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Role of Humoral Defense in Severe Asthma.

Bhavsar PK.

Am J Respir Crit Care Med. 2018 Jun 1;197(11):1369-1371. doi: 10.1164/rccm.201802-0288ED. No abstract available.


Life-threatening Medical Complications Due to Ovarian Hyperstimulation Syndrome: A Hidden Etiology.

Bhavsar PN, Padwal NJ, Bhide M, Ghagare SP, Joshi AR, Karnik ND.

J Assoc Physicians India. 2017 Nov;65(11):87-91.


Reduced suppressive effect of β2-adrenoceptor agonist on fibrocyte function in severe asthma.

Lo CY, Michaeloudes C, Bhavsar PK, Huang CD, Chang PJ, Wang CH, Kuo HP, Chung KF.

Respir Res. 2017 Nov 21;18(1):194. doi: 10.1186/s12931-017-0678-7.


Dealing with Stress: Defective Metabolic Adaptation in Chronic Obstructive Pulmonary Disease Pathogenesis.

Michaeloudes C, Bhavsar PK, Mumby S, Chung KF, Adcock IM.

Ann Am Thorac Soc. 2017 Nov;14(Supplement_5):S374-S382. doi: 10.1513/AnnalsATS.201702-153AW. Review.


Anterior Tibial Artery Perforator Plus Flaps: Role in Coverage of Posttumor Excision Defects Around the Knee Joint and Upper Leg.

Sahijwani H, Warikoo V, Salunke AA, Shah J, Bhavsar P, Wagh R, Pathak S.

Asia Pac J Oncol Nurs. 2017 Oct-Dec;4(4):342-347. doi: 10.4103/apjon.apjon_32_17.


Mesenchymal stem cells alleviate oxidative stress-induced mitochondrial dysfunction in the airways.

Li X, Michaeloudes C, Zhang Y, Wiegman CH, Adcock IM, Lian Q, Mak JCW, Bhavsar PK, Chung KF.

J Allergy Clin Immunol. 2018 May;141(5):1634-1645.e5. doi: 10.1016/j.jaci.2017.08.017. Epub 2017 Sep 11.


Intracellular interactions of umeclidinium and vilanterol in human airway smooth muscle.

Shaikh N, Johnson M, Hall DA, Chung KF, Riley JH, Worsley S, Bhavsar PK.

Int J Chron Obstruct Pulmon Dis. 2017 Jun 30;12:1903-1913. doi: 10.2147/COPD.S134420. eCollection 2017.


Airway Microbiota in Severe Asthma and Relationship to Asthma Severity and Phenotypes.

Zhang Q, Cox M, Liang Z, Brinkmann F, Cardenas PA, Duff R, Bhavsar P, Cookson W, Moffatt M, Chung KF.

PLoS One. 2016 Apr 14;11(4):e0152724. doi: 10.1371/journal.pone.0152724. eCollection 2016.


Defective sirtuin-1 increases IL-4 expression through acetylation of GATA-3 in patients with severe asthma.

Colley T, Mercado N, Kunori Y, Brightling C, Bhavsar PK, Barnes PJ, Ito K.

J Allergy Clin Immunol. 2016 May;137(5):1595-1597.e7. doi: 10.1016/j.jaci.2015.10.013. Epub 2015 Nov 25. No abstract available.


Oxidants induce a corticosteroid-insensitive phosphorylation of histone 3 at serine 10 in monocytes.

Marwick JA, Tudor C, Khorasani N, Michaeloudes C, Bhavsar PK, Chung KF.

PLoS One. 2015 Apr 23;10(4):e0124961. doi: 10.1371/journal.pone.0124961. eCollection 2015.


Reversal of corticosteroid insensitivity by p38 MAPK inhibition in peripheral blood mononuclear cells from COPD.

Khorasani N, Baker J, Johnson M, Chung KF, Bhavsar PK.

Int J Chron Obstruct Pulmon Dis. 2015 Feb 4;10:283-91. doi: 10.2147/COPD.S72403. eCollection 2015.


Increased phenotypic differentiation and reduced corticosteroid sensitivity of fibrocytes in severe asthma.

Lo CY, Michaeloudes C, Bhavsar PK, Huang CD, Wang CH, Kuo HP, Chung KF.

J Allergy Clin Immunol. 2015 May;135(5):1186-95.e1-6. doi: 10.1016/j.jaci.2014.10.031. Epub 2014 Dec 6.


Impaired nuclear translocation of the glucocorticoid receptor in corticosteroid-insensitive airway smooth muscle in severe asthma.

Chang PJ, Michaeloudes C, Zhu J, Shaikh N, Baker J, Chung KF, Bhavsar PK.

Am J Respir Crit Care Med. 2015 Jan 1;191(1):54-62. doi: 10.1164/rccm.201402-0314OC.


Sputum-to-serum hydrogen sulfide ratio in COPD.

Saito J, Mackay AJ, Rossios C, Gibeon D, Macedo P, Sinharay R, Bhavsar PK, Wedzicha JA, Chung KF.

Thorax. 2014 Oct;69(10):903-9. doi: 10.1136/thoraxjnl-2013-204868. Epub 2014 Jul 17.


Impaired macrophage phagocytosis of bacteria in severe asthma.

Liang Z, Zhang Q, Thomas CM, Chana KK, Gibeon D, Barnes PJ, Chung KF, Bhavsar PK, Donnelly LE.

Respir Res. 2014 Jun 27;15:72. doi: 10.1186/1465-9921-15-72.


Bromodomain and extraterminal proteins suppress NF-E2-related factor 2-mediated antioxidant gene expression.

Michaeloudes C, Mercado N, Clarke C, Bhavsar PK, Adcock IM, Barnes PJ, Chung KF.

J Immunol. 2014 May 15;192(10):4913-4920. doi: 10.4049/jimmunol.1301984. Epub 2014 Apr 14.


Utility of Serum Creatinine, Creatine Kinase and Urinary Myoglobin in Detecting Acute Renal Failure due to Rhabdomyolysis in Trauma and Electrical Burns Patients.

Bhavsar P, Rathod KJ, Rathod D, Chamania CS.

Indian J Surg. 2013 Feb;75(1):17-21. doi: 10.1007/s12262-012-0451-6. Epub 2012 Mar 22.


Effects of N-acetylcysteine in ozone-induced chronic obstructive pulmonary disease model.

Li F, Wiegman C, Seiffert JM, Zhu J, Clarke C, Chang Y, Bhavsar P, Adcock I, Zhang J, Zhou X, Chung KF.

PLoS One. 2013 Nov 18;8(11):e80782. doi: 10.1371/journal.pone.0080782. eCollection 2013.


Lipid-laden bronchoalveolar macrophages in asthma and chronic cough.

Gibeon D, Zhu J, Sogbesan A, Banya W, Rossios C, Saito J, Rocha JP, Hull JH, Menzies-Gow AN, Bhavsar PK, Chung KF.

Respir Med. 2014 Jan;108(1):71-7. doi: 10.1016/j.rmed.2013.10.005. Epub 2013 Oct 10.


Domiciliary diurnal variation of exhaled nitric oxide fraction for asthma control.

Saito J, Gibeon D, Macedo P, Menzies-Gow A, Bhavsar PK, Chung KF.

Eur Respir J. 2014 Feb;43(2):474-84. doi: 10.1183/09031936.00048513. Epub 2013 Aug 15.


A polymorphism affecting MYB binding within the promoter of the PDCD4 gene is associated with severe asthma in children.

Binia A, Van Stiphout N, Liang L, Michel S, Bhavsar PK, Fan Chung K, Brightling CE, Barnes PJ, Kabesch M, Bush A, Cookson WO, Moffatt MF.

Hum Mutat. 2013 Aug;34(8):1131-9. doi: 10.1002/humu.22340. Epub 2013 May 20.


Fast, variable system delay correction for spiral MRI.

Bhavsar PS, Zwart NR, Pipe JG.

Magn Reson Med. 2014 Feb;71(2):773-82. doi: 10.1002/mrm.24730.


Multifunctional finishing of cotton using chitosan extracted from bio-waste.

Teli MD, Sheikh J, Bhavsar P.

Int J Biol Macromol. 2013 Mar;54:125-30. doi: 10.1016/j.ijbiomac.2012.12.007. Epub 2012 Dec 13.


IL-22 suppresses IFN-γ-mediated lung inflammation in asthmatic patients.

Pennino D, Bhavsar PK, Effner R, Avitabile S, Venn P, Quaranta M, Marzaioli V, Cifuentes L, Durham SR, Cavani A, Eyerich K, Chung KF, Schmidt-Weber CB, Eyerich S.

J Allergy Clin Immunol. 2013 Feb;131(2):562-70. doi: 10.1016/j.jaci.2012.09.036. Epub 2012 Nov 19.


Sputum hydrogen sulfide as a novel biomarker of obstructive neutrophilic asthma.

Saito J, Zhang Q, Hui C, Macedo P, Gibeon D, Menzies-Gow A, Bhavsar PK, Chung KF.

J Allergy Clin Immunol. 2013 Jan;131(1):232-4.e1-3. doi: 10.1016/j.jaci.2012.10.005. Epub 2012 Nov 10. No abstract available.


Obesity-associated severe asthma represents a distinct clinical phenotype: analysis of the British Thoracic Society Difficult Asthma Registry Patient cohort according to BMI.

Gibeon D, Batuwita K, Osmond M, Heaney LG, Brightling CE, Niven R, Mansur A, Chaudhuri R, Bucknall CE, Rowe A, Guo Y, Bhavsar PK, Chung KF, Menzies-Gow A.

Chest. 2013 Feb 1;143(2):406-414. doi: 10.1378/chest.12-0872.


Corticosteroid insensitivity of chemokine expression in airway smooth muscle of patients with severe asthma.

Chang PJ, Bhavsar PK, Michaeloudes C, Khorasani N, Chung KF.

J Allergy Clin Immunol. 2012 Oct;130(4):877-85.e5. doi: 10.1016/j.jaci.2012.07.017. Epub 2012 Sep 1.


Analysis of Rho GTPase expression in T-ALL identifies RhoU as a target for Notch involved in T-ALL cell migration.

Bhavsar PJ, Infante E, Khwaja A, Ridley AJ.

Oncogene. 2013 Jan 10;32(2):198-208. doi: 10.1038/onc.2012.42. Epub 2012 Feb 20.


EMMPRIN (CD147) regulation of MMP-9 in bronchial epithelial cells in COPD.

Jouneau S, Khorasani N, DE Souza P, Macedo P, Zhu J, Bhavsar PK, Chung KF.

Respirology. 2011 May;16(4):705-12. doi: 10.1111/j.1440-1843.2011.01960.x.


The secrets women keep: intimate partner violence screening in the female trauma patient.

Hewitt LN, Bhavsar P, Phelan HA.

J Trauma. 2011 Feb;70(2):320-3. doi: 10.1097/TA.0b013e31820958d3.


TGF-β regulates Nox4, MnSOD and catalase expression, and IL-6 release in airway smooth muscle cells.

Michaeloudes C, Sukkar MB, Khorasani NM, Bhavsar PK, Chung KF.

Am J Physiol Lung Cell Mol Physiol. 2011 Feb;300(2):L295-304. doi: 10.1152/ajplung.00134.2010. Epub 2010 Dec 3.


Chromosome 17q21 SNP and severe asthma.

Binia A, Khorasani N, Bhavsar PK, Adcock I, Brightling CE, Chung KF, Cookson WO, Moffatt MF.

J Hum Genet. 2011 Jan;56(1):97-8. doi: 10.1038/jhg.2010.134. Epub 2010 Oct 28. No abstract available.


Inhibition of p38 MAPK-dependent bronchial contraction after ozone by corticosteroids.

Li F, Zhang M, Hussain F, Triantaphyllopoulos K, Clark AR, Bhavsar PK, Zhou X, Chung KF.

Eur Respir J. 2011 Apr;37(4):933-42. doi: 10.1183/09031936.00021110. Epub 2010 Aug 6.


Clenbuterol induces cardiac myocyte hypertrophy via paracrine signalling and fibroblast-derived IGF-1.

Bhavsar PK, Brand NJ, Felkin LE, Luther PK, Cullen ME, Yacoub MH, Barton PJ.

J Cardiovasc Transl Res. 2010 Dec;3(6):688-95. doi: 10.1007/s12265-010-9199-1. Epub 2010 Jun 25.


Corticosteroid suppression of lipoxin A4 and leukotriene B4 from alveolar macrophages in severe asthma.

Bhavsar PK, Levy BD, Hew MJ, Pfeffer MA, Kazani S, Israel E, Chung KF.

Respir Res. 2010 Jun 7;11:71. doi: 10.1186/1465-9921-11-71.


Transfusions and long-term functional outcomes in traumatic brain injury.

Warner MA, O'Keeffe T, Bhavsar P, Shringer R, Moore C, Harper C, Madden CJ, Sarode R, Gentilello LM, Diaz-Arrastia R.

J Neurosurg. 2010 Sep;113(3):539-46. doi: 10.3171/2009.12.JNS091337.


Effect of p38 MAPK inhibition on corticosteroid suppression of cytokine release in severe asthma.

Bhavsar P, Khorasani N, Hew M, Johnson M, Chung KF.

Eur Respir J. 2010 Apr;35(4):750-6. doi: 10.1183/09031936.00071309. Epub 2009 Oct 19.


Vav GEFs regulate macrophage morphology and adhesion-induced Rac and Rho activation.

Bhavsar PJ, Vigorito E, Turner M, Ridley AJ.

Exp Cell Res. 2009 Nov 15;315(19):3345-58. doi: 10.1016/j.yexcr.2009.08.010. Epub 2009 Aug 26.


Relative corticosteroid insensitivity of alveolar macrophages in severe asthma compared with non-severe asthma.

Bhavsar P, Hew M, Khorasani N, Torrego A, Barnes PJ, Adcock I, Chung KF.

Thorax. 2008 Sep;63(9):784-90. doi: 10.1136/thx.2007.090027. Epub 2008 May 20.


Steroid resistance in asthma: mechanisms and treatment options.

Adcock IM, Ford PA, Bhavsar P, Ahmad T, Chung KF.

Curr Allergy Asthma Rep. 2008 Apr;8(2):171-8. Review.


The role of histone deacetylases in asthma and allergic diseases.

Bhavsar P, Ahmad T, Adcock IM.

J Allergy Clin Immunol. 2008 Mar;121(3):580-4. doi: 10.1016/j.jaci.2007.12.1156. Epub 2008 Jan 30. Review.


Glucocorticoid suppression of CX3CL1 (fractalkine) by reduced gene promoter recruitment of NF-kappaB.

Bhavsar PK, Sukkar MB, Khorasani N, Lee KY, Chung KF.

FASEB J. 2008 Jun;22(6):1807-16. doi: 10.1096/fj.07-094235. Epub 2008 Jan 29.


Epigenetic regulation of airway inflammation.

Adcock IM, Tsaprouni L, Bhavsar P, Ito K.

Curr Opin Immunol. 2007 Dec;19(6):694-700. Epub 2007 Aug 27. Review.


Role of TLR2, TLR4, and MyD88 in murine ozone-induced airway hyperresponsiveness and neutrophilia.

Williams AS, Leung SY, Nath P, Khorasani NM, Bhavsar P, Issa R, Mitchell JA, Adcock IM, Chung KF.

J Appl Physiol (1985). 2007 Oct;103(4):1189-95. Epub 2007 Jul 12.


GRO-alpha regulation in airway smooth muscle by IL-1beta and TNF-alpha: role of NF-kappaB and MAP kinases.

Issa R, Xie S, Lee KY, Stanbridge RD, Bhavsar P, Sukkar MB, Chung KF.

Am J Physiol Lung Cell Mol Physiol. 2006 Jul;291(1):L66-74. Epub 2006 Apr 14.


Relative corticosteroid insensitivity of peripheral blood mononuclear cells in severe asthma.

Hew M, Bhavsar P, Torrego A, Meah S, Khorasani N, Barnes PJ, Adcock I, Chung KF.

Am J Respir Crit Care Med. 2006 Jul 15;174(2):134-41. Epub 2006 Apr 13.


Induction and regulation of matrix metalloproteinase-12 in human airway smooth muscle cells.

Xie S, Issa R, Sukkar MB, Oltmanns U, Bhavsar PK, Papi A, Caramori G, Adcock I, Chung KF.

Respir Res. 2005 Dec 16;6:148.


Vav1 and Vav2 play different roles in macrophage migration and cytoskeletal organization.

Wells CM, Bhavsar PJ, Evans IR, Vigorito E, Turner M, Tybulewicz V, Ridley AJ.

Exp Cell Res. 2005 Nov 1;310(2):303-10. Epub 2005 Aug 31.


Phenylephrine requires the TATA box to activate transcription of GLUT1 in neonatal rat cardiac myocytes.

Santalucía T, Sánchez-Feutrie M, Felkin LE, Bhavsar PK, Barton PJ, Zorzano A, Yacoub MH, Brand NJ.

J Mol Cell Cardiol. 2005 Apr;38(4):677-84.


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