;18(11):1997-2007. doi: 10.1158/1535-7163.MCT-18-1019. Epub 2019 Jul 25.


Prevalence of Dental Anxiety Level in 6- to 12-Year- Old South Indian Children.

Kumar V, Goud EVSS, Turagam N, Mudrakola DP, Ealla KKR, Bhoopathi PH.

J Pharm Bioallied Sci. 2019 May;11(Suppl 2):S321-S324. doi: 10.4103/JPBS.JPBS_22_19.


MDA-7/IL-24 regulates the miRNA processing enzyme DICER through downregulation of MITF.

Pradhan AK, Bhoopathi P, Talukdar S, Scheunemann D, Sarkar D, Cavenee WK, Das SK, Emdad L, Fisher PB.

Proc Natl Acad Sci U S A. 2019 Mar 19;116(12):5687-5692. doi: 10.1073/pnas.1819869116. Epub 2019 Mar 6.


Dormancy and cancer stem cells: An enigma for cancer therapeutic targeting.

Talukdar S, Bhoopathi P, Emdad L, Das S, Sarkar D, Fisher PB.

Adv Cancer Res. 2019;141:43-84. doi: 10.1016/bs.acr.2018.12.002. Epub 2019 Jan 16.


Regulation of protective autophagy in anoikis-resistant glioma stem cells by SDCBP/MDA-9/Syntenin.

Talukdar S, Pradhan AK, Bhoopathi P, Shen XN, August LA, Windle JJ, Sarkar D, Furnari FB, Cavenee WK, Das SK, Emdad L, Fisher PB.

Autophagy. 2018;14(10):1845-1846. doi: 10.1080/15548627.2018.1502564. Epub 2018 Aug 17.


Recombinant MDA-7/IL24 Suppresses Prostate Cancer Bone Metastasis through Downregulation of the Akt/Mcl-1 Pathway.

Pradhan AK, Bhoopathi P, Talukdar S, Shen XN, Emdad L, Das SK, Sarkar D, Fisher PB.

Mol Cancer Ther. 2018 Sep;17(9):1951-1960. doi: 10.1158/1535-7163.MCT-17-1002. Epub 2018 Jun 22.


Cephalometric aspects of thalassemic children in the Indian subcontinent: A cross-sectional study.

Samba AA, Bhoopathi PH, Sundaram RM, Patil AK, Gupta BV, Rao VT.

Indian J Dent Res. 2018 May-Jun;29(3):286-290. doi: 10.4103/ijdr.IJDR_32_17.


Caries Assessment Spectrum and Treatment: Would It direct Future Epidemiological Surveys?

Bhoopathi PH, Voruganti S, Suma NS, Samudrala T, Kamath BV, Jahagirdar A.

J Contemp Dent Pract. 2018 May 1;19(5):546-553.


MDA-9/Syntenin regulates protective autophagy in anoikis-resistant glioma stem cells.

Talukdar S, Pradhan AK, Bhoopathi P, Shen XN, August LA, Windle JJ, Sarkar D, Furnari FB, Cavenee WK, Das SK, Emdad L, Fisher PB.

Proc Natl Acad Sci U S A. 2018 May 29;115(22):5768-5773. doi: 10.1073/pnas.1721650115. Epub 2018 May 14.


The MDA-9/Syntenin/IGF1R/STAT3 Axis Directs Prostate Cancer Invasion.

Das SK, Pradhan AK, Bhoopathi P, Talukdar S, Shen XN, Sarkar D, Emdad L, Fisher PB.

Cancer Res. 2018 Jun 1;78(11):2852-2863. doi: 10.1158/0008-5472.CAN-17-2992. Epub 2018 Mar 23.


Role of MDA-7/IL-24 a Multifunction Protein in Human Diseases.

Menezes ME, Bhoopathi P, Pradhan AK, Emdad L, Das SK, Guo C, Wang XY, Sarkar D, Fisher PB.

Adv Cancer Res. 2018;138:143-182. doi: 10.1016/bs.acr.2018.02.005. Epub 2018 Mar 2. Review.


Benzodiazepines for antipsychotic-induced tardive dyskinesia.

Bergman H, Bhoopathi PS, Soares-Weiser K.

Cochrane Database Syst Rev. 2018 Jan 20;1:CD000205. doi: 10.1002/14651858.CD000205.pub3. Review.


mda-7/IL-24 Mediates Cancer Cell-Specific Death via Regulation of miR-221 and the Beclin-1 Axis.

Pradhan AK, Talukdar S, Bhoopathi P, Shen XN, Emdad L, Das SK, Sarkar D, Fisher PB.

Cancer Res. 2017 Feb 15;77(4):949-959. doi: 10.1158/0008-5472.CAN-16-1731. Epub 2016 Dec 9.


Knockout of MDA-9/Syntenin (SDCBP) expression in the microenvironment dampens tumor-supporting inflammation and inhibits melanoma metastasis.

Das SK, Guo C, Pradhan AK, Bhoopathi P, Talukdar S, Shen XN, Emdad L, Subler MA, Windle JJ, Sarkar D, Wang XY, Fisher PB.

Oncotarget. 2016 Jul 26;7(30):46848-46861. doi: 10.18632/oncotarget.10040.


mda-7/IL-24 Induces Cell Death in Neuroblastoma through a Novel Mechanism Involving AIF and ATM.

Bhoopathi P, Lee N, Pradhan AK, Shen XN, Das SK, Sarkar D, Emdad L, Fisher PB.

Cancer Res. 2016 Jun 15;76(12):3572-82. doi: 10.1158/0008-5472.CAN-15-2959. Epub 2016 Apr 13.


The Quest for an Effective Treatment for an Intractable Cancer: Established and Novel Therapies for Pancreatic Adenocarcinoma.

Quinn BA, Lee NA, Kegelman TP, Bhoopathi P, Emdad L, Das SK, Pellecchia M, Sarkar D, Fisher PB.

Adv Cancer Res. 2015;127:283-306. doi: 10.1016/bs.acr.2015.04.009. Epub 2015 May 21. Review.


Pancreatic Cancer Combination Therapy Using a BH3 Mimetic and a Synthetic Tetracycline.

Quinn BA, Dash R, Sarkar S, Azab B, Bhoopathi P, Das SK, Emdad L, Wei J, Pellecchia M, Sarkar D, Fisher PB.

Cancer Res. 2015 Jun 1;75(11):2305-15. doi: 10.1158/0008-5472.CAN-14-3013.


Oral health related knowledge, attitude and practices among the primary health care workers of a district in India.

Bhoopathi PH, Reddy PR, Kotha A, Mancherla M, Boinapalli P, Samba A.

J Int Soc Prev Community Dent. 2014 Nov;4(Suppl 1):S11-7. doi: 10.4103/2231-0762.144563.


Targeting tumor invasion: the roles of MDA-9/Syntenin.

Kegelman TP, Das SK, Emdad L, Hu B, Menezes ME, Bhoopathi P, Wang XY, Pellecchia M, Sarkar D, Fisher PB.

Expert Opin Ther Targets. 2015 Jan;19(1):97-112. doi: 10.1517/14728222.2014.959495. Epub 2014 Sep 15. Review.


Pancreatic cancer-specific cell death induced in vivo by cytoplasmic-delivered polyinosine-polycytidylic acid.

Bhoopathi P, Quinn BA, Gui Q, Shen XN, Grossman SR, Das SK, Sarkar D, Fisher PB, Emdad L.

Cancer Res. 2014 Nov 1;74(21):6224-35. doi: 10.1158/0008-5472.CAN-14-0819. Epub 2014 Sep 9.


MDA-7/IL-24: multifunctional cancer killing cytokine.

Menezes ME, Bhatia S, Bhoopathi P, Das SK, Emdad L, Dasgupta S, Dent P, Wang XY, Sarkar D, Fisher PB.

Adv Exp Med Biol. 2014;818:127-53. doi: 10.1007/978-1-4471-6458-6_6. Review.


Enterovirus 2Apro targets MDA5 and MAVS in infected cells.

Feng Q, Langereis MA, Lork M, Nguyen M, Hato SV, Lanke K, Emdad L, Bhoopathi P, Fisher PB, Lloyd RE, van Kuppeveld FJ.

J Virol. 2014 Mar;88(6):3369-78. doi: 10.1128/JVI.02712-13. Epub 2014 Jan 3.


Novel mechanism of MDA-7/IL-24 cancer-specific apoptosis through SARI induction.

Dash R, Bhoopathi P, Das SK, Sarkar S, Emdad L, Dasgupta S, Sarkar D, Fisher PB.

Cancer Res. 2014 Jan 15;74(2):563-74. doi: 10.1158/0008-5472.CAN-13-1062. Epub 2013 Nov 26.


The secreted protein acidic and rich in cysteine (SPARC) induces endoplasmic reticulum stress leading to autophagy-mediated apoptosis in neuroblastoma.

Sailaja GS, Bhoopathi P, Gorantla B, Chetty C, Gogineni VR, Velpula KK, Gondi CS, Rao JS.

Int J Oncol. 2013 Jan;42(1):188-96. doi: 10.3892/ijo.2012.1678. Epub 2012 Oct 24.


Notch signaling regulates tumor-induced angiogenesis in SPARC-overexpressed neuroblastoma.

Gorantla B, Bhoopathi P, Chetty C, Gogineni VR, Sailaja GS, Gondi CS, Rao JS.

Angiogenesis. 2013 Jan;16(1):85-100. doi: 10.1007/s10456-012-9301-1. Epub 2012 Sep 6.


Selected approaches for rational drug design and high throughput screening to identify anti-cancer molecules.

Hedvat M, Emdad L, Das SK, Kim K, Dasgupta S, Thomas S, Hu B, Zhu S, Dash R, Quinn BA, Oyesanya RA, Kegelman TP, Sokhi UK, Sarkar S, Erdogan E, Menezes ME, Bhoopathi P, Wang XY, Pomper MG, Wei J, Wu B, Stebbins JL, Diaz PW, Reed JC, Pellecchia M, Sarkar D, Fisher PB.

Anticancer Agents Med Chem. 2012 Nov;12(9):1143-55. Review.


SPARC overexpression inhibits cell proliferation in neuroblastoma and is partly mediated by tumor suppressor protein PTEN and AKT.

Bhoopathi P, Gorantla B, Sailaja GS, Gondi CS, Gujrati M, Klopfenstein JD, Rao JS.

PLoS One. 2012;7(5):e36093. doi: 10.1371/journal.pone.0036093. Epub 2012 May 2.


SPARC mediates Src-induced disruption of actin cytoskeleton via inactivation of small GTPases Rho-Rac-Cdc42.

Bhoopathi P, Gondi CS, Gujrati M, Dinh DH, Lakka SS.

Cell Signal. 2011 Dec;23(12):1978-87. doi: 10.1016/j.cellsig.2011.07.008. Epub 2011 Jul 23.


SPARC stimulates neuronal differentiation of medulloblastoma cells via the Notch1/STAT3 pathway.

Bhoopathi P, Chetty C, Dontula R, Gujrati M, Dinh DH, Rao JS, Lakka SS.

Cancer Res. 2011 Jul 15;71(14):4908-19. doi: 10.1158/0008-5472.CAN-10-3395. Epub 2011 May 25.


Suppression of MMP-2 attenuates TNF-α induced NF-κB activation and leads to JNK mediated cell death in glioma.

Kesanakurti D, Chetty C, Bhoopathi P, Lakka SS, Gorantla B, Tsung AJ, Rao JS.

PLoS One. 2011 May 4;6(5):e19341. doi: 10.1371/journal.pone.0019341.


MMP-2 mediates mesenchymal stem cell tropism towards medulloblastoma tumors.

Bhoopathi P, Chetty C, Gogineni VR, Gujrati M, Dinh DH, Rao JS, Lakka SS.

Gene Ther. 2011 Jul;18(7):692-701. doi: 10.1038/gt.2011.14. Epub 2011 Mar 3.


uPAR/cathepsin B overexpression reverse angiogenesis by rescuing FAK phosphorylation in uPAR/cathepsin B down regulated meningioma.

Gupta R, Nalla AK, Gogineni VR, Chetty C, Bhoopathi P, Klopfenstein JD, Tsung AJ, Mohanam S, Rao JS.

PLoS One. 2011 Feb 11;6(2):e17123. doi: 10.1371/journal.pone.0017123.


Downregulation of uPA/uPAR inhibits intermittent hypoxia-induced epithelial-mesenchymal transition (EMT) in DAOY and D283 medulloblastoma cells.

Gupta R, Chetty C, Bhoopathi P, Lakka S, Mohanam S, Rao JS, Dinh DE.

Int J Oncol. 2011 Mar;38(3):733-44. doi: 10.3892/ijo.2010.883. Epub 2010 Dec 22.


Suppression of uPAR retards radiation-induced invasion and migration mediated by integrin β1/FAK signaling in medulloblastoma.

Nalla AK, Asuthkar S, Bhoopathi P, Gujrati M, Dinh DH, Rao JS.

PLoS One. 2010 Sep 24;5(9):e13006. doi: 10.1371/journal.pone.0013006.


Urokinase plasminogen activator receptor and/or matrix metalloproteinase-9 inhibition induces apoptosis signaling through lipid rafts in glioblastoma xenograft cells.

Chetty C, Lakka SS, Bhoopathi P, Gondi CS, Veeravalli KK, Fassett D, Klopfenstein JD, Dinh DH, Gujrati M, Rao JS.

Mol Cancer Ther. 2010 Sep;9(9):2605-17. doi: 10.1158/1535-7163.MCT-10-0245. Epub 2010 Aug 17.


Cathepsin B facilitates autophagy-mediated apoptosis in SPARC overexpressed primitive neuroectodermal tumor cells.

Bhoopathi P, Chetty C, Gujrati M, Dinh DH, Rao JS, Lakka S.

Cell Death Differ. 2010 Oct;17(10):1529-39. doi: 10.1038/cdd.2010.28. Epub 2010 Mar 26.


The effect of educational games on medical students' learning outcomes: a systematic review: BEME Guide No 14.

Akl EA, Pretorius RW, Sackett K, Erdley WS, Bhoopathi PS, Alfarah Z, Schünemann HJ.

Med Teach. 2010 Jan;32(1):16-27. doi: 10.3109/01421590903473969. Review.


The role of MMP-9 in the anti-angiogenic effect of secreted protein acidic and rich in cysteine.

Bhoopathi P, Chetty C, Gujrati M, Dinh DH, Rao JS, Lakka SS.

Br J Cancer. 2010 Feb 2;102(3):530-40. doi: 10.1038/sj.bjc.6605538. Epub 2010 Jan 19.


MMP-2 alters VEGF expression via alphaVbeta3 integrin-mediated PI3K/AKT signaling in A549 lung cancer cells.

Chetty C, Lakka SS, Bhoopathi P, Rao JS.

Int J Cancer. 2010 Sep 1;127(5):1081-95. doi: 10.1002/ijc.25134.


Ziprasidone versus other atypical antipsychotics for schizophrenia.

Komossa K, Rummel-Kluge C, Hunger H, Schwarz S, Bhoopathi PS, Kissling W, Leucht S.

Cochrane Database Syst Rev. 2009 Oct 7;(4):CD006627. doi: 10.1002/14651858.CD006627.pub2. Review.


Tissue inhibitor of metalloproteinase 3 suppresses tumor angiogenesis in matrix metalloproteinase 2-down-regulated lung cancer.

Chetty C, Lakka SS, Bhoopathi P, Kunigal S, Geiss R, Rao JS.

Cancer Res. 2008 Jun 15;68(12):4736-45. doi: 10.1158/0008-5472.CAN-07-6612.


Educational games for health professionals.

Akl EA, Sackett K, Pretorius R, Erdley S, Bhoopathi PS, Mustafa R, Schünemann HJ.

Cochrane Database Syst Rev. 2008 Jan 23;(1):CD006411. doi: 10.1002/14651858.CD006411.pub2. Review. Update in: Cochrane Database Syst Rev. 2013;1:CD006411.


Blockade of tumor growth due to matrix metalloproteinase-9 inhibition is mediated by sequential activation of beta1-integrin, ERK, and NF-kappaB.

Bhoopathi P, Chetty C, Kunigal S, Vanamala SK, Rao JS, Lakka SS.

J Biol Chem. 2008 Jan 18;283(3):1545-52. Epub 2007 Nov 8.


Educational games for mental health professionals: a Cochrane review.

Bhoopathi PS, Sheoran R, Adams CE.

Int J Psychiatr Nurs Res. 2007 May;12(3):1497-502. Review.


MMP-2 siRNA induced Fas/CD95-mediated extrinsic II apoptotic pathway in the A549 lung adenocarcinoma cell line.

Chetty C, Bhoopathi P, Lakka SS, Rao JS.

Oncogene. 2007 Dec 6;26(55):7675-83. Epub 2007 Jun 25.


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